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Kouhen F, Chahid M, Mjabber RE, Bensalah O, Naciri M, Gouach HE, Kaanouch O, Benslima N, Karmi R, Mahdi Y, Khannoussi BE, Afif M. Maxillary aggressive chondrosarcoma: A rare and challenging case. Radiol Case Rep 2025; 20:2521-2526. [PMID: 40129793 PMCID: PMC11930519 DOI: 10.1016/j.radcr.2025.02.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2025] [Revised: 01/25/2025] [Accepted: 02/04/2025] [Indexed: 03/26/2025] Open
Abstract
Chondrosarcomas represent 20%-30% of primary malignant bone tumors, but only about 1% occur in the head and neck region. Maxillary chondrosarcomas constitute a mere 5.76% of head and neck cases, predominantly affecting adults between the second and sixth decades of life. Symptoms, including facial swelling, pain, and nasal obstruction, often lead to delayed diagnoses and increased tumor aggressiveness. This case report details a 45-year-old Moroccan male with an aggressive maxillary chondrosarcoma presenting as a progressive left cheek swelling accompanied by significant pain and vision impairment. Imaging studies revealed a large, lytic maxillary lesion, and biopsy confirmed a low-grade chondrosarcoma. Given the tumor's unresectability, the patient underwent radiotherapy, receiving a total dose of 70 Gy with modest reduction in tumor size but ultimately developed metastatic pulmonary lesions, leading to palliative chemotherapy. Despite aggressive management, the patient succumbed after the fourth cycle of chemotherapy. This case underscores the importance of timely diagnosis and multidisciplinary collaboration in managing maxillary chondrosarcomas, highlighting the challenges posed by their aggressive nature and the need for long-term surveillance to monitor for recurrence and metastasis.
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Affiliation(s)
- Fadila Kouhen
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
- Laboratory of Neurooncology, Oncogenetic and Personalized Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
| | - Malak Chahid
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
| | - Reyzane El Mjabber
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
| | - Othmane Bensalah
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
| | - Meryem Naciri
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
| | - Hanae El Gouach
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
- Laboratory of Neurooncology, Oncogenetic and Personalized Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
| | - Othmane Kaanouch
- Radiotherapy Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
- Hassan First University of Settat, High Institute of Health Sciences, Laboratory of Sciences and Health Technologies, Settat, Morocco
| | - Najwa Benslima
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Radiology Departmenent, International University Mohammed VI Hospital, Casablanca, Morocco
| | - Rajaa Karmi
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
| | - Youssef Mahdi
- Pathology Department, National Institute of Oncology, Rabat, Morocco
| | - Basma El Khannoussi
- Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- Pathology Department, International University Sheikh Khalifa Hospital, Casablanca, Morocco
| | - Mohammed Afif
- Department of Radiotherapy, Faculty of Medicine of Tangier, Abdelmalek Essaadi University, Tangier, Morocco
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Abdo Shouman A, Mohammed KA, Kaadeh HM, Haphian YM, Hamzeh MM. Mesenchymal chondrosarcoma of maxilla misdiagnosed as a benign fibrous lesion: A rare case report from Syria. Int J Surg Case Rep 2025; 127:110874. [PMID: 39837044 PMCID: PMC11788735 DOI: 10.1016/j.ijscr.2025.110874] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/07/2024] [Revised: 01/03/2025] [Accepted: 01/11/2025] [Indexed: 01/23/2025] Open
Abstract
INTRODUCTION Mesenchymal chondrosarcoma (MC) is a high-grade variant of chondrosarcoma, essentially composed of poorly differentiated spindle cells interspersed with areas of cartilage or chondroid matrix. MC is extremely rare; it only accounts for 0.1 % of head and neck tumors and for only 1 % of all chondrosarcomas (CSs). CASE PRESENTATION A 21-year-old man presented with a medical history of a painful irritation at the dextral maxillary region, presented as a mass at the vestibule of the oral cavity near the upper molars, and had been misdiagnosed as a benign fibrous lesion and excised without performing a biopsy. Magnetic resonance imaging (MRI) revealed an invasive lesion filling the right maxillary sinus and penetrating the orbital floor. A biopsy was then performed and revealed an MC. CLINICAL DISCUSSION The patient underwent a wide surgical resection, except for the infraorbital region, in which the tumor was surrounded by a fibrous capsule separating it from the anatomical structures of the eye. Due to the lack of wide resection in the orbital floor area (to preserve the eyeball), we applied the chemotherapy that was done with cisplatin and doxorubicin. CONCLUSION Confirmed diagnosis by biopsy and treatment, both surgical and chemical, with frequent follow-up are decisive factors in progressing MC.
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Affiliation(s)
| | | | - Hadeel M Kaadeh
- Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic
| | - Yehia M Haphian
- Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic
| | - Mohamad M Hamzeh
- Faculty of Medicine, University of Damascus, Damascus, Syrian Arab Republic
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Ismail A, Boujguenna I, Hattab K, Mansouri N, El Ganouni NCI, Idrissi MO, Hazmiri FE, Rais H. A cartilage-forming tumor of the mandibular angle: a case report. J Med Case Rep 2022; 16:176. [PMID: 35484609 PMCID: PMC9047383 DOI: 10.1186/s13256-022-03359-x] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2021] [Accepted: 03/04/2022] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Mandible can be the site of benign or malignant lesions of different origins, including odontogenic and non-odontogenic lesions. Cartilage-forming tumors have been rarely reported at this site. Chondrosarcoma is a rare malignant cartilage-producing neoplasm that is extremely rare in the mandible. The rarity of cartilage-forming tumor occurrence in the mandible can make diagnosis difficult for pathologists, as they do not expect this type of tumor at this anatomical site. Here we report a case of chondrosarcoma of mandibular angle. CASE PRESENTATION A 70-year-old Moroccan male patient consulted a dentist for wisdom tooth pain. Wisdom tooth extraction was conducted. After 6 months, the patient reported the recurrence of pain associated with swelling in the mandibular area and paresthesia along the path of the mandibular nerve. A panoramic radiograph demonstrated a mixed radiolucent-opaque lesion involving the mandibular angle. Computed tomography showed a large osteolytic spontaneously hypointense and multilobulated lesion. A biopsy was done. Histopathological examination revealed sheets and irregular lobules of atypical cells presenting cartilaginous differentiation. Tumor cells showed severe nuclear atypia and were located within a hyaline cartilage matrix. Some foci of necrosis were noted. Osteoid deposits were not found. The patient was diagnosed with grade III chondrosarcoma and underwent a right segmental mandibulectomy with submandibular lymph node dissection. Macroscopically, the tumor was localized in the mandibular angle with extension in the mandibular body. Histopathology confirmed the previous diagnosis of grade III chondrosarcoma and did not show any lymph node metastasis. CONCLUSIONS Owing to many histological similarities, grade III chondrosarcoma must be distinguished from chondroblastic osteosarcoma and metastatic lesions. In addition, chondroblastic osteosarcoma of the jawbones has a worse prognosis than chondrosarcoma, making the distinction between these two malignant tumors the most important concern of the pathologist when dealing with a cartilage-forming tumor at this site. Surgery with wide excision margins remains the best therapeutic approach, while the role of radiotherapy is controversial. The management of mandibular chondrosarcoma requires a multidisciplinary approach involving maxillofacial surgeons, radiologists, pathologists, and oncologists.
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Affiliation(s)
- Ayman Ismail
- Department of Pathology and Biopathology Unit, Clinical Research Center, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco.
| | - Imane Boujguenna
- Department of Pathology and Biopathology Unit, Clinical Research Center, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Koussay Hattab
- Department of Oral and Maxillofacial surgery, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Nadia Mansouri
- Department of Oral and Maxillofacial surgery, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Najat Cherif Idrissi El Ganouni
- Department of Radiology, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Mariem Ouali Idrissi
- Department of Radiology, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Fatima Ezzahra Hazmiri
- Laboratory of Histology and Embryology, Department of Preclinical Science, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
| | - Hanane Rais
- Department of Pathology and Biopathology Unit, Clinical Research Center, MOHAMMED VI University Hospital of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University of Marrakech, Marrakech, Morocco
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Edetanlen BE, Ehizonaga JI, Omoregie O. Management of Chondrosarcomas of the Jaws in a Nigerian Tertiary Hospital. JOURNAL OF THE WEST AFRICAN COLLEGE OF SURGEONS 2021; 11:15-20. [PMID: 35873872 PMCID: PMC9302391 DOI: 10.4103/jwas.jwas_22_21] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 06/23/2021] [Accepted: 04/01/2022] [Indexed: 06/15/2023]
Abstract
Background There is a dearth of literature on the diagnostic characteristics and treatment outcomes for chondrosarcomas of the jaws in our environment due to the rarity of the lesion. Objectives The aim of this study was to review the demographic data, presenting symptoms, location, radiographic findings, histological findings, treatment, and outcomes in chondrosarcoma of the jaws. Materials and Methods A retrospective medical record review was undertaken of all patients diagnosed with chondrosarcoma of the jaws at our center between 2000 and 2020. Results Ten patients (3%) were identified among 333 patients with orofacial neoplastic lesions. The mean age was 26.6 years (standard deviation [SD] 20.6 years, range 14-82 years). The male-to-female ratio was 1:1. Eight (80.0%) patients had jaw swelling and the average duration of symptoms on presentation was 18 months. Maxillary location occurred in six (60.0%) patients. Radiographically, all the lesions appeared radiolucent without clearly defined borders. All patients had only radical resection, except one who had adjuvant chemotherapy as well. Recurrence occurred in three (30.0%) patients and one of the patients died. The mean follow-up was 3 years (range 1-5 years). Conclusions Chondrosarcomas in this study affected relatively young patients, with painless jaw swelling being the most common presenting symptom. Men and women were equally affected. Radiolucent lesions and conventional histological types were the most common. Radical surgery alone was the most common modality of treatment and the outcomes were good.
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Affiliation(s)
- Benlance Ekaniyere Edetanlen
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, College of Medical Sciences, University of Benin, Benin-city, Edo State, Nigeria
| | - Jovana Ivie Ehizonaga
- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, College of Medical Sciences, University of Benin, Benin-city, Edo State, Nigeria
| | - Osawe Omoregie
- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, College of Medical Sciences, University of Benin, Benin-city, Edo State, Nigeria
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Cuevas-González JC, Reyes-Escalera JO, González JL, Sánchez-Romero C, Espinosa-Cristóbal LF, Reyes-López SY, Tovar Carrillo KL, Donohue Cornejo A. Primary maxillary chondrosarcoma: A case report. World J Clin Cases 2020; 8:126-132. [PMID: 31970178 PMCID: PMC6962084 DOI: 10.12998/wjcc.v8.i1.126] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/26/2019] [Revised: 11/22/2019] [Accepted: 11/30/2019] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND Sarcomas of the head and neck region are rare tumors, constituting less than 1% of malignant neoplasms in this area, of which few cases (20%) originate from bone or cartilage. Chondrosarcoma is a malignant neoplasm that develops in bone, with a predilection for the pelvis, chest wall, and scapula, and is uncommon in the maxilla and jaw. Although this type of lesion has locally aggressive behavior, destroying the affected bone, it can metastasize when it is not diagnosed early and compromise the patient's life.
CASE SUMMARY On intraoral examination of a 32-year-old female with a tumor in the middle third of the face, a well-defined rise in volume of approximately 3 cm in diameter was observed. Computed tomography with 3-dimensional reconstruction was performed, and we observed that the osteolytic lesion affected the vestibular cortex as the palatal bone. Hematoxylin and eosin staining revealed an appearance that was similar to mature hyaline cartilage, hypercellularity, nuclear and cellular pleomorphism, and multinucleated cells, with significant vacuolization.
CONCLUSION Determination of the clinical and histopathological characteristics of rare neoplasms in the maxillofacial region, such as chondrosarcomas, allows the pathologist and surgeon to make the appropriate therapeutic decisions, optimizing the patient’s prognosis.
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Affiliation(s)
- Juan Carlos Cuevas-González
- Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Ciudad Juárez 32310, Mexico
| | - Jesús Oscar Reyes-Escalera
- Maxillofacial Surgery Department, Faculty of Dentistry, Juarez University of the State of Durango, Durango 34000, Mexico
| | | | - Celeste Sánchez-Romero
- Molecular Pathology Area, Faculty of Dentistry, University of the Republic, Montevideo 10000, Uruguay
| | | | - Simón Yobanny Reyes-López
- Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Ciudad Juárez 32310, Mexico
| | - Karla Lizette Tovar Carrillo
- Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Ciudad Juárez 32310, Mexico
| | - Alejandro Donohue Cornejo
- Stomatology Department, Biomedical Sciences Institute, Autonomous University of Ciudad Juárez, Ciudad Juárez 32310, Mexico
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Choo CS, Wan Abdul Rahman WF, Jaafar H, Ramli RR. Mesenchymal chondrosarcoma of maxilla in paediatric patient. BMJ Case Rep 2019; 12:12/3/e228969. [PMID: 30852518 DOI: 10.1136/bcr-2018-228969] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/03/2022] Open
Abstract
Chondrosarcoma (CS) is a malignant tumour of long and flat bone characterised by the formation of cartilage. Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. The diagnosis is mainly based on the histopathological appearance of biphasic pattern of undifferentiated small round cells separated by islands of well-differentiated hyaline cartilage. We report a case of 13-year-old boy who initially presented with gum swelling and the biopsy result suggested a benign fibrous lesion. Following an extensive lesion shown in radiologic findings, the tumour excision was done and finally was diagnosed as an MCS of the maxilla. The patient was given postoperative chemotherapy (EURO-EWING 99 regimen), and now on regular follow-up for monitoring of local recurrence or tumour metastasis.
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Affiliation(s)
- Choon Sean Choo
- Department of Otorhinolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia
| | - Wan Faiziah Wan Abdul Rahman
- Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia.,Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
| | - Hasnan Jaafar
- Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia.,Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
| | - Ramiza Ramza Ramli
- Department of Otorhinolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia.,Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
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7
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de Souza LL, Pontes FSC, Fonseca FP, da Mata Rezende DS, Vasconcelos VCS, Pontes HAR. Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors. Int J Oral Maxillofac Surg 2018; 48:452-460. [PMID: 30528199 DOI: 10.1016/j.ijom.2018.11.006] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2017] [Revised: 10/25/2018] [Accepted: 11/14/2018] [Indexed: 12/13/2022]
Abstract
The objective was to integrate the available published data on chondrosarcoma (CHS) of the jaw bones into a comprehensive analysis of its clinical and histological features, treatment, and prognostic factors. An electronic search was undertaken in October 2017. To be eligible, the publication had to provide sufficient clinical/histological data to confirm the diagnosis. One hundred and ten publications (224 cases of CHS) were identified and included. There was a slightly higher prevalence of CHS in males than in females. Most subjects with CHS were in the second to fifth decades of life. The most common symptom was swelling and the most commonly observed location was the maxilla. Histologically, most tumours were of the conventional type and were low grade tumours. The treatment of choice was tumour resection. Histological grade, treatment with chemotherapy alone, and the presentation of recurrence or metastasis were found to be significant independent prognostic factors: patients who presented high-grade tumours, who received chemotherapy alone as the treatment of choice, and those who presented recurrence or metastasis were more likely to have a worse prognosis. In addition, radical surgery associated with radiotherapy as the treatment protocol showed a better prognosis.
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Affiliation(s)
- L L de Souza
- Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil.
| | - F S C Pontes
- Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
| | - F P Fonseca
- Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
| | - D S da Mata Rezende
- Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
| | - V C S Vasconcelos
- Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil
| | - H A R Pontes
- Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Pará, Brazil; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
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8
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Kerketa M, Shah N, Kundu S, Pal M. Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. J Oral Maxillofac Pathol 2017; 21:132-135. [PMID: 28479701 PMCID: PMC5406794 DOI: 10.4103/jomfp.jomfp_57_16] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2022] Open
Abstract
Mesenchymal chondrosarcoma (MC) is a rare variety of chondrosarcoma (CS), which is both clinically unique and histologically distinct compared with conventional CS. Maxillofacial MCs are aggressive, have a tendency for recurrence and significant distant metastasis to lung and bone, and are associated with overall poor prognosis. Histopathologically, it is a biphasic tumor comprising of islands of hyaline cartilage with undifferentiated small round cells. Here, we present an interesting case of MC involving the left half of maxilla along with a brief review of the relevant literature.
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Affiliation(s)
- Mrinmoy Kerketa
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Neha Shah
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Sanchita Kundu
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Mousumi Pal
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
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9
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Liu H, Chen X, Wan T, Li R. Chondrosarcoma in the mental foramen region of the mandible: A case report. Oncol Lett 2016; 12:2081-2083. [PMID: 27602143 DOI: 10.3892/ol.2016.4863] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/28/2014] [Accepted: 01/27/2016] [Indexed: 11/06/2022] Open
Abstract
Chondrosarcoma is a malignant tumor that is characterized by the formation of cartilage by tumor cells. The tumor is commonly observed in regions where cartilage is already present. In total, 5-12% of chondrosarcomas occur in the head and neck region. However, the occurrence of chondrosarcoma in the mental foramen region is extremely rare. The aim of the present study was to report a case of chondrosarcoma in the mental foramen region. An 18-year-old man presented with a 3-month history of a painless mass over the labial aspect of the right mandible, which was associated with the patient feeling unwell and the loosening of the lower anterior teeth. The patient underwent segmental mandibulectomy and the final pathological diagnosis was chondrosarcoma. Following mandibulectomy, the patient continued to receive routine follow-up. In addition, the present study reviewed the literature concerning chondrosarcomas in the head and neck region.
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Affiliation(s)
- Hongwei Liu
- Department of Oral and Maxillofacial Surgery, Jining First People's Hospital, Jining, Shandong 272100, P.R. China
| | - Xiuhong Chen
- Department of Oral and Maxillofacial Surgery, Jining First People's Hospital, Jining, Shandong 272100, P.R. China
| | - Teng Wan
- Department of Oral and Cranio-Maxillofacial Science, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
| | - Ren Li
- Department of Pathology, Jining First People's Hospital, Jining, Shandong 272100, P.R. China
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10
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Mishra N, Singh AK, Agrawal R, Singh S. Massive dedifferentiated chondrosarcoma affecting whole mandible with high recurrence potential. Natl J Maxillofac Surg 2016; 6:224-8. [PMID: 27390502 PMCID: PMC4922238 DOI: 10.4103/0975-5950.183874] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/10/2022] Open
Abstract
Chondrosarcomas (CS) are slow-growing, malignant mesenchymal tumors characterized by the formation of cartilage by the tumor cells. Benign cartilage-producing tumors within the jaws are extremely uncommon, but most ultimately prove to represent low-grade CS. In the maxillofacial region, the maxilla is more commonly affected than the mandible, it comprises less than 2% of all jaw tumors. Clinically, the tumor presents as a swelling that may be painful and cause loosening of the involved teeth, with widening of the periodontal ligament space. The treatment of such lesions is wide surgical excision with regular follow up. The present report discusses the case of a 55-year-old female patient with massive multiple recurring dedifferentiated CS of mandible.
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Affiliation(s)
- Niranjan Mishra
- Department of Oral and Maxillofacial Surgery, Sriram Chandra Bhanja Dental College and Hospital, Cuttack, Odisha, India
| | - Akhilesh Kumar Singh
- Department of Oral and Maxillofacial Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
| | - Rahul Agrawal
- Department of Oral and Maxillofacial Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
| | - Shreya Singh
- Department of Orthodontics and Dentofacial Orthopaedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
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Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report. Case Rep Oncol Med 2016; 2016:5419737. [PMID: 26904332 PMCID: PMC4745617 DOI: 10.1155/2016/5419737] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2015] [Revised: 01/03/2016] [Accepted: 01/05/2016] [Indexed: 12/01/2022] Open
Abstract
Myxoid variant of chondrosarcoma is an uncommon potentially lethal malignant tumor which is even rare in pediatric age group. In the present paper, we report one such case of intermediate grade myxoid chondrosarcoma of left side of maxilla in a 12-year-old girl. The present case had a firm, painless, and lobulated growth in premolar-molar region which was associated with bicortical expansion. Maxillofacial imaging showed ill-defined radiolucency with displaced maxillary molars. Osteolytic changes were evident with the alveolus and walls of maxillary sinus. Owing to the age of the patient, surgical excision was selected as the modality of management followed by postoperative radiotherapy. This report encompasses the entire gamut of clinicopathological, radiological, and treatment modalities employed for chondrosarcoma.
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12
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Chauhan NP, Pai KM, Mutalik S, Balakrishnan R, Valiathan M, Sujir N. A progressively enlarging swelling of the palate. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117:132-7. [DOI: 10.1016/j.oooo.2012.06.024] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2012] [Revised: 06/10/2012] [Accepted: 06/19/2012] [Indexed: 10/27/2022]
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Mahajan AM, Ganvir S, Hazarey V, Mahajan MC. Chondrosarcoma of the maxilla: A case report and review of literature. J Oral Maxillofac Pathol 2013; 17:269-73. [PMID: 24250092 PMCID: PMC3830240 DOI: 10.4103/0973-029x.119759] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/10/2023] Open
Abstract
We report a case of recurrent chondrosarcoma of the maxilla in a 29 yr old male patient. The lesion presented as a small diffuse swelling on the left maxillary anterior region which had progressed over a period of one year. On aspiration, a chondromyxoid matrix was noted with cells arranged singly or in groups. Bi and tri-nucleation was noted with a moderate degree of nuclear pleomorphism. A diagnosis of well differentiated chondrosarcoma was made which was confirmed on histopathology. The clinicopathological findings of this case and a review of chondrosarcoma is presented and discussed.
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Affiliation(s)
- Aarti M Mahajan
- Department of Oral Pathology and Microbiology, Mahatma Gandhi Vidya Mandir's Karmaveer Bhausaheb Hiray Dental College & Hospitall, Nasik, Maharashtra, India
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14
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Takahama A, Alves FDA, Prado FO, Lopes MA, Kowalski LP. Chondrosarcoma of the maxilla: Report of two cases with different behaviours. J Craniomaxillofac Surg 2012; 40:e71-4. [DOI: 10.1016/j.jcms.2011.04.015] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2010] [Revised: 03/02/2011] [Accepted: 04/27/2011] [Indexed: 10/17/2022] Open
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15
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Garzino-Demo P, Tanteri G, Boffano P, Ramieri G, Pacchioni D, Maletta F, Bianchi CC, Bianchi SD, Berrone S. Chondrosarcoma of the Temporomandibular Joint: A Case Report and Review of the Literature. J Oral Maxillofac Surg 2010; 68:2005-11. [DOI: 10.1016/j.joms.2009.09.077] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/18/2009] [Revised: 08/02/2009] [Accepted: 09/23/2009] [Indexed: 11/15/2022]
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16
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17
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Chondrosarcoma of the jaw: a closer look at its management. J Oral Maxillofac Surg 2008; 66:2349-55. [PMID: 18940505 DOI: 10.1016/j.joms.2006.05.069] [Citation(s) in RCA: 15] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/23/2005] [Revised: 02/08/2006] [Accepted: 05/25/2006] [Indexed: 01/04/2023]
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18
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Bernasconi G, Preda L, Padula E, Baciliero U, Sammarchi L, Bellomi M. Parosteal chondrosarcoma, a very rare condition of the mandibular condyle. Clin Imaging 2004; 28:64-8. [PMID: 14996452 DOI: 10.1016/s0899-7071(03)00100-1] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/16/2003] [Indexed: 11/21/2022]
Abstract
We present a rare case of parosteal chondrosarcoma of the madibular condyle. The patient was referred for a functional limitation of the left temporo-mandibular joint. CT and MRI examinations demonstrated a 3.5-cm cystic mass with a peripheral rim of contrast enhancement located in the left pterygo-maxillary space. The mass had partial intraarticular spread causing deformation and focal cortical erosion of the medial aspect of the condylar head. The lesion was surgically removed; the histological diagnosis was of low-grade chondrosarcoma.
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Affiliation(s)
- Giorgio Bernasconi
- Department of Odontostomatology, UO of Maxillofacial Surgery, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
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19
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Theodorou DJ, Theodorou SJ, Sartoris DJ. Primary non-odontogenic tumors of the jawbones: an overview of essential radiographic findings. Clin Imaging 2003; 27:59-70. [PMID: 12504325 DOI: 10.1016/s0899-7071(02)00518-1] [Citation(s) in RCA: 36] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
Abstract
The jawbones, namely the maxilla and mandible, can be the sites of a multitude of neoplastic conditions. Given the variety of processes affecting this particular anatomic area, formulation of a precise diagnosis often can be challenging to the radiologist and the clinician, who may not be familiar with the imaging findings fundamental to diagnosis. Although advanced imaging methods have been developed, routine radiography remains the mainstay in the initial assessment of osseous lesions involving the jawbones. We review and summarize the imaging appearances of non-odontogenic tumors of the jawbones and illustrate example cases of these uncommon neoplasms of bone. Detailed patient history, physical examination, laboratory evaluation and histopathologic analysis are of paramount importance in diagnostic approach and, in most cases, are to be considered in the imaging evaluation of a given lesion. Correct interpretation of the imaging features of lesions involving the jawbones suggests the diagnosis, aids in presurgical planning and improves patient management.
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Affiliation(s)
- Daphne J Theodorou
- Department of Radiology, School of Medicine, University of California, San Diego Medical Center, USA.
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20
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Gorsky M, Epstein JB. Craniofacial osseous and chondromatous sarcomas in British Columbia--a review of 34 cases. Oral Oncol 2000; 36:27-31. [PMID: 10889915 DOI: 10.1016/s1368-8375(99)00042-1] [Citation(s) in RCA: 38] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
Abstract
Head and neck sarcomas are very rare diseases. The aim of this study was to assess the prevalence and presentation of hard tissue sarcomas in the head and neck and jaws. A search of the British Columbia Tumor Registry identified 34 craniofacial hard tissue sarcomas (11 chondrosarcomas, 23 osteosarcomas) over a period of 29 years. A male predominance (1.8:1) and a mean age of 40.4 years at diagnosis were seen. Of the 23 patients with osteosarcoma, one-third survived for 5 years and 12 (52%) died within a mean of 20 months. Of the 11 patients with chondrosarcoma, 45% survived for 5 years and two (18%) of the patients died within a mean of 6 months. In nine of the osteosarcoma patients (39%) the jaws were involved, and in six of those cases (67%) there was mandibular involvement. Swelling was the first sign in all jaw patients, with a mean age of 41.1 years at diagnosis and a male predominance with a ratio of 8:1. Three of the eight male patients with osteosarcoma of the jaw (38%) died within a mean of less than 1 year. Improved prognosis is related to early recognition and diagnosis to allow for adequate surgical resection. The benefit of a combination of surgery with irradiation or chemotherapy continues to be investigated.
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Affiliation(s)
- M Gorsky
- Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Ramat Aviv, Israel
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21
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Sesenna E, Tullio A, Ferrari S. Chondrosarcoma of the temporomandibular joint: a case report and review of the literature. J Oral Maxillofac Surg 1997; 55:1348-52. [PMID: 9371134 DOI: 10.1016/s0278-2391(97)90200-7] [Citation(s) in RCA: 28] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023]
Affiliation(s)
- E Sesenna
- Department of Maxillofacial Surgery, Hospital of Parma, Italy
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22
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Kawasaki T, Ono N, Watanabe K, Hoshi K. Chondroblastic osteosarcoma of the mandible: report of a case. J Oral Maxillofac Surg 1996; 54:1123-7. [PMID: 8811827 DOI: 10.1016/s0278-2391(96)90175-5] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/02/2023]
Affiliation(s)
- T Kawasaki
- Department of Dentistry and Oral Surgery, Fukushima Medical College, Japan
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23
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Rassekh CH, Nuss DW, Kapadia SB, Curtin HD, Weissman JL, Janecka IP. Chondrosarcoma of the nasal septum: skull base imaging and clinicopathologic correlation. Otolaryngol Head Neck Surg 1996; 115:29-37. [PMID: 8758626 DOI: 10.1016/s0194-5998(96)70132-8] [Citation(s) in RCA: 34] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/02/2023]
Abstract
Chondrosarcoma arising in the head and neck and craniofacial region is an uncommon lesion. The nasal septum is a particularly rare site of origin, with approximately 30 cases previously reported in the English literature. We present six new cases of chondrosarcoma arising in the nasal septum. Each of these tumors required cranial base surgical approaches for removal. Current imaging techniques allow a very accurate diagnosis to be made before biopsy. The characteristic ring-forming calcifications seen on computed tomography scans can be correlated with the histologic pattern of calcification. Magnetic resonance imaging techniques allow precise definition of tumor extent, which is particularly important because the disease is best treated with primary surgery. Advances in imaging and surgical techniques allow a much more complete tumor removal. It is hoped that this will increase the likelihood of cure in these patients. Surgical management and indications for adjuvant therapy are discussed.
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Affiliation(s)
- C H Rassekh
- Department of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555-0521, USA
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Betts NJ, Abaza NA, Kazemi A. An expansile bony lesion of the posterior mandible in a 12-year-old girl. J Oral Maxillofac Surg 1996; 54:203-9. [PMID: 8604071 DOI: 10.1016/s0278-2391(96)90448-6] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2023]
Affiliation(s)
- N J Betts
- Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia 19104-6003, USA
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25
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Nishioka G, Holt GR, Aufdemorte TB, Triplett RG. An extraskeletal chondrosarcoma of the maxilla: a case report. J Oral Maxillofac Surg 1995; 53:193-5. [PMID: 7830187 DOI: 10.1016/0278-2391(95)90401-8] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/27/2023]
Affiliation(s)
- G Nishioka
- Division of Otolaryngology-Head and Neck Surgery, University of Missouri-Columbia Health Sciences Center
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26
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Ormiston IW, Piette E, Tideman H, Wu PC. Chondrosarcoma of the mandible presenting as periodontal lesions: report of 2 cases. J Craniomaxillofac Surg 1994; 22:231-5. [PMID: 7962571 DOI: 10.1016/s1010-5182(05)80563-3] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/28/2023] Open
Abstract
A review of the literature and the addition of 2 cases in the mandibular symphyseal region serve to illustrate the protean presentation of chondrosarcomas. These 2 cases presented as periodontal lesions with associated bone loss. A high index of suspicion is required to make an early diagnosis. The importance of submitting biopsy specimens for histology is stressed, and it is recommended that definitive treatment be carried out as rapidly as possible after diagnosis is known. The surgical procedures undertaken were conservative, and patients have remained disease-free after 3.5 years and 3 years respectively. For small lesions, early segmental resection is not necessary in this region. Only recurrence should be treated by symphyseal resection with its increased morbidity. Close follow-up is mandatory.
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Affiliation(s)
- I W Ormiston
- Department of Oral and Maxillofacial Surgery, University of Hong Kong
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