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Bang SP, Sabesan R, Yoon G. Effects of long-term neural adaptation to habitual sspherical aberration on through-focus visual acuity in adults. Sci Rep 2024; 14:26842. [PMID: 39500753 PMCID: PMC11538307 DOI: 10.1038/s41598-024-75289-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/01/2024] [Accepted: 10/03/2024] [Indexed: 11/08/2024] Open
Abstract
We investigated how long-term visual experience with habitual spherical aberration (SA) influences subjective depth of focus (DoF). Nine healthy cycloplegic eyes with habitual SAs of different signs and magnitudes were enrolled. An adaptive optics (AO) visual simulator was used to measure through-focus high-contrast visual acuity after correcting all monochromatic aberrations and imposing + 0.5 μm and - 0.5 μm SAs for a 6-mm pupil. The positive (n = 6) and negative (n = 3) habitual SA groups ranged from 0.17 to 0.8 μm and from - 1.2 to - 0.12 μm for a 6-mm pupil, respectively. Although all optical conditions were identical, and the subjective DoFs were expected to be the same for all participants, the DoFs of individuals differed between the positive and negative habitual SA groups. For the positive habitual SA group, the mean DoF with positive AO-induced SA (2.14 D) was larger than that with negative AO-induced SA (1.88 D); for the negative habitual SA group, a smaller DoF was measured with positive AO-induced SA (1.94 D) than that with negative AO-induced SA (2.14 D). Subjective DoF tended to be larger when the induced SA in terms of sign and magnitude was closer to the participant's habitual SA. Our findings suggest that neural adaptation to habitual SA compensated for optical blur at multiple object distances, perceptually expanding DoF. As a result, the outcomes of optical treatments for presbyopia may differ due to the neural compensation mechanism influenced by an individual's visual experience with their habitual optics.
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Affiliation(s)
- Seung Pil Bang
- Department of Ophthalmology, Keimyung University School of Medicine, Daegu, South Korea
- Department of Biomedical Engineering, University of Rochester, Rochester, NY, United States
| | - Ramkumar Sabesan
- Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA, USA
| | - Geunyoung Yoon
- College of Optometry, University of Houston, Houston, TX, 77004, USA.
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Salah-Mabed I, Debellemanière G, Rampat R, Dubois M, Gatinel D. High hyperopic LASIK with reduction of corneal prolateness to control-induced spherical aberration. J Cataract Refract Surg 2024; 50:919-925. [PMID: 38758195 PMCID: PMC11338020 DOI: 10.1097/j.jcrs.0000000000001475] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2023] [Revised: 03/21/2024] [Accepted: 04/30/2024] [Indexed: 05/18/2024]
Abstract
PURPOSE To evaluate visual outcomes of high hyperopic laser in situ keratomileusis (LASIK), using corneal aspherization to control the induced spherical aberration. SETTING Fondation Ophtalmologique Adolphe de Rothschild, Paris, France. DESIGN Prospective interventional case series. METHODS Prospective interventional study of consecutive high hyperopes (≥+3 diopters [D] of spherical equivalent [SE]) undergoing LASIK with the WaveLight FS200 femtosecond and EX500 excimer laser platform. An aspheric ablation profile (planned change in corneal asphericity ΔQ = +0.2) was delivered using the Custom-Q nomogram on an optical zone of ≥6.5 mm centered near the corneal vertex. Uncorrected corrected distance visual acuity (UDVA) and corrected distance visual acuity, as well as changes in SE, corneal asphericity (ΔQ), and higher-order aberrations, were analyzed preoperatively and on day 1, 1, 3, 6, and 12 months. RESULTS 117 eyes of 63 patients (mean age of 30.1 ± 5.6 years) were included. Preoperatively and at 12 months postoperatively, the mean SE was 5.1 ± 1.1 D and 0.00 ± 0.7 D, respectively. 88% of eyes achieved 0 logMAR or better UDVA at 12 months. 1 month postoperatively, there was a statistically significant induction of positive spherical aberration decreasing progressively and significantly until the last visit (preop SA4 = 0.09 ± 0.11 μm, day 1 SA4 = 0.30 ± 0.32 μm, 12 months SA4 = 0.08 ± 0.21 μm, P = .056). 2 eyes needed enhancement at 12 months. CONCLUSIONS LASIK for high levels of hyperopia showed good outcomes mainly due to aspheric-customized ablation profile with a change of ΔQ = +0.2 in corneal asphericity.
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Affiliation(s)
- Imene Salah-Mabed
- From the Department of Anterior Segment and Refractive Surgery, Rothschild Foundation, Paris, France; CEROC: Center of Expertise and Research in Optics for Clinicians, Paris, France
| | - Guillaume Debellemanière
- From the Department of Anterior Segment and Refractive Surgery, Rothschild Foundation, Paris, France; CEROC: Center of Expertise and Research in Optics for Clinicians, Paris, France
| | - Radhika Rampat
- From the Department of Anterior Segment and Refractive Surgery, Rothschild Foundation, Paris, France; CEROC: Center of Expertise and Research in Optics for Clinicians, Paris, France
| | - Mathieu Dubois
- From the Department of Anterior Segment and Refractive Surgery, Rothschild Foundation, Paris, France; CEROC: Center of Expertise and Research in Optics for Clinicians, Paris, France
| | - Damien Gatinel
- From the Department of Anterior Segment and Refractive Surgery, Rothschild Foundation, Paris, France; CEROC: Center of Expertise and Research in Optics for Clinicians, Paris, France
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Wolffsohn JS, Naroo SA, Bullimore MA, Craig JP, Davies LN, Markoulli M, Schnider C, Morgan PB. BCLA CLEAR Presbyopia: Definitions. Cont Lens Anterior Eye 2024; 47:102155. [PMID: 38609792 DOI: 10.1016/j.clae.2024.102155] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/14/2024]
Abstract
Presbyopia is often the first sign of ageing experienced by humans. Standardising terminology and adopting it across the BCLA CLEAR Presbyopia reports, improves consistency in the communication of the evidence-based understanding of this universal physiological process. Presbyopia can be functionally and psychologically debilitating, especially for those with poor access to eyecare. Presbyopia was defined as occurring when the physiologically normal age-related reduction in the eye's focusing range reaches a point that, when optimally corrected for far vision, the clarity of vision at near is insufficient to satisfy an individual's requirements. Accommodation is the change in optical power of the eye due to a change in crystalline lens shape and position, whereas pseudo-accommodation is the attainment of functional near vision in an emmetropic or far-corrected eye without changing the refractive power of the eye. Other definitions specific to vision and lenses for presbyopia were also defined. It is recommended that these definitions be consistently adopted in order to standardise future research, clinical evaluations and education.
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Affiliation(s)
- James S Wolffsohn
- College of Health & Life Sciences, Aston University, Birmingham, United Kingdom.
| | - Shehzad A Naroo
- College of Health & Life Sciences, Aston University, Birmingham, United Kingdom
| | | | - Jennifer P Craig
- Department of Ophthalmology, The University of Auckland, Auckland, New Zealand
| | - Leon N Davies
- College of Health & Life Sciences, Aston University, Birmingham, United Kingdom
| | - Maria Markoulli
- School of Optometry & Vision Science, University of New South Wales, Sydney, Australia
| | - Cristina Schnider
- Eurolens Research, Division of Pharmacy and Optometry, University of Manchester, United Kingdom
| | - Philip B Morgan
- Eurolens Research, Division of Pharmacy and Optometry, University of Manchester, United Kingdom
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Wolffsohn JS, Berkow D, Chan KY, Chaurasiya SK, Fadel D, Haddad M, Imane T, Jones L, Sheppard AL, Vianya-Estopa M, Walsh K, Woods J, Zeri F, Morgan PB. BCLA CLEAR Presbyopia: Evaluation and diagnosis. Cont Lens Anterior Eye 2024; 47:102156. [PMID: 38641525 DOI: 10.1016/j.clae.2024.102156] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/21/2024]
Abstract
It is important to be able to measure the range of clear focus in clinical practice to advise on presbyopia correction techniques and to optimise the correction power. Both subjective and objective techniques are necessary: subjective techniques (such as patient reported outcome questionnaires and defocus curves) assess the impact of presbyopia on a patient and how the combination of residual objective accommodation and their natural DoF work for them; objective techniques (such as autorefraction, corneal topography and lens imaging) allow the clinician to understand how well a technique is working optically and whether it is the right choice or how adjustments can be made to optimise performance. Techniques to assess visual performance and adverse effects must be carefully conducted to gain a reliable end-point, considering the target size, contrast and illumination. Objective techniques are generally more reliable, can help to explain unexpected subjective results and imaging can be a powerful communication tool with patients. A clear diagnosis, excluding factors such as binocular vision issues or digital eye strain that can also cause similar symptoms, is critical for the patient to understand and adapt to presbyopia. Some corrective options are more permanent, such as implanted inlays / intraocular lenses or laser refractive surgery, so the optics can be trialled with contact lenses in advance (including differences between the eyes) to better communicate with the patient how the optics will work for them so they can make an informed choice.
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Affiliation(s)
- James S Wolffsohn
- School of Optometry, Health and Life Sciences, Aston University, Birmingham, United Kingdom.
| | - David Berkow
- Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel
| | - Ka Yin Chan
- Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong
| | - Suraj K Chaurasiya
- Department of Contact Lens and Anterior Segment, CL Gupta Eye Institute, Moradabad, India; Department of Optometry and Vision Science, CL Gupta Eye Institute, Moradabad, India
| | - Daddi Fadel
- Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Canada
| | - Mera Haddad
- Faculty of Applied Medical Sciences, Department of Allied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
| | - Tarib Imane
- Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, United States
| | - Lyndon Jones
- Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong; Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Canada
| | - Amy L Sheppard
- School of Optometry, Health and Life Sciences, Aston University, Birmingham, United Kingdom
| | - Marta Vianya-Estopa
- Vision and Hearing Research Centre, Anglia Ruskin University, Cambridge, United Kingdom
| | - Karen Walsh
- CooperVision Inc., San Ramon, CA, United States
| | - Jill Woods
- Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Canada
| | - Fabrizio Zeri
- School of Optometry, Health and Life Sciences, Aston University, Birmingham, United Kingdom; University of Milano-Bicocca, Department of Materials Science, Milan, Italy
| | - Philip B Morgan
- Eurolens Research, Division of Pharmacy and Optometry, University of Manchester, United Kingdom
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Bang SP, Sabesan R, Yoon G. Effects of Neural Adaptation to Habitual Spherical Aberration on Depth of Focus. RESEARCH SQUARE 2024:rs.3.rs-3917931. [PMID: 38410431 PMCID: PMC10896392 DOI: 10.21203/rs.3.rs-3917931/v1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/28/2024]
Abstract
We investigated how long-term visual experience with habitual spherical aberration (SA) influences subjective depth of focus (DoF). Nine healthy cycloplegic eyes with habitual SAs of different signs and magnitudes were enrolled. An adaptive optics (AO) visual simulator was used to measure through-focus high-contrast visual acuity after correcting all monochromatic aberrations and imposing +0.5 μm and -0.5 μm SAs for a 6-mm pupil. The positive (n=6) and negative (n=3) SA groups ranged from 0.17 to 0.8 μm and from -1.2 to -0.12 μm for a 6-mm pupil, respectively. For the positive habitual SA group, the median DoF with positive AO-induced SA (2.18D) was larger than that with negative AO-induced SA (1.91D); for the negative habitual SA group, a smaller DoF was measured with positive AO-induced SA (1.81D) than that with negative AO-induced SA (2.09D). The difference in the DoF of individual participants between the induced positive and negative SA groups showed a quadratic relationship with the habitual SA. Subjective DoF tended to be larger when the induced SA in terms of the sign and magnitude was closer to the participant's habitual SA, suggesting the importance of considering the habitual SA when applying the extended DoF method using optical or surgical procedures.
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Zhang G, Cao H, Qu C. Efficacy, Safety, Predictability, and Stability of LASIK for Presbyopia Correction: A Systematic Review and Meta-analysis. J Refract Surg 2023; 39:627-638. [PMID: 37675909 DOI: 10.3928/1081597x-20230802-02] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/08/2023]
Abstract
PURPOSE To determine the efficacy, safety, predictability, and stability of laser in situ keratomileusis (LASIK) in the treatment of presbyopia. METHODS The databases of CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Registry, PubMed, The Cochrane Library, Web of Science, Embase, and ClinicalTrials.gov were searched until March 2023. The authors chose the studies of LASIK in the treatment of presbyopia. Outcomes were efficacy, safety, predictability, and stability. The review was registered in the international platform of registered systematic review and meta-analysis protocols (INPLASY202350005). RESULTS A total of 28 non-randomized controlled trials (15,861 eyes) were included. The results showed that after LASIK, (1) the distance efficacy decreased (mean difference [MD]: 0.02, 95% CI: 0.0 to 0.03, P < .05) and the near efficacy increased (MD: -0.01, 95% CI: -0.19 to-0.02, P < .05); (2) the distance safety decreased (MD: 0.07, 95% CI: 0.04 to 0.10, P < .0001) and near safety increased (MD: -0.19, 95% CI: -0.39 to 0.02, P > .05); (3) the predictability within ±1.00 and ±0.50 D was 94% (relative risk [RR]: 0.94, 95% CI: 0.90 to 0.98, P < .001) and 80% (RR: 0.80, 95% CI: 0.74 to 0.86, P < .001), respectively; and (4) 6 months postoperatively, the percentage of spherical equivalent changing within ±0.50 D was 95% (RR: 0.95, 95% CI: 0.89 to 0.99, P < .001). CONCLUSIONS The near efficacy, predictability, and stability of LASIK for presbyopia correction were satisfactory; however, the distance efficacy and distance safety decreased. [J Refract Surg. 2023;39(9):627-638.].
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Fernández J, Molina-Martín A, Rocha-de-Lossada C, Rodríguez-Vallejo M, Piñero DP. Clinical outcomes of presbyopia correction with the latest techniques of presbyLASIK: a systematic review. Eye (Lond) 2023; 37:587-596. [PMID: 35864161 PMCID: PMC9998429 DOI: 10.1038/s41433-022-02175-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2021] [Revised: 06/20/2022] [Accepted: 07/01/2022] [Indexed: 11/08/2022] Open
Abstract
The aim of this study was to collect the scientific literature on the correction of presbyopia with laser in situ keratomileusis (presbyLASIK) in last years and to analyse the quality of such scientific evidence using a validated methodology for conducting a systematic review. A total of 42 articles were initially identified, but after applying the selection criteria and an additional manual search a total of 23 articles were finally included: 2 non-randomized controlled clinical trials (NRCT) and 21 case series. Quality assessment of NRCTs and case series was performed with the ROBINS-I and the 20-criterion quality appraisal checklist defined by Moga et al. (IHE Publ 2012), respectively. For NRCT, the risk of bias was moderate in one study and serious in the other NRCT, being the main sources of risk, the domains related to confounding, selection of participants and measurement of outcomes. For case series studies, the main source of risk of bias was subjects not entering the study at the same point of the conditions (different levels of presbyopia). Likewise, a significant level of uncertainty was detected for the following items: consecutive recruitment of patients, blinding of outcome assessors to the intervention that the patient received, and conclusions of the study not supported by the results. Research on presbyLASIK to this date is mainly focused on case series generating a limited level of scientific evidence. The two NRCTs identified only demonstrated the potential benefit of combining the multiaspheric profile with some level of monovision in the non-dominant eye.
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Affiliation(s)
- Joaquin Fernández
- Department of Ophthalmology (Qvision), VITHAS Hospital, Almería, Spain
| | - Ainhoa Molina-Martín
- Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain
| | - Carlos Rocha-de-Lossada
- Department of Ophthalmology (Qvision), VITHAS Hospital, Almería, Spain
- Department of Ophthalmology, Hospital Virgen de las Nieves, Granada, Spain
- Department of Surgery, Area of Ophthalmology, University of Seville, Seville, Spain
| | | | - David P Piñero
- Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain.
- Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain.
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Marcos S, Artal P, Atchison DA, Hampson K, Legras R, Lundström L, Yoon G. Adaptive optics visual simulators: a review of recent optical designs and applications [Invited]. BIOMEDICAL OPTICS EXPRESS 2022; 13:6508-6532. [PMID: 36589577 PMCID: PMC9774875 DOI: 10.1364/boe.473458] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/18/2022] [Revised: 10/26/2022] [Accepted: 10/27/2022] [Indexed: 05/02/2023]
Abstract
In their pioneering work demonstrating measurement and full correction of the eye's optical aberrations, Liang, Williams and Miller, [JOSA A14, 2884 (1997)10.1364/JOSAA.14.002884] showed improvement in visual performance using adaptive optics (AO). Since then, AO visual simulators have been developed to explore the spatial limits to human vision and as platforms to test non-invasively optical corrections for presbyopia, myopia, or corneal irregularities. These applications have allowed new psychophysics bypassing the optics of the eye, ranging from studying the impact of the interactions of monochromatic and chromatic aberrations on vision to neural adaptation. Other applications address new paradigms of lens designs and corrections of ocular errors. The current paper describes a series of AO visual simulators developed in laboratories around the world, key applications, and current trends and challenges. As the field moves into its second quarter century, new available technologies and a solid reception by the clinical community promise a vigorous and expanding use of AO simulation in years to come.
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Affiliation(s)
- Susana Marcos
- Center for Visual Sciences; The Institute of Optics and Flaum Eye Institute, University of Rochester, New York 14642, USA
| | - Pablo Artal
- Laboratorio de Optica, Universidad de Murcia, Campus Universitario de Espinardo, 30100, Spain
| | - David A. Atchison
- Centre for Vision and Eye Research, Queensland University of Technology, Brisbane Q, 4059, Australia
| | - Karen Hampson
- Department of Optometry, University of Manchester, Manchester M13 9PL, UK
| | - Richard Legras
- LuMIn, CNRS, ENS Paris-Saclay, Université Paris-Saclay, CentraleSupelec, Université Paris-Saclay Orsay, 91400, France
| | - Linda Lundström
- KTH (Royal Institute of Technology), Stockholm, 10691, Sweden
| | - Geunyoung Yoon
- College of Optometry, University of Houston, Houston, 77004, USA
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Chen XY, Wang YC, Zhao TY, Wang ZZ, Wang W. Tilt and decentration with various intraocular lenses: A narrative review. World J Clin Cases 2022; 10:3639-3646. [PMID: 35647149 PMCID: PMC9100733 DOI: 10.12998/wjcc.v10.i12.3639] [Citation(s) in RCA: 23] [Impact Index Per Article: 7.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/09/2021] [Revised: 12/23/2021] [Accepted: 03/06/2022] [Indexed: 02/06/2023] Open
Abstract
We find that tilt and decentration of intraocular lens (IOL) commonly cause visual quality deterioration after cataract surgery. Multiple factors affect IOL tilt and decentration in the pre-, mid-, and post-operation phases. Moreover, the tilt and decentration of 1-piece IOL are less correlated with internal ocular HOAs than those of 3-piece IOL. Aspherical IOLs are more sensitive to decentration or tilt than spherical IOLs. Furthermore, the optical performance of toric IOLs with an accurate axis remains stable irrespective of tilt and decentration. The optical quality of asymmetric multifocal IOLs varies significantly after decentration and tilt in different directions. The image quality enhances or deteriorates in the direction of the decentered IOL. An extended depth of focus IOL can achieve good visual acuity in the distant, intermediate, and near range. Additionally, its tilt and decentration have less impact on the vision than bifocal and trifocal IOL. This is the first review that compares the effect of IOL tilt and decentration on image quality for various IOL designs. The result indicates that a deeper understanding of tilt and decentration of various IOLs can help achieve a better visual effect to visually improve refractive cataract surgery.
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Affiliation(s)
- Xiao-Yong Chen
- Department of Ophthalmology, Peking University The Third Hospital, Beijing 100191, China
| | - Yu-Chen Wang
- Department of Ophthalmology, Peking University The Third Hospital, Beijing 100191, China
| | - Tian-Yao Zhao
- Department of Ophthalmology, Peking University The Third Hospital, Beijing 100191, China
| | - Zi-Zhen Wang
- Department of Ophthalmology, Peking University The Third Hospital, Beijing 100191, China
| | - Wei Wang
- Department of Ophthalmology, Peking University The Third Hospital, Beijing 100191, China
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Assessment of a New Trifocal Diffractive Corneal Inlay for Presbyopia Correction Using an Adaptive Optics Visual Simulator. PHOTONICS 2022. [DOI: 10.3390/photonics9030135] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
Abstract
In this work, we analyze a proposal of a new intracorneal diffractive lens for presbyopia correction that could allow good, distance, intermediate and near vision. By using an adaptive optics visual simulator, we study the influence of two factors in the inlay performance: the spherical aberration (SA) and the potential errors of in thickness, induced in the manufacturing process. We show that the inlay through-the-focus imaging performance can be customized with the SA value, favoring either distance–intermediate or intermediate–near vision. Moreover, we found that with thickness variations of 10%, the inlay still maintains its trifocal nature.
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Fernández J, Rodríguez-Vallejo M, Burguera N, Rocha-de-Lossada C, Piñero DP. Spherical aberration for expanding depth of focus. J Cataract Refract Surg 2021; 47:1587-1595. [PMID: 34128496 DOI: 10.1097/j.jcrs.0000000000000713] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2021] [Accepted: 06/05/2021] [Indexed: 11/26/2022]
Abstract
The increase in the depth of focus (DoF) for the treatment of presbyopia or cataracts is a topic of great interest for anterior segment surgeons who have seen how new surgical possibilities to achieve DoF enlargement have emerged. Nowadays, several technologies to extend the DoF are available, from corneal laser refractive surgery procedures in presbyopia to intraocular lens (IOL) implantation in cataract or refractive lens exchange. Some of these procedures are based on aspheric profiles, either in the cornea or in the IOL, which modulate the spherical aberration (SA) and, therefore, extend the light energy on different focal planes. The aim of this narrative review was to give an overall picture about the reasons why there is not a general solution persistent along time of SA induction to extend DoF, especially considering that SA depends on pupil diameter and this decreases with age.
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Affiliation(s)
- Joaquín Fernández
- From the Department of Ophthalmology (Qvision), VITHAS Hospital, Almería, Spain (Fernández, Rodríguez-Vallejo, Burguera, Rocha-de-Lossada), the Department of Ophthalmology, Hospital Virgen de las Nieves, Av. de las Fuerzas Armadas, Granada, Spain (Rocha-de-Lossada), the Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain (Piñero), and the Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain (Piñero)
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Small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism. PLoS One 2021; 16:e0257667. [PMID: 34555080 PMCID: PMC8460088 DOI: 10.1371/journal.pone.0257667] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2021] [Accepted: 09/07/2021] [Indexed: 01/19/2023] Open
Abstract
Purpose To quantitatively evaluate outcomes after small incision lenticule extraction
(SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia
with astigmatism. Methods It’s a retrospective cohort study. Twenty-four eyes of 15 patients with more
than 0.75 diopters (D) of astigmatism in hyperopic eyes were enrolled in
this study. The hyperopic eye with astigmatism was first treated with SMILE
to correct astigmatism; then a lenticule was extracted from a donor myopic
eye and subsequently implanted into the hyperopic eye with astigmatism.
Patients were examined preoperatively and 1 day, 1 week, 1,3 months and 1
year after surgery. The main outcome measures were the uncorrected and
corrected distance visual acuity (UDVA and CDVA), uncorrected near visual
acuity (UNVA), spherical equivalent (SE), corneal topography, anterior
segment optical coherence topography (OCT) and ocular response analyzer
(ORA) parameters: corneal hysteresis (CH) and corneal resistance factor
(CRF). Repeated–measures analyses of variance (ANOVA) and post hoc tests
were used to analyze data of different follow-up visits. Results The mean preoperative cylinder was 1.95±1.04(D). The UDVA (from 0.37±0.23 to
0.09±0.09), UNVA (from 0.49±0.21 to 0.08±0.06), SE (from +7.42±3.12 to
-0.75±0.79) and astigmatism (+1.95±1.04 to -0.65±0.63) postoperatively were
obviously better than those before surgery. Five eyes (26.3%) gained one
line of CDVA, and 3 eyes (15.8%) gained two lines of CDVA one year after
surgery compared with preoperative levels. The average corneal curvature was
changed from (43.19±4.37) D to (49.19±3.87) D one year after surgery. The
anterior segment OCT images of corneas with lenticule inlays at each
follow-up visit showed that the implanted lenticule was shaped like a
crescent in the corneal stroma. The CH and CRF didn’t change significantly
after surgery (p = 0.189 and p = 0.107respectively). Conclusions SMILE combined with intrastromal lenticule inlay can be used to correct high
hyperopia with astigmatism with good safety, efficacy and
reproducibility.
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Alsaqr AM. Remarks on the use of Pearson’s and Spearman’s correlation coefficients in assessing relationships in ophthalmic data. AFRICAN VISION AND EYE HEALTH 2021. [DOI: 10.4102/aveh.v80i1.612] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/19/2023] Open
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Marcos S, Martinez-Enriquez E, Vinas M, de Castro A, Dorronsoro C, Bang SP, Yoon G, Artal P. Simulating Outcomes of Cataract Surgery: Important Advances in Ophthalmology. Annu Rev Biomed Eng 2021; 23:277-306. [PMID: 33848431 DOI: 10.1146/annurev-bioeng-082420-035827] [Citation(s) in RCA: 19] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022]
Abstract
As the human eye ages, the crystalline lens stiffens (presbyopia) and opacifies (cataract), requiring its replacement with an artificial lens [intraocular lens (IOL)]. Cataract surgery is the most frequently performed surgical procedure in the world. The increase in IOL designs has not been paralleled in practice by a sophistication in IOL selection methods, which rely on limited anatomical measurements of the eye and the surgeon's interpretation of the patient's needs and expectations. We propose that the future of IOL selection will be guided by 3D quantitative imaging of the crystalline lens to map lens opacities, anticipate IOL position, and develop fully customized eye models for ray-tracing-based IOL selection. Conversely, visual simulators (in which IOL designs are programmed in active elements) allow patients to experience prospective vision before surgery and to make more informed decisions about which IOL to choose. Quantitative imaging and optical and visual simulations of postsurgery outcomes will allow optimal treatments to be selected for a patient undergoing modern cataract surgery.
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Affiliation(s)
- Susana Marcos
- Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid 28006, Spain;
| | - Eduardo Martinez-Enriquez
- Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid 28006, Spain;
| | - Maria Vinas
- Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid 28006, Spain;
| | - Alberto de Castro
- Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid 28006, Spain;
| | - Carlos Dorronsoro
- Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid 28006, Spain; .,2EyesVision, Madrid 28760, Spain
| | - Seung Pil Bang
- Flaum Eye Institute, The Institute of Optics, Center for Visual Science, Department of Biomedical Engineering, University of Rochester, Rochester, New York 14632, USA
| | - Geunyoung Yoon
- Flaum Eye Institute, The Institute of Optics, Center for Visual Science, Department of Biomedical Engineering, University of Rochester, Rochester, New York 14632, USA
| | - Pablo Artal
- Laboratorio de Óptica, Universidad de Murcia, Murcia 30100, Spain
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Hervella L, Villegas EA, Robles C, Artal P. Spherical Aberration Customization to Extend the Depth of Focus With a Clinical Adaptive Optics Visual Simulator. J Refract Surg 2021; 36:223-229. [PMID: 32267952 DOI: 10.3928/1081597x-20200212-02] [Citation(s) in RCA: 20] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/08/2019] [Accepted: 02/10/2020] [Indexed: 01/19/2023]
Abstract
PURPOSE To evaluate the use of the VAO adaptive optics visual simulator (Voptica SL, Murcia, Spain) for customization of spherical aberration to increase depth of focus. METHODS Through-focus visual acuity with both high- and low-contrast letters from +1.00 to -3.00 diopters (D) was measured in 17 dilated eyes with three different induced amounts of spherical aberration for a 4.5-mm pupil diameter: control (0 µm), -0.15 µm, and -0.30 µm. RESULTS The defocus curves followed the same behavior with both values of contrast, but the visual acuity was 0.2 logMAR lower with low contrast. The mean values of high-contrast logMAR visual acuity at far, intermediate (67 cm), and near (40 cm) were -0.10, 0.11, and 0.37 for control, 0.04, 0.00, and 0.15 for -0.15 µm, and 0.23, 0.00, and 0.06 for -0.30 µm conditions. The 95% confidence interval ranged from ±0.14 to ±0.45 logMAR and the middle 50% of the distribution was approximately 0.2 logMAR. CONCLUSIONS Negative values of spherical aberration extend the depth of focus in different ways depending on each patient. The VAO is a new instrument that allows the visual customization of spherical aberration to enhance depth of focus. [J Refract Surg. 2020;36(4):223-229.].
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Rahmania N, Salah I, Rampat R, Gatinel D. Clinical Effectiveness of Laser-Induced Increased Depth of Field for the Simultaneous Correction of Hyperopia and Presbyopia. J Refract Surg 2021; 37:16-24. [DOI: 10.3928/1081597x-20201013-03] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/21/2020] [Accepted: 10/08/2020] [Indexed: 01/19/2023]
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Gatinel D, Rampat R, Malet J, Dumas L. Wavefront sensing, novel lower degree/higher degree polynomial decomposition and its recent clinical applications: A review. Indian J Ophthalmol 2020; 68:2670-2678. [PMID: 33229642 PMCID: PMC7856982 DOI: 10.4103/ijo.ijo_1760_20] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/19/2023] Open
Abstract
We are in the midst of a shift towards using novel polynomials to decompose wavefront aberrations in a more ophthalmologically relevant way. Zernike polynomials have useful mathematical properties but fail to provide clinically relevant wavefront interpretation and predictions. We compared the distribution of the eye's aberrations and demonstrate some clinical applications of this using case studies comparing the results produced by the Zernike decomposition and evaluating them against the lower degree/higher degree (LD/HD) polynomial decomposition basis which clearly dissociates the higher and lower aberrations. In addition, innovative applications validate the LD/HD polynomial basis. Absence of artificial reduction of some higher order aberrations coefficients lead to a more realistic analysis. Here we summarize how wavefront analysis has evolved and demonstrate some of its new clinical applications.
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Rouimi F, Ouanezar S, Goemaere I, Bayle AC, Borderie V, Laroche L, Bouheraoua N. Presbyopia management with Q-factor modulation without additive monovision: One-year visual and refractive results. J Cataract Refract Surg 2019; 45:1074-1083. [PMID: 31126780 DOI: 10.1016/j.jcrs.2019.02.039] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/17/2018] [Revised: 02/20/2019] [Accepted: 02/23/2019] [Indexed: 01/19/2023]
Abstract
PURPOSE To analyze refractive results after hyperopic presbyopia surgery by Q-factor modulation without additive monovision. SETTING Quinze-Vingts National Ophthalmology Hospital, Paris, France. DESIGN Prospective nonrandomized study. METHODS Forty-five hyperopic presbyopic patients not tolerating monovision were included. The target for the dominant eye was emmetropia, whereas that for the nondominant eye was emmetropia associated with a target Q factor of -0.8. The postoperative follow-up included assessments of spherical equivalent (SE) refraction, monocular and binocular corrected and uncorrected (UDVA) distance visual acuities, and binocular corrected and uncorrected (UNVA) near visual acuities. Corneal pachymetry, topography, aberrometry and an analysis of patient satisfaction were performed at the 12-month examination. RESULTS The study comprised 90 eyes of 45 consecutive patients. The mean age at surgery was 53.8 years ± 4.99 (SD). The mean preoperative SE was +2.33 ± 1.16 diopters (D) in the dominant eyes and +2.26 ± 1.17 D in the nondominant eyes. At 12 months postoperatively, 42 patients (93%) had a binocular UDVA of Snellen 20/20 and 37 patients (82%) had a binocular UNVA of Jaeger 2 (Parinaud 3). The mean SE at 12 months was -0.22 ± 0.35 D in the dominant eyes (P < .0001) and -0.83 ± 0.50 D in the nondominant eyes (P < .0001). Two eyes required retreatment. Overall, 39 patients (87%) said that they were satisfied and would recommend the intervention. CONCLUSION The Q-factor modulation without additive monovision aims to compensate for presbyopia by changing the Q factor of the nondominant eye to generate a greater depth of field in hyperopic presbyopic patients who are unable to tolerate monovision. The visual outcomes and quality of vision were satisfactory, and only a few patients required additional correction.
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Affiliation(s)
- Fabien Rouimi
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France
| | - Sofiane Ouanezar
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France
| | - Isabelle Goemaere
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France
| | - Anne Charlotte Bayle
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France
| | - Vincent Borderie
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France; Institut de la Vision, INSERM UMR S 968, UPMC - Sorbonne Université, Paris, France
| | - Laurent Laroche
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France; Institut de la Vision, INSERM UMR S 968, UPMC - Sorbonne Université, Paris, France
| | - Nacim Bouheraoua
- Quinze-Vingts National Ophthalmology Hospital, UPMC - Sorbonne Université, Paris, France; Institut de la Vision, INSERM UMR S 968, UPMC - Sorbonne Université, Paris, France.
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Shetty N, Kochar S, Paritekar P, Artal P, Shetty R, Nuijts RMMA, Webers CAB, Sinha Roy A. Patient-specific determination of change in ocular spherical aberration to improve near and intermediate visual acuity of presbyopic eyes. JOURNAL OF BIOPHOTONICS 2019; 12:e201800259. [PMID: 30381915 DOI: 10.1002/jbio.201800259] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/11/2018] [Revised: 10/03/2018] [Accepted: 10/30/2018] [Indexed: 06/08/2023]
Abstract
The purpose was to determine the optimum negative spherical aberration induction required to improve near and intermediate visual acuity (VA) of presbyopic eyes. A total of 174 normal and diabetic (no retinopathy) presbyopic eyes (age ≥ 40 years) were measured with visual adaptive optics simulator (Voptica, Spain). First, baseline uncorrected VA and aberrations were measured. VA at 40 cm (near), 80 cm (intermediate) and distance was measured. Then, a negative spherical aberration (SA) was added to baseline ocular SA, and VA at all targets was reassessed after correction of distance refractive error. Clinically, baseline SA and root mean square of higher order aberrations were similar between the normal and diabetic presbyopic eyes. Baseline VA of the diabetic eyes at near and intermediate was better than the same of normal eyes (P = 0.001). After SA change, VA at near and intermediate of both normal and diabetic presbyopic eyes improved. However, fewer diabetic eyes needed higher SA change than normal eyes (P = 0.03). The corresponding trends with change in VA at near and intermediate were also similar between the normal and diabetic eyes. Patient-specific modulation of ocular SA to improve near and intermediate VA in a large cohort of eyes was successful in improving VA, sometimes even distance VA.
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Affiliation(s)
- Naren Shetty
- Department of Cornea and Cataract Services, Narayana Nethralaya Eye Hospital, Bangalore, India
| | - Shruti Kochar
- Department of Cornea and Cataract Services, Narayana Nethralaya Eye Hospital, Bangalore, India
| | - Prajakta Paritekar
- Department of Cornea and Cataract Services, Narayana Nethralaya Eye Hospital, Bangalore, India
| | - Pablo Artal
- Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain
| | - Rohit Shetty
- Department of Cornea and Cataract Services, Narayana Nethralaya Eye Hospital, Bangalore, India
| | - Rudy M M A Nuijts
- Department of Ophthalmology, Maastricht University Medical Center, Maastricht, The Netherlands
| | - Carroll A B Webers
- Department of Ophthalmology, Maastricht University Medical Center, Maastricht, The Netherlands
| | - Abhijit Sinha Roy
- Imaging, Biomechanics and Mathematical Modeling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India
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Romero M, Castillo A, Carmona D, Palomino C. Visual quality after presbyopia correction with excimer laser ablation using micromonovision and modulation of spherical aberration. J Cataract Refract Surg 2019; 45:457-464. [DOI: 10.1016/j.jcrs.2018.10.048] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2018] [Revised: 10/24/2018] [Accepted: 10/29/2018] [Indexed: 01/19/2023]
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21
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Albou-Ganem C. [Presbyopia and refractive surgery]. J Fr Ophtalmol 2019; 42:790-798. [PMID: 30857805 DOI: 10.1016/j.jfo.2018.08.009] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/20/2018] [Accepted: 08/27/2018] [Indexed: 01/19/2023]
Abstract
Presbyopia is the progressive loss of accommodation. Accommodation is a quick, precise and involuntary action which enables the eye to change the power of the young crystalline lens to see clearly at all distances. Presbyopia is and age-linked physiologic phenomenon: it results from aging of the lens, which loses its elasticity, gradually becomes rigid and loses the ability to accommodate. Presbyopia has attained a prevalence of 80% in Europe and is increasing regularly due to the aging of the population. Various surgical techniques can be proposed. Indications depend on age, ophthalmological exam, and any associated ametropia. The main techniques act by either changing the curvature of the cornea with laser or with an intrastromal inlay to create pseudoaccomodation, or by intraocular lens surgery with a multifocal or accommodating IOL. Once the surgical choice has been made, the information must be clearly conveyed and consent obtained.
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Affiliation(s)
- C Albou-Ganem
- Appartenance clinique de la vision, 230, rue du Fg St Honoré, 75008 Paris, France.
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22
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Villegas EA, Manzanera S, Lago CM, Hervella L, Sawides L, Artal P. Effect of Crystalline Lens Aberrations on Adaptive Optics Simulation of Intraocular Lenses. J Refract Surg 2019; 35:126-131. [PMID: 30742228 DOI: 10.3928/1081597x-20181212-02] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/04/2018] [Accepted: 12/10/2018] [Indexed: 01/19/2023]
Abstract
PURPOSE To evaluate the impact of the lens aberrations on the adaptive optics visual simulation of pseudophakic intraocular lens (IOL) profiles. METHODS In 20 right phakic eyes, lens higher order aberrations (HOAs) were calculated as the whole eye minus the corneal aberrations. Visual simulation using low and high contrast corrected distance visual acuity (CDVA) testing was carried out with the VAO instrument (Voptica, SL, Murcia, Spain), considering three optical conditions of the lens: removing HOA (no lens-HOA), removing spherical aberration (no lens-SA), and with lens HOA (natural condition). In addition, a through-focus visual simulation of a trifocal diffractive IOL profile with high contrast CDVA was also measured in two conditions: no lens-HOA and natural condition. Three different pupil sizes (3, 4.5, and 6 mm) were tested for all conditions. RESULTS There were no significant intersubject differences between the three optical conditions and in the IOL simulation for all pupil sizes (P > .05). For 4.5- and 6-mm pupils, mean VA values of the no-lens SA and no lens-HOA conditions were similar and slightly worse than those of the natural condition. Individual differences between the no lens-HOA condition and the other two optical conditions, estimated as 95% limits of agreement, were acceptable for 3-mm pupil but worse as pupil diameter increased. CONCLUSIONS The effect of lens aberrations on visual simulation is imperceptible for a small pupil diameter of 3 mm. Although the increment of pupil size increases the probability of patients with significant visual impact of lens HOAs, the mean intersubject VA differences are negligible. [J Refract Surg. 2019;35(2):126-131.].
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23
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Yoo YS, Whang WJ, Byun YS, Piao JJ, Kim DY, Joo CK, Yoon G. Through-Focus Optical Bench Performance of Extended Depth-of-Focus and Bifocal Intraocular Lenses Compared to a Monofocal Lens. J Refract Surg 2018; 34:236-243. [DOI: 10.3928/1081597x-20180206-04] [Citation(s) in RCA: 28] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2017] [Accepted: 01/22/2018] [Indexed: 01/19/2023]
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Abstract
PURPOSE To evaluate the outcomes of myopic small incision lenticule extraction (SMILE) monovision in presbyopic patients. METHODS This study included 49 presbyopic patients older than 45 years seeking surgical correction of myopia or myopic astigmatism who underwent bilateral SMILE with planned monovision in the SMILE Eyes Clinic Linz, Austria. Target refraction was plano for dominant (distance) eyes and ranged between -1.25 and -0.50 D for nondominant (near) eyes. Best-corrected distance visual acuity, uncorrected distance visual acuity (UDVA), uncorrected near visual acuity, as well as spectacle dependence were assessed after a mean postoperative period of 7.2 ± 4.8 months. RESULTS Mean age was 49 ± 3 years and female to male ratio was 30:19. Distance eyes achieved a spherical equivalent correction of ±0.50 D from target refraction in 80% of patients and 96% were within ±1.0 D. Binocular UDVA of 20/20 or better was achieved by 90% of patients and all patients achieved 20/25 or better. The proportion of patients with a binocular UDVA of 20/20 or better who could read J2 or better amounted to 84%. Complete spectacle independence was achieved by 84% of patients and independence from reading glasses was achieved in 92% of cases. No patient requested refractive enhancement or monovision reversal. CONCLUSIONS This first evaluation of SMILE monovision endorses the approach as a safe and effective option for the correction of presbyopia in myopic patients seeking refractive surgery.
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Marcos S, Werner JS, Burns SA, Merigan WH, Artal P, Atchison DA, Hampson KM, Legras R, Lundstrom L, Yoon G, Carroll J, Choi SS, Doble N, Dubis AM, Dubra A, Elsner A, Jonnal R, Miller DT, Paques M, Smithson HE, Young LK, Zhang Y, Campbell M, Hunter J, Metha A, Palczewska G, Schallek J, Sincich LC. Vision science and adaptive optics, the state of the field. Vision Res 2017; 132:3-33. [PMID: 28212982 PMCID: PMC5437977 DOI: 10.1016/j.visres.2017.01.006] [Citation(s) in RCA: 82] [Impact Index Per Article: 10.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/20/2016] [Revised: 01/24/2017] [Accepted: 01/25/2017] [Indexed: 12/27/2022]
Abstract
Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The editors of this feature issue have posed a series of question to scientists involved in using adaptive optics in vision science. The questions are focused on three main areas. In the first we investigate the use of adaptive optics for psychophysical measurements of visual system function and for improving the optics of the eye. In the second, we look at the applications and impact of adaptive optics on retinal imaging and its promise for basic and applied research. In the third, we explore how adaptive optics is being used to improve our understanding of the neurophysiology of the visual system.
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Affiliation(s)
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - Yuhua Zhang
- University of Alabama at Birmingham, Birmingham, USA
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Abstract
PURPOSE The objective of this study was to review the advances in the field of refractive surgery as reported in the peer-reviewed literature during the previous year. DESIGN A literature review. METHODS In this review, we highlight the most pertinent articles in the field from June 2014 to the end of July 2015. RESULTS This past year has seen a growing body of research on small-incision lenticule extraction, presbyopic inlays, and phakic intraocular lenses, as more clinicians are adopting these techniques into their armamentarium. CONCLUSIONS Laser-assisted in situ keratomileusis and photorefractive keratectomy continue to dominate the keratorefractive literature, as they remain the most frequently performed refractive surgeries.
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Affiliation(s)
- Angelique Pillar
- From the Department of Refractive Surgery, Cole Eye Institute, Cleveland Clinic, Cleveland, OH
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Pang Y, Frantz KA, Roberts DK. Association of refractive error with optic nerve hypoplasia. Ophthalmic Physiol Opt 2016; 35:570-6. [PMID: 26303450 DOI: 10.1111/opo.12229] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2015] [Accepted: 05/20/2015] [Indexed: 12/30/2022]
Abstract
PURPOSE To evaluate the association of refractive error with optic nerve hypoplasia (ONH). METHODS A total of 30 ONH subjects were recruited and underwent comprehensive eye exams. Refractive error data from this group was compared to data from a group of 3232 non-ONH subjects from the same facility. Spherical equivalent was calculated to assess refractive error. Multiple logistic regression was used to evaluate the relationship between ONH and refractive error while controlling for age, race, and gender. RESULTS The prevalence of hyperopia (≥+1.00 D), myopia (<-0.75 D), and anisometropia (≥1.00 D) was higher in ONH subjects than in controls. ONH subjects were 9.1 times more likely to be hyperopic than emmetropic (OR = 9.1, 95% CI = 2.9-28.4, p < 0.001) and 3.8 times more likely to be myopic than emmetropic (OR = 3.8, 95% CI = 1.2-11.5, p = 0.02). Unilateral ONH subjects were 10.0 times more likely to have anisometropia than controls (OR = 10.0, 95% CI = 3.9-25.6, p < 0.0001). Bilateral ONH subjects were 3.8 times more likely to have anisometropia than controls (OR = 3.8, 95% CI = 1.1-12.7, p = 0.03). CONCLUSIONS Optic nerve hypoplasia subjects were more likely than control subjects to exhibit significant refractive errors, particularly hyperopia. Anisometropia tended to be more likely to occur in subjects with unilateral ONH than in bilateral ONH. Based on our findings, we recommend that clinicians perform a comprehensive eye examination on all patients with ONH and prescribe for existing refractive error when visual acuity or general visual function can realistically be improved.
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Affiliation(s)
- Yi Pang
- Illinois College of Optometry, Chicago, USA
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