• bibliometric analysis
• cognitive behavioral therapy
• hotspots
• tinnitus
• trends

• Natural Science Foundation of Hubei Province

• Auditory oddball paradigm
• Event-related potential
• Machine learning
• Source localization
• Tinnitus

• Humans
• Tinnitus/diagnosis
• Tinnitus/physiopathology
• Tinnitus/psychology
• Male
• Female
• Middle Aged
• Electroencephalography
• Adult
• Machine Learning
• Case-Control Studies
• Cognition/physiology
• Evoked Potentials, Auditory
• Chronic Disease
• Evoked Potentials

• IITP-2024-RS-2022- 00156439 Ministry of Science and ICT, South KoreaMSIT (Ministry of Science and ICT), Korea, under the ICAN (ICT Challenge and Advanced Network of HRD) program, Grant of the Medical data-driven hospital support project through the Korea Health Information Service (KHIS), funded by the Ministry of Health and Welfare, Republic of Korea, Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety), Ansan-Si hidden champion fostering and supporting project funded by Ansan city

• cognitive behavioral therapy
• psychotherapy
• tinnitus

• Electrophysiology
• Inferior colliculus
• Spontaneous activity
• Tinnitus assessment

• Tinnitus/physiopathology
• Tinnitus/diagnosis
• Humans
• Animals
• Acoustic Stimulation
• Auditory Pathways/physiopathology
• Auditory Perception
• Evoked Potentials, Auditory
• Predictive Value of Tests
• Electrophysiological Phenomena

• Emotion-regulation
• Functional hearing disorders
• Person-centred psychotherapy
• Psychological formulation
• Psychosomatics

• bone conduction implant
• hearing loss
• hearing rehabilitation
• quality of life
• tinnitus
• utility gain

• NA Swedish Institute
• NA Cochlear (Australia)

• amygdala
• auditory system
• hippocampus
• limbic system
• pharmacology
• synaptic plasticity
• tinnitus

• 2110 PRG Neurological Foundation of New Zealand
• 7720015 Jean Cathie Bequest Grant
• 7722005 Jean Cathie Bequest Grant

• Anxiety
• Chronic tinnitus
• Idiopathic
• Insomnia
• Psychosocial factors
• Somatization
• Stress

• Cannabis
• Medical marijuana
• Tinnitus

• Attempted suicide
• Epidemiology
• Suicide
• Tinnitus

• Adult
• Humans
• Suicide, Attempted/psychology
• Follow-Up Studies
• Retrospective Studies
• Tinnitus/epidemiology
• Risk Factors

• tinnitus
• tinnitus improvements
• tinnitus management
• tinnitus quality of life
• tinnitus treatment

• Humans
• Artificial Intelligence
• Communication
• Physicians
• Quality of Life
• Tinnitus/diagnosis
• Tinnitus/therapy

• risk factors
• diseases

• Mandarin Tinnitus Questionnaire (MTQ)
• Minimal clinically important difference (MCID)
• Tinnitus

• 8-item short form health survey (SF-8)
• Tinnitus Functional Index (TFI)
• Tinnitus Handicap Inventory (THI)
• health related quality of life (HRQoL) questionnaires
• quality of life
• tinnitus
• world health organization quality-of-life (WHOQOL-BREF)

In this systematic review, we aim to evaluate the evidence regarding the correlation between tinnitus distress and the severity of depressive symptoms in patients with chronic tinnitus. Also, the prevalence of clinically relevant depressive symptoms scores in patients with chronic tinnitus was evaluated.

We performed a systematic review in PubMed, EMBASE, and the Cochrane library in June 2021 using the terms “depression” and “tinnitus,” and their synonyms, following PRISMA guidelines. Studies were selected on relevance and critically appraised regarding risk of bias using the Newcastle–Ottowa Quality Assessment Scale.

A total of 1,912 articles were screened on title and abstract after the removal of the duplicates. Eventually, 33 (1.5%) articles were included for the final analysis. Only cross-sectional cohort studies and case–control studies with a low level of evidence and a high risk of bias due to the study design and patient selection were found. Statistically significant correlations between the experienced tinnitus distress and depressive symptoms were reported in 31 out of 33 studies. Clinically relevant depression scores had a prevalence of 4.6–41.7%.

In this systematic review, in which mostly cross-sectional studies were included, a statistically significant correlation was found between the experienced tinnitus distress and the reported severity of symptoms of depression in patients with chronic tinnitus. A wide range of clinically relevant depression scores were reported in included studies. Due to the high risk of bias of included studies it is not possible to provide a definite answer on the existence of this relationship. Future population-based studies are necessary to provide more clarity.

• affect
• bottom-up model
• mood
• multisensory stimulation
• top-down model

Tinnitus is the perception of a sound without an external source, often associated with adverse psychological and emotional effects leading to impaired quality of life (QoL). The present study investigated QoL and psychological distress in tinnitus patients and analysed the effects of associated comorbidities. Tonal and speech audiometry, tinnitus assessment, and clinical interviews were obtained from 122 Portuguese individuals (aged from 55 to 75). Portuguese versions of the Brief Symptoms Inventory (BSI), the Medical Outcomes Study Short Form Health Survey (MOS SF-36) and Tinnitus Handicap Inventory (THI) were used to evaluate psychological distress, health-related QoL, social difficulties and tinnitus severity. The presence of tinnitus was significantly associated with hearing loss. The increases in tinnitus severity were associated with decreases in QoL, particularly regarding MOS SF-36 subscales “perception of health”, “social functioning”, and “mental health”. Regarding BSI, patients with greater tinnitus severity had more severe psychopathology symptoms, measured with scales “Obsessive–compulsive”, “Depression”, “Anxiety”, “Hostility” and “Phobic Anxiety”. Our study supports the notion of the negative impact of increased tinnitus severity on QoL and psychological distress in older adults. Presented data strengthen the importance of a multidisciplinary approach to tinnitus assessment and treatment.

• psychological distress
• quality of life
• tinnitus

• Dichotic listening
• Executive attention
• Speaker gender
• Speech
• Tinnitus
• Voice perception

• THC
• cannabinoid receptors
• cannabis
• cochlear nucleus
• endocannabinoid
• hearing loss
• marijuana
• otolaryngology
• tinnitus

• UL1 TR001863 NCATS NIH HHS

Background: Tinnitus is the perception of sound without an external stimulus. A large part of the adult population experiences this symptom but never seeks professional help, where others have devastating complaints in daily life. This suggests that the impact of tinnitus varies among patients and may be influenced by coping strategies and multiple psychological factors.

Method: Cross- sectional study of patients visiting the tertiary tinnitus referral center of the University Medical Center Utrecht, the Netherlands. Three hundred and twenty-one consecutive chronic tinnitus patients were evaluated by the tinnitus care group Utrecht from 6–2007 till 11–2012 of which 308 patients were included. Patients completed two tinnitus distress questionnaires (THI, TQ), a coping questionnaire (CISS) as well as a psychopathological questionnaire (SCL-90-R).

Results: Emotional-orientated coping and distraction-orientated coping strategies were significantly correlated with the experienced tinnitus burden. Also a significant negative correlation with task orientated coping was found. The effect size was small. Tinnitus distress also had a significant positive correlation with anxiety, agoraphobia, depression, insufficiency of handling, distrust & personal sensitivity, hostility and sleeping problems.

Conclusion: Patients with higher tinnitus handicap scores demonstrated the use different coping strategies than the patients with lower distress scores. This insight in coping strategies in a group of patients with high tinnitus burden is useful for counseling patients. As tinnitus coping strategy might be related to the extent and success of habituation, this outcome could be of interest to optimize tinnitus treatments in the near future.

• CISS
• THI
• TQ
• coping
• tinnitus

Tinnitus can become a strong stressor for some individuals, leading to imbalance of the autonomous nervous system with reduction of parasympathetic activity. It can manifest itself as sleep disturbances, anxiety and even depression. This condition can be reversed by bioelectrical vagal nerve stimulation (VNS). Conventional invasive VNS is an approved treatment for epilepsy and depression. Transcutaneous VNS (taVNS) stimulating the auricular branch of the vagus nerve has been shown to activate the vagal pathways similarly as an implanted VNS. Therefore, taVNS might also be a therapeutic alternative in health conditions such as tinnitus-related mental stress (TRMS). This retrospective study in 171 TRMS patients reports the clinical features, psychophysiological characteristics, and results of the heart rate variability (HRV) tests before and after test-taVNS. This study also reports the therapy outcomes of 113 TRMS patients treated with taVNS, in combination with standard tinnitus therapy.

Diagnostic tinnitus and hearing profiles were defined. To detect possible cardiac adverse effects, test-taVNS with heart rate monitoring as well as pre- and post-stimulation HRV tests were performed. Daily taVNS home therapy was prescribed thereafter. To assess therapeutic usefulness of taVNS, 1-year follow-up outcome was studied. Results of HRV tests were retrospectively analyzed and correlated to diagnostic data.

The large majority of patients with TRMS suffer from associated symptoms such as sleep disturbances and anxiety. Baseline HRV data showed that more than three quarters of the 171 patients had increased sympathetic activity before test-taVNS. Test-taVNS shifted mean values of different HRV parameters toward increased parasympathetic activity in about 80% of patients. Test-taVNS did not cause any cardiac or other side effects. No significant adverse effects were reported in follow-up questionnaires.

TRMS is an example of a stress condition in which patients may benefit from taVNS. As revealed by HRV, test-taVNS improved parasympathetic function, most efficiently in patients with a low starting HRV level. Our tinnitus treatment program, including taVNS, effectively alleviated tinnitus stress and handicap. For wider clinical use, there is a great need for more knowledge about the optimal methodology and parameters of taVNS.

• neuromodulation
• parasympathetic
• patients
• stress
• tinnitus
• vagus

• Anxiety
• Clinical trials
• Depression
• Neurotransmitters
• Pharmacology
• Psychoacoustic
• Tinnitus

• Depression
• Ear
• Emotion
• Major depressive disorder
• Tinnitus

Tinnitus is defined as perception of a sound without sound stimulation. This study aims to investigate the correlation between chronic tinnitus and the most significant clinical comorbidities and pharmacological treatments. We recruited 130 consecutive outpatients with a tinnitus for least from three months and 100 subjects without tinnitus. All patients had a full medical and audiological evaluation and all filled in Tinnitus Handicap Inventory questionnaire and Khalfa’s Hyperacusis questionnaire. We also analyzed the qualitative variables: audiometry exam, tinnitus characteristics and psychometric questionnaires. Univariate logistic regression was performed to evaluate the associations between the presence of tinnitus and the presence of comorbidities and drug intake. The statistical analysis provided the following results in the group of patients with tinnitus. We obtained an Odds Ratio statistically significant for the following categories taken into consideration: the presence of anxiety and depression, neurological diseases, headache, temporomandibular joint (TMJ) disorders, intake of levothyroxine and proton-pump inhibitor. In this study, we tried to evaluate the audiological characteristics in the subjects affected by chronic tinnitus in order to find a possible correlation with the comorbidities and any drugs intake. We found a statistically significant correlation between tinnitus and comorbidities like anxiety, depression, TMJ disorders, dysthyroidism, headache and levothyroxine and PPI intake.

• Tinnitus
• comorbidity
• drugs medication
• levothyroxine
• proton-pump inhibitor

Audiologists, globally, are generally challenged when assessing and creating intervention plans to help patients suffering from tinnitus. Tinnitus is very common among individuals and may significantly affect one’s quality of life, especially if not addressed by health care professionals. In South Africa, there seems to be limited published studies regarding the current practices of tinnitus management by audiologists. This is mainly because of limited training and a lack of guidelines and strategies for the management of tinnitus. In particular, some participants reported being unfamiliar on how to approach the identification of tinnitus and difficulty is also encountered when counselling tinnitus patients.

The aim of this study was to describe the preparedness, perspectives and practices of audiologists who manage adult patients with tinnitus.

Two hundred and forty-three registered Health Professions Council of South Africa (HPCSA) participants were involved in the study by responding to an electronic questionnaire survey. Data were collected online from Survey Monkey and were exported to Statistical Packages for the Social Sciences (SPSS) (Version 23) for statistical analysis. Data were analysed using descriptive and inferential statistics. Closed-ended questions were analysed within a quantitative framework and thematic analysis for open-ended questions that were descriptively quantified.

The results of the study are presented according to the objectives. Approximately 44% of participants (44.3%) disagreed that the undergraduate university training had sufficiently prepared them to manage adult patients with tinnitus. Very few (12.3%) had the opportunity to attend specialist training on how to assess patients with tinnitus. Similarly, only 11.6% received any specialist training with regard to tinnitus intervention. With regard to its overall management, 49.4% felt adequately informed in the assessment of patients with tinnitus, while a further 39.2% rated their experience as being limited with regard to tinnitus intervention. There is no statistical significance relationship between participants’ years of experience and tinnitus intervention (p = 0.075). Most participants did not follow any standard guidelines for its management. Some participants (26.8%) reported that further education and training are required in the overall management of patients with tinnitus, while a further 17.7% required training in all areas of tinnitus.

The feedback relating to the study suggests that overall management of tinnitus seems to be a challenge among South African audiologists, irrespective of their years of experience. Audiologists in the study perceived that tinnitus services are limited mainly because of a lack of or limited knowledge, training and guidelines, these being affected by contextual restraints.

• Audiologists
• STA’s
• intervention
• management.
• speech therapist and audiologists
• tinnitus

Tinnitus (ie, ear or head noises not caused by external sounds) is common among the general population and is the most prevalent service-connected disability in the United States’ Department of Veterans Affairs system. While numerous clinical interventions have been created to systematically address the range of issues caused by tinnitus, only a few tinnitus interventions have focused on both teaching and assessing coping strategies. The present pilot study involved a randomized clinical trial comparing 3 brief group interventions to a usual-care (UC) group (ie, a wait-list control group): the first intervention based on acceptance and commitment therapy (ACT), a second based on cognitive-behavioral therapy (CBT), and a third based on coping effectiveness training (CET). Each intervention group also received tinnitus-related audiological education.

Forty individuals met the eligibility requirements and were randomized into 1 of the 4 groups (ACT, CBT, CET, or UC). An intent-to-treat analysis was used in this study.

The Brief COPE scale was used to assess coping. Coping was assessed at 3 time points (pre-intervention, post-intervention, and at 4-week follow-up). The outcomes were 3 coping factors (engagement coping, disengagement coping, and social support coping).

When examining differences among the groups on mean coping scores over time, significant group differences were found on social support coping, with the CET group scores significantly higher than the UC group.

While all 3 brief interventions teach stress-reduction techniques, ACT and CBT focus primarily on managing one’s unwanted thoughts and emotions. CET teaches participants both a range of coping strategies (eg, stress-management approaches) to more effectively manage stressors that cannot be changed, as well as coping strategies (eg, such as problem-solving) that can be used to eliminate stressors that can be changed. CET also teaches communication skills for telling others about one’s tinnitus-related issues. CET instructs individuals on how to select coping strategies that are appropriate for different kinds of stressors and how to seek social support, which is a skill not explicitly taught by ACT or CBT. Results of this study were derived from a small sample size, and thus, future research should focus on replicating the results among a larger sample. In addition, future research could focus on adapting the CET intervention to a different delivery format.

• acceptance and commitment therapy
• brief intervention
• cognitive-behavioral therapy
• coping
• coping effectiveness training
• tinnitus

• Veterans
• adaptation
• auditory rehabilitation
• chronic health condition
• coping
• disability
• impairment
• psychometrics
• rehabilitation
• tinnitus

• Anxiety sensitivity
• Anxiety sensitivity index
• Hearing loss
• Tinnitus
• Tinnitus handicap inventory

• National Center for Mental Health

• Personality disorder
• Psychiatric disorder
• SCID
• Structured clinical interview for DSM disorders
• Tinnitus

• noise-induced hearing loss
• occupational noise exposure
• pure tone audiometry
• tinnitus

Objective: Considering the heterogeneity of the symptoms shown by patients suffering from chronic tinnitus, there are surprisingly few interdisciplinary treatments available, and mostly available only for inpatients. In order to provide an interdisciplinary treatment, we developed a day care concept in which each patient was treated by an ENT doctor, a cognitive behavioral therapist, a specialist for medical rehabilitation and an audiologist (Jena Interdisciplinary Treatment for Tinnitus, JITT). The aim of this study was to observe the changes of tinnitus related distress due to interdisciplinary day care treatment and to determine which factors mediate this change.

Subjects and Methods: Tinnitus annoyance was measured using the Tinnitus Questionnaire on 308 patients with chronic tinnitus. They were treated in the day care unit over five consecutive days between July 2013 and December 2014. Data were collected before treatment when screened (T0), at the beginning (T1) and at the end of the 5 day treatment (T2), as well as 20 days (T3) and 6 months after treatment (T4).

Results: Overall, tinnitus annoyance improved significantly from the screening day to the beginning of treatment, and to a much larger degree from the beginning to the end of treatment. The treatment outcome remained stable 6 months after treatment. Patients with the following symptoms displayed higher tinnitus annoyance at T0: dizziness at tinnitus onset, tinnitus sound could not be masked with background noise, tinnitus worsening during physical stress, comorbid psychiatric diagnosis, higher age and higher hearing loss. Loudness of tinnitus perceived in the right ear correlated with tinnitus annoyance significantly. Demographic, tinnitus and strain variables could only explain 12.8% of the variance of the change in tinnitus annoyance from T0 to T4. Out of 39 predictors, the only significant ones were “sick leave 6 months before treatment” and “tinnitus annoyance at T0.”

Conclusion: The newly developed JITT represents a valuable treatment for chronic tinnitus patients with improvement remaining stable for at least 6 months after treatment. Using a large number of variables did not allow predicting treatment outcome which underlines the heterogeneity of tinnitus.

• chronic tinnitus
• day care
• interdisciplinary
• prediction
• tinnitus questionnaire
• treatment

• Acoustic neuroma
• Brain tumor
• Outcomes
• Short-Form 36-item Health Questionnaire
• Stereotactic radiosurgery

• Tinnitus
• anxiety
• depression
• productivity
• sleep
• substance abuse
• work

• Absenteeism
• Adult
• Alcohol Drinking/epidemiology
• Alcohol Drinking/psychology
• Anxiety Disorders/epidemiology
• Anxiety Disorders/psychology
• Cross-Sectional Studies
• Depressive Disorder/epidemiology
• Depressive Disorder/psychology
• Female
• Health Surveys
• Humans
• Male
• Sleep Deprivation/epidemiology
• Sleep Deprivation/psychology
• Statistics as Topic
• Tinnitus/epidemiology
• Tinnitus/psychology
• United States

• KL2 TR001416 NCATS NIH HHS
• UL1 TR001414 NCATS NIH HHS

Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicenter questionnaire study.

Tinnitus was retrospectively assessed prior to DBS and at the current situation (with DBS). From the 685 questionnaires, 443 were returned. A control group was one-to-one matched to DBS patients who had tinnitus before DBS (n = 61). Tinnitus was assessed by the tinnitus handicap inventory (THI) and visual analog scales (VAS) of loudness and burden.

The THI decreased significantly during DBS compared to the situation prior to surgery (from 18.9 to 15.1, P < .001), which was only significant for DBS in the subthalamic nucleus (STN). The THI in the control group (36.9 to 35.5, P = 0.50) and other DBS targets did not change. The VAS loudness increased in the control group (5.4 to 6.0 P < .01).

DBS might have a modulatory effect on tinnitus. Our study suggests that DBS of the STN may have a beneficial effect on tinnitus, but most likely other nuclei linked to the tinnitus circuitry might be even more effective.

• Deep brain stimulation
• neuromodulation
• survey study
• tinnitus

• Tinnitus
• hearing-related symptoms
• psychosocial/emotional

• Anxiety/diagnosis
• Anxiety/psychology
• Auditory Perception
• Cost of Illness
• Depression/diagnosis
• Depression/psychology
• Emotions
• Hearing
• Humans
• Personality
• Risk Factors
• Social Behavior
• Stress, Psychological/psychology
• Tinnitus/diagnosis
• Tinnitus/physiopathology
• Tinnitus/psychology

• Depressive symptoms
• Health-related quality of life
• Tinnitus
• Tinnitus handicap inventory
• Tinnitus loudness

• Auditory
• Connectivity
• Frontostriatal
• Limbic
• MRI
• Tinnitus