1
|
Carrazco Ávila PY, Rosales Leal JI, Rodríguez Valverde MÁ, Morales Hernandez ME. Design strategies for titanium surfaces to adsorb and release drugs: An in vitro study. Biomed Mater Eng 2025:9592989251346461. [PMID: 40491160 DOI: 10.1177/09592989251346461] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/11/2025]
Abstract
BACKGROUND During the early postoperative period, it is important that the patient recovers without pain and inflammation, while preserving their quality of life. In this sense, coated titanium surfaces have been designed to release anti-inflammatory and analgesic drugs during the first postoperative hours. OBJECTIVE Evaluate the adsorption capacity and release profile of different bioactive titanium surfaces treated with three different drugs: acetaminophen, doxepin and ibuprofen. METHODS Four bioactive surfaces (polished, oxidized, hydroxyapatite precipitate, and polyvinyl alcohol coating surfaces) were physiochemically treated and analyzed. RESULTS Hydroxyapatite coatings were the roughest, while PVA coating was the softest. Acetaminophen was the only drug detected on all the surfaces. In contrast, higher drug doses were loaded into the PVA coatings, showing a satisfactory release profile. CONCLUSION The results suggest that a rougher or ionically charged surface does not guarantee drug adsorption. In contrast, the use of a transport vehicle such as a polyvinyl coating ensures the release of the drug, initiating its therapeutic effect within the first minutes, and maintained for a period of between 120 and 180 min.
Collapse
Affiliation(s)
- Pablo Yael Carrazco Ávila
- Department of Stomatology (Prosthodontics Division), School of Dentistry, University of Granada, Campus de Cartuja s/n., Granada, 18071, Spain
- Faculty of Dentistry, Autonomous University of Sinaloa, Culiacan, 80010, Sinaloa, México
| | - Juan Ignacio Rosales Leal
- Department of Stomatology (Prosthodontics Division), School of Dentistry, University of Granada, Campus de Cartuja s/n., Granada, 18071, Spain
| | | | - María Encarnación Morales Hernandez
- Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus de Cartuja s/n., Granada, 18071, Spain
| |
Collapse
|
2
|
Wei L, Zha X, Ji J, Yuan C, Guo H, Wang P. Accuracy of the over-preparation technique in implant surgery in the maxillary anterior region: an in vitro study. BMC Oral Health 2025; 25:143. [PMID: 39871197 PMCID: PMC11773935 DOI: 10.1186/s12903-025-05546-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2024] [Accepted: 01/23/2025] [Indexed: 01/29/2025] Open
Abstract
BACKGROUND In the maxillary anterior region, differences in bone density along the drilling path can impact the accuracy of implant placement despite the use of a surgical guide. Hence, the aim of this in vitro study was to investigate the accuracy of implant placement using the over-preparation technique in different drilling environments in the maxillary anterior region. METHODS Three experimental models (a, b, and c) were designed and fabricated to simulate the following drilling environments (n = 60 each): unhealed bone, less dense bone, and dense bone after tooth extraction. The models were subjected to implant cavity preparation and placement using the over-preparation technique (group OPT) and conventional surgical guide technique (group CGT). Differences between the actual positions and the planned positions of the implants were calculated. RESULTS The deviations of the implants in the group OPT in Model a and Model b were significantly smaller than those in the group CGT (P < 0.05). Among the group OPT, Model c presented with the smallest deviation, followed by Model b and Model a (P < 0.05), and the CGT group showed the same trend. CONCLUSIONS In the maxillary anterior region, differences in bone density along the drilling path can adversely affect the accuracy of implant placement. These discrepancies can be significantly minimized using the over-preparation technique.
Collapse
Affiliation(s)
- Luming Wei
- Department of Oral Implantology, The Affiliated Stomatological Hospital of Xuzhou Medical University, 130 Huaihai West Road, Xuzhou, 221003, PR China
| | - Xuzhe Zha
- School of Stomatology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, PR China
| | - Jianhua Ji
- School of Stomatology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, PR China
| | - Changyong Yuan
- Department of Oral Implantology, The Affiliated Stomatological Hospital of Xuzhou Medical University, 130 Huaihai West Road, Xuzhou, 221003, PR China
- School of Stomatology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, PR China
| | - Huiying Guo
- Department of Oral Implantology, The Affiliated Stomatological Hospital of Xuzhou Medical University, 130 Huaihai West Road, Xuzhou, 221003, PR China
| | - Penglai Wang
- Department of Oral Implantology, The Affiliated Stomatological Hospital of Xuzhou Medical University, 130 Huaihai West Road, Xuzhou, 221003, PR China.
- School of Stomatology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, PR China.
| |
Collapse
|
3
|
Imber JC, Roccuzzo A, Irani DR, Bellón B, Bosshardt DD, Sculean A, Pippenger BE. Histological evaluation of osseointegration between conventional and novel bone-level tapered implants in healed bone-A preclinical study. J Periodontal Res 2024; 59:1210-1219. [PMID: 38764144 PMCID: PMC11626690 DOI: 10.1111/jre.13285] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Revised: 04/10/2024] [Accepted: 04/24/2024] [Indexed: 05/21/2024]
Abstract
AIMS To histologically compare osseointegration and crestal bone healing between newly introduced tapered, self-cutting bone-level test implants and tapered bone-level control implants in sites with fully healed sites. METHODS Sixty-six implants (33 test, 33 control) were placed 1 mm subcrestally in a minipig model and underwent qualitative histologic and quantitative histometric analyses after 3, 6 and 12 weeks of submerged healing. The primary and secondary outcomes were the bone-to-implant contact (BIC) and first bone-to-implant contact (fBIC). Outcomes between the test and control implants were statistically compared. RESULTS The BIC values of the test implants were comparable and non-inferior over the time points studied, except for the 12 weeks time point which showed statistically significantly higher BIC values of the test (88.07 ± 5.35%) compared to the control implants (80.88 ± 7.51%) (p = .010). Similarly comparable and non-inferior were the fBIC values, except for the 6-week outcome, which showed statistically higher values for the test (-546.5 ± 450.80 μm) compared to the control implants (-75.7 ± 100.59 μm). fBIC results for the test implants were qualitatively more stable and consistent between test time points. CONCLUSION Novel self-cutting bone-level test implants demonstrated superior osseointegration and similar bone levels compared to conventional bone-level implants after a healing period of 12 weeks in healed ridges.
Collapse
Affiliation(s)
- Jean-Claude Imber
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
| | - Andrea Roccuzzo
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
| | - Delia R Irani
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
| | - Benjamin Bellón
- Department of Preclinical Research, Institut Straumann, Basel, Switzerland
- Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland
- Department of Periodontology, Faculty of Dentistry, University of Zurich, Zurich, Switzerland
| | - Dieter D Bosshardt
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
| | - Anton Sculean
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
| | - Benjamin E Pippenger
- Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
- Department of Preclinical Research, Institut Straumann, Basel, Switzerland
| |
Collapse
|
4
|
Cinar IC, Zboun M, Saglanmak A, Mijiritsky E. Immediate Implantation with Autologous Mineralized Dentin Graft versus Deproteinized Bovine Bone as Space-Filling Substitute in Maxillary Anterior Zone: Retrospective Radiological and Clinical Study. J Clin Med 2024; 13:5521. [PMID: 39337008 PMCID: PMC11432380 DOI: 10.3390/jcm13185521] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/25/2024] [Revised: 09/13/2024] [Accepted: 09/16/2024] [Indexed: 09/30/2024] Open
Abstract
Background/Objectives: Various bone substitutes have been recommended to augment the horizontal gap following immediate implantation. The purpose of this study was to compare the effectiveness of an autogenous mineralized dentin graft or a deproteinized bovine bone in horizontal gap augmentation following immediate implant placement in the maxillary anterior region. Methods: A total of 110 patients underwent tooth extraction followed by immediate implant placement. The patients were divided into two groups. The first group received an autogenous mineralized dentin graft (the test group) while the second group received a deproteinized bovine bone (the control group) to augment the horizontal gap. Preoperative (T0), immediate postoperative (T1), and 1-year postoperative (T2) cone beam computed tomography scans were taken from all the patients. Linear measurements were recorded 1 mm (R1) and 5 mm (R2) points apical to the implant platform at both T1 and T2 time intervals. Pink Esthetic Scores and prosthetic complications were evaluated as well. Results: There were 57 patients with a mean age of 45.42 ± 9.86 (range 24-63 years) selected as the test group and 53 patients with a mean age of 40.28 ± 11.69 (range 20-63 years) as the control group. The mean reduction in the buccal bone plate at R1 was 6.39 ± 3.78% in the test group and 6.99 ± 5.01% in the control group (p > 0.05). The mean reduction in the buccal bone plate at R2 was 5.46 ± 4.98% in the test group and 6.77 ± 7.60% in the control group (p < 0.05). The PES and prosthetic-related complications were shown to be negligible between the groups (p > 0.05). Conclusions: The efficiency of using an autogenous mineralized dentin graft for horizontal gap augmentation showed similar results in comparison to using a deproteinized bovine bone in relation to buccolingual socket reduction following immediate implantation.
Collapse
Affiliation(s)
- Ihsan Caglar Cinar
- Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Fatih, Istanbul 34093, Türkiye
| | - Mohammed Zboun
- Department of Oral & Maxillofacial Surgery and Periodontology, Faculty of Dentistry, Arab American University, 13 Zababdeh, Jenin 240, Palestine
| | - Alper Saglanmak
- Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Fatih, Istanbul 34093, Türkiye
| | - Eitan Mijiritsky
- Department of Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, School of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
| |
Collapse
|
5
|
Kanayama M, Ferri M, Guzon FMM, Asano A, Alccayhuaman KAA, Rossi EFD, Botticelli D. Influence on marginal bone levels at implants equipped with blades aiming to control the lateral pressure on the cortical bone. An experimental study in dogs. Oral Maxillofac Surg 2024; 28:1139-1149. [PMID: 38429433 DOI: 10.1007/s10006-024-01228-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2023] [Accepted: 02/18/2024] [Indexed: 03/03/2024]
Abstract
BACKGROUND To avoid cortical compression, several implant systems have included in the protocol dedicated drills aimed at widening the cortical region of osteotomy. However, the manual execution of this operation does not guarantee the necessary precision. Hence, the present study aimed to determine the optimal size of the recipient site at the level of the alveolar crest in relation to the size of the coronal region of the implant to achieve the best healing result. MATERIALS AND METHODS Blades of different diameters were incorporated into the coronal part of the implant to prepare the cortical region of the mandibular alveolar bone crest in different dimensions in relation to the collar of the implant. The differences in diameter of the blades in relation to the collar of the implant were as follows: one control group, -175 μm, and three test groups, 0 μm, + 50 μm, or + 200 μm. RESULTS The marginal bone loss (MBL) at the buccal aspect was 0.7 mm, 0.5 mm, 0.2 mm, and 0.7 mm in the - 175 μm, 0.0 μm, + 50 μm, + 200 μm groups, respectively. The differences were statistically significant between group + 50 μm and control group - 175 μm (p = 0.019), and between + 50 μm and + 200 μm (p < 0.01) groups. The level of osseointegration at the buccal aspect was more coronally located in the test groups than in the control group, whereas the bone-to-implant contact percentage was higher in the + 50 μm and + 200 μm groups. However, these differences were not statistically significant. CONCLUSIONS The lowest bone crest resorption and highest levels of osseointegration were observed in the 0.0 μm and + 50 μm groups. The cortical region where the blades had performed their cutting action showed regular healing with perfect hard and soft tissues sealing in all the groups. Cortical blades gathered bone particles, particularly in the + 200 μm group, which were incorporated into the newly formed bone. The results from the present experiment provide support to the use of blades that produce a marginal gap of 50 μm after implant insertion.
Collapse
Affiliation(s)
| | - Mauro Ferri
- Private Practice, Cartagena de Indias, 130001, Colombia
| | - Fernando M Muñoz Guzon
- Ibonelab SL, Department of Veterinary Clinical Sciences, University of Santiago de Compostela, Lugo, Spain
| | - Akihisa Asano
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan
| | | | | | | |
Collapse
|
6
|
Ferreira Balan V, Ferri M, Pires Godoy E, Artioli LG, Botticelli D, Silva ER, Xavier SP. Controlled Lateral Pressure on Cortical Bone Using Blade-Equipped Implants: An Experimental Study in Rabbits. Bioengineering (Basel) 2024; 11:835. [PMID: 39199793 PMCID: PMC11352121 DOI: 10.3390/bioengineering11080835] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/07/2024] [Revised: 08/05/2024] [Accepted: 08/12/2024] [Indexed: 09/01/2024] Open
Abstract
BACKGROUND This study aimed to evaluate the biological behavior of a novel implant design incorporating decompressive cervical blades. Hence, the aim of the present study was to evaluate the healing outcomes in cortical regions where decompressive protocols were implemented using implants equipped with blades and installed applying a bicortical anchorage. MATERIALS AND METHODS Blades with varying diameters were integrated into the coronal portion of the implant to prepare the cortical region of rabbit tibiae. The blade diameters differed from the implant collar by the following amounts: control group (0 µm), +50 µm, and +200 µm. RESULTS No marginal bone loss was detected. Instead, all implants exhibited new bone formation in the coronal region. Complete closure was observed in the CG-0 group, as well as in the TG-50 and TG-200 groups, despite the presence of marginal gaps without primary bone contact at installation. In the apical region, most implants breached the cortical layer. Nevertheless, new bone formation in this region completely closed the osteotomy, effectively isolating the internal environment of the tibia from the external. CONCLUSIONS The use of a blade incorporated into the implant body enabled precise preparation of the cortical layer, allowing for controlled decompression in the targeted area. This technique resulted in optimal osseointegration with no loss of marginal bone, and complete restoration of marginal gaps ranging from 0 µm to 200 µm.
Collapse
Affiliation(s)
- Vitor Ferreira Balan
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto 14040-904, SP, Brazil; (V.F.B.); (L.G.A.); (E.R.S.); (S.P.X.)
| | - Mauro Ferri
- Private Practice, Cartagena de Indias 130001, Colombia;
| | - Eduardo Pires Godoy
- Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil;
| | - Leticia Gabriela Artioli
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto 14040-904, SP, Brazil; (V.F.B.); (L.G.A.); (E.R.S.); (S.P.X.)
| | | | - Erick Ricardo Silva
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto 14040-904, SP, Brazil; (V.F.B.); (L.G.A.); (E.R.S.); (S.P.X.)
| | - Samuel Porfirio Xavier
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto 14040-904, SP, Brazil; (V.F.B.); (L.G.A.); (E.R.S.); (S.P.X.)
| |
Collapse
|
7
|
Vivek, Chaudhuri NG, Patel S, Mahajan A, Luniyal S, Srivastava S, Makkad RS. Comparative Evaluation of Immediate Implant Placement in Fresh Extraction Socket with and without the use of Platelet-Rich Fibrin. JOURNAL OF PHARMACY AND BIOALLIED SCIENCES 2024; 16:S2315-S2317. [PMID: 39346391 PMCID: PMC11426751 DOI: 10.4103/jpbs.jpbs_250_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2024] [Revised: 03/24/2024] [Accepted: 03/26/2024] [Indexed: 10/01/2024] Open
Abstract
Background Immediate implant placement after tooth extraction has been found to be a workable and reliable treatment for tooth loss based on clinical and radiographic evaluation. Aim This study was conducted for comparative evaluation of immediate implant placement in fresh extraction socket with and without the use of platelet-rich fibrin (PRF). Materials and Method Forty sites in all were chosen, and they were split into two groups at random. Twenty of these were placed immediately with PRF (test category), while the remaining 20 were placed immediately without the use of any comparable adjunct (control group). Using cone beam computed tomography, radiographic characteristics were evaluated both at the time of implant implantation and a year later. Results The crestal bone at the mesial surface was 2.74 ± 1.44 and 1.96 ± 1.41 mm at baseline and 12-month follow-up in the control group. The crestal bone at the mesial surface was 2.93 ± 1.44 and 2.57 ± 1.57 mm at baseline and 12-month follow-up in the test group. Conclusion Immediate implant placement in fresh extraction socket showed better results with the use of PRF.
Collapse
Affiliation(s)
- Vivek
- Department of Prosthodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
| | - Nabagata G Chaudhuri
- Department of Prosthodontics and Crown and Bridge, Agartala Goverment Dental College and IGM Hospital, Agartala, Tripura, India
| | - Shivam Patel
- Private Practitioner, Monica Dental Clinic and Implant Centre, Nadiad, Gujarat, India
| | - Aishwarya Mahajan
- Department of Prosthodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
| | - Shikha Luniyal
- Department of Prosthodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
| | - Sonal Srivastava
- Department of Prosthodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
| | - Ramanpal S Makkad
- Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India
| |
Collapse
|
8
|
Park JY, Kwon YH, Song YW, Cha JK, Jung UW, Jung RE, Thoma DS. Flapless early implant placement into the uncalcified provisional matrix-Does it lead to osseointegration of the implant? A preclinical study. J Clin Periodontol 2024; 51:766-773. [PMID: 38356227 DOI: 10.1111/jcpe.13963] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2023] [Revised: 01/08/2024] [Accepted: 02/01/2024] [Indexed: 02/16/2024]
Abstract
AIM To test whether early implant placement into the extraction socket containing an uncalcified provisional matrix leads to successful osseointegration and stable marginal bone levels. MATERIALS AND METHODS In six mongrel dogs, the mandibular molars were extracted. Three weeks later, early implant placement was performed according to three experimental protocols: (i) flapless implant placement with preservation of the provisional matrix; (ii) flap elevation, socket debridement and implant placement; and (iii) flap elevation, socket debridement, implant placement and guided bone regeneration (GBR). One untreated extraction socket served as a control group. Data analyses were based on histologic slides 3 months after implant placement. RESULTS There were no differences in bone-to-implant contact between the three experimental groups (66.97%, 58.89% and 60.89%, respectively) (inter-group comparison p = .42). Marginal bone levels, first bone-to-implant contact as well as the thickness of the connective tissue did not reveal any significant differences between the groups (p = .85, .60 and .65, respectively). CONCLUSIONS Flapless early implant placement into posterior extraction sockets was as effective as an open flap approach in conjunction with GBR. Mineralization of the socket seems to occur irrespective of the presence of dental implants or biomaterials.
Collapse
Affiliation(s)
- Jin-Young Park
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
- Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul, South Korea
| | - Yoon-Hee Kwon
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
| | - Young Woo Song
- Department of Periodontology, Dental Hospital, Veterans Health Service Medical Center, Seoul, South Korea
| | - Jae-Kook Cha
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
- Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul, South Korea
| | - Ui-Won Jung
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
| | - Ronald E Jung
- Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland
| | - Daniel S Thoma
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
- Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland
| |
Collapse
|
9
|
Asano A, Xavier SP, Silva ER, Morinaga K, Botticelli D, Nakajima Y, Baba S. Critical-sized marginal defects around implants treated with xenografts in rabbits. Oral Maxillofac Surg 2024; 28:827-838. [PMID: 38285089 DOI: 10.1007/s10006-024-01216-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/19/2023] [Accepted: 01/19/2024] [Indexed: 01/30/2024]
Abstract
BACKGROUND Healing of critical-size defects is a well-known problem that has been challenged in several studies. The aim of the experiment was to evaluate bone formation and osseointegration of implants installed in critical defects of the mandibular body simultaneously grafted with Bio-Oss® or Cerabone®. MATERIAL AND METHODS Defects, 10 mm wide and 3 mm deep, were prepared at both lateral aspects of the mandible in 12 rabbits. One implant was installed in the center of the defect, and bovine xenografts produced either at low (Bio-Oss®; Low-T) or high (Cerabone®; High-T) temperatures were used to fill the defects. A collagen membrane was placed to cover the sites. Healing was evaluated 10 weeks after surgery. RESULTS In both groups, most sites showed optimal healing with closure of the coronal entrance of the defects. However, residual defects occupied by soft tissues and biomaterial particles were observed, even though generally limited to some regions of the defect. Osseointegration of the implant surface in the region of the defect was poor in both groups. CONCLUSIONS Circumferential marginal critical-size defects around implants filled with bovine xenografts presented regions with a complete healing in both groups. However, the healing was not complete at all regions in most defects; therefore, a complete optimal healing of critical-size marginal defects cannot be predicted.
Collapse
Affiliation(s)
- Akihisa Asano
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan
| | - Samuel Porfirio Xavier
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. Do Café - Subsetor Oeste - 11 (N-11), Ribeirão Preto, SP, 14040-904, Brazil
| | - Erick Ricardo Silva
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. Do Café - Subsetor Oeste - 11 (N-11), Ribeirão Preto, SP, 14040-904, Brazil
| | - Kenzo Morinaga
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan
| | - Daniele Botticelli
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan.
- ARDEC Academy, 47923, Rimini, Italy.
| | - Yasushi Nakajima
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan
| | - Shunsuke Baba
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan
| |
Collapse
|
10
|
Naiem SN, Al-Nawas B, Tawfik OK, El-Nahass H. Jumping gap in immediate implant placement in the esthetic zone: A virtual implant planning using cone-beam computed tomography. J Prosthodont Res 2024; 68:347-353. [PMID: 37574277 DOI: 10.2186/jpr.jpr_d_23_00033] [Citation(s) in RCA: 5] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/15/2023]
Abstract
PURPOSE A jumping gap (JG) refers to the implant's future buccal wall; this study aims to estimate the jumping gap dimension in relation to virtual implant placement and subsequently link the implant diameter and implant position with the anatomical site. METHODS This observational study was conducted to analyze the maxillary teeth in the esthetic zone from cone-beam computed tomography (CBCT) scans using OnDemand software. The horizontal jumping gap dimension of each tooth was assessed by subtracting the calculated virtual implant diameter from the socket dimensions. RESULTS A total of 253 anterior and premolar maxillary teeth were analyzed from 52 CBCT scans. The estimated JG dimensions were 1.23 ± 0.59 mm, 1.80 ± 0.64 mm, 3.02 ± 0.69 mm, for central incisors, lateral incisors and canines respectively, 3.70 ± 0.68 mm for the first premolars showing the highest horizontal gap and 3.19 ± 0.88 mm for second premolars. The incisors showed the smallest horizontal gap compared to the canines and premolars. CONCLUSIONS In terms of JG, immediate implant placement is more favorable at the canine and premolar sites. By contrast, the incisors sites should be handled with extreme caution, where the use of narrower implants is advisable when necessary.
Collapse
Affiliation(s)
- Suzy Nabil Naiem
- Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University, Egypt
| | - Bilal Al-Nawas
- Oral and Maxillofacial Surgery, Plastic surgery department, Mainz University, Germany
| | - Omnia Khaled Tawfik
- Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University, Egypt
| | - Hani El-Nahass
- Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University, Egypt
| |
Collapse
|
11
|
Yu W, Luo D, Yang J, Yuan M, Yang Y, Gao Y. Immediate implant placement for chronic peri-apical periodontitis in the molar region: a randomised controlled trial. Int J Oral Maxillofac Surg 2024; 53:223-230. [PMID: 37673734 DOI: 10.1016/j.ijom.2023.08.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2022] [Revised: 03/03/2023] [Accepted: 08/02/2023] [Indexed: 09/08/2023]
Abstract
The aim of this study was to evaluate the feasibility of immediate implantation for chronic peri-apical periodontitis in the molar region. Seventy-four molars were selected and allocated randomly to two groups. The experimental group (n = 38) received immediate implantation by flap surgery and the control group (n = 36) received delayed implantation. CBCT was performed immediately after surgery (T1) and 12 months after the permanent repair (T3). The implant survival rate at T3 was 100% in both groups. There was no significant difference in buccal or lingual vertical marginal bone loss between the groups (P = 0.515, P = 0.736). However, the buccal horizontal margin bone loss was significantly greater in the experimental group: 0.98 ± 0.34 mm vs 0.77 ± 0.27 mm in the control group (P = 0.003). In the experimental group, the highest point of buccal and lingual implant-bone contact increased at T3. The buccal and lingual jump gap widths were 3.21 ± 1.10 mm and 2.92 ± 1.01 mm at T1, and CBCT showed no jump gap around the implants at T3. The clinical outcomes showed immediate implantation to be feasible for chronic peri-apical periodontitis in the molar region.
Collapse
Affiliation(s)
- W Yu
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China; School of Stomatology of Qingdao University, Qingdao, Shandong, PR China
| | - D Luo
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China; School of Stomatology of Qingdao University, Qingdao, Shandong, PR China
| | - J Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China.
| | - M Yuan
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China; School of Stomatology of Qingdao University, Qingdao, Shandong, PR China
| | - Y Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China; School of Stomatology of Qingdao University, Qingdao, Shandong, PR China
| | - Y Gao
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China; School of Stomatology of Qingdao University, Qingdao, Shandong, PR China
| |
Collapse
|
12
|
Betha H, Rajmohan M, Subhada B, Thakkar R, Ranjith Surya B, Shetty A, Tiwari R. Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research. JOURNAL OF PHARMACY AND BIOALLIED SCIENCES 2024; 16:S258-S260. [PMID: 38595343 PMCID: PMC11000930 DOI: 10.4103/jpbs.jpbs_484_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2023] [Revised: 08/23/2023] [Accepted: 09/17/2023] [Indexed: 04/11/2024] Open
Abstract
Background To replace missing periodontal tissues in vertical defects during periodontal surgery, bone graft materials are frequently used. A frequent occurrence that can affect healing outcomes is postoperative edema. The purpose of this study was to evaluate postoperative edema in various vertical bone graft defects following periodontal surgery. Materials and Methods 50 participants were split into two groups for a prospective study: Group A received xenografts, whereas Group B received synthetic grafts. Up to 14 days after surgery, baseline and routine postoperative edema measurements were made. Edema levels in each group were compared using statistical analysis. Results At all postoperative time points, Group A showed substantially more edema than Group B (P < 0.05). Furthermore, edema persisted longer in Group A than it did in Group B. Conclusion In conclusion, the substance of the bone graft used in vertical defects during periodontal surgery affects postoperative edema. Compared to synthetic grafts, xenografts caused swelling to last longer and at higher levels. To maximize healing results, clinicians should take these findings into account when choosing graft materials.
Collapse
Affiliation(s)
- Hymasree Betha
- Periodontist, CLOVE Dental, Visakhapatnam, Andhra Pradesh, India
| | - M. Rajmohan
- Department of Dental Surgery, KAPV Government Medical College and Hospital, Trichy, Tamil Nadu, India
| | - B. Subhada
- Department of Periodontics, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India
| | - Radhika Thakkar
- Eastman Institute for Oral Health, University of Rochester, New York, United States
| | - Bezgam Ranjith Surya
- Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India
| | - Athma Shetty
- Department of Prosthodontics and Crown and Bridge, AB Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Mangalore, Karnataka, India
| | - Rahul Tiwari
- Oral and Maxillofacial Surgeon, CLOVE Dental, Visakhapatnam, Andhra Pradesh, India
| |
Collapse
|
13
|
Sakaguchi R, Xavier SP, Morinaga K, Botticelli D, Silva ER, Nakajima Y, Baba S. Histological Comparison of Collagenated Cancellous Equine Bone Blocks Used as Inlay or Onlay for Lateral Bone Augmentation in Rabbits. MATERIALS (BASEL, SWITZERLAND) 2023; 16:6742. [PMID: 37895725 PMCID: PMC10608602 DOI: 10.3390/ma16206742] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/09/2023] [Revised: 10/12/2023] [Accepted: 10/17/2023] [Indexed: 10/29/2023]
Abstract
BACKGROUND The conformation of the recipient site for an inlay graft presents an increased contact with the parent bone compared to an onlay graft. This might favor bone growth within the inlay compared to onlay grafts. Hence, the objective of this study was to compare the bone incorporation and remodeling processes of xenogeneic en bloc grafts placed using two bone grafting techniques, i.e., onlay vs. inlay. METHODS In this prospective, randomized, split-mouth study (test and control sides in the same animal), two bone grafting techniques were comparatively evaluated. The lateral aspect of the rabbit mandible was used as the recipient site, bilaterally. On one side of the mandible, the cortical bone was perforated with drills to allow a better bone formation from the bone wound and the marrow spaces. A xenogeneic bone block was fixed in the center of the prepared region, representing the onlay site. On the other side of the mandible, a 7 mm wide and 3 mm deep circumferential defect was prepared using trephines and drills. A xenogeneic bone block was fixed in the center of the defect, representing the inlay site. Two healing periods were applied in the study: 2 and 10 weeks, each represented by 10 rabbits (n = 10 for each period). RESULTS After 2 weeks of healing, the mean percentage of new bone was 10.4% and 23.3% at the onlay and inlay grafts, respectively (p = 0.022). After 10 weeks of healing, new bone increased to 13.2% at the onlay sites and 25.4% at the inlay sites (p = 0.080). In the 10-week period, the inlay grafts presented a homogeneous growth of new bone in all regions, while in the onlay grafts, low percentages of new bone were observed in the external regions. CONCLUSION The percentage of new bone increased faster and was higher in the inlay grafts than in the onlay grafts. This outcome might be related to the self-contained conformation of the recipient site in the inlay group, which offered more sources for new bone formation compared to the one-wall conformation of the recipient sites in the onlay group. The osteoconductive properties of the biomaterial allowed the newly formed bone to reach the most peripheral regions in both groups. The osteoconductive properties of the biomaterial, together with the protection offered by the collagen membrane, allowed marginal closure of the defects by newly formed bone in the inlay group.
Collapse
Affiliation(s)
- Ryuichi Sakaguchi
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan; (R.S.); (K.M.); (Y.N.); (S.B.)
| | - Samuel Porfirio Xavier
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, Subsetor Oeste, 11 (N-11), Ribeirao Preto 14040-904, SP, Brazil; (S.P.X.); (E.R.S.)
| | - Kenzo Morinaga
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan; (R.S.); (K.M.); (Y.N.); (S.B.)
| | - Daniele Botticelli
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan; (R.S.); (K.M.); (Y.N.); (S.B.)
- ARDEC Academy, 47923 Rimini, Italy
| | - Erick Ricardo Silva
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, Subsetor Oeste, 11 (N-11), Ribeirao Preto 14040-904, SP, Brazil; (S.P.X.); (E.R.S.)
| | - Yasushi Nakajima
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan; (R.S.); (K.M.); (Y.N.); (S.B.)
- Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, Subsetor Oeste, 11 (N-11), Ribeirao Preto 14040-904, SP, Brazil; (S.P.X.); (E.R.S.)
| | - Shunsuke Baba
- Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan; (R.S.); (K.M.); (Y.N.); (S.B.)
| |
Collapse
|
14
|
Liñares A, Dopico J, Magrin G, Blanco J. Critical review on bone grafting during immediate implant placement. Periodontol 2000 2023; 93:309-326. [PMID: 37658586 DOI: 10.1111/prd.12516] [Citation(s) in RCA: 10] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/29/2023] [Revised: 07/11/2023] [Accepted: 07/24/2023] [Indexed: 09/03/2023]
Abstract
In the last 20 years, immediate implant placement has been proposed as a predictable protocol to replace failing teeth. The research conducted in preclinical and clinical studies have focused on soft and hard tissue changes following tooth extraction and immediate implant placement. Different approaches for hard and soft tissue grafting together with provisional restorations have been proposed to compensate tissue alterations. This review analyzed some relevant clinical and preclinical literature focusing on the impact of bone grafting procedures on immediate implant placement in terms of hard and soft tissue changes, aesthetic results, and patient-related outcomes.
Collapse
Affiliation(s)
- Antonio Liñares
- Unit of Periodontology, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain
| | - José Dopico
- Unit of Periodontology, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain
| | - Gabriel Magrin
- Unit of Periodontology, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain
- Department of Dentistry, Centre for Education and Research on Dental Implants (CEPID), Federal University of Santa Catarina, Florianopolis, Brazil
| | - Juan Blanco
- Unit of Periodontology, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain
| |
Collapse
|
15
|
Yang H, Luo D, Yuan MJ, Yang JJ, Wang DS. Five-year outcomes of immediate implant placement for mandibular molars with and without chronic apical periodontitis: A retrospective study. World J Clin Cases 2023; 11:5218-5229. [DOI: 10.12998/wjcc.v11.i22.5218] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/29/2023] [Revised: 06/26/2023] [Accepted: 07/10/2023] [Indexed: 08/03/2023] Open
Abstract
BACKGROUND Most physicians consider molars with chronic apical periodontitis (CAP) lesions as contraindications for immediate implant placement. At the patient’s request, we perform immediate implant placement of the mandibular molars with CAP in clinical practice.
AIM To retrospectively analyze and compare the 5-year outcomes of immediate implant placement of the mandibular molars with CAP and those without obvious inflammation.
METHODS The clinical data of patients with immediate implant placement of the mandibular molars in the Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, from June 2015 to June 2017 were collected. The patients were divided into CAP (n = 52) and no-CAP (n = 45) groups. Changes in bone mineral density and bone mass around implants were analyzed 5 years after implant restoration.
RESULTS At 5 years after implantation, the peri-implant bone mineral density was 528.2 ± 78.8 Hounsfield unit (HU) in the CAP group and 562.6 ± 82.9 HU in the no-CAP group (P = 0.126). Marginal bone resorption around implants did not differ significantly between the two groups, including buccal (P = 0.268) or lingual (P = 0.526) resorption in the vertical direction or buccal (P = 0.428) or lingual (P = 0.560) resorption in the horizontal direction. Changes in the peri-implant jump space did not differ significantly between the two groups, including the buccal (P = 0.247) or lingual (P = 0.604) space in the vertical direction or buccal (P = 0.527) or lingual (P = 0.707) space in the horizontal direction. The gray value of cone-beam computed tomography measured using Image J software can reflect the bone mineral density. In the CAP area, the gray values of the bone tissue immediately and 5 years after implant placement differed significantly from those of the surrounding bone tissue (P < 0.01).
CONCLUSION The results of this study suggest that immediate implant placement of the mandibular molars with CAP can achieve satisfactory 5-year clinical results, without significant differences in the complications, survival rate, or bone tissue condition from the no-CAP mandibular molars.
Collapse
Affiliation(s)
- Hua Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Dan Luo
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Mu-Jie Yuan
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Jian-Jun Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Da-Shan Wang
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
- Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
| |
Collapse
|
16
|
Yang H, Luo D, Yuan MJ, Yang JJ, Wang DS. Five-year outcomes of immediate implant placement for mandibular molars with and without chronic apical periodontitis: A retrospective study. World J Clin Cases 2023; 11:5224-5235. [PMID: 37621586 PMCID: PMC10445073 DOI: 10.12998/wjcc.v11.i22.5224] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/29/2023] [Revised: 06/26/2023] [Accepted: 07/10/2023] [Indexed: 08/04/2023] Open
Abstract
BACKGROUND Most physicians consider molars with chronic apical periodontitis (CAP) lesions as contraindications for immediate implant placement. At the patient's request, we perform immediate implant placement of the mandibular molars with CAP in clinical practice. AIM To retrospectively analyze and compare the 5-year outcomes of immediate implant placement of the mandibular molars with CAP and those without obvious inflammation. METHODS The clinical data of patients with immediate implant placement of the mandibular molars in the Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, from June 2015 to June 2017 were collected. The patients were divided into CAP (n = 52) and no-CAP (n = 45) groups. Changes in bone mineral density and bone mass around implants were analyzed 5 years after implant restoration. RESULTS At 5 years after implantation, the peri-implant bone mineral density was 528.2 ± 78.8 Hounsfield unit (HU) in the CAP group and 562.6 ± 82.9 HU in the no-CAP group (P = 0.126). Marginal bone resorption around implants did not differ significantly between the two groups, including buccal (P = 0.268) or lingual (P = 0.526) resorption in the vertical direction or buccal (P = 0.428) or lingual (P = 0.560) resorption in the horizontal direction. Changes in the peri-implant jump space did not differ significantly between the two groups, including the buccal (P = 0.247) or lingual (P = 0.604) space in the vertical direction or buccal (P = 0.527) or lingual (P = 0.707) space in the horizontal direction. The gray value of cone-beam computed tomography measured using Image J software can reflect the bone mineral density. In the CAP area, the gray values of the bone tissue immediately and 5 years after implant placement differed significantly from those of the surrounding bone tissue (P < 0.01). CONCLUSION The results of this study suggest that immediate implant placement of the mandibular molars with CAP can achieve satisfactory 5-year clinical results, without significant differences in the complications, survival rate, or bone tissue condition from the no-CAP mandibular molars.
Collapse
Affiliation(s)
- Hua Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Dan Luo
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Mu-Jie Yuan
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Jian-Jun Yang
- Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
| | - Da-Shan Wang
- School of Stomatology, Qingdao University, Qingdao 266003, Shandong Province, China
- Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
| |
Collapse
|
17
|
Gulati K, Chopra D, Kocak-Oztug NA, Verron E. Fit and forget: The future of dental implant therapy via nanotechnology. Adv Drug Deliv Rev 2023; 199:114900. [PMID: 37263543 DOI: 10.1016/j.addr.2023.114900] [Citation(s) in RCA: 30] [Impact Index Per Article: 15.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2023] [Revised: 05/11/2023] [Accepted: 05/21/2023] [Indexed: 06/03/2023]
Abstract
Unlike orthopedic implants, dental implants require the orchestration of both osseointegration at the bone-implant interface and soft-tissue integration at the transmucosal region in a complex oral micro-environment with ubiquitous pathogenic bacteria. This represents a very challenging environment for early acceptance and long-term survival of dental implants, especially in compromised patient conditions, including aged, smoking and diabetic patients. Enabling advanced local therapy from the surface of titanium-based dental implants via novel nano-engineering strategies is emerging. This includes anodized nano-engineered implants eluting growth factors, antibiotics, therapeutic nanoparticles and biopolymers to achieve maximum localized therapeutic action. An important criterion is balancing bioactivity enhancement and therapy (like bactericidal efficacy) without causing cytotoxicity. Critical research gaps still need to be addressed to enable the clinical translation of these therapeutic dental implants. This review informs the latest developments, challenges and future directions in this domain to enable the successful fabrication of clinically-translatable therapeutic dental implants that would allow for long-term success, even in compromised patient conditions.
Collapse
Affiliation(s)
- Karan Gulati
- The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia.
| | - Divya Chopra
- The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia
| | - Necla Asli Kocak-Oztug
- The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia; Istanbul University, Faculty of Dentistry, Department of Periodontology, 34116 Istanbul, Turkey
| | - Elise Verron
- Nantes Université, CNRS, CEISAM, UMR 6230, 44000 Nantes, France
| |
Collapse
|
18
|
Muacevic A, Adler JR, Sharma PK, Sabu K I, Singh Parihar A, Mandal A, Sahoo AR. A Comparative Clinical Evaluation of Effectiveness of Platelet-Rich Plasma, Synthetic Allograft, and Bioresorbable Xenograft During Immediate Implant Placement. Cureus 2022; 14:e32121. [PMID: 36601172 PMCID: PMC9805548 DOI: 10.7759/cureus.32121] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 12/01/2022] [Indexed: 12/03/2022] Open
Abstract
BACKGROUND The use of an appropriate graft material helps in an adequate amount of osseointegration. The objective of this study was to compare the efficacy of platelet-rich plasma (PRP), a synthetic allograft (PerioGlas), and Bio-Oss, a bioresorbable xenograft in immediate implant procedures. METHODS In this randomized, prospective study, 90 patients were categorized into three groups with 30 samples in each as Group A: patients who received PRP with an immediate implant; Group B: immediate implants with synthetic allograft (PerioGlas); and Group C: patients with immediate implants placed using bioresorbable xenograft (Bio-Oss). Postoperative follow-up was done based on plaque and gingival index, measurement of probing depths, and resorption of bone. Obtained data were statistically analyzed using the "one-way analysis of variance (ANOVA)" test. RESULTS Inter-group statistical comparisons between gingival and plaque indices at three, six, and 12 months of follow-up in the study groups demonstrated no statistical significance (p > 0.05). The mean probing depths and resorption of bone at three, six, and 12 months of follow-up were statistically nonsignificant (p > 0.05) on the inter-group comparison. CONCLUSION It could be concluded from the present study that there is no statistical superiority observed among PRP, PerioGlas, or Bio-Oss in terms of their usage as a graft material along with immediate implant placement procedure.
Collapse
|
19
|
Benalcázar Jalkh EB, Tovar N, Arbex L, Kurgansky G, Torroni A, Gil LF, Wall B, Kohanbash K, Bonfante EA, Coelho PG, Witek L. Effect of leukocyte-platelet-rich fibrin in bone healing around dental implants placed in conventional and wide osteotomy sites: A pre-clinical study. J Biomed Mater Res B Appl Biomater 2022; 110:2705-2713. [PMID: 35771197 DOI: 10.1002/jbm.b.35122] [Citation(s) in RCA: 10] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2021] [Revised: 04/20/2022] [Accepted: 06/17/2022] [Indexed: 12/15/2022]
Abstract
Leukocyte-platelet-rich fibrin (L-PRF) has been suggested for gap management for immediate implant placement when the distance is greater than 2 mm. However, there remains a paucity in hierarchically designed research to support this application. The present study aimed to evaluate the effect of L-PRF on the osseointegration parameters of dental implants placed after conventional osteotomy of surgically created bone defects that simulate post extraction sockets in a canine model after 3, 6, and 12 weeks in vivo. Eighty dental implants (Intra-Lock, Boca Raton, FL) were placed in the radius of 13 beagle dogs. The experiment consisted of 4 groups (n = 20 implants/group): 1) Regular osteotomy (Reg n/L-PRF); 2) Regular osteotomy and implant placement with L-PRF membrane (Reg L-PRF); 3) Wide osteotomy with no gap management performed, where an osteotomy/bony defect (6 mm of diameter and ~5 mm deep) was created to simulate immediate implant placement in post-extraction sockets, and the gap was left for spontaneous healing (Wide nL-PRF); and 4) Wide osteotomy with L-PRF gap management (Wide L-PRF). L-PRF membranes were obtained by blood drawn from each subject and centrifuged at 2700 rpm (408 RCF-clot) for 12 min. In the experimental groups where L-PRF was utilized, the membrane was inserted into the osteotomy site prior to implant placement. Six dogs had implants placed in the radius for 3 weeks; and 7 dogs had implants placed in the left radius for 6 weeks and in the right radius for 12 weeks. At the corresponding experimental time points, samples were harvested, and subjected to histological processing for qualitative and quantitative analyses, via bone-to-implant contact (BIC) and bone-area-fraction occupancy (BAFO). Qualitative analysis demonstrated increased amounts of bone formation around the implant and within the healing chambers over time for all groups. While comparable histological features were observed for both Reg groups (L-PRF and nL-PRF), the gap management performed in Wide L-PRF group resulted in effective gap filling with improved bone growth in close proximity to the implant surface. Quantitative analyses of BIC and BAFO yielded higher values for both variables at 3 weeks for Wide L-PRF (~38% and ~56% respectively) compared to Wide nL-PRF (~20% for BIC and BAFO) (p < .03). No statistical differences were detected between Wide groups at 6 and 12 weeks, neither between Reg groups, independent of the association with or without the L-PRF membrane at all healing times. L-PRF placed within wide osteotomies, prior to implant placement, resulted in increased early bone formation compared to unfilled wide osteotomies at the early healing time (3 weeks in vivo).
Collapse
Affiliation(s)
- Ernesto B Benalcázar Jalkh
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.,Department of Prosthodontics and Periodontology, University of Sao Paulo, Bauru School of Dentistry, Bauru, Brazil
| | - Nick Tovar
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.,Department of Oral and Maxillofacial Surgery, New York University, Langone Medical Center and Bellevue Hospital Center, New York, New York, USA
| | - Leticia Arbex
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA
| | - Gregory Kurgansky
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA
| | - Andrea Torroni
- Hansjörg Wyss Department of Plastic Surgery, NYU Langone Medical Center, New York, New York, USA
| | - Luiz F Gil
- Department of Morphological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
| | - Brittany Wall
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA
| | - Kimia Kohanbash
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA
| | - Estevam A Bonfante
- Department of Prosthodontics and Periodontology, University of Sao Paulo, Bauru School of Dentistry, Bauru, Brazil
| | - Paulo G Coelho
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.,Hansjörg Wyss Department of Plastic Surgery, NYU Langone Medical Center, New York, New York, USA.,Department of Mechanical and Aerospace Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA.,University of Miami Miller School of Medicine, Miami, Florida, USA
| | - Lukasz Witek
- Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA.,Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA
| |
Collapse
|
20
|
Bhombe KR, Bajaj P, Mundada B, Dhadse P, Subhadarsanee C, Oza RR. Combined Effect of Platelet-Rich Fibrin Matrix (PRFM) and Demineralized Freeze-Dried Bone Allograft (DFDBA) in Immediate Implant Placement: A Single-Arm Clinical Trial. Cureus 2022; 14:e29728. [PMID: 36324343 PMCID: PMC9617181 DOI: 10.7759/cureus.29728] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/13/2022] [Accepted: 09/23/2022] [Indexed: 12/05/2022] Open
Abstract
Introduction Placement of immediate implants in contrast to delayed implant placement may be favorable. The factors contributing to this are shortened overall treatment time, aid in ideal orientation and fixture placement, bone preservation following extraction, and achieving optimal aesthetics involving soft tissue. However, the gap distance between the surface of the implant and the buccal bony wall during implant placement is critical for subsequent bone healing in a fresh extraction socket. Considering that as the gap broadens, the amount of bone-to-implant contact (BIC) decreases, causing an apical shift of the highest bone-implant contact. Incorporating a bone substitute material (BSM) within the fixture-socket gap preserves alveolar ridge volume by minimizing socket remodeling and encouraging de-novo bone formation. Aim and objectives To evaluate the efficacy of platelet-rich fibrin matrix (PRFM) and demineralized freeze-dried bone allograft (DFDBA) in fresh extraction socket with simultaneous implant placement. Methods Implants were immediately placed in 12 patients following a two-stage submerged protocol. The combination of PRFM and DFDBA was used to fill the gap between the implant body and the surrounding socket wall. The final restoration was placed after 3 months following implant placement. The full mouth plaque, gingival bleeding index, and gingival esthetics scores were assessed at baseline, 3, and 6 months. The crestal changes were evaluated using intraoral periapical radiographs (IOPA) at baseline, 3, and 6 months. Cone beam computed tomography (CBCT) images were obtained at baseline and 6 months after implant loading to analyze the buccolingual changes. Results At 6 months follow-up, the coronal bone remodeling detected on CBCT revealed a minimal (0.1 mm) narrowing of the alveolar ridge in a buccolingual direction, with a mean bone loss of 0.10+0.09, which was statistically non-significant (p > 0.05). Implant success was 100% at 6 months after loading as determined by Akbrektsson’s criteria for implant success. Conclusions The adjunctive use of PRFM with DFDBA following immediate implant placement yielded a significant reduction in bone resorption and maintenance of buccolingual dimensions.
Collapse
|
21
|
Elaskary A, Abdelrahman H, Elsabagh HH, El-Kimary GI. Does Grafting The Jumping Gap In Immediately Placed Anterior Implants Using Vestibular Socket Therapy Influence The Labial Bone Thickness? J Oral Maxillofac Surg 2022; 80:1398-1407. [DOI: 10.1016/j.joms.2022.05.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/04/2022] [Revised: 05/02/2022] [Accepted: 05/03/2022] [Indexed: 10/18/2022]
|
22
|
Elbrashy A, Osman AH, Shawky M, Askar N, Atef M. Immediate implant placement with platelet rich fibrin as space filling material versus deproteinized bovine bone in maxillary premolars: A randomized clinical trial. Clin Implant Dent Relat Res 2022; 24:320-328. [PMID: 35353941 DOI: 10.1111/cid.13075] [Citation(s) in RCA: 11] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/14/2021] [Revised: 02/07/2022] [Accepted: 02/08/2022] [Indexed: 11/28/2022]
Abstract
BACKGROUND Several biomaterials have been suggested to augment the jumping gap during immediate implant placement. PURPOSE The aim of this study was to compare the effect of xenograft or platelet derived growth factor (PRF) to graft the jumping gap in immediate implant placement in the maxillary premolar region. MATERIALS AND METHODS Twenty patients underwent atraumatic extraction followed by immediate placement. The patients were equally divided into two groups. The first group received xenograft as a jumping gap filling material. The second group received PRF to graft the jumping gap. All patients received preoperative, immediate postoperative, and 6 months postoperative cone beam CT scan (CBCT). Implant stability quotient ISQ values were taken for the installed implants immediate postoperative and at 6 months. RESULTS Implants receiving PRF as a jumping gap graft material demonstrated a significantly greater amount of crestal bone loss 1.85 ± 0.89 mm as compared to xenograft group 0.77 ± 0.32 mm (t = 3.52, p = 0.005). PRF group showed significantly greater reduction in buccopalatal direction 1.63 mm as compared to xenograft group 0.59 mm (t = 4014, p <0.001). ISQ values were similar immediately postoperative (t = 0.070, p = 0.945) while the ISQ values were significantly lower in PRF group as compared to xenograft graft at the six-month interval (t = 0.248, p = 0.023). CONCLUSION The use of xenograft material as a jumping gap filling material resulted in superior results compared to PRF with regards to crestal bone loss, buccolingual socket reduction, and ISQ values.
Collapse
Affiliation(s)
- Ahmed Elbrashy
- Department of Implantology, Faculty of Dentistry, Cairo University, Cairo, Egypt
| | - Ahmed H Osman
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, British University of Egypt, Cairo, Egypt
| | - Mohamed Shawky
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Egyptian Russian University, Cairo, Egypt
| | - Niveen Askar
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
| | - Mohamed Atef
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt
| |
Collapse
|
23
|
Kotsu M, Apaza Alccayhuaman KA, Ferri M, Iezzi G, Piattelli A, Fortich Mesa N, Botticelli D. Osseointegration at Implants Installed in Composite Bone: A Randomized Clinical Trial on Sinus Floor Elevation. J Funct Biomater 2022; 13:jfb13010022. [PMID: 35323222 PMCID: PMC8950152 DOI: 10.3390/jfb13010022] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/29/2021] [Revised: 02/19/2022] [Accepted: 02/24/2022] [Indexed: 02/08/2023] Open
Abstract
Osseointegration of implants installed in conjunction with sinus floor elevation might be affected by the presence of residual graft. The implant surface characteristics and the protection of the access window using a collagen membrane might influence the osseointegration. To evaluate these factors, sinus floor elevation was performed in patients using a natural bovine bone grafting material. The access windows were either covered with a collagen membrane made of porcine corium (Mb group) or left uncovered (No-Mb group) and, after six months, two mini-implants with either a moderate rough or turned surfaces were installed. After 3 months, biopsies containing the mini-implants were retrieved, processed histologically, and analyzed. Twenty patients, ten in each group, were included in the study. The two mini-implants were retrieved from fourteen patients, six belonging to the Mb group, and eight to the No-Mb group. No statistically significant differences were found in osseointegration between groups. However, statistically significant differences were found between the two surfaces. It was concluded that implants with a moderately rough surface installed in a composite bone presented much higher osseointegration compared to those with a turned surface. The present study failed to show an effect of the use of a collagen membrane on the access window.
Collapse
Affiliation(s)
| | | | - Mauro Ferri
- ARDEC Foundation, Cartagena de Indias 130001, Colombia;
| | - Giovanna Iezzi
- Department of Medical Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy; (G.I.); (A.P.)
| | - Adriano Piattelli
- Department of Medical Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy; (G.I.); (A.P.)
| | - Natalia Fortich Mesa
- School of Dentistry, University Corporation Rafael Núñez, Cartagena de Indias 130001, Colombia;
| | | |
Collapse
|
24
|
Tiwari B, Sharma A, Maheshwari K, Naik D. Socket shield technique: An unconventional method for immediate implant placement - A review. Natl J Maxillofac Surg 2022; 13:S24-S35. [DOI: 10.4103/njms.njms_53_20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2020] [Revised: 06/08/2020] [Accepted: 08/04/2020] [Indexed: 11/04/2022] Open
|
25
|
An MK, Kim HJ, Choi JU, Kim KH, Lee YM, Rhyu IC, Seol YJ. The healing pattern of a 4 mm proximal infrabony defect was not significantly different from a 2 mm defect adjacent to dental implant in a canine mandible. J Periodontal Implant Sci 2022; 52:422-434. [PMID: 36302648 PMCID: PMC9614175 DOI: 10.5051/jpis.2106420321] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2021] [Revised: 03/30/2022] [Accepted: 04/20/2022] [Indexed: 11/09/2022] Open
Abstract
Purpose The purpose of this study was to evaluate and compare the healing patterns of 2-mm and 4-mm proximal infrabony defects adjacent to dental implants in canine mandibles. Methods Four male beagles were used. Two groups were created: a 2-mm group (n=4) and a 4-mm group (n=4) depending on the horizontal dimension of proximal infrabony defects adjacent to implants. Bone healing patterns between the 2 groups were evaluated and compared at 8 and 16 weeks using radiographic, histological, histomorphometric, and fluorescent labelling analyses. Results According to microcomputed tomography, the median bone volume fraction, bone mineral density, and the percentage of radiographic distance from the defect bottom to the most coronal bone-to-implant contact (radio-mcBIC) were 32.9%, 0.6 g/cm3, and 73.7% (8 weeks) and 45.7%, 0.7 g/cm3, and 76.0% (16 weeks) in the 2-mm group and 57.7%, 0.8 g/cm3, and 75.7% (8 weeks) and 50.9%, 0.8 g/cm3, and 74.7% (16 weeks) in the 4-mm group, respectively. According to histomorphometry, the median bone area fraction, mcBIC and the percentage of BIC amounted to 36.7%, 3.4 mm, and 58.4% (8 weeks) and 49.2%, 3.4 mm, and 70.2% (16 weeks) in the 2-mm group and 50.0%, 3.0 mm, and 64.8% (8 weeks) and 55.7%, 3.0 mm, and 69.6% (16 weeks) in the 4-mm group, respectively. No statistically significant differences were found between the groups for any variables (P>0.05). Conclusions The proximal defects that measured 2 mm and 4 mm showed similar healing patterns at 8 and 16 weeks, and the top of bone formation in the defects was substantially limited to a maximum of 1.6 mm below the implant shoulder in both groups.
Collapse
Affiliation(s)
- Min Kuk An
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| | - Hyun Ju Kim
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
- Department of Periodontics, Seoul National University Dental Hospital, Seoul, Korea
| | - Jin Uk Choi
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| | - Kyoung-Hwa Kim
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| | - Yong-Moo Lee
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| | - In-Chul Rhyu
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| | - Yang-Jo Seol
- Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
| |
Collapse
|
26
|
Le Thieu MK, Homayouni A, Hæren LR, Tiainen H, Verket A, Ellingsen JE, Rønold HJ, Wohlfahrt JC, Cantalapiedra AG, Muñoz FMG, Mendaña MP, Lyngstadaas SP, Haugen HJ. Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomater Res 2021; 25:43. [PMID: 34823602 PMCID: PMC8620131 DOI: 10.1186/s40824-021-00245-3] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2021] [Accepted: 11/15/2021] [Indexed: 12/31/2022] Open
Abstract
Background Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthetic TiO2 block scaffold was placed in circumferential peri-implant defects with buccal fenestrations. Methods The mandibular premolars were extracted and the alveolar bone left to heal for 4 weeks prior to implant placement in six minipigs. Two cylindrical defects were created in each hemi-mandible and were subsequent to implant placement allocated to treatment with either TiO2 scaffold or sham in a split mouth design. After 12 weeks of healing time, the samples were harvested. Microcomputed tomography (MicroCT) was used to investigate defect fill and integrity of the block scaffold. Distances from implant to bone in vertical and horizontal directions, percentage of bone to implant contact and defect fill were analysed by histology. Results MicroCT analysis demonstrated no differences between the groups for defect fill. Three of twelve scaffolds were partly fractured. At the buccal sites, histomorphometric analysis demonstrated higher bone fraction, higher percentage bone to implant contact and shorter distance from implant top to bone 0.5 mm lateral to implant surface in sham group as compared to the TiO2 group. Conclusions This study demonstrated less bone formation with the use of TiO2 scaffold block in combination with implant placement in cylindrical defects with buccal bone fenestrations, as compared to sham sites.
Collapse
Affiliation(s)
- Minh Khai Le Thieu
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway
| | - Amin Homayouni
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway
| | - Lena Ringsby Hæren
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway
| | - Hanna Tiainen
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway
| | - Anders Verket
- Department of Periodontology, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway
| | - Jan Eirik Ellingsen
- Department of Prosthetic Dentistry and Oral Function, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway
| | - Hans Jacob Rønold
- Department of Prosthetic Dentistry and Oral Function, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway
| | - Johan Caspar Wohlfahrt
- Department of Periodontology, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway
| | - Antonio Gonzalez Cantalapiedra
- Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario, s/n, 27002, Lugo, Spain.,Ibonelab S.L., Laboratory of Biomaterials, Avda. da Coruña, 500 (CEI-NODUS), 27003, Lugo, Spain
| | - Fernando Maria Guzon Muñoz
- Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario, s/n, 27002, Lugo, Spain.,Ibonelab S.L., Laboratory of Biomaterials, Avda. da Coruña, 500 (CEI-NODUS), 27003, Lugo, Spain
| | - Maria Permuy Mendaña
- Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario, s/n, 27002, Lugo, Spain.,Ibonelab S.L., Laboratory of Biomaterials, Avda. da Coruña, 500 (CEI-NODUS), 27003, Lugo, Spain
| | - Ståle Petter Lyngstadaas
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway
| | - Håvard Jostein Haugen
- Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway.
| |
Collapse
|
27
|
De Angelis N, Signore A, Alsayed A, Hai Hock W, Solimei L, Barberis F, Amaroli A. Immediate Implants in the Aesthetic Zone: Is Socket Shield Technique a Predictable Treatment Option? A Narrative Review. J Clin Med 2021; 10:4963. [PMID: 34768483 PMCID: PMC8584280 DOI: 10.3390/jcm10214963] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2021] [Revised: 10/20/2021] [Accepted: 10/25/2021] [Indexed: 02/07/2023] Open
Abstract
(1) Background. Dental implant placement in the anterior region requires extreme precision due to relatively high aesthetic demand. This narrative review aimed to analyse some of the available clinical studies of the socket-shield technique and determine its viability for dental implant survival/success and complication rates. (2) Methods. An electronic search for publications was performed using the Cochrane, PubMed-MEDLINE, Web of Science, and Google Scholar databases. All electronic searches included human clinical and animal studies and were performed by three independent examiners. (3) Results. A total of 1383 records were identified with the initial search strategies, but only 25 full texts + five abstracts clinical studies were kept after the recruitment criteria screening. The technical details, advantages, and limitations of the techniques were illustrated. (4) Conclusion. Within the limitations of the present review, it would be merely justified that immediate dental implant placement in conjunction with the socket-shield technique can be a promising strategy for dental implant therapy.
Collapse
Affiliation(s)
- Nicola De Angelis
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
- Department of Dentistry, University Tunku Abdul Raman (UTAR), Sungai Buloh 47000, Malaysia
| | - Antonio Signore
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
- Therapeutic Dentistry Department, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
| | - Arwa Alsayed
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
| | - Wong Hai Hock
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
| | - Luca Solimei
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
| | - Fabrizio Barberis
- Department of Civil, Chemical and Environmental Engineering, University of Genoa, 16100 Genoa, Italy;
| | - Andrea Amaroli
- Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy; (A.S.); (A.A.); (W.H.H.); (L.S.)
- Department of Orthopedic Dentistry, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
| |
Collapse
|
28
|
Liu L, Yu WH, Li XT, Zhao H, Yang JJ. Clinical application study of immediate implantation without bone grafting in maxillary molars: a clinical study with one-year follow up. Br J Oral Maxillofac Surg 2021; 60:332-336. [PMID: 34742603 DOI: 10.1016/j.bjoms.2021.07.023] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/14/2021] [Accepted: 07/28/2021] [Indexed: 10/20/2022]
Abstract
Our aim was to evaluate the clinical effect and feasibility of immediate implant placement combined with flap surgery with no bone grafting and non-submerged healing in the maxillary molar area. Thirty-five patients with failed single teeth in the molar area were selected. After minimally invasive extraction of the tooth, the flaps were elevated, and an implant inserted immediately; thereafter a healing abutment was connected. The mucoperiosteal flaps were sutured around the abutment without tension, and a permanent repair was performed six months later. During the study period, the implant survival rate, cone-beam computed tomography (CBCT) data, torque value, and the results of a subjective satisfaction survey conducted with a visual analogue scale (VAS), were evaluated to assess the procedure's therapeutic effect and feasibility. All 35 teeth were successfully implanted immediately after flap surgery. The mean (SD) torque value was 42.79 (5.70) N∙cm at the time of placement. During the six-month follow up and after one year of restoration, all 35 teeth showed no loosening, shedding of implants and restoration, or inflammation around the site. The mean (SD) value of the bony space around the implant immediately after the operation was 2.47 (0.56) mm. The bony spaces were filled with new bone after six months postoperatively. The mean (SD) VAS for satisfaction was 8.71 (1.05). Immediate implant placement combined with flap surgery without bone grafting and non-submerged healing is feasible for the maxillary molar area and produces a satisfactory clinical effect.
Collapse
Affiliation(s)
- Lu Liu
- The Affiliated Hospital of Qingdao University, Department of Oral and Maxillofacial Surgery, NO. 16 Jiangsu Road, Qingdao, Shandong 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China
| | - Wen-Hui Yu
- The Affiliated Hospital of Qingdao University, Department of Oral and Maxillofacial Surgery, NO. 16 Jiangsu Road, Qingdao, Shandong 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China
| | - Xi-Tao Li
- The Affiliated Hospital of Qingdao University, Department of Oral and Maxillofacial Surgery, NO. 16 Jiangsu Road, Qingdao, Shandong 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China
| | - Hui Zhao
- The Affiliated Hospital of Qingdao University, Department of Oral and Maxillofacial Surgery, NO. 16 Jiangsu Road, Qingdao, Shandong 266003, China; School of Stomatology of Qingdao University, Qingdao 266003, China
| | - Jian-Jun Yang
- The Affiliated Hospital of Qingdao University, Department of Oral and Maxillofacial Surgery, NO. 16 Jiangsu Road, Qingdao, Shandong 266003, China.
| |
Collapse
|
29
|
Ketabi M, Deporter D, Khoshkhounejad A, Khoshkhounejad N. A new classification of peri implant gaps based on gap location (A case series of 210 immediate implants). Dent Res J (Isfahan) 2021. [DOI: 10.4103/1735-3327.313124] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
|
30
|
Dos Santos Trento G, Hassumi JS, Buzo Frigério P, Farnezi Bassi AP, Okamoto R, Gabrielli MAC, Pereira-Filho VA. Gene expression, immunohistochemical and microarchitectural evaluation of bone formation around two implant surfaces placed in bone defects filled or not with bone substitute material. Int J Implant Dent 2020; 6:80. [PMID: 33258065 PMCID: PMC7704835 DOI: 10.1186/s40729-020-00279-7] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/17/2020] [Accepted: 11/06/2020] [Indexed: 11/19/2022] Open
Abstract
Objective The aim of this study is to evaluate through gene expression, immunohistochemical and microtomographic (micro-CT) analysis the response of peri-implant bone tissue around titanium implants with different surface treatments, placed in bone defects filled or not with bone substitute materials. In addition, to investigate the hypothesis that porous-hydrophilic surface induces a faster bone formation. Materials and methods Twenty-six animals were divided into two groups according to implant surface treatment. In each tibia, a bone defect was created followed by the placement of one implant. On the left tibia, the defect was filled with blood clot (BC), and on the right tibia, the defect was filled with biphasic hydroxyapatite/β-tricalcium-phosphate (HA/TCP) generating four subgroups: BC-N: bone defect filled with blood clot and porous surface titanium implant installed; BC-A: bone defect filled with blood clot and porous-hydrophilic surface titanium implant installed; HA/TCP-N: bone defect filled with bone substitute material and porous surface titanium implant installed; and HA/TCP-A: bone defect filled with bone substitute material and porous-hydrophilic surface titanium implant installed. The animals were submitted to euthanasia at 15, 30, and 60 days after implant installation. The expression of two genes was evaluated: RUNX2 and BSP. Immunohistochemical analyses were performed for detection of RUNX2, OPN, OCN, OPG, and RANKL antibodies and bone matrix proteins. Finally, four parameters were chosen for micro-CT analysis: trabecular number, separation and thickness, and connectivity density. Results Descriptive analysis showed similar findings among the experimental groups. Moreover, porous-hydrophilic surfaces presented a higher expression of RUNX2, which is probably an indicative of better osteogenesis; although the data from this study may be considered an insufficient support for a concrete statement. Conclusion Porous hydrophilic surface can improve and accelerate protein expression and bone formation.
Collapse
Affiliation(s)
- Guilherme Dos Santos Trento
- Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil.
| | - Jaqueline Suemi Hassumi
- Department of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil
| | - Paula Buzo Frigério
- Department of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil
| | - Ana Paula Farnezi Bassi
- Department of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil
| | - Roberta Okamoto
- Department of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, Brazil
| | - Marisa Aparecida Cabrini Gabrielli
- Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil
| | - Valfrido Antonio Pereira-Filho
- Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University (Unesp), 1680th Humaitá Street, Araraquara, SP, 14801-903, Brazil
| |
Collapse
|
31
|
The Effect of Atmospheric Pressure Cold Plasma Application on Titanium Barriers: A Vertical Bone Augmentation. J Craniofac Surg 2020; 31:2054-2058. [PMID: 32604299 DOI: 10.1097/scs.0000000000006643] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Abstract
OBJECTIVE The aim of the present, microcomputed tomographic (μCT) and histological study, was to evaluate the effect of surface modification by atmospheric pressure cold plasma (APCP) on vertical guided bone regeneration in a rabbit calvaria model. MATERIAL-METHODS The experimental study was conducted on 12 male New Zealand rabbits with healing periods of 45 and 90 days. Following surgical exposure of the calvarium, 4 customized titanium cylindricalders were fixed. Surface modification was achieved by application of APCP on 2 of cylinders (P+) in each calvarium and other cylinders were set as control (P-). In both experimental and control groups, one of the cylinders was filled with bone graft (G+) while the other one was left empty (G-). To evaluate short term effects, randomly selected 6 animals were sacrificed at the end of 45 days and remaining 6 animals were left for observing long term effects. Histological and μCT evaluations were used to examine new bone formation. RESULTS In μCT imaging; the bone volume was greater (P < 0.05) in grafted groups than nongrafted groups in both short and long term. The bone height values were significantly different in (P-G-) group than other groups (P < 0.05) in both evaluation periods. The histological evaluations revealed significant differences between P+G+ group and other groups but in long term both plasma treated groups revealed more bone formation than non plasma treated groups. CONCLUSION Modification of the surfaces of titanium cylinders by APCP treatment, accelerated the bone regeneration either bone graft used or not in a rabbit calvaria model.
Collapse
|
32
|
Kabi S, Kar R, Samal D, Deepak KC, Kar IB, Mishra N. Immediate dental implant placement with or without autogenous bone graft: A comparative study. Natl J Maxillofac Surg 2020; 11:46-52. [PMID: 33041576 PMCID: PMC7518474 DOI: 10.4103/njms.njms_59_19] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/30/2019] [Revised: 11/05/2019] [Accepted: 12/25/2019] [Indexed: 11/04/2022] Open
Abstract
Introduction Immediate dental implants are the most accepted contemporary treatment option for the replacement of missing teeth. One pitfall of immediate implant use, however, is the inevitable residual space that remains between the implant and the socket wall, called the jumping distance, which may lead to bone resorption and formation of a bony defect, decreasing the implant stability. When this jumping distance is more than 2 mm, use of bone grafts is recommended. However, the use of grafts when the jumping distance is <2 mm is not defined in the literature. Aim To evaluate the peri-implant hard and soft tissue changes following immediately placed implants with a jumping distance of 2 mm with or without autogenous bone grafts. Settings The study was conducted between January 2016 and December 2017 in the Department of Oral and Maxillofacial Surgery. Subjects and Methods This was a prospective, single-center, two-arm, parallel, randomized study on patients undergoing replacement of missing anterior teeth with immediate implants. There were two groups: the study group which received bone graft and the control group which did not receive any graft. Temporary prosthesis was placed following implant placement which was replaced with definitive prosthesis 4 months later. Patients were followed up for a period of 9 months. The alveolar bone loss was evaluated radiologically using cone-beam computed tomography, and pain, suppuration, mobility, and periodontal probing depth were evaluated clinically. Results There were 16 participants in the study group and 17 in the control group. The alveolar bone loss was greater in the study group; however, pain, suppuration, and mobility showed no difference between the groups. Conclusion The immediate implants placed with or without bone grafts had similar alveolar hard and soft tissue changes when the jumping distance was <2 mm.
Collapse
Affiliation(s)
- Sonalika Kabi
- Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Rosalin Kar
- Department of Prosthetic Dentistry, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Dipti Samal
- Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Kumar C Deepak
- Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Indu Bhusan Kar
- Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Niranjan Mishra
- Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India
| |
Collapse
|
33
|
Histological and Histomorphometrical Evaluation of a New Implant Macrogeometry. A Sheep Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2020; 17:ijerph17103477. [PMID: 32429405 PMCID: PMC7277453 DOI: 10.3390/ijerph17103477] [Citation(s) in RCA: 21] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/08/2020] [Revised: 05/12/2020] [Accepted: 05/13/2020] [Indexed: 02/06/2023]
Abstract
Decompression or healing chambers between the threads have been proposed to improve and accelerate the osseointegration process of dental implants. The aim of the present work was to test, in an in vivo sheep study, if healing chambers between the threads could produce a better osseointegration process. Thirty titanium implants (15 conventional design (control) and 15 implants with healing chambers (test)) were inserted in a random fashion in the tibia of 3 sheep. The animals were euthanized after 30 days of healing, and the retrieved specimens treated to obtain thin ground sections. Histological observations showed that the quantity of newly formed bone growing in an apical direction was lower in the control group (1095 µm) when compared to the Test group (1658 µm). This difference was statistically significant. Moreover, a layer of osteogenic matrix was present around the portion of implants immersed in the marrow spaces. This osteogenic tissue was thicker in the test group. In conclusion, the present study confirmed the very good results in implants with healing chambers that presented a higher percentage of new bone formation.
Collapse
|
34
|
Hirota A, Iezzi G, Piattelli A, Ferri M, Tanaka K, Apaza Alccayhuaman KA, Botticelli D. Influence of the position of the antrostomy in sinus floor elevation on the healing of mini-implants: a randomized clinical trial. Oral Maxillofac Surg 2020; 24:299-308. [PMID: 32363552 DOI: 10.1007/s10006-020-00846-7] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2019] [Accepted: 04/15/2020] [Indexed: 02/05/2023]
Abstract
AIM To evaluate histologically the healing of mini-implants installed after sinus floor elevation using a lateral approach and placing the antrostomy at different level from the sinus floor. MATERIAL AND METHODS Sinus floor elevation using a lateral approach was performed in 24 healthy volunteers. The antrostomy was randomly placed either close to the base of the sinus floor (group base) or at about 3-4 mm cranially to it (group standard). After 6 months of healing, mini-implants were installed within the grafted region, through the alveolar crest. Three months later, biopsies were collected. RESULTS Sixteen biopsies from 16 patients were available for histological analyses. The new bone reached fractions of 40.9 ± 11.9% and 48.5 ± 20.1% at the base and standard groups, respectively (p = 0.208). Xenograft particles were found in contact with the implant surface at percentages of 12.1 ± 11.0% in the base group, and 15.9 ± 23.7% in the standard group (p = 0.674). CONCLUSIONS Based on the present study, the choice of one or the other position of antrostomy did not influence significantly the outcome and, therefore, should be left to the preference of the surgeon.
Collapse
Affiliation(s)
- Atsuya Hirota
- Department of Oral Implantology, Osaka Dental University, Osaka, Japan.,ARDEC Academy, Viale Giovanni Pascoli 67, 47923, Rimini, Italy
| | - Giovanna Iezzi
- Dept. of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy
| | - Adriano Piattelli
- Dept. of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy
| | - Mauro Ferri
- Corporación Universitaria Rafael Núñez, Cartagena, Colombia
| | - Kazushige Tanaka
- Department of Oral Implantology, Osaka Dental University, Osaka, Japan.,ARDEC Academy, Viale Giovanni Pascoli 67, 47923, Rimini, Italy
| | | | | |
Collapse
|
35
|
Tribst JPM, Dal Piva AMDO, Borges ALS, Bottino MA. Influence of Socket-shield technique on the biomechanical response of dental implant: three-dimensional finite element analysis. Comput Methods Biomech Biomed Engin 2020; 23:224-231. [PMID: 31910647 DOI: 10.1080/10255842.2019.1710833] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/25/2022]
Abstract
This study evaluated the bone microstrain, displacement, and stress distribution according to the surgical technique (conventional or Socket-shield) and evaluation period (immediately after implant installation or after healing). Each condition was modeled for the finite element analysis, totaling four groups, with a morse-taper implant and a cemented prosthesis. The maximum displacement, von Mises stress, and bone microstrain yielded higher values during the immediate stage, without a difference between Socket-shield and conventional treatments. The use of the Socket-shield technique does not negatively impact the biomechanical behavior of an implant-supported prosthesis immediately after healing from the implant installation.
Collapse
Affiliation(s)
- João Paulo Mendes Tribst
- Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil
| | - Amanda Maria de Oliveira Dal Piva
- Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil
| | - Alexandre Luiz Souto Borges
- Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil
| | - Marco Antonio Bottino
- Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil
| |
Collapse
|
36
|
Clinical and radiographic findings without the use of bone substitute materials in extraction sockets and delayed implant placement- A case series. J Oral Biol Craniofac Res 2020; 10:141-145. [PMID: 32489812 DOI: 10.1016/j.jobcr.2020.03.011] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2020] [Accepted: 03/31/2020] [Indexed: 11/23/2022] Open
Abstract
Aim To observe clinically and radiographically (CBCT), the extent of bone resorption in extraction socket without the use of bone graft substitutes and delayed implant placement. Material and methods 50 compliant patients were selected for study. All the patients who were advised extraction were followed up for entire duration of the treatment, at 5th week CBCT showed horizontal and vertical bone loss. To prevent further bone resorption, after 5 weeks implant was placed along with bone graft. Results Bone resorption after extraction is an unavoidable phenomenon. Clinical and radiographic (CBCT) analysis showed massive bone resorption by 5th week. At 5 month CBCT, all patients showed stable implant integration. There was no implant failure at the end of the study. Conclusion Alveolar preservation is proven to slow down socket wall collapse with the use of a bone substitute material without which larger procedures maybe needed to restore alveolar integrity and harmony. Immediate implant placement is effective when bone graft is placed in the jumping distance.
Collapse
|
37
|
Trento G, de A Carvalho PH, de C Reis ENR, Spin-Neto R, Bassi APF, Pereira-Filho VA. Bone formation around two titanium implant surfaces placed in bone defects with and without a bone substitute material: A histological, histomorphometric, and micro-computed tomography evaluation. Clin Implant Dent Relat Res 2020; 22:177-185. [PMID: 32090450 DOI: 10.1111/cid.12880] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2019] [Revised: 11/20/2019] [Accepted: 12/09/2019] [Indexed: 12/25/2022]
Abstract
OBJECTIVE To evaluate the histological and microtomographic response of peri-implant bone tissue around titanium implants with different surface treatments, placed in bone defects filled or not filled with bone substitute materials. MATERIALS AND METHODS Thirty rabbits were divided into two groups according to the implant surface treatment. A bone defect was created in both tibias of all the rabbits, followed by the placement of one implant in each of these defects. On the left tibia, the defect was filled with a blood clot (BC), and on the right tibia, the defect was filled with biphasic hydroxyapatite/β-tricalcium-phosphate (HA/TCP); thus, there were four groups in total: BC-N: bone defect filled with a BC and porous surface titanium implant (control group); BC-A: bone defect filled with a BC and porous-hydrophilic surface titanium implant; HA/TCP-N: bone defect filled with a bone substitute material and porous surface titanium implant; HA/TCP-A: bone defect filled with a bone substitute material and porous-hydrophilic surface titanium implant. The animals were submitted for euthanasia at three distinct periods: 15, 30, and 60 days after implant installation. The samples were evaluated histologically and histometrically, to assess the quantity and quality of cells and the remaining bone substitute material in the grafted areas. The bone quantity was assessed by micro-computed tomography (CT). RESULTS For both surface types, the presence of a bone substitute material led to higher values in all evaluated micro-CT parameters, except in the bone surface/volume ratio parameter. No significant statistical difference was found for new bone formation between the four groups (P < .05; CI 95%). At all periods, the HA/TCP-A group had a higher percentage of new bone formation. CONCLUSION These results suggest that a porous hydrophilic surface in the presence of bone substitute material can accelerate peri-implant bone tissue formation.
Collapse
Affiliation(s)
- Guilherme Trento
- Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University, Araraquara, Brazil
| | | | - Erik N R de C Reis
- Department of Dentistry and Oral Health, Section of Oral Radiology, Faculty of Health, Aarhus University, Aarhus, Denmark
| | - Rubens Spin-Neto
- Department of Oral and Maxillofacial Surgery, School of Dentistry, São Paulo State University, Araçatuba, Brazil
| | - Ana Paula F Bassi
- Department of Dentistry and Oral Health, Section of Oral Radiology, Faculty of Health, Aarhus University, Aarhus, Denmark
| | | |
Collapse
|
38
|
Carcuac O, Abrahamsson I, Derks J, Petzold M, Berglundh T. Spontaneous progression of experimental peri-implantitis in augmented and pristine bone: A pre-clinical in vivo study. Clin Oral Implants Res 2020; 31:192-200. [PMID: 31838762 DOI: 10.1111/clr.13564] [Citation(s) in RCA: 19] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/12/2019] [Revised: 12/02/2019] [Accepted: 12/07/2019] [Indexed: 12/17/2022]
Abstract
OBJECTIVE To examine the progression of experimental peri-implantitis around different implants placed in augmented and pristine sites. MATERIALS AND METHODS Six labrador dogs were used. Three months after tooth extraction, four implants with different surface modifications were installed on each side of the mandible. A standard osteotomy was applied on one side, while on the contralateral side the osteotomy was modified, resulting in a gap between the implant and the bone wall. The gap was filled with a bone substitute and covered by a resorbable membrane. Three months after implant installation, implants were exposed and healing abutments were connected. Two months later, oral hygiene procedures were abandoned and a cotton ligature was placed in a submarginal position around the neck of all implants and kept in place for 4 weeks. Following ligature removal, plaque formation continued for 6 months (spontaneous progression period). Radiographs were obtained throughout the experiment, and biopsies were collected and prepared for histological evaluation at the end of the spontaneous progression period. RESULTS Differences in bone loss during the spontaneous progression period between pristine and augmented sites were small. The size and vertical dimension of the peri-implantitis lesion were larger at augmented than at pristine sites. Implants with non-modified surfaces exhibited smaller amounts of bone loss and smaller dimensions of peri-implantitis lesions than implants with modified surfaces. CONCLUSION Small differences in spontaneous progression of peri-implantitis were detected between pristine and augmented sites. Implants with modified surfaces exhibited more bone loss and larger lesions than implants with non-modified surfaces, irrespective of the type of surrounding bone.
Collapse
Affiliation(s)
- Olivier Carcuac
- Department of Periodontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Ingemar Abrahamsson
- Department of Periodontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Jan Derks
- Department of Periodontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Max Petzold
- Centre for Applied Biostatistics, Occupational and Environmental Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Tord Berglundh
- Department of Periodontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| |
Collapse
|
39
|
3D laser-printed porous Ti6Al4V dental implants for compromised bone support. J Formos Med Assoc 2020; 119:420-429. [DOI: 10.1016/j.jfma.2019.07.023] [Citation(s) in RCA: 19] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2019] [Revised: 06/22/2019] [Accepted: 07/24/2019] [Indexed: 11/19/2022] Open
|
40
|
Mourya A, Mishra SK, Gaddale R, Chowdhary R. Socket-shield technique for implant placement to stabilize the facial gingival and osseous architecture: A systematic review. ACTA ACUST UNITED AC 2019; 10:e12449. [PMID: 31433130 DOI: 10.1111/jicd.12449] [Citation(s) in RCA: 25] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2019] [Revised: 06/15/2019] [Accepted: 07/22/2019] [Indexed: 12/19/2022]
Abstract
The aim of the present study was to establish the efficacy of the socket-shield technique (SST) for the stabilization of the facial gingival and osseous architecture. An electronic search including the Cochrane databases, EBSCOhost, Medline/PubMed and Web of Science was performed. Articles related to SST for placing dental implants were included. Articles and abstracts not written in English were excluded. The initial literature search resulted in 113 articles related to questions raised. Hand searching of the journals related to implants and cross-referencing related to SST within the selected articles resulted in 1 more paper. Finally, 20 full texts and abstract of 1 article were included in the present systematic review: 11 case reports, 6 case series, 1 human randomized control trial (RCT), 1 technical report and 2 animal RCT. Recent modifications in SST, along with long follow-up studies with increased sample size, provided promising results. This systematic review still recommends that SST should not be used in routine clinical practise until a higher level of evidence established. Further RCT on SST are required to establish the clinical efficacy of this technique.
Collapse
Affiliation(s)
- Akanksha Mourya
- Department of Prosthodontics, People's College of Dental Sciences and Research Center, Bhopal, India
| | - Sunil Kumar Mishra
- Department of Prosthodontics, People's College of Dental Sciences and Research Center, Bhopal, India
| | - Reetika Gaddale
- Department of Periodontology, AME'S Dental College and Hospital, Raichur, India
| | - Ramesh Chowdhary
- Department of Prosthodontics, Rajarajeswari Dental College and Hospital, Bengaluru, India
| |
Collapse
|
41
|
Morelli F, Apaza Alccayhuaman KA, Viganò P, Bengazi F, Urbizo J, Cesaretti G, Botticelli D. Peri-implantitis at implants with different diameters: a pilot study in dogs. Int J Implant Dent 2019; 5:21. [PMID: 31257562 PMCID: PMC6599811 DOI: 10.1186/s40729-019-0177-3] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2019] [Accepted: 05/06/2019] [Indexed: 12/28/2022] Open
Abstract
Aim To evaluate the progression of an induced peri-implantitis at implants with different diameters and the outcome of a corrective surgical debridement. Methods Three months after the extraction of the mandibular premolars and first molars in six dogs, non-submerged narrow implants (3.3 mm in diameter) or standard implants (3.8 mm and 4.1 mm) were installed in the molar regions, bilaterally. After 3 months, peri-implantitis lesions were induced with ligatures and plaque accumulation for 3 months. Plaque accumulation was allowed for a further month after ligatures removal. A surgical mechanical decontamination of the surfaces was subsequently performed using gauzes soaked in saline and irrigation. Five months after, biopsies were retrieved and histological slides prepared. X-rays were taken at treatment and 5 months after. Results Fourth months after peri-implantitis induction, 2.2 ± 1.0 mm at the standard implants and 3.2 ± 0.4 mm at the narrow implants were observed. Five months after treatment, a mean gain of marginal bone of 0.5 ± 0.6 mm was obtained at the standard implants and of 0.9 ± 0.4 at the narrow implants (p = 0.249). The vertical and horizontal defects were found partially closed. At the histological analysis, the coronal level of osseointegration after 5 months of healing was at 2.1 ± 0.8 mm at the standard implants, and 2.8 ± 0.3 mm at narrow implants (p = 0.116). Conclusions In conclusion, the narrow implants showed a tendency of a faster progression of the induced peri-implantitis compared to standard implants. The implant diameter did not influence the outcome of a surgical treatment of an induced peri-implantitis.
Collapse
Affiliation(s)
- Fabrizio Morelli
- Faculty of Dentistry, University of Medical Science, La Habana, Cuba
| | | | - Paolo Viganò
- ARDEC Academy, Ariminum Odontologica SRL, Viale Pascoli 67, 47923, Rimini, Italy
| | - Franco Bengazi
- Faculty of Dentistry, University of Medical Science, La Habana, Cuba
| | - Joaquin Urbizo
- Faculty of Dentistry, University of Medical Science, La Habana, Cuba
| | - Gianfranco Cesaretti
- ARDEC Academy, Ariminum Odontologica SRL, Viale Pascoli 67, 47923, Rimini, Italy
| | - Daniele Botticelli
- ARDEC Academy, Ariminum Odontologica SRL, Viale Pascoli 67, 47923, Rimini, Italy
| |
Collapse
|
42
|
Hattingh A, De Bruyn H, Vandeweghe S. A retrospective study on ultra‐wide diameter dental implants for immediate molar replacement. Clin Implant Dent Relat Res 2019; 21:879-887. [DOI: 10.1111/cid.12759] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/13/2019] [Revised: 03/06/2019] [Accepted: 03/07/2019] [Indexed: 12/26/2022]
Affiliation(s)
- André Hattingh
- Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health SciencesGhent University Gent Belgium
- Private Practice for Periodontology and Oral Implantology Sevenoaks United Kingdom
| | - Hugo De Bruyn
- Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health SciencesGhent University Gent Belgium
- Section Implantology and Periodontology, Department of DentistryRadboud University Medical Centre Nijmegen The Netherlands
| | - Stefan Vandeweghe
- Reconstructive DentistryDental School, Faculty of Medicine and Health Sciences, Ghent University Gent Belgium
| |
Collapse
|
43
|
Natto ZS. Flapless Extraction and Immediate Implant Placed Into a Mandibular Molar Site: A Clinical Case Report and 5-Year Follow-Up. J ORAL IMPLANTOL 2019; 45:159-164. [DOI: 10.1563/aaid-joi-d-17-00154] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022]
Affiliation(s)
- Zuhair S. Natto
- Department of Dental Public Health, School of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Periodontology, School of Dental Medicine, Tufts University, Boston, Mass; Department of Oral Health Policy and Epidemiology, School of Dental Medicine, Harvard University Boston, Mass
| |
Collapse
|
44
|
Fraser D, Mendonca G, Sartori E, Funkenbusch P, Ercoli C, Meirelles L. Bone response to porous tantalum implants in a gap-healing model. Clin Oral Implants Res 2019; 30:156-168. [PMID: 30636059 DOI: 10.1111/clr.13402] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2018] [Revised: 10/31/2018] [Accepted: 12/22/2018] [Indexed: 01/30/2023]
Abstract
OBJECTIVES The objective of this study was to determine the relative osteogenic behavior of titanium implants with or without a porous tantalum modification when placed with a gap between the implant and existing bone. MATERIALS AND METHODS A gap-healing model in the rabbit tibia was used for placement of titanium implants. Forty-eight rabbits received 96 implants, with 48 of the implants containing a porous tantalum middle section and the remaining 48 implants were composed of solid titanium. After 4, 8, and 12 weeks of healing, biomechanical stability was measured with removal torque testing, implant-adherent cells were isolated for analysis of osteogenic gene expression, and histomorphometric analysis was performed on sections of the implants and surrounding bone. RESULTS Increased osteogenic activity at 4 weeks was demonstrated by upregulation of key osteogenic genes at implants containing porous tantalum which was accompanied by greater bone-implant contact at 4, 8, and 12 weeks and significantly greater removal torque at 8 and 12 weeks. CONCLUSIONS Implants containing porous tantalum demonstrated increased peri-implant bone formation within this gap-healing model as shown by significant differences in biomechanical and histomorphometric outcomes. Such implants may represent an alternative to influence bone healing in surgical sites with an existing gap.
Collapse
Affiliation(s)
- David Fraser
- Eastman Institute for Oral Health, University of Rochester, Rochester, New York
| | - Gustavo Mendonca
- Department of Biologic and Material Science, University of Michigan, Ann Arbor, Michigan
| | - Elisa Sartori
- Department of Biologic and Material Science, University of Michigan, Ann Arbor, Michigan
| | - Paul Funkenbusch
- Department of Mechanical Engineering, University of Rochester, Rochester, New York
| | - Carlo Ercoli
- Eastman Institute for Oral Health, University of Rochester, Rochester, New York
| | - Luiz Meirelles
- Eastman Institute for Oral Health, University of Rochester, Rochester, New York
| |
Collapse
|
45
|
Pessanha-Andrade M, Sordi MB, Henriques B, Silva FS, Teughels W, Souza JCM. Custom-made root-analogue zirconia implants: A scoping review on mechanical and biological benefits. J Biomed Mater Res B Appl Biomater 2018; 106:2888-2900. [PMID: 30070423 DOI: 10.1002/jbm.b.34147] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/15/2018] [Revised: 03/18/2018] [Accepted: 04/09/2018] [Indexed: 12/26/2022]
Abstract
The aim of this study was to conduct a literature review on the potential benefits of custom-made root-analogue zirconia implants. A PubMed and ScienceDirect bibliographical search was carried out from 1969 to 2017. The increased interest in zirconia-based dental structures linked to aesthetic and biological outcomes have been reported in literature. Recent technological advances have focused on novel strategies for modification of zirconia-based surfaces to accelerate osseointegration. However, only a few studies revealed mechanical and biological benefits of custom-made root-analogue zirconia implants and therefore further studies should investigate the influence of different design and surface modification on the performance of such implants. Custom-made root-analogue zirconia implants have become a viable alternative to overcome limitations concerning stress distribution, aesthetics, and peri-implantitis induced by biofilms. However, further in vitro and in vivo studies on surface-bone interactions and mechanical behavior of zirconia should be evaluated to reduce clinical issues regarding mechanical failures and late peri-implant bone loss. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2888-2900, 2018.
Collapse
Affiliation(s)
- Miguel Pessanha-Andrade
- Division of Oral Implantology, School of Dentistry, Universidade Fernando Pessoa (UFP), Porto, Portugal
| | - Mariane B Sordi
- Post-graduate Program in Dentistry (PPGO), Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil
| | - Bruno Henriques
- Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus Azurém, Guimarães, Portugal
| | - Filipe S Silva
- Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus Azurém, Guimarães, Portugal
| | - Wim Teughels
- Department of Oral Health Sciences, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
| | - Júlio C M Souza
- Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus Azurém, Guimarães, Portugal
| |
Collapse
|
46
|
Cheng AW, Berridge JP, McGary RT, Erley KJ, Johnson TM. The Extraction Socket Management Continuum: A Hierarchical Approach to Dental Implant Site Development. Clin Adv Periodontics 2018; 9:91-104. [DOI: 10.1002/cap.10049] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2018] [Accepted: 07/16/2018] [Indexed: 01/03/2023]
Affiliation(s)
- Albert W. Cheng
- United States Army Advanced Education Program in Periodontics Fort Gordon GA
- Department of PeriodonticsArmy Postgraduate Dental SchoolUniformed Services University of the Health Sciences Fort Gordon GA
| | - Joshua P. Berridge
- United States Army Advanced Education Program in Periodontics Fort Gordon GA
- Department of PeriodonticsArmy Postgraduate Dental SchoolUniformed Services University of the Health Sciences Fort Gordon GA
| | - Ryan T. McGary
- United States Army Advanced Education Program in Periodontics Fort Gordon GA
- Department of PeriodonticsArmy Postgraduate Dental SchoolUniformed Services University of the Health Sciences Fort Gordon GA
| | - Kenneth J. Erley
- United States Army Advanced Education Program in Periodontics Fort Gordon GA
- Department of PeriodonticsArmy Postgraduate Dental SchoolUniformed Services University of the Health Sciences Fort Gordon GA
| | - Thomas M. Johnson
- United States Army Advanced Education Program in Periodontics Fort Gordon GA
- Department of PeriodonticsArmy Postgraduate Dental SchoolUniformed Services University of the Health Sciences Fort Gordon GA
| |
Collapse
|
47
|
Diana C, Mohanty S, Chaudhary Z, Kumari S, Dabas J, Bodh R. Does platelet-rich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial. Int J Oral Maxillofac Surg 2018; 47:1178-1188. [DOI: 10.1016/j.ijom.2018.01.001] [Citation(s) in RCA: 19] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/09/2017] [Revised: 10/30/2017] [Accepted: 01/02/2018] [Indexed: 12/24/2022]
|
48
|
Healing at sites prepared using different drilling protocols. An experimental study in the tibiae of sheep. PLoS One 2018; 13:e0202957. [PMID: 30157237 PMCID: PMC6114797 DOI: 10.1371/journal.pone.0202957] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/04/2018] [Accepted: 08/13/2018] [Indexed: 11/19/2022] Open
Abstract
The aim of the experiment was to study the healing at implants installed in site prepared in bone type 1 using different rotation speeds and cooling strategies. The tibiae of twelve sheep were used as experimental sites. Two implant sites were prepared in each tibia using drills either at a high or a mixed speed under irrigation. At the mixed-speed sites, 60 rpm without irrigation were applied for the last drill, the countersink and during implant installation. Biopsies representing the healing after 1, 2, and 6 weeks were obtained and ground sections were prepared. At the histological analyses, after 1 week of healing, no new bone was found at both high- and mixed-speed sites. After 2 weeks of healing, small amounts of newly formed bone were observed in the cortical layer, reaching percentages of 3.6±3.0% at the mixed-speed sites, and of 2.2±1.5% at the high-speed sites. An irrelevant quantity of new bone was seen in the marrow compartments of a few specimens. After 6 weeks of healing, new bone was found in higher quantity, reaching in the cortical compartment 66.9±6.8% and 67.3±17.7% at the mixed- and high-speed sites, respectively. The respective percentages in the marrow compartment were 23.2±13.0% and 30.6±29.2%. No statistically significant differences between high- and mixed-speed groups were found. It was concluded that the use of the last drill and the installation of the implant with or without irrigation yielded similar bone healing and osseointegration.
Collapse
|
49
|
Is Bone Graft or Guided Bone Regeneration Needed When Placing Immediate Dental Implants? A Systematic Review. IMPLANT DENT 2018; 26:936-944. [PMID: 29095788 DOI: 10.1097/id.0000000000000689] [Citation(s) in RCA: 30] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
AIMS To systematically review the effect and type of bone graft and guided bone regeneration around immediate implants on hard and soft tissue changes. METHODS Three electronic databases were searched up to June 2015. Outcomes consisted of hard and soft tissue dimensional changes. RESULTS Eight studies were included according to inclusion criteria. Immediate implants with bone grafting had superior soft tissue stability and preserved horizontal ridge dimension and buccal plate thickness, when compared to no grafting. The use of a barrier alone significantly decreased buccal plate resorption and the remaining defects around the implants, and the use of both bone graft and membrane aided in soft tissue preservation. The optimal type of bone graft material was a combination of cortical autogenous and synthetic particulate when compared to each separately, whereas no difference was found between demineralized allograft and hydroxyapatite in decreasing bone loss. CONCLUSIONS Quantitative data analysis was not possible due to heterogeneity of the included studies. Further randomized clinical trials with homogenous samples and proper controls are needed to support the results of this report.
Collapse
|
50
|
Kan JYK, Rungcharassaeng K, Deflorian M, Weinstein T, Wang HL, Testori T. Immediate implant placement and provisionalization of maxillary anterior single implants. Periodontol 2000 2018; 77:197-212. [PMID: 29478284 DOI: 10.1111/prd.12212] [Citation(s) in RCA: 115] [Impact Index Per Article: 16.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/30/2022]
Abstract
An inevitable loss of soft and hard tissue after tooth extraction often results in a compromised site for anterior implant esthetics in both vertical and horizontal dimensions. Immediate implant placement and provisionalization has been a viable option for replacing failing maxillary anterior teeth as it preserves the vertical existing osseous and gingival architecture. With the simultaneous addition of soft- and hard-tissue grafts, the peri-implant horizontal tissue topography can also be maintained. The esthetic success of immediate implant placement and provisionalization procedures is influenced by a number of factors that can be identified as patient-dependent or clinician-dependent. This article describes in detail the process of patient selection, indications, contraindications, diagnosis, treatment planning and treatment execution required to achieve functional and esthetic success with immediate implant placement and provisionalization.
Collapse
|