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1
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Adrian J, Pecheva D, Sawyer C, Akshoomoff N. Associations between mathematical skills and white matter microstructure in children born preterm. Child Neuropsychol 2025:1-18. [PMID: 40399781 DOI: 10.1080/09297049.2025.2497331] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2024] [Accepted: 04/19/2025] [Indexed: 05/23/2025]
Abstract
Preterm birth affects both white matter microstructure and mathematical skills, but little is known about the association between these outcomes. Using a hypothesis-driven ROI approach, we studied five white matter tracts previously associated with mathematical cognition: the corpus callosum, corticospinal tract (CST), inferior longitudinal fasciculus (ILF), inferior frontal occipital fasciculus (IFOF), and superior longitudinal fasciculus. Forty-eight children born before 33 weeks of gestation and twenty-seven children born full-term received a diffusion weighted MRI scan and completed a standardized mathematics test at age 5 and again at age 7. Term status significantly moderated the effect of fractional anisotropy (FA) of the right and left CST, left ILF, and left IFOF when predicting mathematical skills at 5 and 7 years of age. Post-hoc analyses of these effects revealed a positive association of FA in these tracts with mathematical skills in the full-term group, while this association was absent or negative in the preterm group. These differences may reflect adaptive processes following preterm birth and the recruitment of alternative pathways during mathematical problem-solving.
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Affiliation(s)
- Julia Adrian
- Center for Human Development, University of California, San Diego, La Jolla, CA, USA
- Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA
| | - Diliana Pecheva
- Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, La Jolla, CA, USA
- Department of Radiology, University of California, San Diego School of Medicine, La Jolla, CA, USA
| | - Carolyn Sawyer
- Center for Human Development, University of California, San Diego, La Jolla, CA, USA
- Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA, USA
| | - Natacha Akshoomoff
- Center for Human Development, University of California, San Diego, La Jolla, CA, USA
- Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
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2
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Kurahashi N, Ogaya S, Maki Y, Nonobe N, Kumai S, Hosokawa Y, Ogawa C, Yamada K, Maruyama K, Miura K, Nakamura M. Reading impairment after neonatal hypoglycemia with parieto-temporo-occipital injury without cortical blindness: A case report. World J Clin Cases 2023; 11:3899-3906. [PMID: 37383118 PMCID: PMC10294167 DOI: 10.12998/wjcc.v11.i16.3899] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/17/2023] [Revised: 04/24/2023] [Accepted: 04/27/2023] [Indexed: 06/02/2023] Open
Abstract
BACKGROUND Perinatal brain injury may lead to later neurodevelopmental disorders, whose outcomes may vary due to neuroplasticity in young children. Recent neuroimaging studies have shown that the left parietotemporal area (which includes the left inferior parietal lobe) is associated with phonological awareness and decoding skills, which are essential skills for reading acquisition in children. However, the literature on the effect of perinatal cerebral injury on the development of phonological awareness or decoding ability in childhood is limited.
CASE SUMMARY We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital lobes. The patient was born at term and was treated for hypoglycemia and seizures during the neonatal period. Diffusion-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital lobe. At the age of 8 years, physical examination was unremarkable, aside from mild clumsiness. Despite occipital lobe injury, the patient had adequate visual acuity, normal eye movement, and no visual field defects. Full-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90, respectively. Further assessment revealed adequate recognition of Japanese Hiragana letters. However, he had significantly slower reading speed in the Hiragana reading test than control children. The phonological awareness test revealed significant errors (standard deviation +2.7) in the mora reversal task.
CONCLUSION Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.
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Affiliation(s)
- Naoko Kurahashi
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Shunsuke Ogaya
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Yuki Maki
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
- Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Aichi, Japan
| | - Norie Nonobe
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
- Division of Neonatology, Center for Maternal-Neonatal Care Nagoya University Hospital, Nagoya 466-8560, Aichi, Japan
| | - Sumire Kumai
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
- Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Aichi, Japan
| | - Yosuke Hosokawa
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Chikako Ogawa
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
- Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, Fuchu 183-0042, Tokyo, Japan
| | - Keitaro Yamada
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Koichi Maruyama
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Kiyokuni Miura
- Department of Pediatric Neurology, Central Hospital, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
| | - Miho Nakamura
- Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Aichi, Japan
- Okazaki Medical Center for Child Development, Okazaki 444-0011, Aichi, Japan
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3
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Kelly KJ, Hutton JS, Parikh NA, Barnes-Davis ME. Neuroimaging of brain connectivity related to reading outcomes in children born preterm: A critical narrative review. Front Pediatr 2023; 11:1083364. [PMID: 36937974 PMCID: PMC10014573 DOI: 10.3389/fped.2023.1083364] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2022] [Accepted: 02/06/2023] [Indexed: 03/06/2023] Open
Abstract
Premature children are at high risk for delays in language and reading, which can lead to poor school achievement. Neuroimaging studies have assessed structural and functional connectivity by diffusion MRI, functional MRI, and magnetoencephalography, in order to better define the "reading network" in children born preterm. Findings point to differences in structural and functional connectivity compared to children born at term. It is not entirely clear whether this discrepancy is due to delayed development or alternative mechanisms for reading, which may have developed to compensate for brain injury in the perinatal period. This narrative review critically appraises the existing literature evaluating the neural basis of reading in preterm children, summarizes the current findings, and suggests future directions in the field.
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Affiliation(s)
- Kaitlyn J. Kelly
- Division of Neonatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
| | - John S. Hutton
- Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
- Division of General & Community Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
| | - Nehal A. Parikh
- Division of Neonatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
- Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
| | - Maria E. Barnes-Davis
- Division of Neonatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
- Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
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4
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Li J, Kean H, Fedorenko E, Saygin Z. Intact reading ability despite lacking a canonical visual word form area in an individual born without the left superior temporal lobe. Cogn Neuropsychol 2023; 39:249-275. [PMID: 36653302 DOI: 10.1080/02643294.2023.2164923] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/20/2023]
Abstract
The visual word form area (VWFA), a region canonically located within left ventral temporal cortex (VTC), is specialized for orthography in literate adults presumbly due to its connectivity with frontotemporal language regions. But is a typical, left-lateralized language network critical for the VWFA's emergence? We investigated this question in an individual (EG) born without the left superior temporal lobe but who has normal reading ability. EG showed canonical typical face-selectivity bilateraly but no wordselectivity either in right VWFA or in the spared left VWFA. Moreover, in contrast with the idea that the VWFA is simply part of the language network, no part of EG's VTC showed selectivity to higher-level linguistic processing. Interestingly, EG's VWFA showed reliable multivariate patterns that distinguished words from other categories. These results suggest that a typical left-hemisphere language network is necessary for acanonical VWFA, and that orthographic processing can otherwise be supported by a distributed neural code.
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Affiliation(s)
- Jin Li
- Department of Psychology, The Ohio State University, Columbus, OH, USA
| | - Hope Kean
- Department of Brain and Cognitive Sciences / McGovern Institute for Brain Research, MIT, Cambridge, MA, USA
| | - Evelina Fedorenko
- Department of Brain and Cognitive Sciences / McGovern Institute for Brain Research, MIT, Cambridge, MA, USA
| | - Zeynep Saygin
- Department of Psychology, The Ohio State University, Columbus, OH, USA
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5
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Dávila G, Moyano MP, Edelkraut L, Moreno-Campos L, Berthier ML, Torres-Prioris MJ, López-Barroso D. Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy. Front Pharmacol 2020; 11:1144. [PMID: 32848757 PMCID: PMC7411310 DOI: 10.3389/fphar.2020.01144] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/12/2019] [Accepted: 07/13/2020] [Indexed: 12/14/2022] Open
Abstract
At present, language therapy is the only available treatment for childhood aphasia (CA). Studying new interventions to augment and hasten the benefits provided by language therapy in children is strongly needed. CA frequently emerges as a consequence of traumatic brain injury and, as in the case of adults, it may be associated with dysfunctional activity of neurotransmitter systems. The use of cognitive-enhancing drugs, alone or combined with aphasia therapy, promotes improvement of language deficits in aphasic adults. In this study we report the case of a 9-year-old right-handed girl, subject P, who had chronic anomic aphasia associated with traumatic lesions in the left temporal-parietal cortex. We performed a single-subject, open-label study encompassing administration of the cholinergic agent donepezil (DP) alone during 12 weeks, followed by a combination of DP and intensive naming therapy (INT) for 2 weeks and thereafter by a continued treatment of DP alone during 12 weeks, a 4-week washout period, and another 2 weeks of INT. Four comprehensive language and neuropsychological evaluations were performed at different timepoints along the study, and multiple naming evaluations were performed after each INT in order to assess performance in treated and untreated words. Structural magnetic resonance imaging (MRI) was performed at baseline. MRI revealed two focal lesions in the left hemisphere, one large involving the posterior inferior and middle temporal gyri and another comprising the angular gyrus. Overall, baseline evaluation disclosed marked impairment in naming with mild-to-moderate compromise of spontaneous speech, repetition, and auditory comprehension. Executive and attention functions were also affected, but memory, visuoconstructive, and visuoperceptive functions were preserved. Treatment with DP alone significantly improved spontaneous speech, auditory comprehension, repetition, and picture naming, in addition to processing speed, selective, and sustained attention. Combined DP-INT further improved naming. After washout of both interventions, most of these beneficial changes remained. Importantly, DP produced no side effects and subject P attained the necessary level of language competence to return to regular schooling. In conclusion, the use of DP alone and in combination with INT improved language function and related cognitive posttraumatic deficits in a child with acquired aphasia. Further studies in larger samples are warranted.
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Affiliation(s)
- Guadalupe Dávila
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain.,Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.,Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
| | - María Pilar Moyano
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain
| | - Lisa Edelkraut
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain.,Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.,Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
| | - Lorena Moreno-Campos
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain
| | - Marcelo L Berthier
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain.,Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain.,Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
| | - María José Torres-Prioris
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain.,Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.,Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
| | - Diana López-Barroso
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain.,Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.,Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
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6
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Berthier ML, Dávila G, Torres-Prioris MJ, Moreno-Torres I, Clarimón J, Dols-Icardo O, Postigo MJ, Fernández V, Edelkraut L, Moreno-Campos L, Molina-Sánchez D, de Zaldivar PS, López-Barroso D. Developmental Dynamic Dysphasia: Are Bilateral Brain Abnormalities a Signature of Inefficient Neural Plasticity? Front Hum Neurosci 2020; 14:73. [PMID: 32265672 DOI: 10.3389/fnhum.2020.00073] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2019] [Accepted: 02/19/2020] [Indexed: 12/30/2022] Open
Abstract
The acquisition and evolution of speech production, discourse and communication can be negatively impacted by brain malformations. We describe, for the first time, a case of developmental dynamic dysphasia (DDD) in a right-handed adolescent boy (subject D) with cortical malformations involving language-eloquent regions (inferior frontal gyrus) in both the left and the right hemispheres. Language evaluation revealed a markedly reduced verbal output affecting phonemic and semantic fluency, phrase and sentence generation and verbal communication in everyday life. Auditory comprehension, repetition, naming, reading and spelling were relatively preserved, but executive function was impaired. Multimodal neuroimaging showed a malformed cerebral cortex with atypical configuration and placement of white matter tracts bilaterally and abnormal callosal fibers. Dichotic listening showed right hemisphere dominance for language, and functional magnetic resonance imaging (fMRI) additionally revealed dissociated hemispheric language representation with right frontal activation for phonology and bilateral dominance for semantic processing. Moreover, subject D also had congenital mirror movements (CMM), defined as involuntary movements of one side of the body that mirror intentional movements of the other side. Transcranial magnetic stimulation and fMRI during voluntary unimanual (left and right) hand movements showed bilateral motor cortex recruitment and tractography revealed a lack of decussation of bilateral corticospinal tracts. Genetic testing aimed to detect mutations that disrupt the development of commissural tracts correlating with CMM (e.g., Germline DCC mutations) was negative. Overall, our findings suggest that DDD in subject D resulted from the underdevelopment of the left inferior frontal gyrus with limited capacity for plastic reorganization by its homologous counterpart in the right hemisphere. Corpus callosum anomalies probably contributed to hinder interhemispheric connectivity necessary to compensate language and communication deficits after left frontal involvement.
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Affiliation(s)
- Marcelo L Berthier
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain
| | - Guadalupe Dávila
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology, University of Malaga, Málaga, Spain
| | - María José Torres-Prioris
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology, University of Malaga, Málaga, Spain
| | | | - Jordi Clarimón
- Department of Neurology and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.,Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain
| | - Oriol Dols-Icardo
- Department of Neurology and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.,Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain
| | - María J Postigo
- Neurophysiology Unit, Regional University Hospital Carlos Haya, Málaga, Spain
| | - Victoria Fernández
- Neurophysiology Unit, Regional University Hospital Carlos Haya, Málaga, Spain
| | - Lisa Edelkraut
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology, University of Malaga, Málaga, Spain
| | - Lorena Moreno-Campos
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain
| | - Diana Molina-Sánchez
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain
| | - Paloma Solo de Zaldivar
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain
| | - Diana López-Barroso
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Málaga, Spain.,Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology, University of Malaga, Málaga, Spain
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7
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Asaridou SS, Demir-Lira ÖE, Goldin-Meadow S, Levine SC, Small SL. Language development and brain reorganization in a child born without the left hemisphere. Cortex 2020; 127:290-312. [PMID: 32259667 DOI: 10.1016/j.cortex.2020.02.006] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/23/2019] [Revised: 11/08/2019] [Accepted: 02/19/2020] [Indexed: 11/18/2022]
Abstract
We present a case of a 14-year-old girl born without the left hemisphere due to prenatal left internal carotid occlusion. We combined longitudinal language and cognitive assessments with functional and structural neuroimaging data to situate the case within age-matched, typically developing children. Despite having had a delay in getting language off the ground during the preschool years, our case performed within the normal range on a variety of standardized language tests, and exceptionally well on phonology and word reading, during the elementary and middle school years. Moreover, her spatial, number, and reasoning skills also fell in the average to above-average range based on assessments during these time periods. Functional MRI data revealed activation in right fronto-temporal areas when listening to short stories, resembling the bilateral activation patterns in age-matched typically developing children. Diffusion MRI data showed significantly larger dorsal white matter association tracts (the direct and anterior segments of the arcuate fasciculus) connecting areas active during language processing in her remaining right hemisphere, compared to either hemisphere in control children. We hypothesize that these changes in functional and structural brain organization are the result of compensatory brain plasticity, manifesting in unusually large right dorsal tracts, and exceptional performance in phonology, speech repetition, and decoding. More specifically, we posit that our case's large white matter connections might have played a compensatory role by providing fast and reliable transfer of information between cortical areas for language in the right hemisphere.
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Affiliation(s)
- Salomi S Asaridou
- University of California, Irvine, Department of Neurology, Biological Sciences III, Irvine, CA, USA.
| | - Ö Ece Demir-Lira
- The University of Iowa, Department of Psychological and Brain Sciences, DeLTA Center, Iowa Neuroscience Institute, Iowa City, IA, USA
| | - Susan Goldin-Meadow
- Department of Psychology, Center for Gesture, Sign and Language, University of Chicago, Chicago, IL, USA
| | - Susan C Levine
- University of Chicago, Department of Psychology, Chicago, IL, USA
| | - Steven L Small
- University of California, Irvine, Department of Neurology, Biological Sciences III, Irvine, CA, USA
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8
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Bruckert L, Borchers LR, Dodson CK, Marchman VA, Travis KE, Ben-Shachar M, Feldman HM. White Matter Plasticity in Reading-Related Pathways Differs in Children Born Preterm and at Term: A Longitudinal Analysis. Front Hum Neurosci 2019; 13:139. [PMID: 31139064 PMCID: PMC6519445 DOI: 10.3389/fnhum.2019.00139] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/21/2018] [Accepted: 04/08/2019] [Indexed: 12/29/2022] Open
Abstract
Children born preterm (PT) are at risk for white matter injuries based on complications of prematurity. They learn to read but on average perform below peers born full term (FT). Studies have yet to establish whether properties of white matter pathways at the onset of learning to read are associated with individual variation later in reading development in PT children. Here, we asked whether fractional anisotropy (FA) at age 6 years is associated with reading outcome at age 8 years in PT children in the same pathways as previously demonstrated in a sample of FT children. PT (n = 34, mean gestational age = 29.5 weeks) and FT children (n = 37) completed diffusion MRI and standardized measures of non-verbal IQ, language, and phonological awareness at age 6 years. Reading skills were assessed at age 8 years. Mean tract-FA was extracted from pathways that predicted reading outcome in children born FT: left arcuate fasciculus (Arc), bilateral superior longitudinal fasciculus (SLF), and left inferior cerebellar peduncle (ICP). We explored associations in additional pathways in the PT children: bilateral inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus. Linear regression models examined whether the prediction of reading outcome at age 8 years based on mean tract-FA at age 6 years was moderated by birth group. Children born PT and FT did not differ significantly in tract-FA at age 6 years or in reading at age 8 years. Sex, socioeconomic status, and non-verbal IQ at age 6 years were associated with reading outcome and were included as covariates in all models. Birth group status significantly moderated associations between reading outcome and mean tract-FA only in the left Arc, right SLF, and left ICP, before and after consideration of pre-literacy skills. Microstructural properties of these cerebral and cerebellar pathways predicted later reading outcome in FT but not in PT children. Children born PT may rely on alternative pathways to achieve fluent reading. These findings have implications for plasticity of neural organization after early white matter injury.
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Affiliation(s)
- Lisa Bruckert
- The Developmental-Behavioral Pediatrics Research Group, Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
| | - Lauren R Borchers
- The Developmental-Behavioral Pediatrics Research Group, Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
| | - Cory K Dodson
- The Developmental-Behavioral Pediatrics Research Group, Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
| | - Virginia A Marchman
- Language Learning Lab, Center for Infant Studies, Department of Psychology, Stanford University, Stanford, CA, United States
| | - Katherine E Travis
- The Developmental-Behavioral Pediatrics Research Group, Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
| | - Michal Ben-Shachar
- The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.,Department of English Literature and Linguistics, Bar-Ilan University, Ramat Gan, Israel
| | - Heidi M Feldman
- The Developmental-Behavioral Pediatrics Research Group, Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
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9
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Torres-Prioris MJ, López-Barroso D, Roé-Vellvé N, Paredes-Pacheco J, Dávila G, Berthier ML. Repetitive verbal behaviors are not always harmful signs: Compensatory plasticity within the language network in aphasia. BRAIN AND LANGUAGE 2019; 190:16-30. [PMID: 30665003 DOI: 10.1016/j.bandl.2018.12.004] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/02/2018] [Revised: 12/14/2018] [Accepted: 12/19/2018] [Indexed: 06/09/2023]
Abstract
Repetitive verbal behaviors such as conduite d'approche (CdA) and mitigated echolalia (ME) are well-known phenomena since early descriptions of aphasia. Nevertheless, there is no substantial fresh knowledge on their clinical features, neural correlates and treatment interventions. In the present study we take advantage of three index cases of chronic fluent aphasia showing CdA, ME or both symptoms to dissect their clinical and neural signatures. Using multimodal neuroimaging (structural magnetic resonance imaging and [18]-fluorodeoxyglucose positron emission tomography during resting state), we found that despite of the heterogeneous lesions in terms of etiology (stroke, traumatic brain injury), volume and location, CdA was present when the lesion affected in greater extent the left dorsal language pathway, while ME resulted from preferential damage to the left ventral stream. The coexistence of CdA and ME was associated with involvement of areas overlapping with the structural lesions and metabolic derangements described in the subjects who showed one of these symptoms (CdA or ME). These findings suggest that CdA and ME represent the clinical expression of plastic changes that occur within the spared language network and its interconnected areas in order to compensate for the linguistic functions that previously relied on the activity of the damaged pathway. We discuss the results in the light of this idea and consider alternative undamaged neural networks that may support CdA and ME.
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Affiliation(s)
- María José Torres-Prioris
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain; Area of Psychobiology, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain; Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.
| | - Diana López-Barroso
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain; Area of Psychobiology, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain; Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.
| | - Núria Roé-Vellvé
- Molecular Imaging Unit, Centro de Investigaciones Médico-Sanitarias, General Foundation of the University of Malaga, Malaga, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain
| | - José Paredes-Pacheco
- Molecular Imaging Unit, Centro de Investigaciones Médico-Sanitarias, General Foundation of the University of Malaga, Malaga, Spain; Molecular Imaging and Medical Physics Group, Department of Psychiatry, Radiology and Public Health, University of Compostela, Galicia, Spain
| | - Guadalupe Dávila
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain; Area of Psychobiology, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain; Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
| | - Marcelo L Berthier
- Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Malaga, Spain; Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain
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10
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Kurahashi N, Futamura Y, Nonobe N, Ogaya S, Maki Y, Yoshimura I, Suzuki T, Hosokawa Y, Yamada K, Aso K, Maruyama K, Nakamura M. Is hiragana decoding impaired in children with periventricular leukomalacia? Brain Dev 2018; 40:850-856. [PMID: 29908673 DOI: 10.1016/j.braindev.2018.05.018] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/02/2018] [Revised: 05/18/2018] [Accepted: 05/25/2018] [Indexed: 11/17/2022]
Abstract
BACKGROUND There are few studies on hiragana reading skill and phonological awareness in Japanese schoolchildren with periventricular leukomalacia (PVL). METHODS Three seven-year-old children with PVL who had no intellectual disabilities or dysarthria were recruited. Their perinatal information, brain magnetic resonance image (MRI) at term equivalent age, accompanying neurodevelopmental disorders, ophthalmologic features, Kaufman Assessment Battery for Children (K-ABC), a hiragana reading test (four tasks), and a phonological awareness task (mora reversal tasks) were analyzed. RESULTS Patient (Pt) 1 and pt2 were male. Pt2 and pt3 were siblings of triplets. Their gestational age was 28 or 32 weeks, and their birth weights were 1196, 1554, and 1848 g, respectively. Their brain MRI revealed cystic or non-cystic periventricular white matter injury involving the deep white matter at the trigone of both lateral ventricles. Pt1 had attention-deficit/hyperactivity disorder and pt3 had pervasive developmental disorder not otherwise specified. All patients had strabismus with spared best-corrected visual acuity. Scores of Reading/Decoding in K-ABC ranged from 89 to 99. As for the single mora reading task or the non-word reading task in the kana reading test, Z scores of their reading time ranged from 2.3 to 5.9 compared to control children. Pt1 and pt3 made significant errors in the mora reversal task of three-mora words, whereas all patients could answer all words correctly in the mora reversal task of two-mora words. CONCLUSION All children showed significantly prolonged reading time despite their adequate letter recognition. Two patients showed delayed phonological awareness. It was suggested that hiragana decoding impairment due to subcortical and/or cortical injury related to PVL affected their reading ability.
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Affiliation(s)
- Naoko Kurahashi
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Yukiko Futamura
- Department of Ophthalmology, General Hospital Minamiseikyo Hospital, Japan
| | - Norie Nonobe
- Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan
| | - Shunsuke Ogaya
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan; Department of Pediatrics, Japanese Red Cross Nagoya Daiichi Hospital, Japan
| | - Yuki Maki
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan; Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
| | - Ikuko Yoshimura
- Department of Child Psychiatry, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Takeshi Suzuki
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Yosuke Hosokawa
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Keitaro Yamada
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Kosaburo Aso
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Koichi Maruyama
- Department of Pediatric Neurology, Aichi Prefectural Colony Central Hospital, Aichi Human Service Center, Japan
| | - Miho Nakamura
- Department of Functioning Science, Institute for Developmental Research, Aichi Human Service Center, Japan; Okazaki Medical Center for Child Development, Japan.
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11
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Vanderauwera J, De Vos A, Forkel SJ, Catani M, Wouters J, Vandermosten M, Ghesquière P. Neural organization of ventral white matter tracts parallels the initial steps of reading development: A DTI tractography study. BRAIN AND LANGUAGE 2018; 183:32-40. [PMID: 29783124 DOI: 10.1016/j.bandl.2018.05.007] [Citation(s) in RCA: 39] [Impact Index Per Article: 5.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/20/2017] [Revised: 02/28/2018] [Accepted: 05/11/2018] [Indexed: 05/05/2023]
Abstract
Insight in the developmental trajectory of the neuroanatomical reading correlates is important to understand related cognitive processes and disorders. In adults, a dual pathway model has been suggested encompassing a dorsal phonological and a ventral orthographic white matter system. This dichotomy seems not present in pre-readers, and the specific role of ventral white matter in reading remains unclear. Therefore, the present longitudinal study investigated the relation between ventral white matter and cognitive processes underlying reading in children with a broad range of reading skills (n = 61). Ventral pathways of the reading network were manually traced using diffusion tractography: the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF). Pathways were examined pre-reading (5-6 years) and after two years of reading acquisition (7-8 years). Dimension reduction for the cognitive measures resulted in one component for pre-reading cognitive measures and a separate phonological and orthographic component for the early reading measures. Regression analyses revealed a relation between the pre-reading cognitive component and bilateral IFOF and left ILF. Interestingly, exclusively the left IFOF was related to the orthographic component, whereas none of the pathways was related to the phonological component. Hence, the left IFOF seems to serve as the lexical reading route, already in the earliest reading stages.
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Affiliation(s)
- Jolijn Vanderauwera
- Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium.
| | - Astrid De Vos
- Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium
| | - Stephanie J Forkel
- Natbrainlab, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, UK; Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neurosciences, King's College London, UK
| | - Marco Catani
- Natbrainlab, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, UK; Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neurosciences, King's College London, UK
| | - Jan Wouters
- Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium
| | - Maaike Vandermosten
- Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium
| | - Pol Ghesquière
- Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium
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12
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Piervincenzi C, Ben-Soussan TD, Mauro F, Mallio CA, Errante Y, Quattrocchi CC, Carducci F. White Matter Microstructural Changes Following Quadrato Motor Training: A Longitudinal Study. Front Hum Neurosci 2017; 11:590. [PMID: 29270117 PMCID: PMC5725444 DOI: 10.3389/fnhum.2017.00590] [Citation(s) in RCA: 29] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/03/2017] [Accepted: 11/21/2017] [Indexed: 01/18/2023] Open
Abstract
Diffusion tensor imaging (DTI) is an important way to characterize white matter (WM) microstructural changes. While several cross-sectional DTI studies investigated possible links between mindfulness practices and WM, only few longitudinal investigations focused on the effects of these practices on WM architecture, behavioral change, and the relationship between them. To this aim, in the current study, we chose to conduct an unbiased tract-based spatial statistics (TBSS) analysis (n = 35 healthy participants) to identify longitudinal changes in WM diffusion parameters following 6 and 12 weeks of daily Quadrato Motor Training (QMT), a whole-body mindful movement practice aimed at improving well-being by enhancing attention, coordination, and creativity. We also investigated the possible relationship between training-induced WM changes and concomitant changes in creativity, self-efficacy, and motivation. Our results indicate that following 6 weeks of daily QMT, there was a bilateral increase of fractional anisotropy (FA) in tracts related to sensorimotor and cognitive functions, including the corticospinal tracts, anterior thalamic radiations, and uncinate fasciculi, as well as in the left inferior fronto-occipital, superior and inferior longitudinal fasciculi. Interestingly, significant FA increments were still present after 12 weeks of QMT in most of the above WM tracts, but only in the left hemisphere. FA increase was accompanied by a significant decrease of radial diffusivity (RD), supporting the leading role of myelination processes in training-related FA changes. Finally, significant correlations were found between training-induced diffusion changes and increased self-efficacy as well as creativity. Together, these findings suggest that QMT can improve WM integrity and support the existence of possible relationships between training-related WM microstructural changes and behavioral change.
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Affiliation(s)
- Claudia Piervincenzi
- Neuroimaging Laboratory, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
| | - Tal D Ben-Soussan
- Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation, Assisi, Italy
| | - Federica Mauro
- Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation, Assisi, Italy
| | - Carlo A Mallio
- Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Yuri Errante
- Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Carlo C Quattrocchi
- Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Filippo Carducci
- Neuroimaging Laboratory, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
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13
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Nikki Arrington C, Kulesz PA, Juranek J, Cirino PT, Fletcher JM. White matter microstructure integrity in relation to reading proficiency☆. BRAIN AND LANGUAGE 2017; 174:103-111. [PMID: 28818624 PMCID: PMC5617339 DOI: 10.1016/j.bandl.2017.08.002] [Citation(s) in RCA: 29] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/05/2016] [Revised: 07/12/2017] [Accepted: 08/07/2017] [Indexed: 06/07/2023]
Abstract
Components of reading proficiency such asaccuracy, fluency, and comprehension require the successful coordination of numerous, yet distinct, cortical regions. Underlying white matter tracts allow for communication among these regions. This study utilized unique residualized tract - based spatial statistics methodology to identify the relations of white matter microstructure integrity to three components of reading proficiency in 49 school - aged children with typically developing phonological decoding skills and 27 readers with poor decoders. Results indicated that measures of white matter integrity were differentially associated with components of reading proficiency. In both typical and poor decoders, reading comprehension correlated with measures of integrity of the right uncinate fasciculus; reading comprehension was also related to the left inferior longitudinal fasciculus in poor decoders. Also in poor decoders, word reading fluency was related to the right uncinate and left inferior fronto - occipital fasciculi. Word reading was unrelated to white matter integrity in either group. These findings expand our knowledge of the association between white matter integrity and different elements of reading proficiency.
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Affiliation(s)
- C Nikki Arrington
- Texas Institute for Measurement, Evaluation and Statistics (TIMES), and Department of Psychology, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA.
| | - Paulina A Kulesz
- Texas Institute for Measurement, Evaluation and Statistics (TIMES), and Department of Psychology, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA
| | - Jenifer Juranek
- Department of Pediatrics, Division of Developmental Pediatrics, The University of Texas Medical School at Houston, 6655 Travis St. Suite 1000, Houston, TX 77030, USA
| | - Paul T Cirino
- Texas Institute for Measurement, Evaluation and Statistics (TIMES), and Department of Psychology, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA
| | - Jack M Fletcher
- Texas Institute for Measurement, Evaluation and Statistics (TIMES), and Department of Psychology, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA
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14
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López-Barroso D, de Diego-Balaguer R. Language Learning Variability within the Dorsal and Ventral Streams as a Cue for Compensatory Mechanisms in Aphasia Recovery. Front Hum Neurosci 2017; 11:476. [PMID: 29021751 PMCID: PMC5623718 DOI: 10.3389/fnhum.2017.00476] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2017] [Accepted: 09/12/2017] [Indexed: 12/28/2022] Open
Abstract
Dorsal and ventral pathways connecting perisylvian language areas have been shown to be functionally and anatomically segregated. Whereas the dorsal pathway integrates the sensory-motor information required for verbal repetition, the ventral pathway has classically been associated with semantic processes. The great individual differences characterizing language learning through life partly correlate with brain structure and function within these dorsal and ventral language networks. Variability and plasticity within these networks also underlie inter-individual differences in the recovery of linguistic abilities in aphasia. Despite the division of labor of the dorsal and ventral streams, studies in healthy individuals have shown how the interaction of them and the redundancy in the areas they connect allow for compensatory strategies in functions that are usually segregated. In this mini-review we highlight the need to examine compensatory mechanisms between streams in healthy individuals as a helpful guide to choosing the most appropriate rehabilitation strategies, using spared functions and targeting preserved compensatory networks for brain plasticity.
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Affiliation(s)
- Diana López-Barroso
- Cognitive Neurology and Aphasia Unit, Cathedra ARPA of Aphasia, Centro de Investigaciones Médico-Sanitarias and Instituto de Investigación Biomédica de Málaga, University of Malaga, Malaga, Spain
- Area of Psychobiology, Faculty of Psychology, University of Malaga, Malaga, Spain
| | - Ruth de Diego-Balaguer
- Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
- Department of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain
- Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
- Institute of Neurosciences, University of Barcelona, Barcelona, Spain
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15
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Travis KE, Ben-Shachar M, Myall NJ, Feldman HM. Variations in the neurobiology of reading in children and adolescents born full term and preterm. Neuroimage Clin 2016; 11:555-565. [PMID: 27158588 PMCID: PMC4845391 DOI: 10.1016/j.nicl.2016.04.003] [Citation(s) in RCA: 33] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2016] [Revised: 04/05/2016] [Accepted: 04/06/2016] [Indexed: 01/18/2023]
Abstract
Diffusion properties of white matter tracts have been associated with individual differences in reading. Individuals born preterm are at risk of injury to white matter. In this study we compared the associations between diffusion properties of white matter and reading skills in children and adolescents born full term and preterm. 45 participants, aged 9-17 years, included 26 preterms (born < 36 weeks' gestation) and 19 full-terms. Tract fractional anisotropy (FA) profiles were generated for five bilateral white matter tracts previously associated with reading: anterior superior longitudinal fasciculus (aSLF), arcuate fasciculus (Arc), corticospinal tract (CST), uncinate fasciculus (UF) and inferior longitudinal fasciculus (ILF). Mean scores on reading for the two groups were in the normal range and were not statistically different. In both groups, FA was associated with measures of single word reading and comprehension in the aSLF, AF, CST, and UF. However, correlations were negative in the full term group and positive in the preterm group. These results demonstrate variations in the neurobiology of reading in children born full term and preterm despite comparable reading skills. Findings suggest that efficient information exchange required for strong reading abilities may be accomplished via a different balance of neurobiological mechanisms in different groups of readers.
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Affiliation(s)
- Katherine E Travis
- Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, United States
| | - Michal Ben-Shachar
- The Gonda Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel; Department of English Literature and Linguistics, Bar Ilan University, Ramat Gan 5290002, Israel
| | - Nathaniel J Myall
- Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, United States
| | - Heidi M Feldman
- Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, United States.
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16
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Affiliation(s)
- Marco Catani
- NatBrainLab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
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17
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Travis KE, Adams JN, Ben-Shachar M, Feldman HM. Decreased and Increased Anisotropy along Major Cerebral White Matter Tracts in Preterm Children and Adolescents. PLoS One 2015; 10:e0142860. [PMID: 26560745 PMCID: PMC4641645 DOI: 10.1371/journal.pone.0142860] [Citation(s) in RCA: 38] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/02/2015] [Accepted: 10/26/2015] [Indexed: 12/15/2022] Open
Abstract
Premature birth is highly prevalent and associated with neurodevelopmental delays and disorders. Adverse outcomes, particularly in children born before 32 weeks of gestation, have been attributed in large part to white matter injuries, often found in periventricular regions using conventional imaging. To date, tractography studies of white matter pathways in children and adolescents born preterm have evaluated only a limited number of tracts simultaneously. The current study compares diffusion properties along 18 major cerebral white matter pathways in children and adolescents born preterm (n = 27) and full term (n = 19), using diffusion magnetic resonance imaging and tractography. We found that compared to the full term group, the preterm group had significantly decreased FA in segments of the bilateral uncinate fasciculus and anterior segments of the right inferior fronto-occipital fasciculus. Additionally, the preterm group had significantly increased FA in segments of the right and left anterior thalamic radiations, posterior segments of the right inferior fronto-occipital fasciculus, and the right and left inferior longitudinal fasciculus. Increased FA in the preterm group was generally associated with decreased radial diffusivity. These findings indicate that prematurity-related white matter differences in later childhood and adolescence do not affect all tracts in the periventricular zone and can involve both decreased and increased FA. Differences in the patterns of radial diffusivity and axial diffusivity suggest that the tissue properties underlying group FA differences may vary within and across white matter tracts. Distinctive diffusion properties may relate to variations in the timing of injury in the neonatal period, extent of white matter dysmaturity and/or compensatory processes in childhood.
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Affiliation(s)
- Katherine E. Travis
- Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94303, United States of America
| | - Jenna N. Adams
- Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94303, United States of America
| | - Michal Ben-Shachar
- The Gonda Brain Research Center, Bar Ilan University, Ramat Gan, 5290002, Israel
- Department of English Literature and Linguistics, Bar Ilan University, Ramat Gan, 5290002, Israel
| | - Heidi M. Feldman
- Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94303, United States of America
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18
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Lai PT, Reilly JS. Language and affective facial expression in children with perinatal stroke. BRAIN AND LANGUAGE 2015; 147:85-95. [PMID: 26117314 PMCID: PMC4520827 DOI: 10.1016/j.bandl.2015.04.002] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/28/2014] [Revised: 04/04/2015] [Accepted: 04/09/2015] [Indexed: 06/04/2023]
Abstract
Children with perinatal stroke (PS) provide a unique opportunity to understand developing brain-behavior relations. Previous research has noted distinctive differences in behavioral sequelae between children with PS and adults with acquired stroke: children fare better, presumably due to the plasticity of the developing brain for adaptive reorganization. Whereas we are beginning to understand language development, we know little about another communicative domain, emotional expression. The current study investigates the use and integration of language and facial expression during an interview. As anticipated, the language performance of the five and six year old PS group is comparable to their typically developing (TD) peers, however, their affective profiles are distinctive: those with right hemisphere injury are less expressive with respect to affective language and affective facial expression than either those with left hemisphere injury or TD group. The two distinctive profiles for language and emotional expression in these children suggest gradients of neuroplasticity in the developing brain.
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Affiliation(s)
- Philip T Lai
- San Diego State University, United States; University of California San Diego, United States.
| | - Judy S Reilly
- San Diego State University, United States; Université de Poitiers-CNRS, France.
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19
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Travis KE, Leitner Y, Feldman HM, Ben‐Shachar M. Cerebellar white matter pathways are associated with reading skills in children and adolescents. Hum Brain Mapp 2015; 36:1536-53. [PMID: 25504986 PMCID: PMC4374012 DOI: 10.1002/hbm.22721] [Citation(s) in RCA: 47] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/15/2014] [Revised: 11/10/2014] [Accepted: 12/04/2014] [Indexed: 01/18/2023] Open
Abstract
Reading is a critical life skill in the modern world. The neural basis of reading incorporates a distributed network of cortical areas and their white matter connections. The cerebellum has also been implicated in reading and reading disabilities. However, little is known about the contribution of cerebellar white matter pathways to major component skills of reading. We used diffusion magnetic resonance imaging (dMRI) with tractography to identify the cerebellar peduncles in a group of 9- to 17-year-old children and adolescents born full term (FT, n = 19) or preterm (PT, n = 26). In this cohort, no significant differences were found between fractional anisotropy (FA) measures of the peduncles in the PT and FT groups. FA of the cerebellar peduncles correlated significantly with measures of decoding and reading comprehension in the combined sample of FT and PT subjects. Correlations were negative in the superior and inferior cerebellar peduncles and positive in the middle cerebellar peduncle. Additional analyses revealed that FT and PT groups demonstrated similar patterns of reading associations within the left superior cerebellar peduncle, middle cerebellar peduncle, and left inferior cerebellar peduncle. Partial correlation analyses showed that distinct sub-skills of reading were associated with FA in segments of different cerebellar peduncles. Overall, the present findings are the first to document associations of microstructure of the cerebellar peduncles and the component skills of reading.
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Affiliation(s)
- Katherine E. Travis
- Division of Neonatal and Developmental MedicineDepartment of PediatricsStanford University School of MedicinePalo AltoCalifornia
| | - Yael Leitner
- Child Development CenterTel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv UniversityTel AvivIsrael
| | - Heidi M. Feldman
- Division of Neonatal and Developmental MedicineDepartment of PediatricsStanford University School of MedicinePalo AltoCalifornia
| | - Michal Ben‐Shachar
- The Gonda Brain Research CenterBar Ilan UniversityRamat GanIsrael
- Department of English literature and LinguisticsBar Ilan UniversityRamat GanIsrael
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20
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Urger SE, De Bellis MD, Hooper SR, Woolley DP, Chen SD, Provenzale J. The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates. J Child Neurol 2015; 30:9-20. [PMID: 24556549 PMCID: PMC4138302 DOI: 10.1177/0883073813520503] [Citation(s) in RCA: 96] [Impact Index Per Article: 9.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
The relationship between superior longitudinal fasciculus microstructural integrity and neuropsychological functions were examined in 49 healthy children (range: 5-17 years) using diffusion tensor imaging. Seven major cognitive domains (intelligence, fine-motor, attention, language, visual-spatial, memory, executive function) were assessed. Data analyses used correlational methods. After adjusting for age and gender, fractional anisotropy and axial diffusivity values in the superior longitudinal fasciculus were positively correlated with executive functions of set shifting, whereas left superior longitudinal fasciculus fractional anisotropy values correlated with attention and language. Apparent diffusion coefficient values in the left superior longitudinal fasciculus negatively correlated with inhibitory control. In the left arcuate fasciculus, fractional anisotropy correlated with IQ and attention, whereas radial diffusivity values negatively correlated with IQ, fine-motor skills, and expressive language. Findings from this study provide an examination of the relationship between superior longitudinal fasciculus integrity and children's neuropsychological abilities that can be useful in monitoring pediatric neurologic diseases.
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Affiliation(s)
- Sacide E Urger
- Istanbul Cerrahi Hastanesi, Tesvikiye mahallesi, Istanbul, Turkey
| | - Michael D De Bellis
- Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA
| | - Stephen R Hooper
- Department of Psychiatry and The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC, USA
| | - Donald P Woolley
- Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA
| | - Steven D Chen
- Department of Radiology, Duke University Medical School, Durham, NC, USA
| | - James Provenzale
- Department of Radiology, Duke University Medical School, Durham, NC, USA Departments of Radiology and Imaging Sciences, Oncology and Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA
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Zheng G, Chen X, Xu B, Zhang J, Lv X, Li J, Li F, Hu S, Zhang T, Li Y. Plasticity of language pathways in patients with low-grade glioma: A diffusion tensor imaging study. Neural Regen Res 2014; 8:647-54. [PMID: 25206710 PMCID: PMC4145989 DOI: 10.3969/j.issn.1673-5374.2013.07.009] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/10/2012] [Accepted: 01/08/2013] [Indexed: 12/30/2022] Open
Abstract
Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.
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Affiliation(s)
- Gang Zheng
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Xiaolei Chen
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Bainan Xu
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Jiashu Zhang
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Xueming Lv
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Jinjiang Li
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Fangye Li
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Shen Hu
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Ting Zhang
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
| | - Ye Li
- Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
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22
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Abstract
The brain is highly plastic after stroke or epilepsy; however, there is a paucity of brain plasticity investigation after traumatic brain injury (TBI). This mini review summarizes the most recent evidence of brain plasticity in human TBI patients from the perspective of advanced magnetic resonance imaging. Similar to other forms of acquired brain injury, TBI patients also demonstrated both structural reorganization as well as functional compensation by the recruitment of other brain regions. However, the large scale brain network alterations after TBI are still unknown, and the field is still short of proper means on how to guide the choice of TBI rehabilitation or treatment plan to promote brain plasticity. The authors also point out the new direction of brain plasticity investigation.
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Affiliation(s)
- Zhifeng Kou
- Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA ; Department of Radiology, Wayne State University, Detroit, MI, USA
| | - Armin Iraji
- Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA
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23
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Berthier ML, Froudist Walsh S, Dávila G, Nabrozidis A, Juárez Y Ruiz de Mier R, Gutiérrez A, De-Torres I, Ruiz-Cruces R, Alfaro F, García-Casares N. Dissociated repetition deficits in aphasia can reflect flexible interactions between left dorsal and ventral streams and gender-dimorphic architecture of the right dorsal stream. Front Hum Neurosci 2013; 7:873. [PMID: 24391569 PMCID: PMC3867969 DOI: 10.3389/fnhum.2013.00873] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2013] [Accepted: 11/29/2013] [Indexed: 01/01/2023] Open
Abstract
Assessment of brain-damaged subjects presenting with dissociated repetition deficits after selective injury to either the left dorsal or ventral auditory pathways can provide further insight on their respective roles in verbal repetition. We evaluated repetition performance and its neural correlates using multimodal imaging (anatomical MRI, DTI, fMRI, and18FDG-PET) in a female patient with transcortical motor aphasia (TCMA) and in a male patient with conduction aphasia (CA) who had small contiguous but non-overlapping left perisylvian infarctions. Repetition in the TCMA patient was fully preserved except for a mild impairment in nonwords and digits, whereas the CA patient had impaired repetition of nonwords, digits and word triplet lists. Sentence repetition was impaired, but he repeated novel sentences significantly better than clichés. The TCMA patient had tissue damage and reduced metabolism in the left sensorimotor cortex and insula. DTI showed damage to the left temporo-frontal and parieto-frontal segments of the arcuate fasciculus (AF) and part of the left ventral stream together with well-developed right dorsal and ventral streams, as has been reported in more than one-third of females. The CA patient had tissue damage and reduced metabolic activity in the left temporoparietal cortex with additional metabolic decrements in the left frontal lobe. DTI showed damage to the left temporo-parietal and temporo-frontal segments of the AF, but the ventral stream was spared. The direct segment of the AF in the right hemisphere was also absent with only vestigial remains of the other dorsal subcomponents present, as is often found in males. fMRI during word and nonword repetition revealed bilateral perisylvian activation in the TCMA patient suggesting recruitment of spared segments of the left dorsal stream and right dorsal stream with propagation of signals to temporal lobe structures suggesting a compensatory reallocation of resources via the ventral streams. The CA patient showed a greater activation of these cortical areas than the TCMA patient, but these changes did not result in normal performance. Repetition of word triplet lists activated bilateral perisylvian cortices in both patients, but activation in the CA patient with very poor performance was restricted to small frontal and posterior temporal foci bilaterally. These findings suggest that dissociated repetition deficits in our cases are probably reliant on flexible interactions between left dorsal stream (spared segments, short tracts remains) and left ventral stream and on gender-dimorphic architecture of the right dorsal stream.
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Affiliation(s)
- Marcelo L Berthier
- Unit of Cognitive Neurology an Aphasia, Department of Medicine, Centro de Investigaciones Médico-Sanitarias, University of Malaga Malaga, Spain
| | - Seán Froudist Walsh
- Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London London, UK
| | - Guadalupe Dávila
- Unit of Cognitive Neurology an Aphasia, Department of Medicine, Centro de Investigaciones Médico-Sanitarias, University of Malaga Malaga, Spain ; Department of Psychobiology and Methodology of Comportamental Sciences, Faculty of Psychology, University of Malaga Malaga, Spain
| | - Alejandro Nabrozidis
- Unit of Molecular Imaging, Centro de Investigaciones Médico-Sanitarias, General Foundation of the University of Malaga Malaga, Spain
| | - Rocío Juárez Y Ruiz de Mier
- Unit of Cognitive Neurology an Aphasia, Department of Medicine, Centro de Investigaciones Médico-Sanitarias, University of Malaga Malaga, Spain
| | - Antonio Gutiérrez
- Department of Psychobiology and Methodology of Comportamental Sciences, Faculty of Psychology, University of Malaga Malaga, Spain
| | - Irene De-Torres
- Unit of Cognitive Neurology an Aphasia, Department of Medicine, Centro de Investigaciones Médico-Sanitarias, University of Malaga Malaga, Spain
| | - Rafael Ruiz-Cruces
- Unit of Cognitive Neurology an Aphasia, Department of Medicine, Centro de Investigaciones Médico-Sanitarias, University of Malaga Malaga, Spain
| | - Francisco Alfaro
- Unit of Molecular Imaging, Centro de Investigaciones Médico-Sanitarias, General Foundation of the University of Malaga Malaga, Spain
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24
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Abstract
Human language requires constant learning of new words, leading to the acquisition of an average vocabulary of more than 30,000 words in adult life. The ability to learn new words is highly variable and may rely on the integration between auditory and motor information. Here, we combined diffusion imaging tractography and functional MRI to study whether the strength of anatomical and functional connectivity between auditory and motor language networks is associated with word learning ability. Our results showed that performance in word learning correlates with microstructural properties and strength of functional connectivity of the direct connections between Broca's and Wernicke's territories in the left hemisphere. This study suggests that our ability to learn new words relies on an efficient and fast communication between temporal and frontal areas. The absence of these connections in other animals may explain the unique ability of learning words in humans.
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25
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Yeatman JD, Dougherty RF, Myall NJ, Wandell BA, Feldman HM. Tract profiles of white matter properties: automating fiber-tract quantification. PLoS One 2012; 7:e49790. [PMID: 23166771 PMCID: PMC3498174 DOI: 10.1371/journal.pone.0049790] [Citation(s) in RCA: 605] [Impact Index Per Article: 46.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/29/2012] [Accepted: 10/17/2012] [Indexed: 11/19/2022] Open
Abstract
Tractography based on diffusion weighted imaging (DWI) data is a method for identifying the major white matter fascicles (tracts) in the living human brain. The health of these tracts is an important factor underlying many cognitive and neurological disorders. In vivo, tissue properties may vary systematically along each tract for several reasons: different populations of axons enter and exit the tract, and disease can strike at local positions within the tract. Hence quantifying and understanding diffusion measures along each fiber tract (Tract Profile) may reveal new insights into white matter development, function, and disease that are not obvious from mean measures of that tract. We demonstrate several novel findings related to Tract Profiles in the brains of typically developing children and children at risk for white matter injury secondary to preterm birth. First, fractional anisotropy (FA) values vary substantially within a tract but the Tract FA Profile is consistent across subjects. Thus, Tract Profiles contain far more information than mean diffusion measures. Second, developmental changes in FA occur at specific positions within the Tract Profile, rather than along the entire tract. Third, Tract Profiles can be used to compare white matter properties of individual patients to standardized Tract Profiles of a healthy population to elucidate unique features of that patient's clinical condition. Fourth, Tract Profiles can be used to evaluate the association between white matter properties and behavioral outcomes. Specifically, in the preterm group reading ability is positively correlated with FA measured at specific locations on the left arcuate and left superior longitudinal fasciculus and the magnitude of the correlation varies significantly along the Tract Profiles. We introduce open source software for automated fiber-tract quantification (AFQ) that measures Tract Profiles of MRI parameters for 18 white matter tracts. With further validation, AFQ Tract Profiles have potential for informing clinical management and decision-making.
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Affiliation(s)
- Jason D Yeatman
- Department of Psychology, Stanford University, Stanford, California, United States of America.
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26
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Yeatman JD, Dougherty RF, Ben-Shachar M, Wandell BA. Development of white matter and reading skills. Proc Natl Acad Sci U S A 2012; 109:E3045-53. [PMID: 23045658 PMCID: PMC3497768 DOI: 10.1073/pnas.1206792109] [Citation(s) in RCA: 238] [Impact Index Per Article: 18.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
Abstract
White matter tissue properties are highly correlated with reading proficiency; we would like to have a model that relates the dynamics of an individual's white matter development to their acquisition of skilled reading. The development of cerebral white matter involves multiple biological processes, and the balance between these processes differs between individuals. Cross-sectional measures of white matter mask the interplay between these processes and their connection to an individual's cognitive development. Hence, we performed a longitudinal study to measure white-matter development (diffusion-weighted imaging) and reading development (behavioral testing) in individual children (age 7-15 y). The pattern of white-matter development differed significantly among children. In the left arcuate and left inferior longitudinal fasciculus, children with above-average reading skills initially had low fractional anisotropy (FA) that increased over the 3-y period, whereas children with below-average reading skills had higher initial FA that declined over time. We describe a dual-process model of white matter development comprising biological processes with opposing effects on FA, such as axonal myelination and pruning, to explain the pattern of results.
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Affiliation(s)
- Jason D Yeatman
- Department of Psychology and Stanford Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA 94035, USA.
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27
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Yeatman JD, Dougherty RF, Ben-Shachar M, Wandell BA. Development of white matter and reading skills. Proc Natl Acad Sci U S A 2012. [PMID: 23045658 DOI: 10.1073/pnas.120679210] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/04/2023] Open
Abstract
White matter tissue properties are highly correlated with reading proficiency; we would like to have a model that relates the dynamics of an individual's white matter development to their acquisition of skilled reading. The development of cerebral white matter involves multiple biological processes, and the balance between these processes differs between individuals. Cross-sectional measures of white matter mask the interplay between these processes and their connection to an individual's cognitive development. Hence, we performed a longitudinal study to measure white-matter development (diffusion-weighted imaging) and reading development (behavioral testing) in individual children (age 7-15 y). The pattern of white-matter development differed significantly among children. In the left arcuate and left inferior longitudinal fasciculus, children with above-average reading skills initially had low fractional anisotropy (FA) that increased over the 3-y period, whereas children with below-average reading skills had higher initial FA that declined over time. We describe a dual-process model of white matter development comprising biological processes with opposing effects on FA, such as axonal myelination and pruning, to explain the pattern of results.
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Affiliation(s)
- Jason D Yeatman
- Department of Psychology and Stanford Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA 94035, USA.
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28
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A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia. Neurosci Biobehav Rev 2012; 36:1532-52. [PMID: 22516793 DOI: 10.1016/j.neubiorev.2012.04.002] [Citation(s) in RCA: 255] [Impact Index Per Article: 19.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2011] [Revised: 03/20/2012] [Accepted: 04/05/2012] [Indexed: 01/18/2023]
Abstract
In this review paper we address whether deficits in reading (i.e. developmental dyslexia) are rooted in neurobiological anomalies in white matter tracts. Diffusion tensor imaging (DTI) offers an index of the connections between brain regions (via tractography) and of the white matter properties of these connections (via fractional anisotropy, FA). The reported studies generally show that lower FA values in left temporoparietal and frontal areas are indicative of poorer reading ability or dyslexia. Second, most studies have indicated that these regions coincide with the left arcuate fasciculus and corona radiata, with fewer studies suggesting a role for the posterior part of the corpus callosum or for more ventral tracts such as the inferior longitudinal fasciculus or the inferior fronto-occipital fasciculus. Finally, a quantitative activation likelihood estimation (ALE) meta-analysis on all reported studies that used a voxel-based approach reveals a cluster located close to the left temporoparietal region (x=-29, y=-17, z=26). Fibertracking through this cluster demonstrates that this region hosts both the left arcuate fasciculus and the left corona radiata.
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