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Mukhopadhyay D, Cocco P, Orrù S, Cherchi R, De Matteis S. The role of MicroRNAs as early biomarkers of asbestos-related lung cancer: A systematic review and meta-analysis. Pulmonology 2025; 31:2416792. [PMID: 38402124 DOI: 10.1016/j.pulmoe.2024.02.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/18/2023] [Revised: 02/01/2024] [Accepted: 02/03/2024] [Indexed: 02/26/2024] Open
Abstract
BACKGROUND Asbestos is still the leading cause of occupational cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, so early diagnosis biomarkers are needed. MicroRNAs (miRNAs) have been proposed as potential early diagnostic biomarkers of asbestos-related LC and MPM. AIM To evaluate the role of miRNAs as diagnostic and prognostic biomarkers of asbestos-related LC and MPM by performing a literature systematic review and meta-analysis. METHODS MEDLINE, EMBASE via Ovid, PUBMED and Cochrane library databases were systematically searched up to April 2023 to identify relevant articles. A grey literature search was also conducted using the Google Scholar platform. MeSH and free text terms for 'asbestos', 'occupational exposure', 'lung cancer', 'mesothelioma' and 'miRNAs' were used to search the literature. Our systematic review protocol was registered in the PROSPERO database. Study quality was assessed via the Newcastle-Ottawa Scale. RESULTS From the search, 331 articles were retrieved, and, after applying our selection criteria, and exclusion of one study for poor quality, 27 studies were included in the review. Most of the studies were hospital-based case-control, conducted in Europe, and evaluated MPM among men only. MiRNAs expression was measured mainly in plasma or serum. MiR-126, miR-132-3p, and miR-103a-3p were the most promising diagnostic biomarkers for MPM, and we estimated a pooled area under the curve (AUC) of 85 %, 73 %, and 50 %, respectively. In relation to MPM prognosis, miR-197‑3p resulted associated with increased survival time. MiR-126, alone and combined with miR-222, was confirmed associated also to LC diagnosis, together with miR-1254 and miR-574-5p; no miRNA was found associated to LC prognosis. CONCLUSION Based on our systematic literature review there is suggestive evidence that the expression of specific miRNAs in the blood serum or plasma are associated with asbestos-related LC and MPM diagnosis and prognosis. Further large longitudinal studies are urgently needed to validate these findings and elucidate the underlying mechanisms given the potential important implications for patients' survival.
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Affiliation(s)
- D Mukhopadhyay
- Molecular and Translational Medicine, Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Cagliari, Italy
| | - P Cocco
- Centre for Occupational and Environmental Health, Division of Population Health, Health Services Research & Primary Care, University of Manchester, Oxford Road, Manchester, United Kingdom
| | - S Orrù
- Operative Unit of Medical Genetics, Health Agency of Sardinia, Hospital Binaghi, Cagliari, Italy
- Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Cagliari, Italy
| | - R Cherchi
- Operative Unit of Thoracic Surgery, Hospital G. Brotzu, Cagliari, Italy
| | - S De Matteis
- Department of Health Sciences, University of Milan, Milan, Italy
- NHLI, Imperial College London, United Knigdom
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Ge W, Zheng C. Outcomes of peripherally inserted central catheter vs conventional central venous catheters in hematological cancer patients: a systematic review and meta-analysis. Hematology 2025; 30:2450572. [PMID: 39809588 DOI: 10.1080/16078454.2025.2450572] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2024] [Accepted: 01/03/2025] [Indexed: 01/16/2025] Open
Abstract
OBJECTIVE This review aimed to examine if there is any difference in the risk of thrombosis and central line-associated bloodstream infection (CLABSI) with the use of peripherally inserted central catheter (PICC) and conventional central venous catheters (CVC) in hematological cancer patients. METHODS We searched the online databases of PubMed, CENTRAL, Scopus, Web of Science, and Embase for all types of studies comparing the risk of thrombosis and CLABSI between PICC and CVC. The search ended on 23rd September 2024. RESULTS Eight studies were included. One was a randomized trial while others were observational studies. Meta-analysis showed no statistically significant difference in the risk of thrombosis between PICC and CVC (OR: 1.69 95% CI: 0.75, 3.82 I2 = 78%). However, these results were not stable on sensitivity analysis. The exclusion of two studies indicated a higher risk of thrombosis with PICC. Pooled analysis showed that the risk of CLABSI was significantly lower with PICC as compared to CVC (OR: 0.52 95% CI: 0.40, 0.66 I2 = 0%). Results of subgroup analysis based on study design and diagnosis showed conflicting results. CONCLUSIONS There is conflicting evidence on the risk of thrombosis between PICC and CVC when used for hematological cancer patients. There could be a tendency of higher risk of thrombosis with PICC which needs to be confirmed by further studies. However, the use of PICC may reduce the risk of CLABSI in such patients. The quality of evidence is low owing to the predominance of observational studies with high inter-study heterogeneity.
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Affiliation(s)
- Weilei Ge
- Memory impairment center, The Second People's Hospital of Lishui, Lishui City, People's Republic of China
| | - Chen Zheng
- Intensive medicine department, Lishui traditional Chinese medicine hospital, Lishui City, People's Republic of China
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Yang H, Xing H, Zou X, Jin M, Li Y, Xiao K, Cai L, Liu Y, Yang X. Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis. Clin Exp Hypertens 2025; 47:2465399. [PMID: 39950574 DOI: 10.1080/10641963.2025.2465399] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Revised: 01/02/2025] [Accepted: 02/02/2025] [Indexed: 05/09/2025]
Abstract
OBJECTIVES To evaluate the efficacy and safety of intensive blood pressure control in patients over 60 years. METHODS Databases including PubMed, Embase and Cochrane library were searched from inception through February 1, 2024. Randomized controlled trials evaluating the efficacy or safety of intensive blood pressure control in patients over 60 years were included in the meta-analysis. RESULTS Intensive blood pressure control in individuals with mild hypertension has been shown to reduce the risk of heart failure, stroke, myocardial infarction, major cardiovascular events, cardiovascular mortality, and all-cause mortality. The benefits of intensive blood pressure control in patients with moderate to severe hypertension are comparable to those observed in individuals with mild hypertension, with the exception of a reduced impact on all-cause mortality and cardiovascular mortality. Compared with maintaining systolic blood pressure (SBP) above 140 mmHg, SBP below 140 mmHg is associated with a decreased risk of major cardiovascular events in patients aged over 70, as well as a reduced risk of stroke in patients aged 60-69. Furthermore, compared to maintaining SBP above 130 mmHg, SBP below 130 mmHg is linked to a lower risk of major cardiovascular events, heart failure and myocardial infarction in patients over 60, a reduced risk of stroke and cardiovascular mortality in patients aged 60-69, and a decreased risk of all-cause mortality in patients over 70. However, a lower baseline blood pressure or more aggressive blood pressure control may be associated with an increased risk of hypotension. CONCLUSIONS Patients with hypertension aged over 60 years can derive benefits from intensive blood pressure management without experiencing significant adverse events, aside from hypotension.
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Affiliation(s)
- Huarong Yang
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
| | - Haiyan Xing
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
| | - Xue Zou
- Department of Cardiovascular Medicine, Daping Hospital, Army Medical University, Chongqing, China
| | - Meihua Jin
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
| | - Yang Li
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
| | - Ke Xiao
- College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, China
| | - Li Cai
- College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, China
| | - Yao Liu
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
| | - Xue Yang
- Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China
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Gong M, Li X, Xin R, Ma Y, Wu X, Zhao Y, Sun Y, Zhu B. A systematic review and meta-analysis of incidence trends and risk factors for metachronous gastric lesions following endoscopic resection. Ann Med 2025; 57:2521443. [PMID: 40562705 DOI: 10.1080/07853890.2025.2521443] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/20/2025] [Revised: 05/04/2025] [Accepted: 05/26/2025] [Indexed: 06/28/2025] Open
Abstract
BACKGROUND AND AIMS Metachronous gastric lesions (MGLs) are a significant concern after endoscopic resection (ER) for precancerous lesions and early gastric cancers (EGCs). The follow-up strategy for the development of MGLs after ER remains unclear. The aim of this study was to compare the trend in the cumulative MGL incidence after ER and to identify risk factors of MGLs. METHODS We searched four databases (PubMed, Embase, Web of Science Core Collection and Cochrane Library) for studies reporting on patients who underwent ER, and performed meta-analysis. A dose-response analysis was performed to examine the association between follow-up time and cumulative MGL incidence after ER. RESULTS Of the 423 studies initially retrieved, 18 studies were finally included in the meta-analysis. The overall cumulative MGL incidence after ER was 9.4% (95% confidence interval (CI) 7.2%-1.9%). The cumulative MGL incidence in China (5.4%, 95% CI: 4.1%-6.8%) was significantly lower than those in Korea (10.2%, 95% CI: 7.2%-13.5%) and Japan (9.0%, 95% CI: 7.0%-13.2%). Dose-response analysis showed that cumulative MGL incidence increased rapidly during 3-7 years follow-up after ER. Male gender (HR = 1.283, 95% CI: 1.029-1.601), older age (HR = 1.025, 95% CI: 1.010-1.040), Helicobacter pylori (H. pylori) infection (HR = 1.573, 95% CI: 1.048-2.362), severe intestinal metaplasia (IM) (HR = 3.423, 95% CI: 1.830-6.042) were significantly associated with MGLs after ER. CONCLUSIONS Nearly 10% of patients develop MGLs after ER. Older age, persistent H. pylori infection, severe intestinal metaplasia, and male sex were independent risk factors. Given the increased incidence 3 year after ER, surveillance with intensified follow-up is necessary for high-risk patients.
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Affiliation(s)
- Meixi Gong
- Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute,Shenyang, China
- Department of Public Health, Dalian Medical University, Dalian, Liaoning, China
| | - Xuanbing Li
- Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute,Shenyang, China
- Department of Public Health, Dalian Medical University, Dalian, Liaoning, China
| | - Ruijun Xin
- Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute,Shenyang, China
- Department of Public Health, Dalian Medical University, Dalian, Liaoning, China
| | - Yuansen Ma
- Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute,Shenyang, China
| | - Xiaomei Wu
- Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Hospital of China Medical University, Shenyang, China
| | - Yan Zhao
- Department of Gastric Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China
| | - Yu Sun
- Liaoning Provincial Health Service Center, Shenyang, Liaoning Province, China
| | - Bo Zhu
- Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute,Shenyang, China
- Department of Public Health, Dalian Medical University, Dalian, Liaoning, China
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Melo GLR, C. Espírito Santo R, Dubey VP, Agostinis-Sobrinho C. Handgrip strength measurement protocols in individuals with Down syndrome: a systematic review and meta-regression. Ann Med 2025; 57:2453077. [PMID: 39840783 PMCID: PMC11755743 DOI: 10.1080/07853890.2025.2453077] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/26/2024] [Revised: 10/22/2024] [Accepted: 01/02/2025] [Indexed: 01/23/2025] Open
Abstract
BACKGROUND Handgrip strength (HGS) serves as a robust predictor of overall strength across various populations, including individuals with Down Syndrome (DS). OBJECTIVE To analyze the HGS measurement protocols used in studies involving individuals with DS. METHODS Primary sources were sourced from six databases: PubMed, Scopus, Ovid, Embase, ERIC, and Web of Science, spanning from inception to 23rd December 2023. Inclusion criteria focused on individuals with DS, compared with control groups, and examined HGS measurement protocols and outcomes. Meta-regression was utilized to assess bias associated with HGS values concerning different measurement protocols. RESULTS Out of 29 studies involving 1816 participants, most controlled for body position (65%), arm position (82%), elbow position (82%), wrist position (62%), handgrip duration (55%), hand adjustment to dynamometer (62%), verbal encouragement (75%), and familiarization (44.8%). The number of reported variables in the HGS protocol was significantly associated with an increase in HGS, with a mean estimate of 20.59 units (SE = 2.59, p < 0.0001, 95% CI [15.49-25.68]), though there was notable heterogeneity (I2 = 94.33%). The spline regression analysis showed that the model explained 82.66% of the variation in HGS, with adults having 47.61 units higher HGS than children (p = 0.0009), while obesity was linked to a decrease of 15.68 units (p = 0.0675). Sample size and group had no significant effects. CONCLUSION Overall, protocols for assessing HGS in DS studies are comprehensive yet heterogeneous. Higher HGS values correlated with adherence to standard protocols.
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Affiliation(s)
- Geiziane L. R. Melo
- Health Research and Innovatioin Science Centre, Klaipeda University, Klaipeda, Lithuania
| | | | - Viney P. Dubey
- Health Research and Innovatioin Science Centre, Klaipeda University, Klaipeda, Lithuania
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Santopetro NJ, Thompson B, Garron A, Keith L, Brush CJ, Schmidt B, Hajcak G. Systematic review and meta-analysis: Impact of unipolar depression on P300 amplitude and latency. Neurosci Biobehav Rev 2025; 175:106230. [PMID: 40412458 DOI: 10.1016/j.neubiorev.2025.106230] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/29/2025] [Revised: 05/05/2025] [Accepted: 05/21/2025] [Indexed: 05/27/2025]
Abstract
Depression is characterized by impairments of cognitive systems such as significant deficits in attention, memory, and cognitive control. The P300 (or P3) event-related potential (ERP) component has been extensively investigated over the past four decades to elucidate the underpinnings of these cognitive dysfunctions. Many studies have observed reduced P300 amplitude and prolonged P300 latency in individuals experiencing depression. The current study provides a comprehensive systematic quantitative review (i.e., meta-analysis) of the depression and P300 literature from 1981 to 2023 employing PubMed and ProQuest databases. Included articles quantitatively measured depression and P300 amplitude or latency. In total, 127 studies (total N = 12,722) comprised the current analyses (i.e., 116 examining P300 amplitude and 51 examining P300 latency), resulting in 601 effect sizes (i.e., 464 depression and P300 amplitude; 137 depression and P300 latency). Robust variance meta-regression results revealed a small significant negative effect size (r = -.15) between P300 amplitude and depression even after correcting for publication bias. There was a similar small significant positive effect size (r = .15) between P300 latency and depression. Findings from moderator analyses indicated that stimulus modality, medication use, and age impacted the P300 amplitude and depression effect size; no moderators of the P300 latency and depression relationship were observed. Regarding limitations, we did not exhaustively test all possible factors that may impact P300 and depression association. The current quantitative review confirms significant differences in P300 (both amplitude and latency) attributed to cognitive dysfunctions common in depression as well as guides future study designs and methodological approaches.
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Affiliation(s)
| | - Brittney Thompson
- Department of Psychology, Florida State University, Tallahassee, USA
| | - Andrew Garron
- Department of Psychology, Florida State University, Tallahassee, USA
| | - Lauren Keith
- Department of Psychology, Florida State University, Tallahassee, USA
| | - C J Brush
- Department of Movement Sciences, University of Idaho, Moscow, USA
| | - Brad Schmidt
- Department of Psychology, Florida State University, Tallahassee, USA
| | - Greg Hajcak
- School of Education and Counseling Psychology, Santa Clara University, Santa Clara, CA, USA
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Celik F, Turan R, Bektas H. The effect of game-based interventions on the nursing students' level of knowledge: A systematic review and meta-analysis of randomized controlled trials. NURSE EDUCATION TODAY 2025; 151:106746. [PMID: 40267601 DOI: 10.1016/j.nedt.2025.106746] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Revised: 03/19/2025] [Accepted: 04/08/2025] [Indexed: 04/25/2025]
Abstract
The adoption of game-based interventions has begun to rise as innovative methods in nursing education have gained prominence. This systematic review and meta-analysis study aimed to analyze the effects of game-based interventions on nursing students' knowledge level. We searched nine electronic databases published in English, without year limitations, until May 2024. We followed the PRISMA 2020 checklist. A random-effects model was used to determine intervention effects. The Cochrane Collaboration technique was used to evaluate potential bias. Six studies involving 718 nursing students were included in this study. We identified the use of different game-based approaches such as video games, serious games, mobile games, board games, gamified flipped classrooms, and virtual gaming simulations. Game-based intervention duration ranged from only once to once weekly throughout the study period. No significant publication bias was observed. Compared to the control group, game-based interventions improved the level of knowledge (SMD = 1.00; 95 % CI [0.26, 1.74]; p < 0.001). Game-based interventions are an effective strategy for achieving learning objectives in the cognitive domain and contribute to increasing nursing students' knowledge levels. Therefore, integrating game-based interventions into nursing education is recommended. Further research is needed to determine how game-based affect nursing students' behavioral and affective learning outcomes.
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Affiliation(s)
- Ferya Celik
- Akdeniz University Faculty of Nursing, Department of Internal Medicine Nursing, Antalya, Turkey.
| | - Recep Turan
- Akdeniz University Institute of Health Science, Department of Internal Medicine Nursing, Antalya, Turkey.
| | - Hicran Bektas
- Akdeniz University Faculty of Nursing, Department of Internal Medicine Nursing, Antalya, Turkey.
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Mouazen B, Bendaouia A, Abdelwahed EH, De Marco G. Machine learning and clinical EEG data for multiple sclerosis: A systematic review. Artif Intell Med 2025; 166:103116. [PMID: 40334524 DOI: 10.1016/j.artmed.2025.103116] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/31/2024] [Revised: 02/21/2025] [Accepted: 03/26/2025] [Indexed: 05/09/2025]
Abstract
Multiple Sclerosis (MS) is a chronic neuroinflammatory disease of the Central Nervous System (CNS) in which the body's immune system attacks and destroys the myelin sheath that protects nerve fibers, leading to a wide range of debilitating symptoms and causing disruption of axonal signal transmission. Accurate prediction, diagnosis, monitoring and treatment (PDMT) of MS are essential to improve patient outcomes. Recent advances in neuroimaging technologies, particularly electroencephalography (EEG), combined with machine learning (ML) techniques - including Deep Learning (DL) models - offer promising avenues for enhancing MS management. This systematic review synthesizes existing research on the application of ML and DL models to EEG data for MS. It explores the methodologies used, with a focus on DL architectures such as Convolutional Neural Networks (CNNs) and hybrid models, and highlights recent advancements in ML techniques and EEG technologies that have significantly improved MS diagnosis and monitoring. The review addresses the challenges and potential biases in using ML-based EEG analysis for MS. Strategies to mitigate these challenges, including advanced preprocessing techniques, diverse training datasets, cross-validation methods, and explainable Artificial Intelligence (AI), are discussed. Finally, the paper outlines potential future applications and trends in ML for MS management. This review underscores the transformative potential of ML-enhanced EEG analysis in improving MS management, providing insights into future research directions to overcome existing limitations and further improve clinical practice.
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Affiliation(s)
- Badr Mouazen
- LINP2 Lab, Paris Nanterre University, UPL Paris, France.
| | - Ahmed Bendaouia
- Institute for Advanced Manufacturing (IAM), University of Texas Rio Grande Valley, United States
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Kunikullaya U K, Pranjić M, Rigby A, Pallás-Ferrer I, Anand H, Kunnavil R, Jaschke AC. The molecular basis of music-induced neuroplasticity in humans: A systematic review. Neurosci Biobehav Rev 2025; 175:106219. [PMID: 40412457 DOI: 10.1016/j.neubiorev.2025.106219] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Revised: 04/28/2025] [Accepted: 05/20/2025] [Indexed: 05/27/2025]
Abstract
Neuroscientific research on music-based activities has grown rapidly, shedding light on the health benefits of music across various domains. However, the molecular mechanisms by which music influences neuroplasticity in humans remain largely unexplored. This review aimed to synthesize and critically appraise existing research on molecular neuroplasticity in humans, with a specific focus on the effects of receptive and active music-based interventions (MBIs) and musical training. Following the PRISMA guidelines, a systematic search was conducted across four databases (MEDLINE, Embase, PsycINFO, and Scopus), for articles published between 2000 and December 2023. From an initial return of 3239 records, 15 studies met the inclusion criteria and were synthesized into three categories of music experiences: (1) receptive MBIs, (2) active MBIs, and (3) musical training. Both active and receptive MBIs were found to enhance neuroplasticity. Specifically, music listening was associated with relaxation and improved immune function, marked by the upregulation of genes related to neuroprotection and synaptic plasticity, while active MBIs consistently enhanced peripheral neurotrophic factors in both healthy and patient populations. Among musicians, neurogenetic alterations linked to music perception and production, neurogenesis, and neurotransmission were identified, with multiple studies highlighting the roles of Brain-Derived Neurotrophic Factor (BDNF), Alpha Synuclein (SNCA), and GATA2 (GATA Binding Protein 2) genes. Collectively, both MBIs and musical training induce neuroplastic changes by modulating neurogenetics, enhancing neurotrophins, altering hormonal levels, and reducing stress in humans. These findings highlight the need for further research to elucidate the molecular mechanisms underlying music's effects on the human brain, which could have implications for advancing therapeutic interventions for neuropsychological disorders.
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Affiliation(s)
- Kirthana Kunikullaya U
- Department of Medicine (Huddinge), Karolinska Institutet, ME Endokrinologi, Karolinska University Hospital Huddinge, Huddinge, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden.
| | - Marija Pranjić
- Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
| | - Alison Rigby
- Neurosciences Graduate Program, University of California San Diego, School of Medicine, La Jolla, CA, United States; Center for Human Development, University of California, San Diego, La Jolla, CA, United States; Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, La Jolla, CA, United States.
| | | | - Harshini Anand
- National Institute of Advanced Studies, Indian Institute of Science Campus, Bengaluru 560012, India.
| | - Radhika Kunnavil
- National Institute of Unani Medicine, (Under Ministry of AYUSH, Govt. of India), Bangalore 560091, India.
| | - Artur C Jaschke
- Department of Psychiatry, University of Cambridge, UK; ArtEZ University of the Arts, Enschede, the Netherlands; University Medical Centre Groningen and University of Cambridge, UK.
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Pourrajab B, Fotros D, Asghari P, Shidfar F. Effect of the Mediterranean Diet Supplemented With Olive Oil Versus the Low-Fat Diet on Serum Inflammatory and Endothelial Indexes Among Adults: A Systematic Review and Meta-analysis of Clinical Controlled Trials. Nutr Rev 2025; 83:e1421-e1440. [PMID: 39530776 DOI: 10.1093/nutrit/nuae166] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2024] Open
Abstract
CONTEXT Inflammation and endothelial dysfunction are important risk factors for chronic diseases, including cardiovascular diseases and related mortality. OBJECTIVE This systematic review and meta-analysis aimed to assess the effects of 2 popular dietary patterns-a Mediterranean (MED) diet supplemented with olive oil and a low-fat diet (LFD)-on factors related to inflammation and endothelial function in adults. DATA SOURCES AND DATA EXTRACTION The following online databases were searched for related studies published until August 7, 2024: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar. Two independent researchers selected the studies based on the eligibility criteria. DATA ANALYSIS The effect sizes were expressed as Hedges' g with 95% CIs. A total of 16 eligible trials with 20 effect sizes were included in the analyses. This meta-analysis revealed that the MED diet supplemented with olive oil significantly improved all of the indicators of the study compared with the LFD, except in the case of E-selectin, in which a low and nonsignificant decrease was reported. CONCLUSION Available evidence suggests that a MED diet supplemented with olive oil compared with the LFD significantly improves inflammation and serum endothelial function in adults. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42023485718.
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Affiliation(s)
- Behnaz Pourrajab
- Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 1981619573, Iran
| | - Danial Fotros
- Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 1981619573, Iran
| | - Parastoo Asghari
- Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran
| | - Farzad Shidfar
- Nutritional Sciences Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran
- Department of Nutritional Sciences, School of Public Health, Iran University of Medical Sciences, Tehran 1449614535, Iran
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Bostan ZZ, Şare Bulut M, Özen Ünaldı B, Albayrak Buhurcu C, Akbulut G. Effect of Plant-Based Diets on Rheumatoid Arthritis: A Systematic Review. Nutr Rev 2025; 83:e1798-e1814. [PMID: 39786551 DOI: 10.1093/nutrit/nuae181] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/12/2025] Open
Abstract
CONTEXT Rheumatoid arthritis (RA) is an autoimmune disease that leads to chronic inflammation and joint damage. Various plant-based diets are thought to have effects on RA symptoms and disease activity. OBJECTIVE Relevant literature on the effect of different types of plant-based diets on RA was reviewed. DATA SOURCES A systematic search was conducted using the Web of Science, PubMed, Scopus, and Cochrane databases and following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. DATA EXTRACTION Articles on observational and interventional human studies carried out in the adult population and published in English between February 2013 and April 2023 were eligible for inclusion. Articles reporting on studies performed in populations under 18 years of age, with unclear methods and results, or for which the full text was unavailable were excluded. The risk of bias in the selected studies was assessed using the Joanna Briggs Institute checklists. DATA ANALYSIS Of 547 screened articles, 15 were included, comprising 4 cross-sectional, 2 cohort, and 9 randomized controlled trials. These studies examined the effects of various diets, including the Mediterranean, low-fat high-carbohydrate, anti-inflammatory, and vegan, on RA. Results indicate adherence to plant-based diets generally reduced disease severity and improved dietary intake, physical activity, body weight, and key clinical markers such as the Disease Activity Score-28, Visual Analog Scale score, Health Assessment Questionnaire Disability Index, erythrocyte sedimentation rate, and C-reactive protein level in patients with in RA. CONCLUSIONS Most of the studies suggested the Mediterranean diet may positively affect the severity of RA. However, the included studies show heterogeneity. Therefore, more randomized controlled studies are needed in this area to increase understanding of the effect of diet on RA and facilitate the implementation of strategies to prevent RA. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42023420577.
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Affiliation(s)
- Zekiye Zeynep Bostan
- Department of Nutrition and Dietetics, İstanbul Gedik University, 34906 İstanbul, Türkiye
| | - Melike Şare Bulut
- Department of Nutrition and Dietetics, Biruni University, 34015 İstanbul, Türkiye
| | - Buket Özen Ünaldı
- Department of Nutrition and Dietetics, Afyonkarahisar Health Sciences University, 03030 Afyonkarahisar, Türkiye
| | | | - Gamze Akbulut
- Department of Nutrition and Dietetics, Kent University, 34406 İstanbul, Türkiye
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12
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Mustafovska J, Wilson PH, Cole MH, McGuckian TB. Locomotor-cognitive dual-tasking is reduced in older adults relative to younger: A systematic review with meta-analysis. Gait Posture 2025; 120:177-191. [PMID: 40262366 DOI: 10.1016/j.gaitpost.2025.04.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/02/2024] [Revised: 04/01/2025] [Accepted: 04/13/2025] [Indexed: 04/24/2025]
Abstract
BACKGROUND The capacity to dual-task is critically important over the lifespan, enabling an individual to respond to demands in their environment, both safely and efficiently. RESEARCH QUESTION Does recent evidence suggest that relative to younger adults, older adults are most disadvantaged when performing locomotor-cognitive dual-tasks under conditions that are more representative of the real-world? METHOD A literature search of major electronic databases was conducted to find relevant peer-reviewed papers published since 2011. Thirty-nine studies that compared proportional dual-task costs (pDTC) between older and younger adults on a locomotor-cognitive dual-task were included. Study quality was assessed using the Appraisal tool for Cross-Sectional Studies. RESULTS pDTC were calculated for a total of 504 motor and 53 cognitive outcomes. Weighted means showed that older adults experienced larger pDTCs than younger adults for motor (mean difference = -6.97) and cognitive (mean difference = -8.15) outcomes. Velocity variability measures produced the largest group difference on motor pDTC (mean difference = -32.83), as did cognitive tasks that targeted arithmetic (mean difference = -18.57) and texting skills (mean difference = -17.43). Cognitive tasks that were 'most representative' resulted in the largest age differences on motor pDTC (mean difference = -16.89). SIGNIFICANCE This meta-analysis showed that dual-tasking challenged the ability of older adults to maintain consistency in the sequential timing of their gait. As well, older adults demonstrated greater pDTCs on motor outcomes, especially when the cognitive tasks were more representative of day-to-day activities. Taken together, this suggests that clinical assessments should focus on measures of variability rather than absolute measures of temporal and spatial gait. It is recommended that future research use more representative paradigms that are sensitive to dual-task interference and predictive of real-world behaviour.
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Affiliation(s)
- Jona Mustafovska
- Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia.
| | - Peter H Wilson
- Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia
| | - Michael H Cole
- Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia
| | - Thomas B McGuckian
- Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia
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13
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Kittel A, Lindsay R, Larkin P, Spittle M, Cunningham I. The effectiveness of decision-making training in team-sport officials: A systematic review and meta-analysis. PSYCHOLOGY OF SPORT AND EXERCISE 2025; 79:102841. [PMID: 40107585 DOI: 10.1016/j.psychsport.2025.102841] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/13/2024] [Revised: 03/12/2025] [Accepted: 03/14/2025] [Indexed: 03/22/2025]
Abstract
PURPOSE Decision making is a critical skill for sports officials, often directly influencing the flow and fairness of a match. While this topic has received considerable interest in the literature, a synthesis of current evidence to understand the effectiveness of decision-making training interventions remains unexplored. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of decision-making interventions in team sport officials. PRINCIPAL RESULTS A total of 14 studies were identified, with a random-effects meta-analysis revealing an overall moderate positive effect of decision-making training on decision-making performance outcomes (g = 0.68, p < .001) compared to control conditions. Notably, decision-making training was more effective in Soccer (g = 1.05), Rugby Union (g = 0.90), but not for Australian Football (g = 0.24). Video-based (i.e., 2-D footage) showed significant improvements, especially for objective decision-making outcomes like offside identification (g = 1.48, p < .001). However, our findings indicated that decision-making training tends to be less effective for subjective decision-making outcomes that requires higher levels of interpretation. Furthermore, shorter interventions (4-6 weeks) were found to be most effective, with performance improvements reducing as interventions increased in time. MAJOR CONCLUSIONS Our findings highlight the need for further research to explore alternative technologies such as virtual reality to understand how to better replicate game scenarios and assess the transferability of decision-making training to real-world officiating contexts. Additionally, this review highlights the need to investigate sports beyond Soccer, Rugby, and Australian Rules Football to develop our understanding further into optimising decision-making training in sports officials.
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Affiliation(s)
- Aden Kittel
- School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia; Centre for Sport Research, Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.
| | - Riki Lindsay
- Institute of Education, Arts and Community, Federation University, Ballarat, Australia
| | - Paul Larkin
- Institute for Health and Sport, Victoria University, Melbourne, Australia; Maribyrnong Sport Academy Research Centre, Melbourne, Australia
| | - Michael Spittle
- Institute for Health and Sport, Victoria University, Melbourne, Australia
| | - Ian Cunningham
- School of Applied Sciences, Edinburgh Napier University, Scotland, UK
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14
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Loomes K, de Grauw J, Gozalo-Marcilla M, Redondo JI, Bettschart-Wolfensberger R. A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023). Equine Vet J 2025; 57:827-861. [PMID: 39449518 DOI: 10.1111/evj.14416] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/23/2024] [Accepted: 08/14/2024] [Indexed: 10/26/2024]
Abstract
BACKGROUND Equine post-operative morbidity represents a significant concern for both veterinary surgeons and horse owners. OBJECTIVES To estimate the prevalence of post-operative complications in horses after elective/non-abdominal surgery or colic surgery. STUDY DESIGN Systematic review. METHODS A database search identified eligible studies which reported the prevalence of equine post-operative complications published as a full paper in English in a peer-reviewed journal between 2000 and 2023. Studies were evaluated using the JBI Critical Appraisal Checklist for Prevalence Studies and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) framework. Data for the most commonly reported complications were analysed using Chi-squared analysis of weighted means to answer 13 PICO (Population, Intervention, Comparator and Outcomes) questions. RESULTS Sixty-seven studies met inclusion criteria. Data for eight post-operative morbidities (colic, surgical site complications, myopathy/neuropathy, laminitis, diarrhoea/colitis, fever/pyrexia, jugular thrombophlebitis/thrombosis, respiratory complications) were sufficient to allow statistical analyses. The weighted mean of the overall proportion of post-operative complications after elective/non-abdominal surgery is 17.48% (95% confidence interval [95% CI]: 13.20-22.92), significantly increasing to 55.62% (95% CI: 45.79-65.03) after colic surgery (odds ratio [OR] 6.63; 95% CI: 5.83-7.56; p < 0.001). The most commonly reported morbidity was post-operative colic, with a weighted mean prevalence of 7.45% (95% CI: 4.83-11.76) after elective/non-abdominal surgery, significantly rising to 26.46% (95% CI: 19.11-35.97) after colic surgery (OR 4.11; 95% CI: 3.60-4.71; p < 0.001). The weighted mean prevalence of surgical site complications, laminitis, diarrhoea/colitis, fever/pyrexia, jugular thrombophlebitis/thrombosis and respiratory complications were significantly higher after colic surgery compared with elective/non-abdominal surgery. Myopathy/neuropathy was the only morbidity where prevalence was not different between groups (OR 1.86; 95% CI: 0.86-4.16; p = 0.16). MAIN LIMITATIONS The majority of studies were retrospective. Morbidity definitions, data collection periods, follow-up time and methods varied between studies. CONCLUSIONS Based on current evidence, the prevalence of post-operative colic, surgical site complications, laminitis, diarrhoea/colitis, fever/pyrexia, jugular thrombophlebitis/thrombosis and respiratory complications is significantly higher after colic surgery compared with elective/non-abdominal surgery under general anaesthesia.
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Affiliation(s)
- Kate Loomes
- Rainbow Equine Hospital, Malton, North Yorkshire, UK
| | - Janny de Grauw
- Royal Veterinary College, Department of Clinical Sciences and Services, University of London, Hatfield, UK
| | - Miguel Gozalo-Marcilla
- The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, UK
| | - José I Redondo
- Universidad Cardenal Herrera - CEU, CEU Universities, Valencia, Spain
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15
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Meinertz NR, Lee J, Kim Y. Are Family Caregiving Programs Appropriate for Minority Caregivers? A Systematic Review of 37 Caregiving Programs. J Appl Gerontol 2025; 44:1125-1141. [PMID: 39501664 DOI: 10.1177/07334648241298109] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/27/2025] Open
Abstract
The extent to which dementia caregiving programs are effective among racially or ethnically diverse caregivers is unknown. Limited information about program effectiveness for minority caregivers may further exacerbate health disparities and contribute to unmet needs. Guided by the PRISMA guidelines, this systematic review aimed to determine whether 37 evidence-based dementia caregiving programs were efficacious with racially and ethnically diverse caregiving populations. Using six databases (APA PsycINFO, APA PsycArticles, Academic Search Elite, Academic Search Premier, CINAHL, and Scopus), 140 empirical studies were identified as program evaluation studies of the 37 programs with diverse populations. After reviewing these articles, 24 empirical studies supported 11 programs as efficacious with racially/ethnically diverse populations. The 24 studies form three categories: no program alterations; targeted recruitment efforts; and program adaptations that address culturally specific needs. The findings of this review underscore the gaps in current family caregiving programs and identify the need for culturally appropriate programs.
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Affiliation(s)
| | | | - Yulri Kim
- Iowa State University, Ames, IA, USA
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16
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Engidaw MT, Lee P, Fekadu G, Mondal P, Ahmed F. Effect of Nutrition Education During Pregnancy on Iron-Folic Acid Supplementation Compliance and Anemia in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis. Nutr Rev 2025; 83:e1472-e1487. [PMID: 39545365 PMCID: PMC12166189 DOI: 10.1093/nutrit/nuae170] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2024] Open
Abstract
CONTEXT Stakeholders implement nutrition education to prevent and control anemia during pregnancy. Nutrition education during pregnancy can increase the consumption of iron-folic acid (IFA) supplements and encourage behavioral changes. However, there is no comprehensive meta-analysis to determine the effectiveness of this intervention. OBJECTIVE This review aimed to determine the effect of nutrition education on IFA supplementation (IFAS) compliance, hemoglobin level change, and prevalence of anemia in low- and middle-income countries. DATA SOURCES The systematic searches on Ovid Medline, Scopus, Embase (Elsevier), Web of Science, Health and Medical Collection (ProQuest), and Google Scholar were conducted until September 11, 2023. The updated searches were performed on November 16, 2023. DATA EXTRACTION In total, 12 436 records were imported to Covidence. Of these, 9109 records were screened by title and abstract. A total of 112 records were evaluated in full, and 53 articles were ultimately included based on eligibility. RESULTS Fifty-three peer-reviewed research articles met the inclusion criteria, involving 13 475 pregnant women. Those who received nutrition education during pregnancy were 2.80 times more likely to comply with IFAS (odds ratio = 2.80; 95% CI: 2.04, 3.83; I2 = 66.20%). There was an average increase of 0.88 g/dL (Cohen's d = 0.88; 95% CI: 0.63, 1.13; I2 = 96.17%) in hemoglobin levels among women who received nutrition education. A meta-regression analysis revealed that 61.85% (adjusted R2 = 61.85%) of heterogeneity between standardized mean differences was explained by anemia status, intervention duration, and geographic region. Also, pregnant women in the nutrition education group had a 34% (relative risk = 0.66; 95% CI: 0.54, 0.80, I2 = 86.85%) lower risk of anemia compared with the control group. CONCLUSION Nutrition education during pregnancy improves compliance with IFAS, increases hemoglobin levels, and reduces the risk of anemia. Therefore, it is crucial to enhance the existing nutrition education program to prevent and control anemia during pregnancy. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42023454241.
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Affiliation(s)
- Melaku Tadege Engidaw
- Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
- Department of Public Health (Human Nutrition), College of Health Sciences, Debre Tabor University, Debre Tabor 6300, Ethiopia
| | - Patricia Lee
- Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
- Department of Medical Research, China Medical University Hospital, Taichung City 404, Taiwan
| | - Gelana Fekadu
- School of Nursing and Midwifery, Griffith University, Gold Coast, Queensland 4222, Australia
- School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar 3200, Ethiopia
| | - Prasenjit Mondal
- Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
| | - Faruk Ahmed
- Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
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17
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Ferrari de Castro MA, Dedivitis RA, Luongo de Matos L, Baraúna JC, Kowalski LP, de Carvalho Moura K, Herman Partezani D. Endoscopic and videofluoroscopic evaluations of swallowing for dysphagia: A systematic review. Braz J Otorhinolaryngol 2025; 91 Suppl 1:101598. [PMID: 40209342 PMCID: PMC12013387 DOI: 10.1016/j.bjorl.2025.101598] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2024] [Accepted: 12/02/2024] [Indexed: 04/12/2025] Open
Abstract
OBJECTIVE This systematic review was performed to compare the diagnostic accuracy of FEES and VFSS in evaluating swallowing in adults with dysphagia. METHODS A search for articles published between January 1991 and March 2020 was carried out in the MEDLINE EMBASE, COCHRANE, SciELO, and LILACS electronic databases. Based on the eligibility criteria, six articles were included. RESULTS FEES demonstrated a higher ability to diagnose pharyngeal residue, penetration, and aspiration compared with VFSS, and slightly better performance in detecting premature spillage. CONCLUSION There were no significant differences on the diagnostic performance of both tests. The choice of test should depend on availability, team experience, and patient's preference. LEVEL OF EVIDENCE Level III.
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Affiliation(s)
| | | | - Leandro Luongo de Matos
- Universidade de São Paulo, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil
| | - José Carlos Baraúna
- Universidade de São Paulo, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil
| | - Luiz Paulo Kowalski
- Universidade de São Paulo, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil
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18
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Orrin M, Barber E, Grainge MJ. Pre-Existing and Gestational Diabetes and Risk of Maternal Venous Thromboembolism: A Systematic Review and Meta-Analysis of Observational Studies. BJOG 2025; 132:1076-1085. [PMID: 39686826 PMCID: PMC12137783 DOI: 10.1111/1471-0528.18043] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/01/2024] [Revised: 11/28/2024] [Accepted: 12/04/2024] [Indexed: 12/18/2024]
Abstract
BACKGROUND Women who are pregnant are at increased risk of venous thromboembolism (VTE), which persists for up to 3 months following childbirth. Diabetes is known to increase the risk of serious cardiovascular outcomes. OBJECTIVE To comprehensively review literature on the extent to which pre-existing or gestational diabetes influences the risk of VTE in both pregnancy and postpartum. SEARCH STRATEGY We used Medline, Embase and Google Scholar to identify observational studies published up to 2 November 2023. SELECTION CRITERIA Studies which quantified the relationship between diabetes on antepartum and/or postpartum VTE, and which provide separate data for pre-existing and gestational diabetes. DATA COLLECTION AND ANALYSIS Results were pooled, where appropriate, using random-effects meta-analysis. MAIN RESULTS Twenty one studies from Europe, the United States and Asia were included. There was an increased risk of antepartum VTE in women with gestational diabetes (RR = 2.48, 95% CI 1.47 - 4.16, I2= 45%, 4 studies) but not pre-existing diabetes (RR = 1.71, 0.43 - 6.77, I2= 68%, 2 studies). For postpartum VTE, there was no clear association with either pre-existing (RR = 1.28, 0.73 - 2.24, I2= 73%, 6 studies) or gestational (RR = 1.39, 0.77 - 2.51, I2= 70%, 10 studies) diabetes. CONCLUSIONS Our results will provide some reassurance for pregnant women with pre-existing or gestational diabetes, owing to no clear evidence of an increased risk of maternal VTE. While some studies report a raised risk of VTE during antepartum specifically, results must be interpreted in light of high levels of heterogeneity.
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Affiliation(s)
- Molly Orrin
- Academic Unit of Lifespan and Population Health, School of MedicineUniversity of NottinghamNottinghamUK
| | - Emilia Barber
- Academic Unit of Lifespan and Population Health, School of MedicineUniversity of NottinghamNottinghamUK
| | - Matthew J. Grainge
- Academic Unit of Lifespan and Population Health, School of MedicineUniversity of NottinghamNottinghamUK
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19
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O'Loghlen J, McKenzie M, Lang C, Paynter J. Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review. J Autism Dev Disord 2025; 55:2307-2321. [PMID: 38652373 PMCID: PMC12167328 DOI: 10.1007/s10803-024-06357-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/12/2024] [Indexed: 04/25/2024]
Abstract
PURPOSE Obsessive-compulsive disorder (OCD) and autism are characterized by the presence of repetitive behaviors. Differentiating between repetitive behaviors attributable to a diagnosis of autism, and those attributable to OCD, poses challenges for differential and co-occurring diagnosis. Differentiation is important to inform appropriate supports and interventions for phenotypically similar but functionally distinct behaviors. In this systematic review, the quantitative literature was examined to explore the similarities and differences in repetitive behaviors (including restricted and repetitive behaviors and interests, and obsessive-compulsive behaviors) in autistic individuals and those with OCD, and those with co-occurring diagnoses, in terms of: (1) expression, (2) content, and (3) associated factors. METHODS Thirty-one studies were identified that compared repetitive behaviors in autistic individuals, individuals with OCD, or individuals with both diagnoses. RESULTS The results suggest considerable overlap in the intensity and content of repetitive behaviors between groups. The findings of this review highlight that research aimed specifically at understanding similarities and differences in repetitive behaviors between autistic individuals and individuals with OCD is limited and frequently only compare at total score or composite measure levels. CONCLUSION Further research into differences in the presentation of repetitive behaviors at a subscale and item level is required to inform clearer differentiation of specific behaviors in autism versus OCD. Understanding and more accurately differentiating is essential for efficient diagnosis, effective treatment, and better outcomes.
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Affiliation(s)
- Jessica O'Loghlen
- , Building N23, -1.03, 170 Kessels Road, Nathan, QLD, 4111, Australia.
| | - Matthew McKenzie
- School of Applied Psychology, Griffith University, 58 Parklands Drive, Southport, QLD, 4215, Australia
| | - Cathryne Lang
- School of Applied Psychology, Griffith University, 58 Parklands Drive, Southport, QLD, 4215, Australia
| | - Jessica Paynter
- School of Applied Psychology, Griffith University, 58 Parklands Drive, Southport, QLD, 4215, Australia
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20
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Song T, Ye M, Teng G, Zhang W, Chen A. The role of action anticipation in specific sport performance: A three-level meta-analysis and systematic review in temporal occlusion paradigm. PSYCHOLOGY OF SPORT AND EXERCISE 2025; 79:102839. [PMID: 40090558 DOI: 10.1016/j.psychsport.2025.102839] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/30/2024] [Revised: 03/05/2025] [Accepted: 03/11/2025] [Indexed: 03/18/2025]
Abstract
Action anticipation is crucial for athletes, enabling them to make the most accurate decisions possible under time constraints and significantly impacting sports performance. This study systematically consolidates key findings from research on action anticipation in sports using the temporal occlusion paradigm to achieve the following five objectives: (1) quantifying the magnitude of the advantage of sports experts in action anticipation; (2) examining whether this expert advantage transfers to familiar and unfamiliar sports and, if so, quantifying its magnitude; (3) testing whether methodological manipulations significantly affect the quantification of action anticipation abilities; (4) reviewing whether temporal occlusion training can improve action anticipation abilities; and (5) inferring the relationship between action anticipation scores in the laboratory and actual movement performance in sports. We identified 111 original articles from databases including Web of Science, APA PsycInfo, PubMed, and Cochrane Library for qualitative analysis. Of these, 127 effect sizes contributed by 100 studies were analyzed using a three-level meta-analysis to achieve objectives (1) to (3), and 12 studies were included in a systematic review to achieve objectives (4) to (5). Corresponding to five objectives, our data indicate that: (1) The magnitude of the advantage of sports experts in action anticipation is strong (Hedges' g = 1.15, 95 % CI [0.97, 1.33], p < 0.001). (2) This expert advantage neither transfers to familiar sports nor unfamiliar sports. (3) Commonly used manipulations, such as stimulus size, response mode, participant selection, and sport category, in the temporal occlusion paradigm consistently yield substantial effects. (4) Temporal occlusion training can improve action anticipation abilities. (5) A small to moderate correlation exists between action anticipation scores in the laboratory and actual movement performance in sports. These findings provide a comprehensive understanding of the crucial role of action anticipation in specific sports performance.
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Affiliation(s)
- Tao Song
- School of Psychology, Research Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China
| | - Mingzhu Ye
- School of Psychology, Research Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China
| | - Gesi Teng
- School of Psychology, Research Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China
| | - Weikun Zhang
- School of Psychology, Research Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China
| | - Antao Chen
- School of Psychology, Research Center for Exercise and Brain Science, Shanghai University of Sport, Shanghai, China.
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21
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Yasin M, Zohoori FV, Kumah EA, Subramanian M, Dean P, Orr CH. Effect of Fluoride on Gut Microbiota: A Systematic Review. Nutr Rev 2025; 83:e1853-e1880. [PMID: 40063073 PMCID: PMC12166178 DOI: 10.1093/nutrit/nuae202] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/16/2025] Open
Abstract
CONTEXT Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology of oral microbiota, thus inhibiting cellular enzymes. However, the effect of systemic fluoride on gut microbiota is unknown. OBJECTIVE To explore the impacts of systemic fluoride on gut microbiota composition and abundance and associated functions such as gene and metabolic regulation. DATA SOURCES A systematic database search was conducted of MEDLINE, Web of Science, Scopus, PubMed, CINAHL, and Embase to find articles on studies reporting the effects of fluoride on gut microbiota. DATA EXTRACTION Forty-nine studies were included (n = 42 in animals, 4 of humans, 3 in vitro studies) after screening for title, abstract, and full text using Covidence to check against eligibility criteria. Data were extracted using Covidence and study quality was assessed using the Mixed Method Appraisal Tool by 2 reviewers independently. DATA ANALYSIS Two human studies of dental fluorosis and 1 of patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences in gut microbial composition, with increased relative abundance of Acidobacteria and Proteobacteria, and decreased abundance of Firmicutes and Bacteroidetes. An ex vivo study of human feces indicated that ≤ 2 mg L-1 NaF might boost "health-associated" taxa, but concentrations (≥ 10 mg L-1 NaF) could increase the ratio of some unhealthy microbes after 24 hours. The animal studies examined the effects of high fluoride doses in water and diet (50-1200 mg L-1 NaF) for long-term (1-6 months) and short-term (6 hours to 7 days) exposure, with all showing a significant disturbance in the Firmicutes to Bacteroidota ratio. CONCLUSION In humans, high doses potentially may be detrimental to the microbiome, whereas ≤ 2 mg L-1 NaF had positive effects. Similarly, in animals, ≥ 50 mg L-1 NaF was unsafe, whereas ≤ 25 mg L-1 NaF had harmless effects. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration No. CRD42022347357.
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Affiliation(s)
- Momina Yasin
- School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom
- National Horizons Centre, Teesside University, Darlington DL1 1HG, United Kingdom
| | - Fatemeh Vida Zohoori
- School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom
- National Horizons Centre, Teesside University, Darlington DL1 1HG, United Kingdom
| | | | - Murali Subramanian
- Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne NE2 4HH, United Kingdom
| | - Paul Dean
- School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom
- National Horizons Centre, Teesside University, Darlington DL1 1HG, United Kingdom
| | - Caroline Hayley Orr
- School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom
- National Horizons Centre, Teesside University, Darlington DL1 1HG, United Kingdom
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22
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Gloviczki ML, Stoughton J, Puggioni A, Gloviczki P, Raffetto JD. Utility of venoactive compounds in post-thrombotic syndrome: A systematic review. J Vasc Surg Venous Lymphat Disord 2025; 13:102228. [PMID: 40101859 PMCID: PMC12018987 DOI: 10.1016/j.jvsv.2025.102228] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/24/2024] [Revised: 01/31/2025] [Accepted: 03/09/2025] [Indexed: 03/20/2025]
Abstract
BACKGROUND Post-thrombotic syndrome (PTS) has been highly prevalent; over 50% of the patients develop PTS after lower extremity acute deep vein thrombosis. Venoactive compounds (VACs) have been recommended for decades for patients with chronic venous insufficiency, including PTS. The objective of our study was to perform a systematic review to determine the quality of evidence on the utility of VACs for both prevention and treatment of PTS. METHODS A systematic review was conducted to search the literature between January 1, 1980, and July 14, 2023, for venoactive drugs or medications, deep vein thrombosis, and PTS using PubMed, MEDLINE, life science journals, and the Cochrane Library. Only randomized controlled trials (RCTs) published in English were included in this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the revised Cochrane risk-of-bias tool for RCTs were used. RESULTS Ninety-four references were identified; 11 RCTs fulfilled the inclusion criteria. VACs administered were diosmin, hidrosmin/rutosides, micronized purified flavonoid fraction (MPFF), and sulodexide. The studies included a highly variable proportion of patients with PTS (8.6%-100%). Some older studies omitted details of the methodology. Two studies suggested benefit of diosmin and MPFF as adjunctive treatment to rivaroxaban in the prevention of PTS and showed low or unclear risk of bias. Evaluation of RCTs for the treatment of post-thrombotic chronic venous insufficiency found low or unclear risk of bias in 81.6% to 85.7%. All studies suggested that VACs were beneficial for PTS treatment; they improved venous symptoms, decreased edema, and helped heal venous ulcers. CONCLUSIONS This systematic review found that VACs had at least moderate quality of evidence in improving venous symptoms, decreasing edema, and accelerating venous ulcer healing. Two pilot RCTs of higher quality suggested the usefulness of diosmin and MPFF as adjunctive treatment to rivaroxaban therapy to reduce the incidence of PTS and improve deep vein recanalization. Because most RCTs were published over two decades ago, and several lacked the required precision in reporting, new high-quality, low-bias RCTs are needed to assess the role of specific VACs for both prevention and treatment of PTS.
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Affiliation(s)
- Monika L Gloviczki
- Department of Internal Medicine and Gonda Vascular Center, Mayo Clinic, Rochester, MN; VASA LLC, Scottsdale, AZ.
| | - Julianne Stoughton
- Division or Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, MA
| | | | - Peter Gloviczki
- Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN; Heart and Vascular Center, Semmelweis University, Budapest, Hungary
| | - Joseph D Raffetto
- Section of Vascular Surgery, VA Boston Healthcare System, Brigham and Women's Hospital, Boston, MA
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23
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Pan Y. A focused review of saliva biomarkers in cognitive fatigue: Current challenges and future directions. Psychoneuroendocrinology 2025; 177:107473. [PMID: 40279730 DOI: 10.1016/j.psyneuen.2025.107473] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/17/2025] [Revised: 04/15/2025] [Accepted: 04/17/2025] [Indexed: 04/29/2025]
Abstract
This study provides a focused review on the use of saliva biomarkers, particularly salivary cortisol, for measuring cognitive fatigue. Through a systematic review and analysis of 25 articles sourced from five academic databases, we examine the relationship between cognitive fatigue and saliva biomarkers. The findings highlight the potential of salivary cortisol as an effective marker of cognitive fatigue, while also identifying limitations in current methodologies, including inconsistent saliva collection and analysis procedures. Although prior reviews have explored saliva biomarkers, our analysis focuses on gaps related to the empirical connection between cognitive fatigue and biomarkers. This review further meta-analysis reveals that cortisol and alpha-amylase levels significantly increased after completing cognitive fatigue-inducing tasks. Moreover, this review emphasizes the need for updated, standardized protocols and real-time detection methods. Future research should aim to conduct more focused empirical investigations to advance the field.
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Affiliation(s)
- Yunxian Pan
- Civil Aviation Medical Center of Civil Aviation Administration of China, Beijing, PR China.
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24
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Lin Y, Ezzati A, McLaren C, Zeidan RS, Anton SD. Adherence and Retention in Early or Late Time-Restricted Eating: A Narrative Review of Randomized Controlled Trials. Nutr Rev 2025; 83:e2082-e2092. [PMID: 39707164 PMCID: PMC12166172 DOI: 10.1093/nutrit/nuae195] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2024] Open
Abstract
Time-restricted eating (TRE) is a form of intermittent fasting that involves reducing the time-period in which food is typically consumed daily. While TRE is known to induce health benefits, particularly for adults with obesity, there is currently debate about whether the time of day in which food is consumed also contributes to the health benefits of TRE. Early TRE (eTRE) and late TRE (lTRE) are subtypes of TRE that involve consuming food and caloric beverages either in the early or later part of the day. A growing body of literature indicates that eTRE may offer additional health benefits compared with lTRE. An important and unanswered question, however, is whether most adults can adhere to this type of eating pattern and whether adherence and retention differ between eTRE and lTRE. This narrative review compared adherence and retention in studies that implemented either eTRE or lTRE in adults for 8 weeks or longer. Five databases were searched, and 10 studies met our eligibility criteria. The key finding was that participants had high and comparable levels of adherence and retention in both eTRE and lTRE interventions. Specifically, the mean adherence rate was 81.4% for eTRE and 82.3% for lTRE, while the mean retention rate was 81% for eTRE and 85.8% for lTRE in eligible studies. Thus, the findings support the feasibility of both approaches. The lowest adherence and retention rates occurred in studies in which either eTRE or lTRE regimens were combined with other dietary interventions. Notably, the duration of the eating window did not seem to negatively affect adherence and retention rates for either eTRE or lTRE. More research is warranted to determine the influence of other factors, such as age and study location, on adherence to and retention of both eTRE and lTRE interventions.
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Affiliation(s)
- Yi Lin
- Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, College of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, United States
- Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States
| | - Armin Ezzati
- Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States
| | - Christian McLaren
- Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States
- Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, United States
| | - Rola S Zeidan
- Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States
- Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL 32610, United States
| | - Stephen D Anton
- Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, United States
- Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, United States
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25
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Giannatiempo F, Hollins Martin C, Patterson J, Welsh N. Exploring parents' experiences and holistic needs following late miscarriage: a narrative systematic review. J Reprod Infant Psychol 2025; 43:879-904. [PMID: 38184816 DOI: 10.1080/02646838.2023.2297905] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2023] [Accepted: 12/17/2023] [Indexed: 01/08/2024]
Abstract
BACKGROUND Up to 2% of all pregnancies result in pregnancy loss between 14 + 0 and 23 + 6 weeks' gestation, which is defined as 'late miscarriage'. Lack of consensus about definition of viability paired with existing multiple definitions of perinatal loss make it difficult to define the term 'late miscarriage'. Parents who experience late miscarriage often have had reassuring scan-milestones, which established their confidence in healthy pregnancy progression and identity formation, which socially integrates their baby into their family. The clinical lexicon alongside the lack of support offered to parents experiencing late miscarriage may disclaim their needs, which has potential to cause adverse psychological responses. AIM To review what primary research reports about parents' experiences and their perceived holistic needs following late miscarriage. METHODS A narrative systematic review was carried out. Papers were screened based on gestational age at time of loss (i.e. between 14 + 0 and 23 + 6 weeks' gestation). The focus was set on experience and holistic needs arising from the loss rather than its clinical care and pathophysiology. Studies were selected using PRISMA-S checklist, and quality assessed using the Critical Appraisal Skills Program (CASP) tool. Thematic analysis was used to guide the narrative synthesis of findings. RESULTS Six studies met the inclusion criteria. Three main themes emerged: communication and information-giving; feelings post-event; and impact of support provision. CONCLUSION Literature about the experience of late miscarriage is scarce, with what was found reporting a lack of compassionate and individually tailored psychological follow-up care for parents following late miscarriage. Hence, more research in this arena is required to inform and develop this area of maternity care provision.
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Affiliation(s)
- Francesca Giannatiempo
- School of Health and Social Care, Edinburgh Napier University (ENU), Edinburgh, Scotland, UK
| | - Caroline Hollins Martin
- School of Health and Social Care, Edinburgh Napier University (ENU), Edinburgh, Scotland, UK
| | - Jenny Patterson
- School of Health and Social Care, Edinburgh Napier University (ENU), Edinburgh, Scotland, UK
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26
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Derin S, Tetik M, Bora E. Autistic traits in obsessive compulsive disorder: A systematic review and meta-analysis. J Psychiatr Res 2025; 187:181-191. [PMID: 40378691 DOI: 10.1016/j.jpsychires.2025.05.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/03/2024] [Revised: 03/11/2025] [Accepted: 05/05/2025] [Indexed: 05/19/2025]
Abstract
BACKGROUND Several lines of evidence point to a strong association between OCD and autism-spectrum disorder and broader autism phenotype. However, the extent and nature of overlapping autistic traits has not been completely understood. METHOD A systematic review in Pubmed and Scopus databases was performed to compare autistic traits between OCD patients and healthy controls (December 1990 to March 2025). A random-effects meta-analyses were conducted. RESULTS Current meta-analysis included 27 studies consisting of 1677 patients with OCD and 1239 healthy controls. Compared to healthy controls, total autistic traits (g = 1.27, CI = 1.02, 1.53), also ratings in social-communication domain (g = 0.98, CI = 0.66, 1.31), and restricted/repetitive behaviors (RRBs) domain (g = 1.65, CI = 1.27, 2.04) were increased in OCD patients. OCD symptoms were more strongly related to RRBs domain scores (r = 0.34, CI = 0.19, 0.48) than social-communication domain scores (r = 0.18, CI = 0.09, 0.27). CONCLUSIONS OCD is associated with significant increases in both RRBs and social-communication domains. A substantial subset of OCD emerges in youth who have autistic traits, particularly RRBs. In adults, elevated social-communication scores might, at least partly, reflect the effect of chronic OCD symptoms on social functioning rather than true increase in this domain.
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Affiliation(s)
- Sıla Derin
- Department of Psychiatry, Faculty of Medicine, Izmir, Turkey
| | - Melike Tetik
- Department of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey
| | - Emre Bora
- Department of Psychiatry, Faculty of Medicine, Izmir, Turkey; Department of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria, 3053, Australia.
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27
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Martin JGC, Scolobig A, Linnerooth-Bayer J, Irshaid J, Aguilera Rodriguez JJ, Fresolone-Caparrós A, Oen A. The nature-based solution implementation gap: A review of nature-based solution governance barriers and enablers. JOURNAL OF ENVIRONMENTAL MANAGEMENT 2025; 388:126007. [PMID: 40449422 DOI: 10.1016/j.jenvman.2025.126007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/07/2025] [Revised: 05/16/2025] [Accepted: 05/25/2025] [Indexed: 06/03/2025]
Abstract
Nature-based solutions (NbS) represent a critical umbrella concept encompassing measures that employ nature's properties to systemically address societal challenges, potentially providing benefits for biodiversity, climate and people. NbS are accordingly emerging on an ever-expanding number of policy agendas, such as the Kunming-Montreal Global Biodiversity Framework and multiple European Union strategies. However, despite this increasing political traction, NbS implementation (that is, the design, planning, construction, monitoring and maintenance of NbS) remains fragmented and is often too context-specific for their wider upscaling and mainstreaming, creating an 'NbS implementation gap' between ambitions and on-the-ground operationalization. Based on a systematic review of grey- and peer-reviewed literature and workshop results (N = 34), we identify and discuss the institutional, legal, regulatory, social and economic enablers (N = 301) and barriers (N = 307) to NbS implementation. Our results highlight the governance factors that currently facilitate or limit NbS implementation and mainstreaming, which are often homologous. These include inclusive stakeholder engagement processes and true co-design; an evidence base on NbS performance and their co-benefits, including quantitative cost-benefit analyses; the existence of or lack of knowledge products and NbS-specific expertise; and available funds earmarked for NbS. We find that polycentric governance arrangements may act as a critical enabler for NbS implementation, yet path dependencies significantly limit NbS by still favouring grey alternatives. By providing an overview of NbS implementation enablers and barriers across literature and workshop findings, this analysis represents a first step towards understanding key pitfalls and leverage points for enhancing NbS implementation and mainstreaming.
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Affiliation(s)
- Juliette G C Martin
- Equity and Justice Research Group, Population and Just Societies Program International Institute for Applied Systems Analysis, Laxenburg, Austria; Institute of Landscape Planning, BOKU University, Vienna, Austria.
| | - Anna Scolobig
- Equity and Justice Research Group, Population and Just Societies Program International Institute for Applied Systems Analysis, Laxenburg, Austria; Institute for Environmental Sciences, Université de Genève, Geneva, Switzerland
| | - JoAnne Linnerooth-Bayer
- Equity and Justice Research Group, Population and Just Societies Program International Institute for Applied Systems Analysis, Laxenburg, Austria
| | - Jenan Irshaid
- Equity and Justice Research Group, Population and Just Societies Program International Institute for Applied Systems Analysis, Laxenburg, Austria
| | | | - Alberto Fresolone-Caparrós
- Equity and Justice Research Group, Population and Just Societies Program International Institute for Applied Systems Analysis, Laxenburg, Austria
| | - Amy Oen
- Norwegian Geotechnical Institute, Oslo, Norway
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28
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Lei L, Wang C, Pinto J. Do Chameleons Lead Better? A Meta-Analysis of the Self-Monitoring and Leadership Relationship. PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN 2025; 51:1139-1158. [PMID: 38006305 PMCID: PMC12130612 DOI: 10.1177/01461672231210778] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/21/2023] [Accepted: 10/11/2023] [Indexed: 11/27/2023]
Abstract
The relationship between self-monitoring and leadership has been debated. We attempt to resolve this debate through a meta-analysis (N = 9,029 across 55 samples). Since this is the first meta-analysis that focuses on this relationship, we were able to study both focal constructs at a granular level. As hypothesized, self-monitoring is positively associated with leadership emergence and leadership effectiveness. Whereas self-monitoring is positively related to managerial leadership, its relationship with transactional leadership is non-significant. Contrary to our prediction that self-monitoring is negatively related to authentic leadership and to transformational leadership, we found positive relationships. Importantly, the relationship between self-monitoring and leadership variables is typically non-significant when the latter is measured by subordinate ratings. This casts doubt on the general finding that self-monitoring is positively related to leadership. Also, the relationships significantly differ when self-monitoring was measured by different scales. Implications for theory and practice are discussed.
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Affiliation(s)
| | - Chen Wang
- Western Michigan University, Kalamazoo, USA
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29
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Sivri D, Şeref B, Şare Bulut M, Gezmen Karadağ M. Evaluation of the Effect of Probiotic Supplementation on Intestinal Barrier Integrity and Epithelial Damage in Colitis Disease: A Systematic Review. Nutr Rev 2025; 83:e1782-e1797. [PMID: 39602817 PMCID: PMC12166190 DOI: 10.1093/nutrit/nuae180] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2024] Open
Abstract
CONTEXT Previous reviews have focused on the effects of probiotics on colitis, but there is a need to understand their impact on barrier integrity and tight junction protein improvement in colitis. OBJECTIVE This study aimed to systematically examine the effects of probiotic use on barrier integrity in colitis disease. This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. DATA SOURCES A systematic search in PubMed, Web of Science, Scopus, and Cochrane databases identified 2537 articles. DATA EXTRACTION As a result of the search, 2537 articles were accessed. Study results were summarized descriptively through discussions by intervention conditions, study population, measurement methods, and key findings. The included studies were independently reviewed and all authors reached consensus on the quality and major findings from the included articles. Forty-six studies that met the inclusion criteria were analyzed within the scope of the systematic review. RESULTS Although the study primarily utilized probiotics from the Lactobacillaceae family (notably, L casei, L reuteri, L rhamnosus, L plantarum, and L pentosus) and the Bifidobacteriaceae family (notably, B breve, B animalis, and B dentium), other probiotics also demonstrated positive effects on tight junction proteins. These effects are attributed to the production of bioactive and metabolic compounds, as well as short-chain fatty acids, which combat pathogens and reduce anti-inflammatory agents. However, it was observed that the effects of these probiotics on tight junction proteins varied depending on the strain and dose. CONCLUSION The beneficial effects of probiotics on remission in inflammatory bowel disease are well documented. Studies show that probiotics generally improve intestinal barrier function, but factors such as dose, duration, and bacterial species combinations need further clarification. Additionally, comprehensive studies are needed to understand how improved barrier function affects absorption in individuals. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42023452774.
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Affiliation(s)
- Dilek Sivri
- Department of Nutrition and Dietetics, Anadolu University, Eskişehir, Türkiye
| | - Betül Şeref
- Department of Nutrition and Dietetics, Karamanoğlu Mehmetbey University, Karaman, Türkiye
| | - Melike Şare Bulut
- Department of Nutrition and Dietetics, Biruni University, Istanbul, Türkiye
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30
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Abdul-Jabbar S, Nebechi C, McClelland GR, Lockett A, Douiri A, Morgan D, Jones SA. Ethnic Differences in Response to Oral Vitamin D Supplementation: A Systematic Review and Meta-analysis. Nutr Rev 2025; 83:e1372-e1382. [PMID: 39432764 DOI: 10.1093/nutrit/nuae150] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2024] Open
Abstract
CONTEXT Individual variability in oral vitamin D supplement response hinders the understanding of its clinical impact, and while ethnicity has been implicated in this variability it has not been well described. OBJECTIVE The aim was to systematically assess the impact of ethnicity on response to oral vitamin D supplementation. DATA SOURCE The Web of Science and PubMed databases were searched for articles published from 1960 to the end of 2020. All trials in adults measuring 25(OH)D3 blood levels were included. DATA EXTRACTION Two reviewers independently extracted the data from the eligible studies. The change in 25(OH)D3 blood levels (95% CI) and P values were extracted, and grouped according to ethnicity, then subjected to random-effects meta-analysis. The primary outcome measurement was mean serum 25(OH)D3 levels and the secondary outcome was dose-adjusted mean serum 25(OH)D3 levels, both compared with baseline. DATA ANALYSIS A total of 18 studies were identified, and data from 1131 participants were extracted. Body mass index (BMI) and dose were significant covariates (Pearson correlation coefficient, P = .016 and .017) and were normalized in the meta-analysis to minimize heterogeneity, but latitude was not (P = .66). Meta-analysis showed an effect of ethnicity on dose and BMI-adjusted mean serum 25(OH)D3 levels compared with baseline (P < .00001, I2 = 98%). Asian and White study participants demonstrated a statistically higher increase in dose and BMI-adjusted 25(OH)D3 blood levels (183 nmol/L [95% CI, 163-203] and 173 nmol/L [95% CI, 152-194], respectively), compared with Arab and Black study participants (37 nmol/L [95% CI, 35-39] and 99 nmol/L [95% CI, 90-108]) using repeated t tests. Sensitivity analysis demonstrated that these findings were not impacted by potential study bias or the inclusion of immigrant populations. CONCLUSION Ethnicity had an impact on oral vitamin D response. Further prospective studies should examine if ethnicity-based dose stratification in both clinical practice and clinical trials is warranted. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration no. CRD42023410076.
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Affiliation(s)
- Sumayah Abdul-Jabbar
- Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
| | - Chukwuebuka Nebechi
- Centre for Pharmaceutical Medicine Research, School of Cancer and Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
| | - Graham R McClelland
- Centre for Pharmaceutical Medicine Research, School of Cancer and Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
| | - Anthony Lockett
- Centre for Pharmaceutical Medicine Research, School of Cancer and Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
| | - Abdel Douiri
- School of Life Course & Population Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, United Kingdom
| | - David Morgan
- Centre for Pharmaceutical Medicine Research, School of Cancer and Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
| | - Stuart A Jones
- Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
- Centre for Pharmaceutical Medicine Research, School of Cancer and Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, London SE1 9NH, United Kingdom
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Wiley CR, Williams DP, Sigrist C, Brownlow BN, Markser A, Hong S, Sternberg EM, Kapuku G, Koenig J, Thayer JF. Differences in inflammation among black and white individuals: A systematic review and meta-analysis. Brain Behav Immun 2025; 127:269-286. [PMID: 40101808 DOI: 10.1016/j.bbi.2025.03.019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/08/2024] [Revised: 02/13/2025] [Accepted: 03/09/2025] [Indexed: 03/20/2025] Open
Abstract
IMPORTANCE Despite persisting health disparities between Black and White individuals, racial differences in inflammation have yet to be comprehensively examined. OBJECTIVE To determine if significant differences in circulating levels of inflammatory markers between Black and White populations exist. DATA SOURCES Studies were identified through systematic searches of four electronic databases in January 2022. Additional studies were identified via reference lists and e-mail contact. STUDY SELECTION Eligible studies included full-text empirical articles that consisted of Black and White individuals and reported statistics for inflammatory markers for each racial group. Of the 1368 potentially eligible studies, 84 (6.6 %) representing more than one million participants met study selection criteria. DATA EXTRACTION AND SYNTHESIS Risk of bias was assessed via meta regressions that considered relevant covariates. Data heterogeneity was tested using both the Cochrane Q-statistic and the standard I2 index. Random effects models were used to calculate estimates of effect size from standardized mean differences. MAIN OUTCOMES AND MEASURES Outcome measures included 12 inflammatory markers, including C-reactive protein (CRP), Fibrinogen, Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-α), and soluble intercellular adhesion molecule 1 (sICAM-1). RESULTS Several markers had robust sample sizes for analysis, including CRP (White N = 934,594; Black N = 55,234), Fibrinogen (White N = 80,880; Black N = 18,001), and IL-6 (White N = 20,269; Black N = 14,675). Initial results indicated significant effects on CRP (k = 56, pooled Hedges' g = 0.24), IL-6 (k = 33, g = 0.15), and Fibrinogen (k = 19, g = 0.49), with Black individuals showing higher levels. Results also indicated significant effects on sICAM-1 (k = 6, g = -0.46), and Interleukin-10 (k = 4, g = -0.18), with White individuals showing higher levels. Sensitivity analyses confirmed robust effects for CRP, IL-6, Fibrinogen, and sICAM-1 while also revealing significant effects on TNF-α (k = 18, g = -0.17) and Interleukin-8 (k = 5, g = -0.19), with White individuals showing higher levels of both. CONCLUSIONS AND RELEVANCE Current meta-analytic results provide evidence for marked racial differences in common circulating inflammatory markers and illustrate the complexity of the inflammatory profile differences between Black and White individuals. Review Pre-Registration: PROSPERO Identifier - CRD42022312352.
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Affiliation(s)
- Cameron R Wiley
- Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Psychological Science, University of California, Irvine, Irvine, CA, United States.
| | - DeWayne P Williams
- Department of Psychological Science, University of California, Irvine, Irvine, CA, United States
| | - Christine Sigrist
- University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, United States
| | - Briana N Brownlow
- Duke University Medical Center, Duke University, Durham, NC, United States
| | - Anna Markser
- University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, United States
| | - Suzi Hong
- Herbert Wertheim School of Public Health, University of California, San Diego, San Diego, CA, United States; Department of Psychiatry, School of Medicine, University of California, San Diego, San Diego, CA, United States
| | - Esther M Sternberg
- Center for Integrative Medicine, The University of Arizona, Tucson, AZ, United States
| | - Gaston Kapuku
- Department of Pediatrics and Medicine, Georgia Prevention Institute, Augusta, GA, United States
| | - Julian Koenig
- University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, United States
| | - Julian F Thayer
- Department of Psychological Science, University of California, Irvine, Irvine, CA, United States; Department of Psychology, The Ohio State University, Columbus, OH, United States
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Krougly N, Tsikrikis K, MacRae F, Pouliopoulou DV, Peters S. Linking brain activation to standing balance performance: A systematic review and meta analysis of functional near-infrared spectroscopy literature. Gait Posture 2025; 120:124-135. [PMID: 40220585 DOI: 10.1016/j.gaitpost.2025.04.009] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/04/2024] [Revised: 02/25/2025] [Accepted: 04/08/2025] [Indexed: 04/14/2025]
Abstract
BACKGROUND Functional Near-Infrared Spectroscopy (fNIRS) holds promise for clinical applications in the field of balance impairment amelioration; however, the relationship between fNIRS metrics and balance performance remains uncertain. We aimed to quantify the correlations between fNIRS-derived brain activation and standing balance performance, and determine variables that influence these associations. METHODS We systematically reviewed English-language studies, published across PuBMed, PsycINFO, Embase, CINAHL, Ovid Medline, and Web of Science from inception up until July 1, 2024, that assessed standing balance tasks in adults > 18 years old with or without medical diagnosis measured with fNIRS. Pooled correlation coefficients were synthesized using a random effects restricted maximum likelihood model. RESULTS Overall, 17 studies were included with 420 participants. Key factors influencing the identified relationships were brain region and participant diagnosis. We identified moderate correlations between balance performance and cortical activation recorded by fNIRS in the supplementary motor area (SMA) (r = 0.52, 95 % CI = 0.39 0.64), and the prefrontal cortex (PFC) (r = 0.47, 95 % CI=0.32 - 0.60). In the PFC, increased oxygenated haemoglobin (HbO) was negatively associated with balance measures. The reverse relationship was reported in the PFC for individuals with physical and cognitive impairment. In the SMA, HbO was positively associated with balance. Few studies found associations between deoxygenated haemoglobin (HbR) and total hemoglobin (HbT) with balance performance. SIGNIFICANCE Current evidence supports a relationship between fNIRS measures, specifically HbO, with standing balance performance. This relationship depends on the brain region measured, age, and the diagnosis of the participants. To better understand this relationship, there is a need to report standardized balance performance metrics alongside other metrics of interest to better synthesize data across publications. Improved understanding the neural basis of standing balance with fNIRS will lead to more informed interventions for balance rehabilitation.
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Affiliation(s)
- Nellie Krougly
- Schulich School of Medicine, Western University, London, ON, Canada; Centre for Brain and Mind, Western University, London, ON, Canada; Gray Centre for Mobility and Activity, St. Joseph's Health Care London, London, ON, Canada
| | - Konstantinos Tsikrikis
- Centre for Brain and Mind, Western University, London, ON, Canada; Gray Centre for Mobility and Activity, St. Joseph's Health Care London, London, ON, Canada; Graduate Program in Neuroscience, Western University, London, ON, Canada
| | - Fraser MacRae
- Centre for Brain and Mind, Western University, London, ON, Canada; Gray Centre for Mobility and Activity, St. Joseph's Health Care London, London, ON, Canada; School of Physical Therapy, Faculty of Health Sciences, Western University, London ON, Canada; Graduate Program in Health and Rehabilitation Sciences, Western University, London, ON, Canada
| | - Dimitra V Pouliopoulou
- School of Physical Therapy, Faculty of Health Sciences, Western University, London ON, Canada; Graduate Program in Health and Rehabilitation Sciences, Western University, London, ON, Canada
| | - Sue Peters
- Centre for Brain and Mind, Western University, London, ON, Canada; Gray Centre for Mobility and Activity, St. Joseph's Health Care London, London, ON, Canada; School of Physical Therapy, Faculty of Health Sciences, Western University, London ON, Canada; Lawson Research Institute, St. Joseph's Health Care London, London, ON, Canada.
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He F, Liu F, Li S, Mu X, Han Q, Song L, Huang JH. A critical review of soil pollution sources and advances in the remediation of arsenic-contaminated soil. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2025; 302:118504. [PMID: 40540893 DOI: 10.1016/j.ecoenv.2025.118504] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/20/2025] [Revised: 05/14/2025] [Accepted: 06/09/2025] [Indexed: 06/22/2025]
Abstract
Arsenic (As) is a hazardous, non-essential semi-metal detrimental to animals, people, and plants. Its environmental levels have risen globally due to increased mining, industrial activities, vehicle emissions, and other human actions, posing significant environmental and health concerns. Hence, the remediation of As-contaminated soils requires urgent attention to ensure the provision of safe and healthy food for humans. This paper delineates the origins of soil As pollution, its environmental ramifications, the complex dynamics of As contamination, contemporary advancements in remediation methods, and suggestions for addressing soil As pollution. The discussion also encompassed success stories and the possibilities of various approaches for remediating As-contaminated soils. The discussion focused on several mechanisms, such as bioaccumulation, bio-sorption, electrostatic attraction and complexation, that mitigate the toxicity of As by transforming As (V) into As (III). Furthermore, it delineated the research gaps that require addressing in subsequent studies. Various techniques are employed globally to remediate As-contaminated soils, categorized into physical, chemical, biological, and other innovative strategies. Physical methods include soil washing and replacement, excavation, containment and encapsulation, vitrification, and soil blending. Chemical treatments include lime application, phosphate amendments, iron oxides and biochar, inorganic additives, and redox manipulation. Biological strategies encompass phytoremediation, bioremediation, microbial detoxification, microbial volatilization, and rhizoremediation. Lastly, other techniques incorporate innovative methods like phytovolatilization, phytostabilization, and electrokinetic remediation. Consequently, the present review will assist in formulating suitable and new techniques to mitigate As bioavailability and toxicity, as well as to sustainably manage As-contaminated soils, thereby diminishing the harmful impacts of As on the surrounding and human health.
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Affiliation(s)
- Fei He
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550081, China; University of Chinese Academy of Sciences, Beijing 100049, China
| | - Fukang Liu
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550081, China; University of Chinese Academy of Sciences, Beijing 100049, China
| | - Shehong Li
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550081, China.
| | - Xiaomin Mu
- School of Life Sciences, Guizhou Normal University, Guiyang 550025, China
| | - Qiao Han
- College of Resource and Environment, Henan Polytechnic University, Jiaozuo 454003, China
| | - Lian Song
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550081, China
| | - Jen-How Huang
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550081, China.
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Liu YC, Tang XY, Lang JX, Qiu Y, Chen Y, Li XY, Cao Y, Zhang CD. Effects of antibiotic exposure on risks of colorectal tumors: a systematic review and meta-analysis. J Transl Med 2025; 23:682. [PMID: 40533779 PMCID: PMC12178024 DOI: 10.1186/s12967-025-06727-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2025] [Accepted: 06/06/2025] [Indexed: 06/22/2025] Open
Abstract
BACKGROUND Increasing evidence suggests that the gut microbiome may play an important role in the development of colorectal tumors. Antibiotic use can affect the gut microbiome and may increase the risks of benign and malignant colorectal tumors. METHODS Eligible studies assessing the relationship between antibiotic exposure and the risk of developing benign or malignant colorectal tumors were identified. Odds ratios (ORs) were pooled for antibiotic use versus no use using a random-effects model. Further subgroup and sensitivity analyses were conducted to confirm the consistence and robustness of the main findings. The study protocol was registered with PROSPERO. RESULTS Twenty-three studies including 1,145,853 participants were finally included in the analysis. People who had used antibiotics had a 13% increased risk of colorectal tumors compared with those who had never used antibiotics [OR: 1.13; 95% confidence interval (CI) 1.04-1.22; P < 0.01]. Subgroup analysis showed that antibiotic exposure was associated with increased risks of both benign (OR: 1.13; 95% CI 1.00-1.27; P < 0.01) and malignant colorectal tumors (OR: 1.13; 95% CI 1.03-1.23; P < 0.01). In addition, colorectal tumor risk was significantly increased by antibiotic exposure, especially the use of combined antibiotics and a longer period after antibiotic exposure. The main findings were consistent and robust across most subgroups and sensitivity analyses. CONCLUSIONS The current findings suggested that antibiotic use increased the risk of developing benign or malignant colorectal tumors. These results highlighted the need for clinicians to prescribe antibiotics cautiously, to reduce colorectal cancer risk.
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Affiliation(s)
- Yi-Cheng Liu
- Clinical Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China
| | - Xiang-Yi Tang
- Clinical Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China
| | - Ji-Xuan Lang
- Department of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China
| | - Yue Qiu
- Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
| | - Ye Chen
- Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, 110004, China
| | - Xin-Yun Li
- Clinical Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China
| | - Yu Cao
- Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
| | - Chun-Dong Zhang
- Department of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
- Central Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
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Zhang P, Lin Y, Yi K, Ma Y, Yang T, An L, Qi Y, Huang X, Su X, Deng Y, Hu J, Li W, Sun D. Efficacy and safety of therapeutic means for postoperative ileus: an umbrella review of meta-analyses. Langenbecks Arch Surg 2025; 410:198. [PMID: 40523983 PMCID: PMC12170703 DOI: 10.1007/s00423-025-03739-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Accepted: 05/10/2025] [Indexed: 06/19/2025]
Abstract
BACKGROUND & AIMS Postoperative ileus is treated using a large number of methods with variable efficacy. This study further clarifies the advantages and disadvantages of existing treatments through umbrella evaluation. METHOD This study conducted a systematic search of databases to select and include meta-analyses discussing the treatment of postoperative ileus. We recalculated the estimated values, 95% confidence intervals, heterogeneity estimates, small study effects, excessive significance tests, and publication biases for each included study using both random and fixed effect models. RESULTS A total of 24 meta-analyses, including 27 treatment protocols, were reviewed in this study. Among them, chewing gum, coffee, ERAS(Enhanced Recovery After Surgery) protocols, acupuncture, opioid receptor antagonists, Da-Cheng-Qi-Tang, early enteral nutrition, and Zusanli point injection therapy have been shown to significantly improve postoperative ileus (Class II). Opioid receptor antagonists, early enteral nutrition, ERAS, and chewing gum have also been found to significantly reduce the postoperative hospital stay (Class II). CONCLUSION Eight treatment options can effectively reduce postoperative ileus, while the effectiveness and safety of other treatment options for postoperative ileus require further confirmation through high-quality research.
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Affiliation(s)
- Pengcheng Zhang
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Yueying Lin
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Keqian Yi
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Yu Ma
- Department of Gastroenterology, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 650101, China
| | - Ting Yang
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Liya An
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Yuxing Qi
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Xingzong Huang
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Xianming Su
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Yinlong Deng
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Jian Hu
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China
| | - Wen Li
- Department of Gastroenterology, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 650101, China.
| | - Dali Sun
- Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University/Second Faculty of Clinical Medicine, Kunming, 65010, China.
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Li HY, Ren L, Wang CJ, Chen CX, Huang HT, Cao S, Jiang LH, Yang XS. A meta-analysis assessing the efficacy of concurrent robotic inguinal hernia repair (RIHR) during robotic-assisted radical prostatectomy (RARP). J Robot Surg 2025; 19:302. [PMID: 40528135 DOI: 10.1007/s11701-025-02437-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2025] [Accepted: 05/27/2025] [Indexed: 06/20/2025]
Abstract
The objective of this study was to investigate the efficacy of concurrent robotic inguinal hernia repair (RIHR) performed during robotic-assisted radical prostatectomy (RARP), as well as to evaluate its safety and feasibility. By April 2024, we have performed comprehensive searches across multiple major databases globally, such as Embase, PubMed, and Web of Science. Data analysis was performed using Review Manager 5.4 (RevMan 5.4). Our study has been registered with PROSPERO (CRD42024592239). A total of eight cohort studies were included in the analysis. Pooled data demonstrated that concurrent robotic inguinal hernia repair (RIHR) during robot-assisted radical prostatectomy (RARP) required significantly longer operative time compared to controls (MD 30.80 min, 95% CI 2.36-59.25, p = 0.03; I2 = 100%). Its total complication rate is higher (OR 1.62, 95% CI 1.15-2.27, p = 0.005, I2 = 0%). Its minor complication rate is higher (OR 1.71, 95% CI 1.02-2.87, p = 0.04, I2 = 14%). No statistically significant differences were observed in major complications, estimated blood loss, or length of hospital stay. The concurrent performance of robot-assisted inguinal hernia repair (RIHR) during robot-assisted radical prostatectomy (RARP) is generally feasible and safe. However, the included studies demonstrated variable methodological quality with significant heterogeneity. Further high-quality studies are warranted to validate these findings.
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Affiliation(s)
- Hong-Yuan Li
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Lin Ren
- Health Management Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Cong-Jian Wang
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Cai-Xia Chen
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Hao-Tian Huang
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Song Cao
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Lin-Han Jiang
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Xue-Song Yang
- Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
- Health Management Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
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Amiri M, Hatoum S, Buyalos RP, Sheidaei A, Azziz R. The Influence of Study Quality, Age, and Geographic Factors on PCOS Prevalence-A Systematic Review and Meta-analysis. J Clin Endocrinol Metab 2025; 110:2082-2103. [PMID: 39758024 DOI: 10.1210/clinem/dgae917] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/25/2024] [Revised: 12/21/2024] [Accepted: 01/01/2025] [Indexed: 01/07/2025]
Abstract
BACKGROUND Polycystic ovary syndrome (PCOS) is a highly prevalent disorder with substantial burden, yet global epidemiological data remains limited. OBJECTIVES To estimate the PCOS prevalence globally. MATERIALS AND METHODS We systematically searched PubMed and Embase for PCOS studies in unselected populations through February 2024. RESULTS Our study included 88 studies (n = 561 287 women) from 7144 records. The highest PCOS prevalence was identified by the Rotterdam criteria, followed by the Androgen Excess and PCOS Society (AE-PCOS) and the National Institutes of Health (NIH). High-quality studies, as assessed using our newly developed PCOS Epidemiology and Phenotype (PEP) tool, indicated prevalences of 10.89%, 10.61%, and 6.63% using Rotterdam, AE-PCOS, and NIH, respectively. Considering only high-quality studies revealed no significant regional disparities using either NIH [ranging from 5.72% in the Eastern Mediterranean Region (EMR) to 6.90% in the Western Pacific Region (WPR)] or Rotterdam (ranging from 11.15% in South-East Asia to 9.12% in EMR). For AE-PCOS, sufficient data was available only for the WPR region (6.9%). No studies were available in the African Region. A higher PCOS prevalence was observed in adults than adolescents using NIH (8.52% vs 4.44%; P = .01), although the difference diminished when considering only high-quality studies (7.25% vs 4.44%; P = .053). Limited data restricted age-group comparisons using Rotterdam and AE-PCOS. CONCLUSION This systematic review and meta-analysis reveals a trend toward regional variations and age differences across diagnostic criteria. The study results suggest considering study quality using instruments tailored for epidemiological studies in PCOS, such as the PEP tool, when carrying out these types of meta-analyses.
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Affiliation(s)
- Mina Amiri
- Foundation for Research and Education Excellence, Vestavia, AL 35243, USA
| | - Sana Hatoum
- Foundation for Research and Education Excellence, Vestavia, AL 35243, USA
| | - Richard P Buyalos
- Foundation for Research and Education Excellence, Vestavia, AL 35243, USA
- Department of Ob/Gyn, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35249, USA
| | - Ali Sheidaei
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
| | - Ricardo Azziz
- Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35249, USA
- Department of Healthcare Organization & Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35249, USA
- Department of Health Policy, Management, and Behavior, School of Public Health, University at Albany, SUNY, Rensselaer, NY 12144, USA
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Wang S, Zhang Y, Balati A, Li B, Dai L, Yu D. Effect of Sodium-glucose Transporter 2 Inhibitors on Cardiovascular Outcomes in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab 2025; 110:2071-2081. [PMID: 39812177 DOI: 10.1210/clinem/dgaf016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/31/2024] [Revised: 10/24/2024] [Accepted: 01/12/2025] [Indexed: 01/16/2025]
Abstract
BACKGROUND Cardiovascular disease is a major cause of increasing morbidity and mortality in type 1 diabetes mellitus (T1DM). Although insulin therapy is the cornerstone of T1DM, its difficult use and narrow therapeutic index make it difficult for patients to reach glycated hemoglobin targets, increasing the risk of cardiovascular events. Therefore, the combination of sodium-glucose transporter 2 inhibitors (SGLT2i) can likely improve or provide more cardiovascular benefits to patients with T1DM. METHODS This study conducted a systematic review and meta-analysis of randomized controlled trials published in PubMed, Scopus, Cochrane Library, Web of Science, and Embase up to June 30, 2024. The data from eligible trials were summarized as mean difference (MD) and SD for continuous methods and 95% CI and risk ratio (RR) for dichotomous approaches. RESULTS There were 16 articles that met the inclusion criteria. Compared with placebo, SGLT2i significantly reduced glycated hemoglobin levels (MD: -0.40%, 95% CI, -0.44 to -0.36; P < .00001, I2 = 37%), and body weight (MD: -3.31 kg, 95% CI, -3.67 to -2.96; P < .00001, I2 = 70%) in insulin-using patients with T1DM, and did not significantly increase the risk of hypoglycemia and severe hypoglycemia. It should be noted that SGLT2i significantly increased the risk of diabetic ketoacidosis acidosis (RR: 4.45, 95% CI, 2.81-7.05, P < .00001, I2 = 0%). CONCLUSION SGLT2i not only significantly improved glycated hemoglobin and body weight in patients with T1DM but also significantly increased the risk of diabetic ketoacidosis acidosis.
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Affiliation(s)
- Songwei Wang
- Department of Cardiac Intensive Care Unit, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China
| | - Yueqi Zhang
- Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
| | - Abudunaibi Balati
- Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
| | - Bing Li
- Department of General Practice, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China
| | - Lei Dai
- Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
| | - Dan Yu
- Department of Cardiac Intensive Care Unit, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China
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Alrasheed SH, Challa NK, Aljohani S, Almutairi NM, Alnawmasi MM. Effectiveness of treatment modalities for childhood esotropia: a systematic review. PeerJ 2025; 13:e19584. [PMID: 40538735 PMCID: PMC12178246 DOI: 10.7717/peerj.19584] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/01/2024] [Accepted: 05/19/2025] [Indexed: 06/22/2025] Open
Abstract
Background Esotropia has several types that commonly manifest in early childhood, with numerous treatment options described in the literature. The aim of this systematic review is to synthesize recent research findings on the management of childhood esotropia (ET) to clarify the relative success rates and specific indications for each treatment option, providing guidance for eye care professionals in selecting the most effective interventions. Methodology A comprehensive search was conducted across multiple databases, including PubMed, Web of Science, ProQuest, Scopus, Google Scholar, EBSCO, and Medline, following PRISMA 2020 guidelines. The search was restricted to articles published between 1990 and 2023 that examined various treatment modalities for different types of childhood esotropia (ET). In this study, success was defined as a post-treatment deviation of less than 10 prism dioptres (PD). The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42024589042. Results The final systematic review included 34 studies from 14 countries, encompassing 3,877 children with a mean age of 4.72 ± 2.08 years. The reviewed studies indicated that optical correction had the highest effectiveness rate at 79.31% after an average follow-up of 5.57 years. Extraocular muscle surgery demonstrated an effectiveness rate of 71.4% with a follow-up period of 2.89 years, while botulinum toxin (BT) injections showed a lower effectiveness rate of 61.24% after a follow-up of 3.15 years. Conclusions The review concluded that substantial evidence supports full cycloplegic hyperopic correction as the most effective first-line treatment for childhood accommodative esotropia (AET). However, surgery may be required for some children with AET if their deviation remains over 15 PD after full cycloplegic hyperopic correction. Prismatic correction was highly successful in managing residual deviation in partial AET. Bilateral BT injections proved effective as a first-line treatment for acute-onset ET and infantile ET without a vertical component. Timely surgical intervention enhances sensory outcomes in infantile ET; however, no surgical technique has demonstrated a distinct advantage.
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Affiliation(s)
- Saif Hassan Alrasheed
- Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
| | - Naveen Kumar Challa
- Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
| | - Saeed Aljohani
- Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
| | - Nawaf M. Almutairi
- Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
| | - Mohammed M. Alnawmasi
- Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia
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Hernandez-Lucas P, Escobio-Prieto I, Moro López-Menchero P. Effects of Hypopressive Techniques on the CORE Complex: A Systematic Review. Healthcare (Basel) 2025; 13:1443. [PMID: 40565470 DOI: 10.3390/healthcare13121443] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/15/2025] [Revised: 06/03/2025] [Accepted: 06/13/2025] [Indexed: 06/28/2025] Open
Abstract
The CORE complex refers to the muscles of the core region of the body, including the abdominal muscles, lower back muscles, and diaphragm. Among the various techniques aimed at improving CORE strength and functionality, abdominal hypopressive techniques have gained popularity. Objectives: To evaluate the available scientific literature on the effects of AHT on the CORE complex. Methods: A systematic search was conducted in January 2025 in PubMed, Web of Science, PEDro, Cochrane, ClinicalTrials.gov and Scopus. Only randomized controlled trials (RCTs) involving adults were included. Two reviewers independently selected studies and extracted data. The review was registered in PROSPERO (CRD-42023424933) and followed PRISMA guidelines. Results: Of 258 studies identified, 13 of them met the eligibility criteria for the final review. Showing the application of abdominal hypopressive techniques could have positive effects on the pelvic floor, transverse abdominis muscle, lumbar region, and diaphragm. The average methodological quality of the articles is 6.6 according to the PEDro scale. The risk of bias was high in 12 articles. Conclusions: Although the results show improvements in the CORE muscles after applying abdominal hypopressive techniques, further research is necessary to confirm these findings, given the insufficient methodological quality of the scientific literature and its high risk of bias.
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Affiliation(s)
- Pablo Hernandez-Lucas
- Department of Functional Biology and Health Sciences, Faculty of Physiotherapy, Universidade de Vigo, Campus A Xunqueira, s/n, 36005 Pontevedra, Spain
- Research Group HI10, 36005 Pontevedra, Spain
| | - Isabel Escobio-Prieto
- Instituto de Biomedicina de Sevilla-IBiS (Hospitales Universitarios Virgen del Rocío y Macarena/CSIC/Universidad de Sevilla), 41092 Sevilla, Spain
- Departamento de Fisioterapia, Universidad de Sevilla, 41092 Sevilla, Spain
- Research Group CTS-1137, Neurological Physiotherapy Innovative Neurorehabilitation and Neurodevelopment Disorders, NEUROPHYSIUS, 41008 Seville, Spain
| | - Paloma Moro López-Menchero
- Department of Physiotherapy, Occupational Therapy, Rehabilitation and Physical Medicine, University Rey Juan Carlos, 28922 Madrid, Spain
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Lane R, Taylor H, Ellis F, Rushworth I, Chiu K. Resilience and its association with mental health among forcibly displaced populations: A systematic review and meta-analyses. J Affect Disord 2025; 379:387-400. [PMID: 40054536 DOI: 10.1016/j.jad.2025.03.015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/15/2024] [Revised: 02/26/2025] [Accepted: 03/03/2025] [Indexed: 03/17/2025]
Abstract
BACKGROUND Forcibly displaced populations are growing exponentially and are at increased risk of experiencing mental health difficulties. However, it remains unclear if, and how, their resilience and mental health are associated. This systematic review and meta-analyses investigated the relationship between resilience and mental health outcomes among forcibly displaced groups. METHODS MEDLINE Ultimate, APA PsycInfo and SCOPUS were searched up until January 2024. Peer-reviewed studies measuring a statistical association between resilience and mental health among forced migrants were eligible for inclusion. Random-effects meta-analyses for each identified mental health category were conducted. Study quality was evaluated using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. RESULTS Thirty-one studies were included in the review (n = 6656). Meta-analyses revealed a significant negative association between resilience and symptoms of post-traumatic stress (k = 13, n = 2446, r = -0.15, 95 % CI [-0.23; -0.06]), depression (k = 14; n = 2952, r = -0.34, 95 % CI [-0.41; -0.26]), anxiety (k = 7, n = 1516, r = -0.19, 95 % CI [-0.27; -0.11]), and psychological distress (k = 10; n = 2712, r = -0.29, 95 % CI [-0.36; -0.23]). LIMITATIONS Effect sizes were highly heterogenous, most studies recruited small samples using non-random sampling strategies, and data was collected cross-sectionally. CONCLUSIONS Our findings point to an association between resilience and mental health difficulties in forcibly displaced groups. Directions for future research are discussed. SYSTEMATIC REVIEW REGISTRATION PROSPERO (CRD42023395925).
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Affiliation(s)
- Rebecca Lane
- Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.
| | - Hannah Taylor
- Norwich and Suffolk NHS Foundation Trust, Norwich, UK.
| | - Fiona Ellis
- Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.
| | - Imogen Rushworth
- Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.
| | - Kenny Chiu
- Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.
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Borazjani R, Khorram R, Ghorbani M, Mohammadi M, Nerys-Figueroa J, Kachooei AR, Parsa A, Parvizi J. Aspirin Versus Other Anticoagulants for the Initial Prevention of Venous Thromboembolism Following Elective Total Hip and Knee Arthroplasty: An Umbrella Review and Meta-Analysis. J Arthroplasty 2025:S0883-5403(25)00712-0. [PMID: 40513910 DOI: 10.1016/j.arth.2025.06.032] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/05/2024] [Revised: 06/06/2025] [Accepted: 06/06/2025] [Indexed: 06/16/2025] Open
Abstract
BACKGROUND Reducing venous thromboembolism (VTE) events is crucial to improving outcomes following total joint arthroplasties. Aspirin, low-molecular-weight heparin (LMWH), factor Xa inhibitors, and warfarin have been investigated to prevent VTE after surgery, but the best option remains uncertain. Our study aimed to clarify aspirin's prophylactic role in hip and knee arthroplasty through an umbrella analysis. METHODS PubMed, Web of Science, Scopus, and Embase databases were queried on September 7, 2023, to identify all published systematic reviews and meta-analyses evaluating the efficacy and safety of aspirin in preventing VTE after primary or revision total hip and total knee arthroplasties. The methodological quality of the included studies was assessed using the "A Measurement Tool to Assess Systematic Reviews 2" (AMSTAR-2) critical appraisal tool. There were two independent reviewers who extracted data focusing on thromboembolic events, bleeding, and mortality rates. RESULTS There were 19 systematic reviews and meta-analyses included. The overall risk of deep venous thrombosis was comparable in the aspirin versus non-aspirin group (OR [odds ratio] = 1.20; 95% CI [confidence interval] = 0.86 to 1.68). Aspirin reduced the risk of pulmonary emboli by 0.58%, while other anticoagulants showed a similar reduction of 0.6%, which was not statistically significant (OR = 1.26; 95% CI = 0.76 to 2.07; I2 = 94%). Aspirin significantly reduced total bleeding risk by 30% compared to other anticoagulants (0.33 versus 1.05%; OR = 0.7; 95% CI = 0.58 to 0.85; I2 = 2%). The all-cause mortality rate did not significantly differ between aspirin (0.18%) and other anticoagulants (0.14%) (OR = 1.25; 95% CI = 0.79 to 1.97). CONCLUSION Aspirin is a viable chemoprophylactic option following primary or revision total hip and knee arthroplasty due to its availability, cost-effectiveness, ease of administration, lack of routine blood monitoring requirement, and comparative effectiveness to other anticoagulants.
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Affiliation(s)
| | - Roya Khorram
- Orthopedic & Rehabilitation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Mohammad Ghorbani
- Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| | | | | | - Amir R Kachooei
- Orthopedic Surgery, Rothman Orthopaedics Florida at AdventHealth, Orlando, USA
| | - Ali Parsa
- American Hip Institute Research Foundation, Chicago, IL, 60018, USA.
| | - Javad Parvizi
- International Joint Center, Acibadem University Hospital, Istanbul, Turkey
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Tejada B, Giannaris ES, Hashemi S, Fountos DM, Ali MM, Mathew JA, German DE. Comparison of the Ivor-Lewis vs McKeown Procedure in Esophageal Cancers: An Updated Meta-Analysis and Systematic Review. Am Surg 2025:31348251346537. [PMID: 40492387 DOI: 10.1177/00031348251346537] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/12/2025]
Abstract
BackgroundThe Ivor Lewis and McKeown techniques are two established approaches for esophagectomy in the treatment of esophageal cancer. Despite their widespread use, limited direct comparisons exist to assess the efficacy of these techniques across key intraoperative and postoperative outcomes. We performed an updated pooled pairwise meta-analysis to discern the relative benefits and risks associated with each approach.MethodsA systematic search of PubMed, Embase, MEDLINE, and the Cochrane Library through September 2024 was conducted. Eligible studies compared Ivor Lewis and McKeown techniques for esophagectomy. Primary outcomes were 12-month mortality and anastomotic complications; secondary outcomes were number of lymph nodes resected, recurrent laryngeal nerve palsy, pulmonary complications, and chyle-leaked complications.ResultsA total of 9 studies comprising 15 341 patients were included. There were no significant differences in terms of 12-month mortality (OR .89, 95% CI .65 to 1.22, P = .48), the number of lymph nodes resected (MD -1.18, 95% CI -4.51 to 2.16, P = .49), and pulmonary complications (OR .87, 95% CI .61 to 1.24, P = .27). However, Ivor Lewis significantly reduced the incidence of anastomotic leakage (OR .42, 95% CI .18 to .98, P = .050), recurrent laryngeal nerve palsy (OR .13, 95% CI .06 to .27, P < .00001), and chyle-related complications (OR .63, 95% CI .39 to 1.04, P = .05) compared to the McKeown technique.ConclusionThis meta-analysis reveals certain significant advantages in Ivor Lewis, while both maintain similarities in other areas.
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Souza TMD, de Abreu Refaxo N, Macari S, Abreu LG. Nasal Symmetry Outcomes After Nasoalveolar Molding (NAM) Plus Cheiloplasty Treatment in Babies With Cleft Lip/Palate: Systematic Review and Meta-Analysis. Cleft Palate Craniofac J 2025:10556656251346368. [PMID: 40491193 DOI: 10.1177/10556656251346368] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/11/2025] Open
Abstract
ObjectiveTo investigate the impact of nasoalveolar molding (NAM) treatment after cheiloplasty surgery on the results of nasal symmetry in individuals with cleft lip and/or cleft palate (CL/P).DesignSystematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.SettingElectronic searches were performed in 6 databases in October 2023. Studies comparing individuals with CL/P undergoing treatment with NAM + cheiloplasty and individuals undergoing cheiloplasty alone were considered. Each selected study was allocated in a table and data were extracted by 2 authors. The risk of bias and meta-analyze were conducted. In total, 416 articles were retrieved and 9 studies were included.Patients, ParticipantsIndividuals with CL/P who underwent cheiloplasty.InterventionsNAM treatment.Main Outcome Measure(s)Nasal symmetry, clef width, or any.ResultsIn the group NAM+ cheiloplasty, there was an increase in nostril height (NH), columellar width, and length (CL) in the short and long term (P < .05). Nostril width (NW) and bialar width (BW) decreased in the short term and increased in the long term in individuals undergoing NAM+ cheiloplasty (P < .05). Six studies exhibited a moderate risk of bias; 3 exhibited a serious risk of bias. The strength of the evidence was very low.ConclusionsTreatment with NAM+ cheiloplasty positively impacted nasal symmetry with increased NH, NW, and CL in the short and long term. NAM treatment improved NW and BW only in the short term.
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Affiliation(s)
- Tânia Mara de Souza
- Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
| | - Natália de Abreu Refaxo
- Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
| | - Soraia Macari
- Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
| | - Lucas Guimarães Abreu
- Department of Child's and Adolescent's Oral Health, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
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Radomski AD, Polihronis C, Cloutier P, Beaudin K, Cappelli M. Brief multidimensional screening tools for young children's mental health and development for administration by primary care providers: a scoping review. BMC PRIMARY CARE 2025; 26:199. [PMID: 40490727 DOI: 10.1186/s12875-025-02869-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/16/2024] [Accepted: 05/01/2025] [Indexed: 06/11/2025]
Abstract
INTRODUCTION Many young children with mental health or developmental concerns go unidentified and untreated, underscoring the need for effective screening. Primary care offers unique opportunities for screening, yet rates are low. Primary care providers often cite time constraints, insufficient training, and costs as barriers to screening. Tools designed for administration by primary care providers hold promise for facilitating personalized assessments and improving communication, collaboration, and follow-up between providers and families. To improve early identification and intervention, it is crucial to understand provider-administered screening tools that align with their practical constraints. AIM To identify and describe the characteristics, limitations, and improvement areas of brief, multidimensional screening for young children's mental health and development, designed for administration by primary care providers. METHODS We conducted a scoping review according to published guidelines. We searched seven electronic databases and used hand-searching strategies. We sought English-language publications on screening tools (English or French) assessing at least one mental health and one development domain in children up to 6 years, designed for administration by primary care providers in under 20 minutes. Two reviewers assessed the articles' eligibility and then extracted, charted, and summarized relevant data. RESULTS Three screening tools from six articles were included. The tools were primarily administered by physicians or nurses to children aged 2 weeks to 4 years and required minimal training to use. The tools varied in their domains (4-6), items (10-110), psychometric properties, and scoring methods, but all included indicators of delayed or at-risk children. Article limitations included study recency and lack of data related to implementation and patient outcomes. CONCLUSIONS This review described the development and evaluation of multidimensional screening tools for young children's mental health and development designed for administration by primary care providers. It found that few tools have been published. This review identifies several knowledge gaps and emphasizes the need for research on the implementation, cost-effectiveness, and comparative performance of screening tools, as well as the development and evaluation of new screening tools that suit providers' needs. Future studies should investigate how these screening tools can improve identification, clinical care, and health outcomes.
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Affiliation(s)
- Ashley D Radomski
- Knowledge Institute on Child and Youth Mental Health and Addictions, Ottawa, ON, Canada.
- CHEO (Children's Hospital of Eastern Ontario) Research Institute, 401 Smyth Road, K1H 8L1, Ottawa, ON, Canada.
| | - Christine Polihronis
- Knowledge Institute on Child and Youth Mental Health and Addictions, Ottawa, ON, Canada
- CHEO (Children's Hospital of Eastern Ontario) Research Institute, 401 Smyth Road, K1H 8L1, Ottawa, ON, Canada
- Department of Psychology, Carleton University, Ottawa, ON, Canada
| | - Paula Cloutier
- CHEO (Children's Hospital of Eastern Ontario) Research Institute, 401 Smyth Road, K1H 8L1, Ottawa, ON, Canada
- CHEO, Ottawa, ON, Canada
| | - Kayla Beaudin
- Knowledge Institute on Child and Youth Mental Health and Addictions, Ottawa, ON, Canada
- CHEO (Children's Hospital of Eastern Ontario) Research Institute, 401 Smyth Road, K1H 8L1, Ottawa, ON, Canada
| | - Mario Cappelli
- Knowledge Institute on Child and Youth Mental Health and Addictions, Ottawa, ON, Canada
- CHEO (Children's Hospital of Eastern Ontario) Research Institute, 401 Smyth Road, K1H 8L1, Ottawa, ON, Canada
- Department of Psychology, Carleton University, Ottawa, ON, Canada
- Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
- School of Psychology, University of Ottawa, Ottawa, ON, Canada
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Oh CU, Kang H. The Effectiveness and Harms of PSA-Based Prostate Cancer Screening: A Systematic Review. Healthcare (Basel) 2025; 13:1381. [PMID: 40565408 DOI: 10.3390/healthcare13121381] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2025] [Revised: 05/31/2025] [Accepted: 06/06/2025] [Indexed: 06/28/2025] Open
Abstract
OBJECTIVES Prostate cancer's prevalence is rapidly increasing in Korea, with incidence rates rising by over 13% annually since 2017 according to the Korea Central Cancer Registry, highlighting the need for effective early detection strategies. This study systematically reviews the benefits and harms of PSA-based prostate cancer screening, focusing on its clinical effectiveness and public health implications. METHODS Following PRISMA 2020 guidelines, we searched five databases (PubMed, Embase, Cochrane Library, Google Scholar, and KMbase) for studies from 2014 to 2024. The eligible studies included RCTs, cohort studies, meta-analyses, and guidelines. Risk of bias was assessed using the Cochrane tool. We synthesized our findings narratively due to their methodological heterogeneity. RESULTS Sixteen studies were included. PSA screening reduced prostate-cancer-specific mortality by 20-31%, as reported in multiple randomized controlled trials, such as ERSPC and ProScreen, among men aged 55-69, but showed minimal impact on all-cause mortality. Advanced tools such as MRI and multi-biomarker models, which were implemented in several included studies, enhanced diagnostic accuracy. The potential harms included overdiagnosis, overtreatment, and psychological distress. Community-based education and shared decision-making, inferred from observational and implementation studies, improved participation and equity in screening. CONCLUSIONS PSA-based screening offers modest mortality benefits but carries the risk of overdiagnosis. Precision diagnostics and risk-stratified strategies improve screening outcomes. Public health approaches, particularly those led by nurses and community health workers, are essential to promoting informed, equitable screening decisions.
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Affiliation(s)
- Chung-Uk Oh
- Department of Nursing, Kangwon National University, Dogye-eup, Samcheok-si 25949, Gangwon-do, Republic of Korea
| | - Hyekyung Kang
- Department of Nursing, Joongbu University, Chubu-myeon, Geumsan-gun 32713, Chungcheongnam-do, Republic of Korea
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Worrall S, Payne E, Fellows RE, Pike O, Carlisle NH, Carter J, Wittkowski A, Burgess K, Storey C, Magee LA, von Dadelszen P, Christiansen P, Fallon V, Khalil A, Silverio SA. Women's psychological experiences of preterm labour and birth which results in an intrapartum stillbirth or a neonatal death: an empty systematic review. Front Psychiatry 2025; 16:1544485. [PMID: 40539025 PMCID: PMC12176837 DOI: 10.3389/fpsyt.2025.1544485] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Accepted: 05/19/2025] [Indexed: 06/22/2025] Open
Abstract
Introduction Nearly three quarters of stillbirths and neonatal deaths occur in infants born prematurely. The mothers of these children may be at increased risk of developing mental health difficulties as a result of their premature labour and/or subsequent loss. Methods This systematic review was conducted to understand the psychological experiences of mothers who gave birth prematurely to a baby who subsequently dies as a result of an intrapartum stillbirth or a neonatal death. Ten databases were searched. Any studies which included women who had suffered a perinatal bereavement as a result of preterm labour and birth, in any country, and in any language were eligible to be included. Studies focusing on antepartum stillbirth or in utero death were excluded due to not having the element of preterm labour and/or birth within the studies. Risk of bias was to be assessed using the Critical Appraisal Skills Programme. Results Following the screening of citations, no studies were eligible for inclusion in the review. The majority of studies were excluded due to a lack of distinction in terms of intrapartum or antepartum stillbirth, or grouping of types of perinatal loss. Had the inclusion criteria been less stringent and the three most common reasons for exclusion been removed, 19 studies would have been eligible for inclusion in the review, and we present a brief summary of these findings. Discussion These review findings highlight the need for more research into the psychological experiences of mothers of preterm infants whose baby subsequently dies, whereby future studies should consider routine reporting of gestational age. To address the identified gaps, future research should consider alternative methods or broader inclusion criteria to capture relevant data. Emphasising the importance of reporting gestational age and distinguishing between types of perinatal loss will enhance the specificity of research findings.
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Affiliation(s)
- Semra Worrall
- Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
| | - Elana Payne
- Department of Women & Children’s Health, School of Life Course & Population Sciences, King’s College London, London, United Kingdom
- Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
| | - Rebecca E. Fellows
- Division of Methodologies, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King’s College London, London, United Kingdom
- School of Health Sciences, College of Medicine and Health, Bangor University, Bangor, United Kingdom
| | - Olivia Pike
- Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
| | - Naomi H. Carlisle
- Division of Methodologies, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King’s College London, London, United Kingdom
| | - Jenny Carter
- Department of Women & Children’s Health, School of Life Course & Population Sciences, King’s College London, London, United Kingdom
| | - Anja Wittkowski
- Division of Psychology and Mental Health, School of Health Sciences, The University of Manchester, Manchester, United Kingdom
| | - Karen Burgess
- PETALS: The Baby Loss Counselling Charity, Cambridge, United Kingdom
- Patient and Participant Involvement and Engagement Group for Perinatal Bereavement, Trauma, and Loss, King’s College London, London, United Kingdom
| | - Claire Storey
- Patient and Participant Involvement and Engagement Group for Perinatal Bereavement, Trauma, and Loss, King’s College London, London, United Kingdom
| | - Laura A. Magee
- Department of Women & Children’s Health, School of Life Course & Population Sciences, King’s College London, London, United Kingdom
| | - Peter von Dadelszen
- Department of Women & Children’s Health, School of Life Course & Population Sciences, King’s College London, London, United Kingdom
| | - Paul Christiansen
- Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
| | - Victoria Fallon
- Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
| | - Asma Khalil
- Fetal Medicine Unit, Liverpool Women’s NHS Foundation Trust, Liverpool, United Kingdom
- Fetal Medicine Unit, St. George’s University Hospitals NHS Foundation Trust, University of London, London, United Kingdom
| | - Sergio A. Silverio
- Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
- Department of Women & Children’s Health, School of Life Course & Population Sciences, King’s College London, London, United Kingdom
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Tang P, Huang M, Xiao W, Wen T, Volotovsky P, Gerasimenko M, Chu S, Liu S, Zhang K, Li Y. Leukocyte-Rich Platelet-Rich Plasma's Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials. Bioengineering (Basel) 2025; 12:617. [PMID: 40564433 DOI: 10.3390/bioengineering12060617] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/22/2025] [Revised: 05/30/2025] [Accepted: 05/31/2025] [Indexed: 06/28/2025] Open
Abstract
Background: Arthroscopic rotator cuff repair faces high retear risks in multi-tendon injuries due to insufficient biological healing; leukocyte-rich PRP may enhance tendon-bone integration through inflammatory modulation and growth factor release. Methods: Four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched until March 2025. Literature screening, quality evaluation, and data extraction were performed according to inclusion and exclusion criteria. GRADE was used to grade the strength of the evidence and the results. Results: The main finding of this study was that leukocyte-rich platelet-rich plasma combined with arthroscopic surgery for rotator cuff injuries can improve the Constant Score (MD = 1.13, 95% CI: 0.19, 2.07, p = 0.02, I2 = 47%), American Shoulder and Elbow Surgeons score (MD = 6.02, 95% CI: 4.67, 7.36, p < 0.01, I2 = 0%), and University of California, Los Angeles score (MD = 1.20, 95% CI: 0.34, 2.06, p < 0.01, I2 = 0%) of patients with rotator cuff tear after treatment, and reduce the postoperative Visual Analog Scale score (MD = -0.62, 95% CI: -1.16, -0.08, p = 0.02, I2 = 83%) of patients. However, there were no statistical differences regarding the Simple Shoulder Test (MD = 0.08, 95% CI: -0.23, 0.39, p = 0.61, I2 = 5%). Conclusions: Based on current evidence, the use of LR-PRP in arthroscopic rotator cuff repair could lessen postoperative pain and improve postoperative functional scores in individuals with rotator cuff injuries.
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Affiliation(s)
- Peiyuan Tang
- Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
| | - Meihui Huang
- Xiangya School of Medicine, Central South University, Changsha 410008, China
| | - Wenfeng Xiao
- Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
| | - Ting Wen
- Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
| | - Pavel Volotovsky
- Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus
| | - Mikhail Gerasimenko
- Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus
| | - Shiyao Chu
- Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus
| | - Shuguang Liu
- Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China
| | - Kai Zhang
- Department of Orthopedics, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde 415003, China
| | - Yusheng Li
- Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
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Vo QD. Gene editing therapy as a therapeutic approach for cardiovascular diseases in animal models: A scoping review. PLoS One 2025; 20:e0325330. [PMID: 40465697 PMCID: PMC12136301 DOI: 10.1371/journal.pone.0325330] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2025] [Accepted: 05/09/2025] [Indexed: 06/19/2025] Open
Abstract
BACKGROUND Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with hereditary genetic factors contributing substantially to disease burden. Current treatments, including lifestyle modifications, pharmacotherapy, and surgical interventions, focus primarily on symptom management but fail to address underlying genetic causes, often resulting in disease progression or recurrence. Gene therapy has emerged as a transformative approach, offering a potential treatment. This review explores its efficacy and safety in animal models, identifying opportunities for future advancements. METHODS This review investigated studies on gene editing interventions in animal models of CVDs, retrieved from PubMed, ScienceDirect, and Web of Science up to December 2024. RESULT A total of 57 studies were included in this review. Mice (86%) were the predominant model, with CRISPR-Cas9 (53%) and AAV vectors (80%) as the most used tools. Key targets included PCSK9 (32%), LDLR (9%), and MYH6/7 (7%), achieving 25-85% editing efficiency in liver/heart tissues. Base editors (ABE/CBE) showed superior safety, with <1% off-targets versus CRISPR-Cas9's 2-5 off-targets per guide. Reported toxicity risks included liver injury (AAVs, 23%) and transient cytokine elevation (LNPs, 14%). CONCLUSION Gene editing therapy shows great potential for treating CVDs, with high efficiency, strong therapeutic outcomes, and favorable safety in animal models. Continued innovation and rigorous evaluation could transform cardiovascular treatment, benefiting patients with untreatable conditions.
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Affiliation(s)
- Quan Duy Vo
- Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama Japan
- Faculty of Medicine, Nguyen Tat Thanh University, Ho Chi Minh, Viet Nam
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Mekonnen CK, Abate HK, Azagew AW, Agimas MC. Health-related quality of life and its predictors among epilepsy patients in Ethiopia: Systematic review and meta-analysis. PLoS One 2025; 20:e0324363. [PMID: 40460171 PMCID: PMC12132937 DOI: 10.1371/journal.pone.0324363] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2024] [Accepted: 04/24/2025] [Indexed: 06/19/2025] Open
Abstract
INTRODUCTION Epilepsy is a common non-communicable neurological disorder associated with recurrent seeding of cerebral neurons or brain cells and episodes of unprovoked seizures with or without loss of consciousness. Although there are studies on the health-related quality of life of epilepsy patients in Ethiopia, there are remarkable variations in the estimates of health-related quality of life. OBJECTIVES This systematic review and meta-analysis aimed to determine the pooled effect size of the health-related quality of life of adult epilepsy patients in Ethiopia. METHODS Original articles about the health-related quality of life among epilepsy patients in Ethiopia were searched through known and international databases (PubMed, Scopus, and Web of Science) and search engines (Google and Google Scholar). Data were extracted using a standard data extraction checklist developed according to Joanna Briggs Institute (JBI). The I2 statistics were used to identify heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. The STATA version 11 software was employed for statistical analysis to pool the mean scores of health-related quality-of-life. RESULT A total of 16 cross-sectional studies with a sample size of 5294 took part. The pooled overall mean score of health-related quality of life among epilepsy patients in Ethiopia was 52.82 ± 13.24 [95%CI (46.41, 59.21)], I2 = 100%, p-value <0.001. Besides, the overall pooled mean score of health-related quality of life based on the measuring tools WHO-QOL-BREF, QOLIE-31, and QOLIE-10 was 51.50 ± 11.32 (49.11, 53.90), 59.99 ± 12.67 (52.22, 67.77), and 44.33 ± 21.23 (13.09, 75.57) respectively. CONCLUSION The least overall pooled mean score of HRQOL was the QOLIE-10 measuring tool epileptic patients' mean score compared to other health-related quality-of-life measuring tools such as WHOQOL-BREF, and QOLIE-31. Moreover, the least overall pooled mean score of HRQOL using the WHOQOL-BREF was the environmental domain followed by the emotional domain, as compared to all other domains in each measuring tool of health-related quality of life.
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Affiliation(s)
- Chilot Kassa Mekonnen
- Department of Medical Nursing, School of Nursing, University of Gondar, Gondar, Ethiopia
| | | | - Abere Woretaw Azagew
- Department of Medical Nursing, School of Nursing, University of Gondar, Gondar, Ethiopia
| | - Muluken Chanie Agimas
- Department of Epidemiology and Biostatics, Institute of Public Health, University of Gondar, Gondar, Ethiopia
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