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1
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Yan J. Granular cell tumor of the breast: A case report and review of literature. World J Clin Cases 2023; 11:8044-8049. [DOI: 10.12998/wjcc.v11.i33.8044] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/21/2023] [Revised: 09/26/2023] [Accepted: 11/13/2023] [Indexed: 11/24/2023] Open
Abstract
BACKGROUND Granular cell tumor (GCT) of the breast (GCTB) is a rare neoplasm that can exhibit malignant characteristics both clinically and radiologically. This tumor can also coexist and colocalize with breast carcinoma.
CASE SUMMARY We present a patient with this uncommon tumor and discuss the diagnostic and therapeutic approaches in order to further the knowledge of GCTB and prevent misdiagnosis and overtreatment. The characteristics of the tumor, methods of diagnosis, therapy and postoperative pathological outcomes were analyzed, and relevant literatures of GCTs were reviewed. The patient underwent surgery after core needle biopsy, and the excised neoplasm was sent for pathological examination. Histological analysis revealed nests of cells with abundant pink granular cytoplasm, confirming the diagnosis of GCTB.
CONCLUSION As manifestations of GCT and malignancy can mimic each other, a careful histological examination is essential before major surgery. Treatment consisting of complete excision with close clinical follow-up is recommended.
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Affiliation(s)
- Jun Yan
- Department of Breast Surgery, The University of Hong Kong - Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China
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2
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Ardeleanu V, Jecan RC, Moroianu M, Teodoreanu RN, Tebeica T, Moroianu LA, Bujoreanu FC, Nwabudike LC, Tatu AL. Case report: Abrikossoff's tumor of the facial skin. Front Med (Lausanne) 2023; 10:1149735. [PMID: 37324160 PMCID: PMC10264634 DOI: 10.3389/fmed.2023.1149735] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2023] [Accepted: 04/28/2023] [Indexed: 06/17/2023] Open
Abstract
Abrikossoff tumors, also known as granular cell tumors (GCT), originate from Schwann cells. The most common location is in the oral cavity, followed by the skin, but they can also be found in the breast, digestive tract, tracheobronchial tree, or central nervous system. They can affect both sexes at any age, with a higher incidence between 30 and 50 years and a slight predisposition for female sex. They are usually solitary tumors but may also be multifocal. Most of the time, they are benign, with malignancy being exceptional in <2% of cases. Clinically, they appear as solid, well-defined, painless tumors, located subcutaneously with dimensions that can reach up to 10 cm. The definitive diagnosis is based on the immunohistochemical examination, and the treatment for benign tumors consists of surgical excision. Chemotherapy or radiotherapy may be required for malignant lesions, but the treatment regimens and their benefits remain unclear. This manuscript presents the case of a 12-year-old girl with a benign GCT, located in the skin on the mandibular line.
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Affiliation(s)
- Valeriu Ardeleanu
- Faculty of Medicine, Doctoral School, “Ovidius” University, Constanţa, Romania
- General Hospital “Căi Ferate, ” Galaţi, Romania
- Arestetic Clinic, Galaţi, Romania
- Faculty of Kinetotherapy, University “Dunărea de Jos, ” Galaţi, Romania
| | - Radu Cristian Jecan
- Department of Plastic Surgery and Reconstructive Microsurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- Clinical Department of Plastic Surgery and Reconstructive Microsurgery, “Prof. Dr. Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, Romania
| | - Marius Moroianu
- Department of Dental Medicine, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania
- Medical Assistance Service of the Municipality of Galaţi, Galaţi, Romania
| | - Razvan Nicolae Teodoreanu
- Department of Plastic Surgery and Reconstructive Microsurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- Clinical Department of Plastic Surgery and Reconstructive Microsurgery, “Prof. Dr. Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, Romania
| | | | - Lavinia Alexandra Moroianu
- “Elisabeta Doamna” Psychiatry Hospital, Galaţi, Romania
- Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania
| | - Florin Ciprian Bujoreanu
- Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania
- Dermatology Department, “Sfanta Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galaţi, Romania
- N. Paulescu National Institute of Diabetes, Bucharest, Romania
| | - Lawrence Chukwudi Nwabudike
- Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), “Dunărea de Jos” University, Galaţi, Romania
| | - Alin Laurentiu Tatu
- Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galaţi, Romania
- Dermatology Department, “Sfanta Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galaţi, Romania
- N. Paulescu National Institute of Diabetes, Bucharest, Romania
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3
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Walter P, Ketoff S, Benichou L, Laurian LJ, Caillot A. Case-report of an Abrikossoff tumor of the temporomandibular joint Rapport de cas d'une tumeur d'Abrikossoff de l'articulation temporo-mandibulaire. JOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY 2022; 123:e306-e309. [PMID: 35487497 DOI: 10.1016/j.jormas.2022.04.016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/02/2022] [Revised: 04/06/2022] [Accepted: 04/20/2022] [Indexed: 06/14/2023]
Abstract
Granular cell tumors are rare tumors with multiple localizations. The most common localizations are in the cervicofacial region in 45-65% of cases. The characterization of this tumor depends on its clinical and histopathological findings. A few cases have been reported describing more unusual localizations, such as in the juxta-axilla or in the gastrointestinal tract. In this article, we describe an original localization: the region of the temporomandibular joint. This case-report describes a clinical case that was managed in the Department of Maxillofacial and Oral Surgery of the Saint-Joseph Hospital. The tumoral lesions usually described for this anatomical location are usually bony or synovial lesions. Here, the clinical examination didn't correspond to any of those descriptions and the MRI also confirmed that this tumor characteristics weren't compatible with this kind of lesion.
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Affiliation(s)
- P Walter
- Interne du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France.
| | - S Ketoff
- Praticien hospitalier du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France
| | - L Benichou
- Chef de service du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France
| | - L J Laurian
- Chef de clinique du service de chirurgie maxillo-faciale et orale de líhôpital Saint-Joseph, Paris, France
| | - A Caillot
- Praticien hospitalier du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France
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4
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Srivastava P, Da Cruz Paula A, Weigelt B, Pareja F, Reis-Filho JS, Yip L, Pantanowitz L, Seethala RR. Granular cell tumor of thyroid: a case series with molecular characterization highlighting unique pitfalls. Endocrine 2022; 76:395-406. [PMID: 35175560 PMCID: PMC9332905 DOI: 10.1007/s12020-022-03006-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/08/2021] [Accepted: 01/31/2022] [Indexed: 11/24/2022]
Abstract
Primary granular cell tumors (GCTs) of the thyroid are exceptionally rare. We report the clinicopathologic and molecular features of three cases and review the literature. Two patients (20-year-old, Case 1, and 26-year-old, Case 2, black American females) presented with painless masses with a preoperative fine-needle aspiration biopsy (FNAB) diagnosis of "Hürthle cell neoplasm," while one additional patient, 51-year-old white American female (Case 3), presented as an incidental finding within a background of chronic lymphocytic thyroiditis. On resection, morphologic, histochemical and immunohistochemical features were typical of GCT in all cases. Cases 1 and 2 had adequate material for molecular testing and demonstrated a clonal ATP6AP1 p.G381Vfs*15 frameshift mutation (Case 1) and a clonal ATP6AP2 p.L182Pfs*22 frameshift mutation along with a PIK3CA H1047R hotspot mutation (Case 2). All patients showed no evidence of GCT following resection (Cases 1, 3: 96-month follow-up; Case 2: 48-month follow-up). A literature review demonstrates similar clinicopathologic features and indolent course with only rare histologically or clinically aggressive outcomes. On FNAB, lesional cells are frequently miscategorized as Hürthle cells or oncocytes. In summary, GCT of the thyroid is rare but shows similar clinical, morphologic, immunophenotypic and genetic characteristics of GCT of other sites. This unusual site poses unique differential diagnostic pitfalls by mimicking other oncocytic head and neck lesions, particularly thyroid Hürthle cell neoplasms. We confirm that thyroid GCT also harbor V-ATPase component inactivating mutations that characterize these tumors, and that additional PI3K pathway alterations may not necessarily predict aggressive behavior.
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Affiliation(s)
| | | | - Britta Weigelt
- Memorial Sloan Kettering Cancer Center, New York, NY, USA
| | - Fresia Pareja
- Memorial Sloan Kettering Cancer Center, New York, NY, USA
| | | | - Linwah Yip
- University of Pittsburgh Medical Center, Pittsburgh, PA, USA
| | | | - Raja R Seethala
- University of Pittsburgh Medical Center, Pittsburgh, PA, USA
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5
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Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity. Am J Dermatopathol 2021; 44:7-16. [PMID: 34783707 DOI: 10.1097/dad.0000000000002088] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
ABSTRACT Granular cell tumors (GCTs) are rare soft tissue tumors of Schwann cell origin that manifest as papulonodular lesions and occur mainly in adults. The diagnosis is usually confirmed by histopathology. Most of GCTs are benign, but some lesions may exhibit malignant criteria. This study is a retrospective case series including all children with histopathologically documented multiple GCTs who attended the dermatology department of the university hospitals between February 2008 and March 2021. The objective of our study was to raise awareness to this unrecognized and rare entity in such age group. The study included 9 patients (6 girls and 3 boys) with multiple GCTs. Their age ranged between 5 and 13 years. The lesions were skin-colored to light brown, firm, smooth-surfaced nodules. Most of the lesions were on the extremities, and their mean diameter was 160.5 mm2. None of the lesions exhibited any malignant criteria on histopathology. No extracutaneous or mucosal lesions were detected. Dermatologists should be aware of this rare condition in children because early recognition allows more conservative resection of the tumor and less invasive reconstruction of the defect. Our study highlights that multifocality does not necessarily indicate malignancy or other systemic comorbidities.
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6
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Guo Y, Ding X, Liu H, Hou F, Jiang Y, Tian Z. Mediastinal granular cell tumor diagnosed with endoscopic ultrasound-guided fine needle aspiration via a modified technique based on wet suction: A case report and literature review. Diagn Cytopathol 2021; 49:E273-E276. [PMID: 33527755 DOI: 10.1002/dc.24704] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2020] [Revised: 01/18/2021] [Accepted: 01/19/2021] [Indexed: 11/09/2022]
Abstract
Granular cell tumor (GCT) represents a less frequently seen tumor originating from Schwann cells. Although GCT develops in various locations in the human body, GCT of the mediastinum is extremely uncommon. A case of mediastinal GCT diagnosed by aspiration using a fine needle assisted by endoscopic ultrasound (EUS-FNA) via a modified technique based on wet suction was reported. An asymptomatic 28-year-old man was referred for assessment of a mass in the mediastinum that was found incidentally via chest computed tomography (CT) at health screening. EUS demonstrated a hypoechoic lesion with a distinct boundary, which was derived from the upper posterior mediastinum and partly located close to the posterior wall of the esophagus. Therefore, EUS-FNA with a modified wet suction technique was performed to harvest adequate specimens for the diagnosis of GCT. Minimally invasive tumor removal was performed, and histological examination of the specimen harvested surgically verified GCT, consistent with histological findings of the specimen obtained by EUS-FNA. The case highlights that a good accuracy of histological diagnosis and specimen quality are achieved for the modified wet-suction technique in EUS-FNA, and a preoperative diagnosis of mediastinal GCT can be made with certainty.
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Affiliation(s)
- Yingjie Guo
- Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China
| | - Xueli Ding
- Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China
| | - Hua Liu
- Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China
| | - Feng Hou
- Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China
| | - Yueping Jiang
- Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China
| | - Zibin Tian
- Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China
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7
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A Rare Intramuscular Tumor in Gracilis Muscle: Granular Cell Tumor. Indian J Surg Oncol 2020; 11:215-218. [PMID: 33364702 DOI: 10.1007/s13193-020-01172-w] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2020] [Accepted: 07/07/2020] [Indexed: 10/23/2022] Open
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8
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Yankov GS, Yanev NA, Valev DG, Yamakova YT, Gabrovska NN, Kostadinov DT. A case of retrotracheal granular cell tumor. Chirurgia (Bucur) 2020. [DOI: 10.23736/s0394-9508.19.05014-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022]
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9
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Pujani M, Singh K, Raychaudhuri S, Agarwal C, Khandelwal A, Menia R, Prajapati D. Granular Cell Tumor Breast Masquerading as a Malignancy Cytologically: a Rare Case Presenting a Diagnostic Dilemma. Indian J Surg Oncol 2020; 11:321-324. [PMID: 32523283 DOI: 10.1007/s13193-020-01055-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2019] [Accepted: 03/09/2020] [Indexed: 11/29/2022] Open
Abstract
Granular cell tumor (GCT) also known as Abrikossoff's tumor is an uncommon soft tissue tumor of neurogenic origin. GCT of the breast accounts for < 0.1% of breast tumors and 6% of all reported cases of granular cell tumor. Although GCT is a benign tumor, malignant GCT can be seen in 1% v of the cases. GCT of the breast is diagnostically challenging as it can imitate carcinoma clinically and radiologically but need to be differentiated from breast malignancy since they have totally different approach in treatment and prognosis. GCT has a great ability to mimic a variety of lesions from benign histiocytic to malignant epithelial/mesenchymal lesions, thereby presenting a diagnostic challenge to the practicing cytopathologist. We report a case of GCT of breast cytologically masquerading as a malignancy in a 45-year-old female. Although, fine needle aspiration (FNA) is a first-line diagnostic tool, the present case reemphasizes the role of histopathology as the gold standard for a definite diagnosis clubbed with ancillary techniques like immunohistochemistry and special stains.
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Affiliation(s)
- Mukta Pujani
- Department of Pathology, ESIC Medical College, Faridabad, Haryana India
| | - Kanika Singh
- Department of Pathology, ESIC Medical College, Faridabad, Haryana India
| | | | - Charu Agarwal
- Department of Pathology, ESIC Medical College, Faridabad, Haryana India
| | - Aparna Khandelwal
- Department of Pathology, ESIC Medical College, Faridabad, Haryana India
| | - Reetika Menia
- Department of Pathology, ESIC Medical College, Faridabad, Haryana India
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10
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Barca I, Cordaro R, Giudice A, Cristofaro MG. Abrikossoff's tumor of the tongue: Report of three cases and review of the literature. J Oral Maxillofac Pathol 2020; 24:S101-S105. [PMID: 32189915 PMCID: PMC7069153 DOI: 10.4103/jomfp.jomfp_330_19] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2019] [Revised: 12/18/2019] [Accepted: 01/16/2020] [Indexed: 11/16/2022] Open
Abstract
Abrikossoff 's tumor, also called granular cell tumor (GCT), is a rare benign neoplasm of the soft tissues. In almost 70% of the cases, it occurs in the head-and-neck region (especially in the tongue), even though it may present in every other part of the body. This neoplasm has a benign behavior usually, but there have been described a malignant transformation in 2%–3% of the cases. The characterization of this tumor depends on its clinical and histopathological findings. The purpose of our work is to report three uncommon cases of oral Abrikossoff 's tumor located on the tongue in young patients referred to our department of maxillofacial surgery of “University Magna Graecia” in Catanzaro, also reviewing of the literature.
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Affiliation(s)
- Ida Barca
- Department of Experimental and Clinical Medicine, Maxillo-Facial Unit, Magna Graecia University, Catanzaro, Italy
| | - Raffaella Cordaro
- Department of Experimental and Clinical Medicine, Maxillo-Facial Unit, Magna Graecia University, Catanzaro, Italy
| | - Amerigo Giudice
- Department of Health Sciences, School of Dentistry, Magna Graecia University, Catanzaro, Italy
| | - Maria Giulia Cristofaro
- Department of Experimental and Clinical Medicine, Maxillo-Facial Unit, Magna Graecia University, Catanzaro, Italy
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12
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Baishya P, Das J, Shangpliang D, Dey B, Marbaniang E, Lynser D, Khonglah Y, Raphael V. Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group. AUTOPSY AND CASE REPORTS 2019; 9:e2019099. [PMID: 31372359 PMCID: PMC6629270 DOI: 10.4322/acr.2019.099] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2019] [Accepted: 04/03/2019] [Indexed: 12/26/2022] Open
Abstract
Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.
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Affiliation(s)
- Pakesh Baishya
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Jonali Das
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Darilin Shangpliang
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Biswajit Dey
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Evarisalin Marbaniang
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Donboklang Lynser
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Radiodiagnosis. Mawdiangdiang, Shillong, India
| | - Yookarin Khonglah
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
| | - Vandana Raphael
- North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India
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13
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Cui Y, Tong SS, Zhang YH, Li HT. Granular cell tumor: A report of three cases and review of literature. Cancer Biomark 2018; 23:173-178. [PMID: 30223384 DOI: 10.3233/cbm-170556] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
Affiliation(s)
- Ying Cui
- Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China
| | - Shan-Shan Tong
- Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China
| | - Yan-Hong Zhang
- Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China
| | - Hui-Ting Li
- Department of Obstetrics and Gynecology, The Hongqi Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157000, Heilongjiang, China
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14
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Mistrangelo M, Cassoni P, Scozzari G, Castellano I, Gavello G, Corno F, Morino M. Perianal Granular Cell Tumor: Report of a Case and Review of the Literature. TUMORI JOURNAL 2018; 95:538-41. [DOI: 10.1177/030089160909500424] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
Abstract
Introduction Granular cell tumor was first described by Abrikossoff in 1926. Over the years several cases of this neoplasm have been reported, with a variety of localizations. We here report a case of perianal granular cell tumor and discuss its histogenesis and its relevance to clinical practice. Methods The clinical course and histopathology of the case are reviewed, and a literature search for other reported cases has been performed. Results A 46-year-old woman presented with a perianal nodular lesion. Pathological examination revealed a granular cell tumor. A literature search produced only 25 other cases of anal and perianal granular cell tumors. Conclusions Granular cell tumors are rarely observed in the perianal region. Their existence must always be borne in mind in the differential diagnosis of perianal neoplasms. In most cases surgical excision is curative, but potential malignant transformation must be considered during therapeutic procedures and follow-up.
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Affiliation(s)
| | - Paola Cassoni
- Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
| | - Gitana Scozzari
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Isabella Castellano
- Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
| | - Giorgia Gavello
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Franco Corno
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Mario Morino
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
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15
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Panunzi A, D'orazi V, Toni F, Coppola GA, D'alessandro V, Pontone S, Pironi D, Ortensi A. Unexpected Granular Cell Tumor in Abdominal Wall: Case Report and Literature Review. TUMORI JOURNAL 2018; 98:e18-21. [DOI: 10.1177/030089161209800132] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
Granular cell tumors (GCTs) are uncommon benign neoplasms deriving from Schwann cells of the peripheral nerve fibers. Although these tumors can be found anywhere in the body, the most frequent site is the tongue, followed by the chest wall and the arm. The abdominal wall is an extremely rare site for GCTs. These tumors are generally asymptomatic and have a slow growth rate. Today, thanks to their immunoreactivity to S-100 and CD68, the differential diagnosis is more straightforward than in the past. We report on a young patient affected by a GCT located in the upper third of the right rectus abdominis muscle. En bloc excision through a diamond-shaped skin incision allowed us to make a correct histological diagnosis, which was confirmed by the immunohistochemical findings. GCT, which is very rare in abdominal wall muscles, should be considered in the differential diagnosis, and surgical excision is the treatment of choice.
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Affiliation(s)
- Andrea Panunzi
- Department of Surgical Sciences,
Sapienza University, Rome
| | | | - Francesca Toni
- Department of Surgical Sciences,
Sapienza University, Rome
| | | | | | | | - Daniele Pironi
- Department of Surgical Sciences,
Sapienza University, Rome
| | - Andrea Ortensi
- Department of Surgical Sciences,
Sapienza University, Rome
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16
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Castillo Lara M, Martínez Herrera A, Torrejón Cardoso R, Lubián López DM. Granular cell tumor in breast: a case report. BREAST CANCER-TARGETS AND THERAPY 2017; 9:245-248. [PMID: 28442932 PMCID: PMC5395275 DOI: 10.2147/bctt.s131446] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]
Abstract
Granular cell tumor (GCT) is a rare neoplasm of the soft tissues, and <1% of all GCTs are malignant. It usually appears in the tongue and sometimes may affect the female breast. Initially, GCT was considered to be a myogenic lesion affecting female breast (myoblastoma). Actually, it is assumed as a tumor originating from perineural or putative Schwann cells of peripheral nerves or their precursors that grows in the lobular breast tissue, due to the immunohistochemical features. Here, we review the importance of differentiating between this tumor and malignant breast carcinoma. Mammographically, by ultrasound scan and clinically, this case appears to be a malignant tumor of the breast, but with a correct and precise diagnosis including histopathologic examination and immunohistochemical studies, it was correctly identified as a GCT. CASE DETAILS We present a case of a 52-year-old premenopausal woman. This report is of interest because of patient's familial oncologic history and personal history of gynecologic cancer. This rare tumor of the breast and the special way to approach the tumor by local anesthesia makes it interesting to communicate. CONCLUSION This is a case of interest because GCT located in the breast is very unusual and knowledge of GCT is required for the differential diagnosis with breast cancer.
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Affiliation(s)
- Maria Castillo Lara
- Department of Obstetrics and Gynecology, Hospital Universitario Puerto Real, Cádiz, Spain
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Ferreira JCB, Oton-Leite AF, Guidi R, Mendonça EF. Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report. BMC Res Notes 2017; 10:14. [PMID: 28057062 PMCID: PMC5217610 DOI: 10.1186/s13104-016-2325-7] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2016] [Accepted: 12/08/2016] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Granular cell tumor is a rare benign tumor that can present a pseudoepitheliomatous hyperplasia of the covering epithelium. This lesion is not encapsulated and can be characterized by a pseudo invasive growth pattern, represented by the tumoral cells that infiltrate between adjacent connective tissue elements. Diagnostic difficulties may arise because histopathological features of the pronounced pseudoepitheliomatous hyperplasia can be confused with a well-differentiated oral squamous cell carcinoma. The aim of this case report is to demonstrate the role of an immunohistochemical panel in the diagnosis of a granular cell tumor in the tongue with clinical and microscopic features resembling an oral squamous cell carcinoma. CASE PRESENTATION A 44-year-old white man with a history of heavy smoking and alcohol abuse presented an ulcerated nodular lesion in the dorsum of the tongue. The lesion was asymptomatic with fast growth. The clinical diagnosis was an oral squamous cell carcinoma. An incisional biopsy was performed and the ensuing histopathological analysis showed a pseudoepitheliomatous hyperplasia in the overlying epithelium mimicking the invasion of epithelial tumor cells into the connective tissue as in an oral squamous cell carcinoma. Immunohistochemical antibodies (S-100, vimentin, CD68, p53, Ki-67, E-cadherin, collagen IV and cytokeratin AE1/AE3) were used to characterize molecular aspects of the lesion. Strong staining of S-100 protein, CD68, vimentin, E-cadherin and low proliferative activity observed with Ki-67 expression confirmed the diagnosis of a granular cell tumor. The patient was submitted to surgical excision of the whole lesion. At a 12-month check-up, there was no evidence of recurrence. CONCLUSION This case report showed that the immunohistochemical profile was helpful in determining the clinical behavior of the tumor and establishing the final diagnosis with appropriate treatment.
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Affiliation(s)
- Jean Carlos Barbosa Ferreira
- Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil
| | - Angélica Ferreira Oton-Leite
- Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil
| | - Rafaela Guidi
- Department of Oral Medicine Dental, Association of Cancer of Combat of Goiás, Araujo Jorge Hospital, Goiânia, Brazil
| | - Elismauro Francisco Mendonça
- Department of Oral Medicine (Oral Pathology), Dental School, Faculdade de Odontologia, Universidade Federal de Goiás, Praça Universitária, S/N, Setor Universitário, Goiânia-Goiás, CEP 74605-220, Brazil.
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Yasak T, Özkaya Ö, Akçay AA, Kayadibi T, Erzurumluoğlu N. Report of two cases of granular cell tumor, a rare tumor in children. JOURNAL OF PEDIATRIC SURGERY CASE REPORTS 2016. [DOI: 10.1016/j.epsc.2016.08.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/21/2022] Open
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Pantaleo G, Amato M, Guerra F, Siano M, Bucci T, Sammartino G. Histochemistry and Immunohistochemistry Evaluation of the Abrikossoff's Tumour of the Tongue: a Case Report. Acta Stomatol Croat 2016; 48:292-5. [PMID: 27688378 DOI: 10.15644/asc48/4/7] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/31/2022] Open
Abstract
Abrikossoff's tumour is a rare benign soft tissue neoplasm that can occur in any part of the body, including the orofacial region. The tumour is usually benign, but there are reports of cases in which the tumour shows a locally aggressive behaviour, malignancy, and distant metastases. The aetiology is unknown, since several studies have shown that different cells are involved. In the present case, a 36-year-old Dominican woman was referred to the Department of Oral and Maxillofacial Surgery in Policlinico Federico II, Naples with a circumscribed lesion and sessile nodule on the dorsum of the tongue measuring about 17 mm in diameter. The treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of Abrikossoff's tumour, which was confirmed by histopathological analysis and histochemistry and immunohistochemistry evaluation. Abrikossoff's tumour is an uncommon neoplasm which must be carefully diagnosed considering all the histological and clinical aspects in order to be treated correctly.
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Affiliation(s)
- Giuseppe Pantaleo
- Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy
| | - Massimo Amato
- Department of Medicine and Surgery, University of Salerno, Fisciano, 84084 Salerno, Italy
| | - Fabiana Guerra
- Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy
| | - Maria Siano
- Department of Advanced Biomedical Sciences - Pathology Section, University of Naples Federico II, 80131 Naples, Italy
| | - Tommaso Bucci
- Department of Oral and Maxillofacial Surgery, Hospital Joan XXIII of Tarragona, Spain
| | - Gilberto Sammartino
- Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy
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Goenka P, Sarawgi A, Asopa K, Gumber P, Dutta S. Oral Cysticercosis in a Pediatric Patient: A Rare Case Report with Review. Int J Clin Pediatr Dent 2016; 9:156-61. [PMID: 27365940 PMCID: PMC4921888 DOI: 10.5005/jp-journals-10005-1355] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2015] [Accepted: 10/17/2015] [Indexed: 11/23/2022] Open
Abstract
Cysticercosis is a condition in which a human acts as the intermediate host of the pork tapeworm Taenia solium. Although cysticercosis is a common disease in some regions of the world and can occur in any body site, oral lesions are rare. In this report, we document the case of oral cysticercosis in a 10-year-old boy who sought treatment for an asymptomatic nodule on the dorsal surface of the tongue. A detailed history, thorough clinical examination, morphological appearance and the histopathologic findings of the excised cyst formed the basis for the diagnosis of the lesion. How to cite this article: Goenka P, Sarawgi A, Asopa K, Gumber P, Dutta S. Oral Cysticercosis in a Pediatric Patient: A Rare Case Report with Review. Int J Clin Pediatr Dent 2016;9(2):156-161.
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Affiliation(s)
- Puneet Goenka
- Associate Professor, Department of Pediatric and Preventive Dentistry, Mahatma Gandhi Dental College, Jaipur, Rajasthan, India
| | - Aditi Sarawgi
- Senior Lecturer, Department of Prosthodontics and Crown and Bridge Mahatma Gandhi Dental College, Jaipur, Rajasthan, India
| | - Kirti Asopa
- Senior Lecturer, Department of Pedodontics, Mahatma Gandhi Dental College Jaipur, Rajasthan, India
| | - Parvind Gumber
- Senior Lecturer, Department of Oral Pathology and Microbiology, Mahatma Gandhi Dental College, Jaipur, Rajasthan, India
| | - Samir Dutta
- Senior Professor, Department of Pedodontics, Government Dental College Rohtak, Haryana, India
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Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, Ward JM. Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse. J Toxicol Pathol 2016; 29:1S-125S. [PMID: 26973378 PMCID: PMC4765498 DOI: 10.1293/tox.29.1s] [Citation(s) in RCA: 84] [Impact Index Per Article: 9.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022] Open
Abstract
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
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Affiliation(s)
- Thomas Nolte
- Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an
der Riss, 88397, Germany
- Chairman of the Digestive Tract INHAND Committee
| | - Patricia Brander-Weber
- Novartis Institutes for BioMedical Research, Novartis Pharma
AG, CH-4002 Basel, Switzerland
| | - Charles Dangler
- Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Present: Sanofi5 The Mountain Road, Framingham, Massachusetts 01740,
USA
| | - Ulrich Deschl
- Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an
der Riss, 88397, Germany
| | - Michael R. Elwell
- Covance Laboratories, Inc. 14500 Avion Parkway, Ste 125,
Chantilly, Virginia 20151, USA
| | - Peter Greaves
- University of Leicester, Department of Cancer Studies and
Molecular Medicine, Robert Kilpatrick Clinical Science Building, Leicester Royal
Infirmary, Leicester LE2 7LX, United Kingdom
| | - Richard Hailey
- GlaxoSmithKline PO Box 14164 Durham, North Carolina 27709,
USA
| | | | - Arun R. Pandiri
- Cellular and Molecular Pathology Branch, National Toxicology
Program, National Institute of Environmental Health Sciences, Research Triangle Park,
North Carolina 27709, USA
- Experimental Pathology Laboratories, Inc. PO Box 12766,
Research Triangle Park, North Carolina 27709, USA
| | - Arlin Rogers
- Tufts University, Department of Biomedical Sciences, 274
Tremont Street, Massachusetts 02111, USA
| | - Cynthia C. Shackelford
- Cellular and Molecular Pathology Branch, National Toxicology
Program, National Institute of Environmental Health Sciences, Research Triangle Park,
North Carolina 27709, USA
| | - Andrew Spencer
- Covance Laboratories Ltd, Alnwick Research Centre,
Willowburn Avenue, Alnwick, Northumberland NE66 2JH United Kingdom
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Emesz M, Arlt EM, Krall EM, Bauer FM, Weger R, Emberger M, Rasp M. [Granular cell tumors of the orbit: diagnostics and therapeutic aspects exemplified by a case report]. Ophthalmologe 2015; 111:866-70. [PMID: 24173669 DOI: 10.1007/s00347-013-2972-1] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
Abstract
BACKGROUND Granular cell tumors (Abrikossoff's tumor) are very rare, mostly benign tumors of neurogenic origin which preferentially occur in the upper aerodigestive tract. Granular cell tumors rarely originate in the orbit and are therefore a diagnostic and therapeutic challenge. METHOD AND PATIENTS A 42-year-old male patient presented to the Orthoptic Department of the University Eye Clinic in Salzburg with motility disturbances and diplopia in the right eye. The clinical examination revealed right-sided exophthalmos and shrinking of the choroid and retina due to a retrobulbar mass. The radiological examination showed an infiltrative tumor 1.7 × 1.3 cm in size in the lower temporal quarter of the orbit. Due to the localization a sonographically controlled fine needle puncture was carried out for preoperative diagnostics by a specialist in clinical cytology. The cytological examination confirmed the presence of a granular cell tumor. The tumor was excised via a conjunctival access route. RESULTS Motility testing in the postoperative course control showed an improvement in the findings and the exophthalmos was clearly regressive. Vision improved from 0.5 preoperatively to 1.0 postoperatively. During the postoperative observational period of 12 months no recurrences occurred. Clinical control examinations are planned every 3 months and imaging controls every 6 months. CONCLUSION Granular cell tumors of the orbit should be included in the differential diagnostics of orbital tumors despite the low incidence. A sonographically controlled fine needle puncture is an adequate procedure with respect to the diagnostics and further therapy for poorly differentiated tumors of the orbit with a suspicion of infiltrative growth and for which in toto resection is questionably possible. A complete surgical excision should be the aim of treatment of granular cell tumors. Continuous clinical and imaging control is necessary to enable early recognition of recurrences.
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Affiliation(s)
- M Emesz
- Universitätsklinik für Augenheilkunde und Optometrie, Paracelsus Medizinische Privat-Universität, PMU, Universitätsklinikum, Müllner Hauptstr. 48, 5020, Salzburg, Österreich,
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Shikatani Y, Okazaki M, Sakao N, Yukumi S, Shigematsu H, Kitazawa S, Sano Y. A Case of Mediastinal Granular Cell Tumor with Horner's Syndrome. Ann Thorac Cardiovasc Surg 2015; 21:567-9. [PMID: 26041255 DOI: 10.5761/atcs.cr.15-00112] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
Granular cell tumor (GCT) is found in various organs but is rare in the mediastinum. We report a case of mediastinal GCT in a 19-year-old woman who presented with left ptosis and miosis. CT and MRI revealed a 29-mm well-circumscribed tumor located close to the first thoracic vertebra with features suggesting a neurogenic tumor. The tumor was completely excised using single-port video-assisted thoracoscopic surgery. Histopathological and immunohistochemical analysis revealed that the tumor was a benign GCT. Postoperatively, left ptosis and miosis had improved slightly. To our knowledge, this is the first report regarding mediastinal GCT presenting with preoperative Horner's syndrome.
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Kusano J, Iguchi F, Takahashi Y, Terada Y, Murai N. Neck and superior mediastinal granular cell tumor excised via a combined approach. Auris Nasus Larynx 2015; 42:72-6. [DOI: 10.1016/j.anl.2014.09.001] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2014] [Revised: 08/31/2014] [Accepted: 09/01/2014] [Indexed: 01/31/2023]
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GRANULAR CELL TUMOR OF TONGUE IN A 12 YEAR OLD GIRL: A CASE REPORT & REVIEW OF LITERATURE. ACTA ACUST UNITED AC 2014. [DOI: 10.14260/jemds/2014/3269] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/31/2022]
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26
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Desimone RA, Ginter PS, Chen YT. Granular cell tumor of the breast eliciting exuberant pseudoepitheliomatous hyperplasia. Int J Surg Pathol 2014; 22:156-7. [PMID: 24663243 DOI: 10.1177/1066896914525234] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
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27
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Vigier S, Traverse-Glehen A, Durbec M, Tringali S, Dubreuil C, Ceruse P. Deep cervical granular cell tumor: An atypic location suggestive of neurogenic origin. Eur Ann Otorhinolaryngol Head Neck Dis 2014; 131:65-7. [DOI: 10.1016/j.anorl.2013.03.004] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2012] [Accepted: 03/22/2013] [Indexed: 10/26/2022]
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Pushpa G, Karve PP, Subashini K, Narasimhan MN, Ahmad PB. Abrikossoff's Tumor: An Unusual Presentation. Indian J Dermatol 2013; 58:407. [PMID: 24082205 PMCID: PMC3778800 DOI: 10.4103/0019-5154.117335] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
Abstract
Abrikossoff's tumor or granular cell tumor is an infrequent benign neoplasm, first described by the Russian pathologist Abrikossoff in 1926. The neoplasm can affect all parts of the body with head and neck areas affected in 45-65% of patients. More than half of the head and neck lesions are localized to the oral cavity, especially the tongue. An aggressive malignant form of granular cell myoblastoma that metastasizes is rare. The treatment of choice of Abrikossoff's tumor is local surgical excision with a wide margin. Here, we present a case of Abrikossoff's tumor, occurring in the upper arm, presenting as a panniculitis-like lesion.
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Affiliation(s)
- Gnanaraj Pushpa
- Department of Dermatology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamilnadu, India
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29
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Hita-Davis P, Edwards P, Conley S, Dyer T. Granular cell tumour of the tongue in a 17-year-old orthodontic patient: a case report. ACTA ACUST UNITED AC 2013. [DOI: 10.1111/ors.12055] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022]
Affiliation(s)
- P. Hita-Davis
- Oral Maxillofacial Surgery; School of Dentistry; Ann Arbor MI USA
| | - P. Edwards
- Department of Oral Pathology, Medicine and Radiology; Indiana University; Indianapolis IN USA
| | - S. Conley
- Department of Orthodontics and Pediatric Dentistry; University of Michigan; Ann Arbor MI USA
| | - T.J. Dyer
- Oral Surgery; Boston University; Boston MA USA
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Souto GR, Caldeira PC, Johann ACBR, Andrade Marigo H, Souza SCOM, Mesquita RA. Evaluation of GLUT-1 in the granular cell tumour and congenital granular cell epulis. J Oral Pathol Med 2013; 42:450-3. [PMID: 23336292 DOI: 10.1111/jop.12035] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/20/2012] [Indexed: 11/30/2022]
Affiliation(s)
- Giovanna Ribeiro Souto
- Department of Oral Surgery and Pathology; School of Dentistry; Universidade Federal de Minas Gerais; Belo Horizonte Brazil
| | - Patrícia Carlos Caldeira
- Department of Oral Surgery and Pathology; School of Dentistry; Universidade Federal de Minas Gerais; Belo Horizonte Brazil
| | | | - Helenicede Andrade Marigo
- Oral Pathology Laboratory; School of Dentistry; Pontifícia Universidade Católica de Minas Gerais; Belo Horizonte Brazil
| | | | - Ricardo Alves Mesquita
- Department of Oral Surgery and Pathology; School of Dentistry; Universidade Federal de Minas Gerais; Belo Horizonte Brazil
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Aoyama K, Kamio T, Hirano A, Seshimo A, Kameoka S. Granular cell tumors: a report of six cases. World J Surg Oncol 2012; 10:204. [PMID: 23021251 PMCID: PMC3502223 DOI: 10.1186/1477-7819-10-204] [Citation(s) in RCA: 34] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2012] [Accepted: 09/10/2012] [Indexed: 12/27/2022] Open
Abstract
Granular cell tumor is a soft tissue neoplasm that originates in the nervous system and arises at virtually any body site, but is mainly found in the skin, oral cavity or digestive tract. Most are benign and reportedly malignant cases are rare, occurring in only 1% or 2% of cases. We report on our findings in six patients who developed granular cell tumor in the mammary gland, esophagus, subcutaneous tissue and muscle. Of six patients, two had granular cell tumor located in the breast, two in the submucosa of the esophagus, and the other two under the skin of the left axillary cavity and in the right latissimus dorsi muscle, respectively. One of the two patients with tumor in the submucosa of the esophagus also had esophageal cancer. Patients' age ranged from 41 to 70 years (average, 59.1 years). Two patients with tumor in the submucosa of the esophagus were men, and the others were women. All of them were given a diagnosis of granular cell tumor by tissue biopsy and examination of excised specimens, but no evidence of malignancy was found. No recurrence has been noted in the patients who underwent surgical tumor removal.
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Affiliation(s)
- Kei Aoyama
- Department of Surgery II, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
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Affiliation(s)
- Pradeoth M Korambayil
- Sushrutha Institute of Plastic, Reconstructive and Aesthetic Surgery, Elite Mission Hospital, Koorkenchery, Thrissur, Kerala, India
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Sena Costa NC, Bertini F, Carvalho YR, Almeida JD, Rodrigues Cavalcante AS. Granular cell tumor presenting as a tongue nodule: two case reports. J Med Case Rep 2012; 6:56. [PMID: 22325570 PMCID: PMC3298519 DOI: 10.1186/1752-1947-6-56] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2011] [Accepted: 02/10/2012] [Indexed: 11/16/2022] Open
Abstract
Introduction Granular cell tumor is an uncommon neoplasm that can occur in any part of the body, including the orofacial region. The tumor is usually benign, but there are reports of cases in which the tumor shows a locally aggressive behavior, malignancy, and distant metastases. The most widely accepted hypothesis is that granular cell tumor arises from the altered metabolism of Schwann cells. The tumor is typically asymptomatic and appears as a nodule that does not exceed 3 cm. Case presentation In case 1, a 26-year-old Caucasian man was seen at the Oral Medicine out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a 'small blister on the tongue', which he had noted approximately three years ago. The nodule was located on the dorsum of the tongue, measured about 1.5 cm in diameter, and was not tender to palpation. Treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of granular cell tumor, which was confirmed by microscopic analysis. In case 2, a 31-year-old Caucasian woman attended the out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a five-year history of a 'painful lump on the tongue'. Intra-oral examination revealed the presence of a nodular lesion measuring approximately 0.8 cm in diameter, which was located deep in the submucosa of the right lateral margin of the tongue. Treatment consisted of an excisional biopsy performed on the basis of the differential diagnosis of neurofibroma and granular cell tumor. Microscopic analysis defined the final diagnosis of granular cell tumor. Conclusions Granular cell tumor is an uncommon tumor that must be carefully diagnosed and treated correctly.
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Affiliation(s)
- Nivea Cristina Sena Costa
- Department of Bioscience and Oral Diagnosis, São José dos Campos Dental School, São José dos Campos, UNESP - Univ Estadual Paulista, São Paulo, Brazil.
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Ulcerative granular cell tumor: a clinicopathological and immunohistochemical study. J Skin Cancer 2011; 2011:497648. [PMID: 22132340 PMCID: PMC3206371 DOI: 10.1155/2011/497648] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/30/2011] [Accepted: 09/02/2011] [Indexed: 11/18/2022] Open
Abstract
Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions.
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Fragulidis G, Chondrogiannis K, Lykoudis P, Karakatsanis A, Georgiou C, Vouza E, Melemeni A. Subcutaneous granular cell tumour of the lumbar region. J Cutan Aesthet Surg 2011; 4:132-4. [PMID: 21976906 PMCID: PMC3183719 DOI: 10.4103/0974-2077.85039] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
Abstract
Granular cell tumour (GCT), also known as Abrikossoff tumour, is an uncommon neoplasm, probably of neural origin derived from Schwann cells. It usually presents as a subcutaneous solitary asymptomatic nodule. It has been the subject of much debate in the literature concerning the tumour origin and the association with other malignancies. We report a case of subcutaneous GCT in the lumbar region in a 31-year-old Caucasian male. Although they are a rare entity, GCTs should be considered in the differential diagnosis of the subcutaneous soft tissue tumours. Surgical removal with wide margins is the treatment of choice as malignant changes have been reported after long-term follow-up.
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Affiliation(s)
- Gp Fragulidis
- Department of Surgery, Aretaieio Hospital, Medical School, University of Athens, Athens, Greece
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36
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Lahmam Bennani Z, Boussofara L, Saidi W, Bayou F, Ghariani N, Belajouza C, Sriha B, Denguezli M, Nouira R. [Childhood cutaneous Abrikossoff tumor]. Arch Pediatr 2011; 18:778-82. [PMID: 21600742 DOI: 10.1016/j.arcped.2011.04.009] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2010] [Revised: 08/25/2010] [Accepted: 04/06/2011] [Indexed: 11/29/2022]
Abstract
INTRODUCTION Granular cell tumor (GCT), also known as Abrikossoff tumor, is a rare and benign neoplasm that more commonly affects the oral cavity in adults. We report here 2 childhood cases of a cutaneous granular cell tumor. CASE REPORTS An 8- and a 12-year-old girl, with no past medical history, presented with pigmented nodular lesions located, respectively, in the left scapular region and the left iliac crest. Histological examination showed sheets and clusters of infiltrating tumor cells with morphologic and immunohistochemical features consistent with granular cell tumor. In both cases, the lesions were excised with 2-cm margins. The patients are presently being reviewed at 6-month and 2-month intervals to evaluate for recurrence and any malignant transformation. They were in good health with no signs of further tumor development. DISCUSSION GCT is a relatively uncommon benign neoplasm probably of neural origin derived from Schwann cells. The tongue and buccal mucosa are commonly affected. It develops between the second and sixth decades of life, more frequently among women and blacks. It can also occur in childhood, but this is rare. The cutaneous forms, as in the present observations, are exceptional. Benign granular cell tumours are generally seen as a solitary asymptomatic nodule less than 3 cm in size involving the subcutaneous or submucosal tissues. Histologically, the tumor is not encapsulated but is well circumscribed. The tumor cells may show a degree of infiltration of the surrounding connective tissue. The cells are polygonal, have abundant cytoplasm, are granular and weakly eosinophilic. The nuclei are small, vesicular, and highly chromatic. Mitotic figures are rare. A key element for the histological diagnosis is the expression of S100 protein, neuron specific enolase (NSE), and vimentin on immunohistochemistry. The treatment of choice is a conservative surgical excision of the lesion. However, as the GCT has a poorly defined margin, it is suggested that the tumor should be excised along with portions of adjacent tissue. A low rate of recurrence of the lesion has been reported. CONCLUSION The specific value of these rare cases is the occurrence in 2 children and the cutaneous location.
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Affiliation(s)
- Z Lahmam Bennani
- Service de dermatologie, centre hospitalo-universitaire Farhat-Hached, 4002 Sousse, Tunisie
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Granular cell tumor of the toe: a case report. Dermatol Res Pract 2010; 2010. [PMID: 20862204 PMCID: PMC2938433 DOI: 10.1155/2010/184125] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/19/2010] [Accepted: 06/21/2010] [Indexed: 12/04/2022] Open
Abstract
Granular cell tumor is a rare tumor of unknown etiology that more commonly affects the oral cavity but can also occur at other sites. The majorities of granular cell tumors are benign and present as a singular dermal nodule. We discuss a case of granular cell tumor of the fourth toe in a 54-year-old patient that was treated with conservative surgery, instead of amputation, and reconstruction with a dermal regeneration template.
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Haikal F, Maceira JP, Dias EP, Ramos-e-Silva M. Histogenesis of Abrikossoff tumour of the oral cavity. Int J Dent Hyg 2010; 8:53-62. [DOI: 10.1111/j.1601-5037.2009.00392.x] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
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Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence. Clin Nucl Med 2009; 34:696-7. [PMID: 19893405 DOI: 10.1097/rlu.0b013e3181b539d2] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
Granular cell tumor of Abrikossoff is a rare neoplasm that may occur in a wide variety of cutaneous and visceral sites. Granular cell tumor generally shows benign behavior. However, malignant outcome with metastatic spread has also been reported. Until now, no data were available on the most useful imaging approach for diagnosis and staging. We present a case of F-18 fluorodeoxyglucose positron emission tomography in Abrikossoff tumor, suggesting that F-18 fluorodeoxyglucose positron emission tomography may have a potential role in the management of this neoplasm.
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Abstract
Granular cell tumour, also known as Abrikossoff tumour, is a relatively uncommon benign neoplasm, which is more commonly found in females in the 4th to 6th decades of life even though it can occur in all ages. It occurs in all areas of the body but about 45-65% of all lesions are reported in the head and neck region. Intraoral lesions represent about 70% of the granular cell tumours of the head and neck, and account for 1/3 of all cases affecting the whole body. Most of the intraoral lesions occur on the tongue, usually on the lateral aspect, followed by the buccal mucosa and hard palate. Although majority of granular cell tumours are benign, some are clinically aggressive and a few frankly malignant forms have been reported. Some benign lesions exhibit surface ulcerations and this clinical appearance, combined with the overlying pseudoepitheliomatous hyperplasia, seen histologically, may lead to misdiagnosis of malignancy if adequate biopsy material was not taken. A case of granular cell tumour which occurred on the midline area of the dorsum of the posterior 1/3 of the tongue is reported in a 20-year-old female patient. It is interesting because the patient was younger than the average age of occurrence and the tumour occurred in a similar site to that of a lingual thyroid.
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Dudrap E, Lemierre G, Auquit-Auckbur I, Courville P, Milliez PY. Tumeur d’Abrikossoff : à propos d’une localisation cutanée du sillon intermammaire et revue de la littérature. ANN CHIR PLAST ESTH 2008; 53:521-5. [DOI: 10.1016/j.anplas.2008.03.002] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2006] [Accepted: 03/17/2008] [Indexed: 10/22/2022]
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Mindea SA, Kaplan KJ, Howard MA, O'Leary ST. Granular cell tumor involving the axillary nerve: an unusual occurrence. Case report. Neurosurg Focus 2007; 22:E24. [PMID: 17613216 DOI: 10.3171/foc.2007.22.6.25] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022]
Abstract
Granular cell tumors (GCTs) are benign lesions that, paradoxically, despite originating from the Schwann cell, are most commonly seen in nonneuronal tissue including the skin, subcutaneous tissue, and tongue. Their presence in the brachial plexus is quite rare, but their involvement of peripheral nerves is exceptional. The authors report on a case of GCT involving the axillary nerve in a 54-year-old woman who underwent complete resection of the lesion. To the author's knowledge, this case marks the first report of a GCT involving the axillary nerve. Aspects pertaining to the radiographic and histopathological features as well as the surgical management of this lesion are discussed.
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Affiliation(s)
- Stefan A Mindea
- Northwestern Memorial Hospital and Evanston Northwestern Healthcare, Evanston, Illinois, USA.
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Abstract
Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract. GCT of the orbit is a rarity, representing a diagnostic and therapeutic challenge. We report on a 26 year old man suffering from unilateral ocular hypertension and retrobulbar pain. Exophthalmos and disturbance of motility were not noted by the patient. The surgical removal of the GCT, extending into the orbital apex, was performed by an interdisciplinary team using a combination of "midfacial degloving" and LeFort I-osteotomy.
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Affiliation(s)
- I Sterker
- Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Leipzig, Liebigstrasse 10-14, 04103 Leipzig.
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Honda K, Tanaka S, Kishimoto M, Iwai K, Tamaki H, Asato R, Ito J. Granular cell tumor of hypopharynx: report of a rare case. Acta Otolaryngol 2007:73-6. [PMID: 17453450 DOI: 10.1080/00016480601068055] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
Abstract
Granular cell tumor is a rare tumor, probably of Schwann cell origin. The head and neck are most frequently affected, but hypopharyngeal lesion is extremely rare. We report the seventh case of hypopharyngeal granular cell tumor. Immunohistochemical staining for S100 protein is helpful for the correct diagnosis. There is some possibility of malignancy despite absence of histological evidence, thus the treatment is exclusively surgical resection. The microlaryngoscopic approach is feasible for hypopharyngeal lesions in most cases. Recurrence can occur even after appropriate resection.
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Affiliation(s)
- Keigo Honda
- Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Tison C, Doubremelle M, Le Rhun M, Cuillière P, Le Borgne J. Tumeur d’Abrikossof rectale : une localisation inhabituelle. ACTA ACUST UNITED AC 2005; 29:289-90. [PMID: 15864180 DOI: 10.1016/s0399-8320(05)80763-8] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
Abstract
Granular cell tumors or Abrikossof tumors are neurogenous ubiquitary submucosal-like tumors that are usually benign. The most frequent locations are the skin and buccal cavity. The usual location in the digestive tract is the esophageal wall. We report a rare case of Abrikossof tumor of the rectum that was not operated on because of a certain diagnosis and a low risk of malignancy.
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Affiliation(s)
- Christine Tison
- Clinique chirurgicale II, Hôtel-Dieu, CHU, 44093 Nantes Cedex
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