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Kaya B, Çiftçi HN, Çelebi Z, Yılmaz O, Şerbetçioğlu MB. Evaluation of the effect of the menstrual cycle on hearing. HEARING, BALANCE AND COMMUNICATION 2022. [DOI: 10.1080/21695717.2022.2148991] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
Affiliation(s)
- Beyza Kaya
- Department of Audiology, Istanbul Medipol University, Beykoz, İstanbul
| | | | - Zehra Çelebi
- Department of Audiology, Istanbul Medipol University, Beykoz, İstanbul
| | - Oğuz Yılmaz
- Department of Audiology, Istanbul Medipol University, Beykoz, İstanbul
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Lyu YL, Zeng FQ, Zhou Z, Yan M, Zhang W, Liu M, Ke ZY. Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy. World J Clin Cases 2020; 8:4051-4058. [PMID: 33024762 PMCID: PMC7520784 DOI: 10.12998/wjcc.v8.i18.4051] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/11/2020] [Revised: 06/23/2020] [Accepted: 08/12/2020] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND As sudden sensorineural hearing loss (SSNHL) rarely occurs in pregnant women, there is a lack of knowledge and relevant research on its management.
AIM To investigate the effect of intratympanic dexamethasone injection in the treatment of pregnant patients with SSNHL.
METHODS A retrospective chart review was made for the period between June 2017 and August 2019 at our Department of Otorhinolaryngology-Head and Neck Surgery. Pregnant women who met the criteria for SSNHL were included and grouped based on the therapeutic modalities. The treatment group received intratympanic dexamethasone (2.5 mg) q.o.d. for a total of four times, while the control group received no medication other than bed rest and medical observations. All the patients were under close care of obstetricians. Pure-tone audiograms were performed before and after treatment.
RESULTS Eleven patients who met the inclusion criteria were assigned to the treatment group (n = 7) and the control group (n = 4). The mean age of patients was 31.2 ± 3.8 years; the right ear was affected in seven (63.64%) cases. Two patients (18.2%) suffered from vertigo, 10 (90.9%) suffered from tinnitus and 6 (54.5%) suffered from aural fullness. The time from onset to clinic visit was relatively short, with a mean time of 1.3 ± 0.9 d. All the women were within the second or third trimester; the average gestation period was 26.0 ± 6.2 wk. The pure-tone averages at onset between the two groups were similar. After one wk of therapy, the treatment group had a curative rate of 57.1% and a significantly better hearing threshold and greater improvement compared to the control group (all P < 0.05). Some patients experienced transient discomfort from intratympanic injections that disappeared after getting rest, while none had permanent complications. All patients delivered healthy full-term neonates with an average Apgar score of 9.7 ± 0.5.
CONCLUSION Intratympanic dexamethasone injections can be used as a first-line therapy in pregnant women with SSNHL.
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Affiliation(s)
- Yan-Lu Lyu
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Fan-Qian Zeng
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Zhou Zhou
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Min Yan
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Wei Zhang
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Ming Liu
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
| | - Zhao-Yang Ke
- Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
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Anatomy of the Surrounding Tissue of the Eustachian Tube in Patulous Eustachian Tube: 3 Tesla Magnetic Resonance Imaging Approach. Otol Neurotol 2019; 40:e107-e114. [DOI: 10.1097/mao.0000000000002086] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
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Abdel-Salam M, Abdel-Naby Awad OG, El-Badry M, Ibrahim A, Ibrahiem MH. The possible effect of human menopausal gonadotropin on the audio-vestibular system. Auris Nasus Larynx 2018; 45:1166-1172. [PMID: 29747963 DOI: 10.1016/j.anl.2018.04.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2018] [Revised: 04/20/2018] [Accepted: 04/23/2018] [Indexed: 10/17/2022]
Abstract
OBJECTIVE Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI). METHODS This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy. Audio-vestibular adverse effects including hearing loss, tinnitus, vertigo, and otalgia were also considered. RESULTS Significant elevations in hearing thresholds were found on comparing thresholds at the day 10 at the onset of the study. The elevations were mostly at frequencies (1000, 2000 and 8000Hz) and did not affect speech perception. For DPOAE, significant differences were observed at all F2 frequencies on comparing both amplitudes and signal to noise ratios. Otologic complaints were significant for tinnitus and hearing loss. CONCLUSION Significant auditory and vestibular adverse effects may result from HMG therapy, indicating the importance of prompt monitoring of auditory functions in these patients.
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Affiliation(s)
- Montaser Abdel-Salam
- Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt
| | | | - Mohamed El-Badry
- Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt
| | - Ahmed Ibrahim
- Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt
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Adriztina I, Adnan A, Adenin I, Haryuna SH, Sarumpaet S. Influence of Hormonal Changes on Audiologic Examination in Normal Ovarian Cycle Females: An Analytic Study. Int Arch Otorhinolaryngol 2016; 20:294-299. [PMID: 27746829 PMCID: PMC5063728 DOI: 10.1055/s-0035-1566305] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/19/2015] [Accepted: 09/28/2015] [Indexed: 01/19/2023] Open
Abstract
Introduction There is only limited information from previous studies that suggest that auditory function may be influenced by hormones. Recent advances in the field have exposed the potential role of hormones in modulating the auditory system. Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination. Methods This is an analytic study with a cross-sectional design. The sampling was a systematic random sampling. We found 49 women with normal menstrual cycle and collected their data through interviews, physical examination, and examination of the ear, with otoscopic and other routine otorhinolaryngology examinations. We evaluated Tympanometry, distortion-product otoacoustic emissions (DPOAE), and pure tone audiometry. Results We found the audiometric threshold worse in the follicular phase than other phases at 4000 Hz of the right ear, and in the ovulation was found best than any other phases at 1000 Hz of the left ear with significant difference. We found significant difference of DPOAE between ovulation time and follicular phase at 3000 Hz and 1000 Hz in the left ear and between ovulation and luteal phased at 2000 Hz, 3000 Hz and 5000 Hz in the right ear and at 1000 Hz in the left ear with p < 0.05. Conclusion The result of this study showed that only a small part of audiometry threshold had a significant difference between each menstrual phase. In other words, we found no correlation between menstrual and audiometry threshold. Nonetheless, there is a correlation between menstrual cycle phase and DPOAE amplitude.
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Affiliation(s)
- Indri Adriztina
- Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
| | - Adlin Adnan
- Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
| | - Ichwanul Adenin
- Department of Obstetrics and Gynecology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
| | - Siti Hajar Haryuna
- Department of Otorhinolaryngology, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
| | - Sorimuda Sarumpaet
- Department of Epidemiology training research advocacy and teaching, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
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Double seal technique to obliterate the eustachian tube orifice: a novel method for the treatment of recalcitrant cerebrospinal fluid leak. The Journal of Laryngology & Otology 2015; 129:1028-31. [PMID: 26304110 DOI: 10.1017/s0022215115002157] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/24/2023]
Abstract
OBJECTIVE To demonstrate a novel and effective surgical technique for the treatment of refractory cerebrospinal fluid rhinorrhoea after skull base surgery. The novel surgical technique is described and the findings of a review of relevant world English-language publications are reported. CASE REPORT A 44-year-old woman, otherwise fit and well, presented with more than a 2-year history of right-sided facial pain. A diagnosis of classical trigeminal neuralgia was made. Surgical treatment was undertaken with a retromastoid suboccipital craniotomy. Post-operatively, the patient showed signs of right-sided cerebrospinal fluid rhinorrhoea which was recalcitrant. In light of a continuous leak and several hospital admissions, a novel technique was performed whereby the eustachian tube orifice was obliterated using an endonasal endoscopic approach. The technique proved to be successful, with no further leakage. CONCLUSION Endoscopic obliteration of the eustachian tube using a double seal technique is a simple, safe and effective procedure in the treatment of a refractory cerebrospinal fluid leak.
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Caras ML. Estrogenic modulation of auditory processing: a vertebrate comparison. Front Neuroendocrinol 2013; 34:285-99. [PMID: 23911849 PMCID: PMC3788044 DOI: 10.1016/j.yfrne.2013.07.006] [Citation(s) in RCA: 67] [Impact Index Per Article: 5.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/26/2013] [Revised: 07/18/2013] [Accepted: 07/21/2013] [Indexed: 11/30/2022]
Abstract
Sex-steroid hormones are well-known regulators of vocal motor behavior in several organisms. A large body of evidence now indicates that these same hormones modulate processing at multiple levels of the ascending auditory pathway. The goal of this review is to provide a comparative analysis of the role of estrogens in vertebrate auditory function. Four major conclusions can be drawn from the literature: First, estrogens may influence the development of the mammalian auditory system. Second, estrogenic signaling protects the mammalian auditory system from noise- and age-related damage. Third, estrogens optimize auditory processing during periods of reproductive readiness in multiple vertebrate lineages. Finally, brain-derived estrogens can act locally to enhance auditory response properties in at least one avian species. This comparative examination may lead to a better appreciation of the role of estrogens in the processing of natural vocalizations and mayprovide useful insights toward alleviating auditory dysfunctions emanating from hormonal imbalances.
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Affiliation(s)
- Melissa L Caras
- Neurobiology and Behavior Graduate Program, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA; Virginia Merrill Bloedel Hearing Research Center, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA.
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Abstract
AbstractBackground:Acute hearing loss is a distressing albeit rare occurrence in pregnancy. Due to its infrequent presentation, little is known of its cause, and the best management is unclear.Objective:To present a summary of current knowledge regarding sudden hearing loss in pregnancy and its management, by reviewing the published literature.Data sources:The following electronic databases: PubMed (MEDLINE), Ovid (MEDLINE), all EBM Reviews (Cochrane DSR, ACP Journal Club, DARE and CCTR) and Embase; plus a hand search of reference lists of retrieved papers.Study selection and data extraction:All papers retrieved using key word searches for ‘sudden hearing loss and pregnancy’ and ‘sudden deafness and pregnancy’ were reviewed. Due to the scarcity of literature, all studies identified were included in this review.Data synthesis and conclusions:All retrieved papers were reviewed. Sudden hearing loss is a rare occurrence during pregnancy, leading to a dearth of literature due to limited clinical experience. Audiological investigation findings for such patients remain equivocal. Recovery can be spontaneous during the postpartum period. In patients who require medical treatment, a dextran 40 infusion can be employed. There remains scope for further research, in the form of larger studies, to ascertain the best management option for this clinical problem.
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Al-Mana D, Ceranic B, Djahanbakhch O, Luxon LM. Alteration in auditory function during the ovarian cycle. Hear Res 2010; 268:114-22. [DOI: 10.1016/j.heares.2010.05.007] [Citation(s) in RCA: 34] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/10/2009] [Revised: 05/17/2010] [Accepted: 05/19/2010] [Indexed: 12/14/2022]
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Horner KC, Troadec JD, Dallaporta M, Pio J. Effect of chronic estradiol administration on vimentin and GFAP immunohistochemistry within the inner ear. Neurobiol Dis 2009; 35:201-8. [DOI: 10.1016/j.nbd.2009.04.008] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2009] [Revised: 04/17/2009] [Accepted: 04/21/2009] [Indexed: 11/15/2022] Open
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Hormones and the auditory system: A review of physiology and pathophysiology. Neuroscience 2008; 153:881-900. [DOI: 10.1016/j.neuroscience.2008.02.077] [Citation(s) in RCA: 81] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/01/2007] [Revised: 02/29/2008] [Accepted: 02/02/2008] [Indexed: 11/30/2022]
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Abstract
OBJECTIVE The patulous eustachian tube (ET) seems to be caused by a longitudinal concave defect in the mucosal valve at the superior aspect of its anterolateral wall and causes troublesome autophony of one's own voice and breathing sounds. Patulous ET reconstruction was evaluated to analyze whether submucosal graft implantation to fill in the concavity within the patulous tubal valve may produce lasting relief of symptoms. STUDY DESIGN Prospective trial. SETTING Tertiary referral center, ambulatory surgery. PATIENTS Fourteen ETs in 11 adults with 1 or more years of confirmed continuous patulous ET symptoms refractory to medical care. INTERVENTION Endoluminal patulous ET reconstruction was performed in 14 separate cases using a combined endoscopic transnasal and transoral approach under general anesthesia. A submucosal flap was raised along the anterolateral wall of the tubal lumen up to the valve and mobilized superiorly off of the basisphenoid. The pocket was filled with autologous cartilage graft or Alloderm implant, restoring the normal convexity and competence to the mucosal lumen valve. MAIN OUTCOME MEASURE Autophony symptoms were scored as 1) complete relief; 2) significant improvement, satisfied; 3)significant improvement, dissatisfied; 4) unchanged; or 5)worse. RESULTS All 14 cases reported immediate complete relief of autophony. Results with an average follow-up of 15.8 months are as follows: 1 (7%) case had complete relief; 5 (36%) had significant improvement, satisfied; 7 (50%) had significant improvement, dissatisfied; and 1 (7%) was unchanged. There were no complications. Correlation between patulous ET and other conditions was strongest with previous tubal dysfunction. Autophony of voice, but not breathing sounds, was also found to be experienced by 17 (94%) of 18 patients with superior semicircular canal dehiscence syndrome and could be easily mistaken for patulous ET autophony. CONCLUSION Patulous ET seems to be caused by a concave defect in the tubal valve's anterolateral wall. Submucosal graft implantation to restore the normal convexity to the valve wall seems to provide lasting relief of symptoms. Long-term study is needed. It is important to differentiate between the autophony of semicircular canal dehiscence syndrome and patulous ET.
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Affiliation(s)
- Dennis S Poe
- Department of Otolaryngology, Children's Hospital Boston, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA.
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Curtis KS, Contreras RJ. Sex differences in electrophysiological and behavioral responses to NaCl taste. Behav Neurosci 2006; 120:917-24. [PMID: 16893297 DOI: 10.1037/0735-7044.120.4.917] [Citation(s) in RCA: 30] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022]
Abstract
We tested the hypothesis that sex differences in preference for NaCl are attributable to estrogen-mediated alterations in gustatory processing. Electrophysiological responses of the chorda tympani nerve to NaCl were blunted by estrogen treatment in ovariectomized female rats, suggesting that females are less sensitive to concentrated NaCl solutions during high estrogen conditions. In contrast, after a taste aversion was conditioned to 150-mM NaCl, estrogen- and oil-treated ovariectomized rats generalized the aversion to a lower concentration of NaCl than did males, suggesting that females are more sensitive to the taste of dilute NaCl solutions regardless of estrogen. Thus, sex differences in NaCl preferences may be attributable to differences in NaCl taste processing that involve both acute and developmental effects of estrogen.
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Affiliation(s)
- Kathleen S Curtis
- Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.
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Doherty JK, Slattery WH. Autologous fat grafting for the refractory patulous eustachian tube. Otolaryngol Head Neck Surg 2003; 128:88-91. [PMID: 12574764 DOI: 10.1067/mhn.2003.34] [Citation(s) in RCA: 50] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022]
Abstract
The patulous eustachian tube (pET) presents a challenging management problem. Patients with the pET disorder are disturbed to the point of mental illness by their symptoms of aural fullness and autophony, especially the echo of their own voice. Thus far, described treatment methods are often temporary or ineffective. Here, we describe a minimally invasive method for the treatment of pET that involves cauterization with autologous fat graft plugging of the ET at its nasopharyngeal orifice, in conjunction with myringotomy and ventilation tube placement. This procedure has been successful for the treatment of refractory pET in 2 patients at the House Ear Clinic with at least 1-year follow-up and we propose that it may accomplish relief of symptoms by permanent stenosis of the ET.
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Affiliation(s)
- Joni K Doherty
- Department of Otolaryngology-Head and Neck Surgery, LAC + USC Medical Center and the House Ear Clinic, Los Angeles, CA, USA
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Abstract
We investigated the nongenomic effects of female sex steroid hormones on the short circuit current (I(sc,probe)) across gerbil stria vascularis using the voltage-sensitive vibrating probe. The strial marginal cell epithelial layer produces I(sc,probe) by secreting K+ via I(Ks) channels in the apical membrane. Application of 17beta-estradiol (E2) caused a decrease of I(sc,probe) in a dose-dependent manner (10 nM-10 microM) within seconds. Tamoxifen, a competitive inhibitor of the intracellular estrogen receptor, did not change the inhibitory effect of E2. Activation of I(Ks) channels by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid in the presence and absence of E2 was used to test the mechanism of action. The results were consistent with a direct inhibitory effect of E2 on the I(Ks) channels. By contrast, progesterone caused a transient increase of I(sc,probe). These results suggest that E2 decreases secretion of K+ by inhibition of I(Ks) channels via a nongenomic mechanism at concentrations near those occurring under some physiologic conditions while progesterone caused only transient effects on I(sc,probe).
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Affiliation(s)
- J H Lee
- Kansas State University, Department of Anatomy and Physiology, 126 Coles Hall, 1600 Denison Ave., Manhattan, KS 66506, USA
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McFadden SL, Henselman LW, Zheng XY. Sex differences in auditory sensitivity of chinchillas before and after exposure to impulse noise. Ear Hear 1999; 20:164-74. [PMID: 10229517 DOI: 10.1097/00003446-199904000-00007] [Citation(s) in RCA: 41] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Abstract
OBJECTIVE To determine if chinchillas exhibit sex differences in 1) basic auditory sensitivity and 2) susceptibility to cochlear damage and hearing loss from high-level impulse noise. DESIGN The auditory sensitivity of 73 chinchillas was assessed by measuring evoked potentials from electrodes implanted in the inferior colliculus (IC-EVPs) and cubic (2f1-f2) distortion product otoacoustic emissions (CDPs). A subgroup of 16 chinchillas were retested after exposure to simulated M16 rifle fire (150 dB pSPL impulse noise). Thresholds and postexposure temporary and permanent threshold shifts were compared as a function of sex and frequency using analysis of variance procedures. Cochleograms, showing the percent of hair cells missing as a function of location on the basilar membrane, were constructed to show inner hair cell (IHC) and outer hair cell (OHC) losses for each group. RESULTS Female chinchillas had slightly lower high-frequency thresholds, and slightly higher low-frequency thresholds than male chinchillas, but similar IC-EVP and CDP amplitude functions. Significant sex differences were observed after exposure to high-level impulse noise. Overall, female chinchillas developed approximately 10 dB more high-frequency hearing loss, but approximately 5 dB less low-frequency hearing loss than males. Hair cell losses, particularly IHC losses, were substantially less for females as compared with males. CONCLUSIONS The results point to close similarities between chinchillas and humans with regard to sex/gender differences in basic auditory sensitivity before noise exposure, suggesting that the chinchilla may be a good model for exploring the anatomical and physiological bases of these differences. In addition, the results show significant sex differences in the physiological and anatomical response of the chinchilla cochlea to high-level noise. Similar differences in humans could have important implications with regard to military assignments and hearing conservation programs.
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Affiliation(s)
- S L McFadden
- Center for Hearing and Deafness, University of Buffalo, New York 14214-3001, USA
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Abstract
Whilst the oral contraceptive pill (OC) has been implicated on a number of occasions as a cause of sensorineural hearing loss, there are no published reports linking hormone replacement therapy (HRT) to otological symptoms. A case of sensorineural loss with tinnitus following commencement of HRT is described, followed by a discussion outlining the fundamental differences between the OC and HRT, thus explaining why a vascular aetiology is unlikely. It is hypothesized that otological symptoms in such cases may be due to the effect of oestrogens on electrolyte balance disturbing inner ear function and also a direct effect on the auditory pathways mediated in part by alterations in neurotransmitter receptor concentrations.
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Affiliation(s)
- D Strachan
- Department of Otolaryngology, St. James' Hospital, Leeds, UK
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Abstract
This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed a rise in frequency of 0.6-1% while asleep and a similar fall while awake. The monthly cycle typically saw frequencies rise and fall by 0.4-0.6%, reaching a minimum near the onset of menstruation, and rising to a peak close to ovulation. A review of the literature revealed that certain cardiovascular parameters such as arterial blood pressure follow, over both daily and menstrual cycles, a broadly similar time course to SOAE frequency. Further experiments produced data supporting a relationship between blood pressure and SOAE frequency, and it is therefore suggested that much of the circadian-linked, menstrual-linked, and background variation in SOAE frequency may arise from cardiovascular changes. A likely causal mechanism, involving cerebrospinal fluid, is discussed.
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Affiliation(s)
- A Bell
- Research School of Biological Sciences, Australian National University, Canberra
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Dye L. Visual Information Processing and the Menstrual Cycle. COGNITION AND THE MENSTRUAL CYCLE 1992. [DOI: 10.1007/978-1-4613-9148-7_3] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/13/2023]
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Abstract
Ovariectomized rats received intra-arterial infusions of phenylephrine and nicotine. Estrogen treatment for five days prior to these challenges diminished laser Doppler measures of cochlear blood flow (CBF) responses to phenylephrine and blood pressure responses to nicotine. Progesterone enhanced CBF responses to both phenylephrine and nicotine; combined progesterone and estrogen treatment enhanced blood pressure responses to phenylephrine. These results suggest that ovarian steroid-mediated cardiovascular effects may influence cochlear blood flow and potentially hearing functions.
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Affiliation(s)
- G R Laugel
- Department of Psychology, Washington State University, Pullman 99164-4830
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Abstract
Different hearing defects have been attributed to prolonged use of oral contraceptives. The aim of the present investigation has been the evaluation by means of a number of audiological tests and of brain-stem evoked responses (BSER) of the possible incidence of subclinical pathology of the nervous hearing structures in these subjects. Twenty healthy subjects taking oral contraceptives from 9 to 30 months and 10 paired controls have been studied. No hearing loss was found but the study of BSER showed the presence of a significantly shorter latency of waves I and III which could be attributed to a functional alteration. Other, less significant, alterations are described and the conclusion is reached that prolonged oral contraception does not affect the hearing function, even if it is investigated with sophisticated techniques. However, the significant alterations of BSER responses and of the stapedial reflex might be considered as an initial non-organic sign of impairment of the central hearing pathways and therefore deserve further investigation.
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MESH Headings
- Acoustic Impedance Tests
- Adult
- Audiometry, Pure-Tone
- Contraceptives, Oral/adverse effects
- Contraceptives, Oral, Hormonal/adverse effects
- Contraceptives, Oral, Hormonal/pharmacology
- Contraceptives, Oral, Sequential/adverse effects
- Contraceptives, Oral, Sequential/pharmacology
- Evoked Potentials, Auditory/drug effects
- Female
- Hearing Disorders/chemically induced
- Hearing Disorders/diagnosis
- Humans
- Reflex, Acoustic/drug effects
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Dengerink JE, Dengerink HA, Swanson S, Thompson P, Chermak GD. Gender and oral contraceptive effects on temporary auditory effects of noise. AUDIOLOGY : OFFICIAL ORGAN OF THE INTERNATIONAL SOCIETY OF AUDIOLOGY 1984; 23:411-25. [PMID: 6466203 DOI: 10.3109/00206098409081534] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/20/2023]
Abstract
The first experiment examined thresholds at 4 and 8 kHz and the threshold of octave masking at 4 kHz before and after noise for males, females, and females using oral contraceptives. Females using oral contraceptives evidenced greater threshold shifts at 4 kHz than either of the other two groups. The second experiment examined thresholds and the loudness discrimination index at 4 kHz for males and females before and after noise exposure. Females evidenced greater loudness discrimination index changes both with and without noise exposure than did males. In addition, females responded to the noise with cutaneous vasodilation while males evidenced vasoconstriction.
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