1
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Chen K, Chipkin B, Grimshaw AA, Bazerbachi F, Li DK. Clinical features and endoscopic management of sharp wooden object ingestions: a systematic review of 479 cases. Gastroenterol Rep (Oxf) 2025; 13:goaf035. [PMID: 40364971 PMCID: PMC12073997 DOI: 10.1093/gastro/goaf035] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/14/2024] [Revised: 11/16/2024] [Accepted: 03/20/2025] [Indexed: 05/15/2025] Open
Abstract
Background and aims Ingested sharp objects pose increased risks of adverse events compared with other foreign bodies. We conducted the largest systematic review to date of sharp wooden object ingestions to elucidate patterns in clinical presentation and guide management practices. Methods Cochrane Library, Google Scholar, Ovid MEDLINE, Ovid Embase, PubMed, Scopus, and Web of Science Core Collection databases were searched for cases of adults who ingested sharp wooden objects. Descriptive statistics were reported for risk factors, clinical presentations, laboratory and imaging findings, adverse events, and treatments. Results Analysis of 479 cases showed that most patients were unaware of ingestion (74.8%) and toothpicks were the most common ingested item (92.5%). Male sex (70.1%), substance use (9.4%), and edentulousness (6.1%) were risk factors. Common symptoms included abdominal pain (83.7%) and fever (36.7%). Imaging identified the object in 48.1% of cases, with computed tomography being the most sensitive (54.7%). Objects were commonly found in the gastrointestinal tract (79.3%). They were consistently found in the gastrointestinal tract when patients were aware of ingestion or imaging showed an intraluminal/transluminal location. Endoscopy visualized the objects 76.1% of the time, with successful removal in 88.8% of cases; 4.7% of patients required surgery following endoscopic removal. Adverse events included perforation (87.5%) and abscess (33.0%), with a mortality rate of 5.0%. Conclusions Ingestion of sharp wooden objects presents heterogeneously and can lead to serious complications. Endoscopic removal is safe and effective. We propose a clinical algorithm to guide physicians in diagnosing and managing suspected sharp wooden object ingestion.
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Affiliation(s)
- Kay Chen
- Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA
| | - Benjamin Chipkin
- Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA
| | - Alyssa A Grimshaw
- Harvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT, USA
| | - Fateh Bazerbachi
- Interventional Endoscopy Program, St Cloud Hospital, CentraCare Health System, St Cloud, MN, USA
| | - Darrick K Li
- Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA
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2
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Vo TN, Le TV, Nguyen VQ, Nguyen TT. Laparoscopic surgery for impacted dentures in the descending colon: A case report. Int J Surg Case Rep 2025; 129:111141. [PMID: 40088849 PMCID: PMC11937695 DOI: 10.1016/j.ijscr.2025.111141] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2024] [Revised: 03/06/2025] [Accepted: 03/11/2025] [Indexed: 03/17/2025] Open
Abstract
INTRODUCTION AND IMPORTANCE Denture ingestion, commonly seen in older adults, can also occur in younger individuals. Most dentures require intervention as they cannot be excreted naturally. We report a case of a young male undergoing laparoscopic surgery to remove dentures impacted in the descending colon two months post-ingestion. CASE PRESENTATION A 30-year-old male presented with intermittent left lower quadrant abdominal pain for three days. He had accidentally swallowed his dentures two months earlier. Abdominal X-ray showed a radiopaque foreign body in the descending colon. Endoscopic retrieval attempts failed, necessitating urgent surgery. The dentures were removed successfully through laparoscopic surgery, and the perforation was closed using continuous horizontal PDS 4.0 sutures. The postoperative course was uneventful and the patient was discharged on postoperative day four. CLINICAL DISCUSSION Denture ingestion poses a significant risk due to the nature of the object, often requiring removal as it cannot pass through the gastrointestinal tract. Removable dentures are a known risk factor for such accidents. Diagnosis typically involves abdominal X-rays or CT scans. Endoscopic retrieval is often attempted first but carries a risk of perforation, which may require emergency surgical intervention. CONCLUSION Surgical approaches depend on the location and extent of perforation and the patient's abdominal condition. Early laparoscopic intervention should be considered in cases where surgery is indicated, as it offers a minimally invasive and effective solution.
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Affiliation(s)
- Trung Nguyen Vo
- Department of Clinical Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam; Training and Scientific Research Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Department of General Surgery, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam
| | - Tung Viet Le
- Training and Scientific Research Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
| | - Vinh Quoc Nguyen
- Department of General Surgery, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
| | - Thanh Tan Nguyen
- Training and Scientific Research Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Viet Nam
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3
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Ishihara Y, Ichita C, Jinushi R, Sasaki A. Clinical assessment of computed tomography for detecting ingested blister packs: A single-center retrospective study. DEN OPEN 2025; 5:e406. [PMID: 39011510 PMCID: PMC11248714 DOI: 10.1002/deo2.406] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 05/28/2024] [Revised: 06/24/2024] [Accepted: 06/30/2024] [Indexed: 07/17/2024]
Abstract
Objectives Blister pack (BP) ingestion poses serious risks, such as gastrointestinal perforation, and accurate localization by computed tomography (CT) is a common practice. However, while it has been reported in vitro that CT visibility varies with the material type of BPs, there have been no reports on this variability in clinical settings. In this study, we investigated the CT detection rates of different BPs in clinical settings. Methods This single-center retrospective study from 2010 to 2022 included patients who underwent endoscopic foreign body removal for BP ingestion. The patients were categorized into two groups for BP components, the polypropylene (PP) and the polyvinyl chloride (PVC)/polyvinylidene chloride (PVDC) groups. The primary outcome was the comparison of CT detection rates between the groups. We also evaluated whether the BPs contained tablets and analyzed their locations. Results This study included 61 patients (15 in the PP group and 46 in the PVC/PVDC group). Detection rates were 97.8% for the PVC/PVDC group compared to 53.3% for the PP group, a significant difference (p < 0.01). No cases of BPs composed solely of PP were detected by CT. Blister packs were most commonly found in the upper thoracic esophagus. Conclusions Even in a clinical setting, the detection rates of PVC and PVDC were higher than that of PP alone. Identifying PP without tablets has proven challenging in clinical. Considering the risk of perforation, these findings suggest that esophagogastroduodenoscopy may be necessary, even if CT detection is negative.
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Affiliation(s)
- Yo Ishihara
- Department of Gastroenterology Medicine CenterShonan Kamakura General HospitalKanagawaJapan
- Department of Palliative MedicineInternational University of Health and Welfare Narita HospitalChibaJapan
| | - Chikamasa Ichita
- Department of Gastroenterology Medicine CenterShonan Kamakura General HospitalKanagawaJapan
- Department of Health Data ScienceYokohama City UniversityKanagawaJapan
| | - Ryuhei Jinushi
- Department of Gastroenterology Medicine CenterShonan Kamakura General HospitalKanagawaJapan
- Department of GastroenterologySaitama Medical University International Medical CenterSaitamaJapan
| | - Akiko Sasaki
- Department of Gastroenterology Medicine CenterShonan Kamakura General HospitalKanagawaJapan
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4
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Poon SHT, Law LHK, Chung TMD. A Case Report and Literature Review on the Management of Foreign Body-Related Duodenal Perforation: Can We Avoid the Scalpel? Cureus 2025; 17:e81534. [PMID: 40171335 PMCID: PMC11957948 DOI: 10.7759/cureus.81534] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/31/2025] [Indexed: 04/03/2025] Open
Abstract
Gastrointestinal perforation remains one of the most commonly encountered surgical emergencies. Despite the advancement in surgical techniques and treatment modalities, retroperitoneal duodenal perforation remains a lethal surgical emergency. While perforations of the gastrointestinal tract are typically managed with laparotomy for repair and decontamination, the advancement in endoscopic technique and equipment shed a light on non-operative management for intestinal perforation. We present here a case of duodenal perforation successfully treated by endoscopic approach.
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Affiliation(s)
- Samuel Ho Ting Poon
- Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong Island, HKG
| | - Lok Hin K Law
- Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong Island, HKG
| | - Tat Ming D Chung
- Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong Island, HKG
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5
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Lalov L, Naccarella N, Rommens J. Medication Blisters: A Rare Cause of Bowel Perforation. Cureus 2025; 17:e77751. [PMID: 39981466 PMCID: PMC11841822 DOI: 10.7759/cureus.77751] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 01/20/2025] [Indexed: 02/22/2025] Open
Abstract
Foreign body ingestion is a common occurrence in vulnerable populations, predominantly at the ends of the age spectrum. While most cases are uncomplicated, some patients may require endoscopic or surgical intervention to prevent serious complications. Therefore, accurate and detailed radiological evaluation is essential for therapeutic decision-making. We present the case of an 80-year-old woman presenting with abdominal pain and radiological evidence of a foreign body in the small intestine. A conservative treatment approach was initially proposed due to the absence of complications and the hypothesis that a fishbone was the cause. However, her condition deteriorated due to bowel injury, complicated by bleeding and perforation. Multiplanar and 3D reconstructions identified the object as a medication blister located in the sigmoid colon. Urgent surgical intervention allowed for the retrieval of the object and the closure of the bowel perforation. This case highlights the importance of early, detailed, and accurate radiological evaluation to identify the characteristics of foreign bodies and guide timely intervention.
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Affiliation(s)
- Lachezar Lalov
- Department of Radiology, CHIREC Delta, Brussels, BEL
- Department of Medicine, Université Libre de Bruxelles, Brussels, BEL
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6
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Xiao JB, Siu JM, Propst EJ, Wolter NE. Consumer Trends Reflected in the Contents of the Pediatric Esophagus: A 20-Year Review. Laryngoscope 2025; 135:438-444. [PMID: 39177065 DOI: 10.1002/lary.31728] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2024] [Revised: 07/15/2024] [Accepted: 08/07/2024] [Indexed: 08/24/2024]
Abstract
OBJECTIVES To evaluate epidemiological trends of pediatric esophageal foreign body (EFB) ingestion over two decades. METHODS A retrospective analysis was performed using data from the National Electronic Injury Surveillance System (NEISS) database for children <18 years who presented to a United States Emergency Department (ED) with EFB between 2003 and 2022. Number of cases and type of EFB were recorded. Rates of EFBs over time were analyzed via linear regression. RESULTS A total of 52,315 EFB cases were identified over the 20-year period, with a national estimate of 1,589,325 cases. The most frequently ingested objects were coins (37.6%), toys (13.5%), and batteries (6.8%). Overall incidence of EFB ingestion increased from 7.3 to 14.2/10,000 children from 2003 to 2022 (R2 = 0.8, p < 0.0001). Incidence of coin ingestion increased from 3 to 4.5/10,000 children (R2 = 0.06, p = 0.335) but represented a smaller proportion of all EFB over time (66% in 2003 versus 43% in 2022). Incidence of magnet, battery, and toy ingestion have increased from 0.3 to 1.0/10,000 (R2 = 0.9, p < 0.0001), 0.3 to 1/10,000 (R2 = 0.7, p < 0.0001), and 0.6 to 2.3/10,000 (R2 = 0.8, p < 0.0001) children, respectively, between 2003 and 2022. The proportion of magnet, battery, and toy ingestion have increased over time (3.2%, 6.5%, and 11.8%, respectively, in 2003 to 11.4%, 11.7%, and 22.2%, respectively, in 2022). CONCLUSION Magnet, battery, and toy ingestion have increased significantly in the past two decades, while the proportion of coin ingestion has decreased. This trend may reflect shifts within the consumer market and increased availability of electronics concurrent with the adoption of digital currency. LEVEL OF EVIDENCE 4 Laryngoscope, 135:438-444, 2025.
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Affiliation(s)
- Jenny B Xiao
- Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
| | - Jennifer M Siu
- Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
| | - Evan J Propst
- Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
| | - Nikolaus E Wolter
- Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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7
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Karad A, Dandi K, Banerjee D, Dahale AS, Bade Y. Accidental Toothbrush Ingestion. Cureus 2024; 16:e62955. [PMID: 39050279 PMCID: PMC11265967 DOI: 10.7759/cureus.62955] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Accepted: 06/23/2024] [Indexed: 07/27/2024] Open
Abstract
The accidental ingestion of a toothbrush is an extremely rare occurrence, typically involving young women with psychiatric disorders such as schizophrenia, bulimia, or anorexia nervosa. There are no known cases of a swallowed toothbrush being expelled naturally through the rectum. Therefore, prompt extraction of an ingested toothbrush from the gastrointestinal tract using a surgical or endoscopic method is a necessity. Here, we report a case of a psychologically healthy woman ingesting a toothbrush accidentally while cleaning her tongue with the back of the toothbrush. In our report, we document the successful extraction of a toothbrush from the esophagus endoscopically without any complications.
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Affiliation(s)
- Abhijeet Karad
- Department of Gastroenterology and Hepatology, Dr. D.Y. Patil Vidyapeeth, Pune, IND
| | - Kranthi Dandi
- Department of Gastroenterology and Hepatology, Dr. D.Y. Patil Vidyapeeth, Pune, IND
| | - Debabrata Banerjee
- Department of Gastroenterology and Hepatology, Dr. D.Y. Patil Vidyapeeth, Pune, IND
| | - Amol S Dahale
- Department of Gastroenterology and Hepatology, Dr. D.Y. Patil Vidyapeeth, Pune, IND
| | - Yogesh Bade
- Department of Gastroenterology and Hepatology, Dr. D.Y. Patil Vidyapeeth, Pune, IND
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8
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Roberts G, McKay B, Nathanson A, Hii MW, Banting S. Endoscopic management of ingested toothpick resulting in duodeno-ureteric fistula. J Surg Case Rep 2024; 2024:rjae214. [PMID: 38638924 PMCID: PMC11026059 DOI: 10.1093/jscr/rjae214] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2024] [Accepted: 03/17/2024] [Indexed: 04/20/2024] Open
Abstract
Toothpicks are commonly used but rarely ingested. Unlike most foreign bodies, if accidentally swallowed these rarely spontaneously pass. The duodenum has been reported as the most common site of toothpick foreign body lodgement in the upper gastrointestinal tract. We report the case of a 57-year-old presenting with recurrent urosepsis after non recognition of a toothpick impaction in the duodenum with fistulisation into the right renal pelvis. Endoscopic removal of the foreign body was successful in management of the urosepsis.
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Affiliation(s)
- Georgia Roberts
- Department of Upper GI & HPB Surgery, St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
| | - Bartholomew McKay
- Department of Upper GI & HPB Surgery, St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
| | - Andrew Nathanson
- Department of Upper GI & HPB Surgery, St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
| | - Michael W Hii
- Department of Upper GI & HPB Surgery, St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
- The Department of Surgery, St Vincent’s Hospital, The University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
| | - Simon Banting
- Department of Upper GI & HPB Surgery, St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
- The Department of Surgery, St Vincent’s Hospital, The University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
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9
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Watanabe A, Nakamatsu D, Nishida T, Fujii Y, Osugi N, Matsumoto K, Yamamoto M, Fukui K. Endoscopic Removal and Conservative Treatment of a Small Bowel Perforation Caused by a Toothpick: A Case Report. Cureus 2024; 16:e57254. [PMID: 38686238 PMCID: PMC11057516 DOI: 10.7759/cureus.57254] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/30/2024] [Indexed: 05/02/2024] Open
Abstract
This case report describes a unique instance of small bowel perforation in a 49-year-old woman caused by an ingested toothpick. Initially suspected of colonic diverticulitis, a final diagnosis of small bowel perforation was made later, and the toothpick was successfully removed via endoscopy. This case emphasizes the need to consider foreign body ingestion in the differential diagnosis of abdominal pain and demonstrates the feasibility of conservative endoscopic approaches in similar cases.
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Affiliation(s)
- Asuka Watanabe
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | - Dai Nakamatsu
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | - Tsutomu Nishida
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | - Yoshifumi Fujii
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | - Naoto Osugi
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | - Kengo Matsumoto
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
| | | | - Koji Fukui
- Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, JPN
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10
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Liao Y, Ma Y, Chao F, Wang Y, Zhao Z, Ren J. A 37-Year-Old Schizophrenic Woman With Abdominal Pain. CLINICAL MEDICINE INSIGHTS-CASE REPORTS 2023; 16:11795476231219076. [PMID: 38106620 PMCID: PMC10725092 DOI: 10.1177/11795476231219076] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2023] [Accepted: 11/21/2023] [Indexed: 12/19/2023]
Abstract
Introduction Internal fistula across the posterior wall of stomach and the transverse colon caused by foreign bodies in the alimentary tract presents an extremely rare medical entity. Presentation of case We report an aschizophrenia female patient with onset of internal fistula across the posterior wall of stomach and the transverse colon triggered by swallowed magnetic metal beads. The patient was admitted to the emergency room of Northern Jiangsu People's Hospital because of acute right lower abdominal pain. Emergency routine abdominal CT scan revealed acute appendicitis and a set of foreign body in digestive tract. Discussion The foreign body in the stomach was removed by open surgery after tentative Endoscopic foreign body removal and laparoscopic appendectomy and exploration. In the process of exploring the gastric wall, it was found that one of magnet beads was embedded in the posterior wall of stomach and adhered to part of the transverse colon. After separation, it was found that an internal fistula was formed across the posterior wall of stomach and the transverse colon. As the patient ate only a small amount of food within 2 days, and the intestines were in good condition, we performed partial transverse colectomy, end-to-side anastomosis and gastric wall repair. Conclusion This case shows that for long-term foreign bodies in the digestive tract, we should be beware of the onset of gastrointestinal perforation. Moreover, perforation caused by the force acting on a blunt foreign body often results in atypical imaging findings, and the diagnosis of perforation cannot be clearly determined by imaging findings such as the presence of free gas downstream of the diaphragm. This poses new challenges for clear diagnosis and treatment.
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Affiliation(s)
- Yiqun Liao
- Department of Clinical Medical college, The Yangzhou School of Clinical Medicine, Dalian Medical University, Dalian, China
| | - Yue Ma
- General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, China
- Northern Jiangsu People’s Hospital Affiliated to Medical School of Nanjing University, Yangzhou, China
| | - Fei Chao
- Department of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China
| | - Yong Wang
- General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, China
- Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China
- Yangzhou Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases, Yangzhou, China
| | - Ziming Zhao
- General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, China
- Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China
| | - Jun Ren
- General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, China
- Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China
- Yangzhou Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases, Yangzhou, China
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11
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Dev S, Pokhrel KM, Mulmi U, Devkota S, Dev B, Bhattarai A. Chicken bone-induced ileal perforation peritonitis mimicking duodenal perforation peritonitis: a case report. Ann Med Surg (Lond) 2023; 85:6202-6205. [PMID: 38098546 PMCID: PMC10718394 DOI: 10.1097/ms9.0000000000001404] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2023] [Accepted: 10/07/2023] [Indexed: 12/17/2023] Open
Abstract
Introduction Foreign body ingestion can lead to bowel perforation and peritonitis. We present a case of a 54-year-old male who ingested a chicken bone, resulting in ileal perforation that mimicked duodenal perforation peritonitis. Case Presentation The patient has a history of peptic ulcer disease and regularly used non-steroidal anti-inflammatory drugs over the counter, adding more evidence to the provisional diagnosis of duodenal perforation. Exploratory laparotomy revealed the ileal perforation and the chicken bone was successfully removed. Wedge resection of the perforated segment and ileo-ileal anastomosis were performed. Discussion Although history, examination, and investigation were more in favor of duodenal ulcer, our patient had ileal perforation due to chicken bone. Prompt identification and early surgical intervention are crucial to prevent complications and reduce mortality rates. The patient had an uneventful recovery. Conclusion Timely referral to a tertiary care center is essential for early surgical intervention and successful management of bowel perforation caused by a foreign body.
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Affiliation(s)
- Santosh Dev
- Department of General Surgery, Tribhuvan University Teaching Hospital
| | - Kailash Mani Pokhrel
- Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu
| | - Utsha Mulmi
- Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu
| | - Shishir Devkota
- Department of General Surgery, Tribhuvan University Teaching Hospital
| | - Barsha Dev
- Nepalgunj Medical College and Teaching Hospital, Banke, Nepal
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12
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Borenstein JT, Cummins G, Dutta A, Hamad E, Hughes MP, Jiang X, Lee HH, Lei KF, Tang XS, Zheng Y, Chen J. Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges. LAB ON A CHIP 2023; 23:4928-4949. [PMID: 37916434 DOI: 10.1039/d3lc00296a] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/03/2023]
Abstract
The development of micro- and nanotechnology for biomedical applications has defined the cutting edge of medical technology for over three decades, as advancements in fabrication technology developed originally in the semiconductor industry have been applied to solving ever-more complex problems in medicine and biology. These technologies are ideally suited to interfacing with life sciences, since they are on the scale lengths as cells (microns) and biomacromolecules (nanometers). In this paper, we review the state of the art in bionanotechnology and bioMEMS (collectively BNM), including developments and challenges in the areas of BNM, such as microfluidic organ-on-chip devices, oral drug delivery, emerging technologies for managing infectious diseases, 3D printed microfluidic devices, AC electrokinetics, flexible MEMS devices, implantable microdevices, paper-based microfluidic platforms for cellular analysis, and wearable sensors for point-of-care testing.
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Affiliation(s)
| | - Gerard Cummins
- School of Engineering, University of Birmingham, Edgbaston, B15 2TT, UK.
| | - Abhishek Dutta
- Department of Electrical & Computer Engineering, University of Connecticut, USA.
| | - Eyad Hamad
- Biomedical Engineering Department, School of Applied Medical Sciences, German Jordanian University, Amman, Jordan.
| | - Michael Pycraft Hughes
- Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates.
| | - Xingyu Jiang
- Department of Biomedical Engineering, Southern University of Science and Technology, China.
| | - Hyowon Hugh Lee
- Weldon School of Biomedical Engineering, Center for Implantable Devices, Purdue University, West Lafayette, IN, USA.
| | | | | | | | - Jie Chen
- Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB T6G 2R3, Canada.
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13
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Saini V, Yadav A, Dadhich SK, Mitrolia B, Bhati R. A Rare Case of Endoscopic Removal of 63 Coins From the Stomach of an Adult. Cureus 2023; 15:e42599. [PMID: 37641776 PMCID: PMC10460503 DOI: 10.7759/cureus.42599] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/28/2023] [Indexed: 08/31/2023] Open
Abstract
The paper focuses on the use of endoscopy in the extraction of 63 coins from the stomach of an adult psychiatric patient. So far, most such cases were dealt with by traditional surgery, and endoscopy was used for the removal of a few coins only. The present work emphasizes that endoscopy is a better option than surgical intervention as it is faster and has a shorter recovery time, lower risk of infection, and lower cost.
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Affiliation(s)
- Vivek Saini
- Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur, IND
| | - Abhishek Yadav
- Medicine, Maulana Azad Medical College, Lok Nayak Hospital, Delhi, IND
- Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur, IND
| | - Sunil K Dadhich
- Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur, IND
| | - Bobby Mitrolia
- Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur, IND
| | - Rajendra Bhati
- Gastroenterology, Dr. Sampurnanand Medical College, Jodhpur, IND
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14
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Little R, Shpoliansky M, Greer ML, Avitzur Y, Au H, Hulst J. Unmasking a New Type of Gastrointestinal Foreign Body in the COVID-19 Era. JPGN REPORTS 2023; 4:e315. [PMID: 37181456 PMCID: PMC10174735 DOI: 10.1097/pg9.0000000000000315] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/19/2022] [Accepted: 02/20/2023] [Indexed: 05/16/2023]
Abstract
The incidence of foreign body ingestion has increased during the coronavirus disease 2019 pandemic. As face masks became increasingly available, we report a case of accidental ingestion of the metal strip insert of a surgical mask. After initially progressing, its progress halted after 24 hours. This case highlights the challenges of timing the endoscopic removal of long objects, especially considering the reduced endoscopic availability during the pandemic. Despite only causing local trauma, the strip was impacted at the duodenojejunal flexure with the potential to cause obstruction. Limiting morbidity relies on urgent removal and prevention of similar ingestions by emphasizing the safe use and storage of masks.
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Affiliation(s)
- Rebecca Little
- From the Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
| | - Michael Shpoliansky
- From the Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
| | - Mary-Louise Greer
- Department of Diagnostic Imaging, Hospital for Sick Children
- Department of Medical Imaging, University of Toronto, Toronto, Canada
| | - Yaron Avitzur
- From the Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
- Department of Paediatrics, University of Toronto, Toronto, Canada
| | - Hosanna Au
- Department of Paediatrics, University of Toronto, Toronto, Canada
- Division of Paediatric Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
| | - Jessie Hulst
- From the Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
- Department of Paediatrics, University of Toronto, Toronto, Canada
- Department of Nutritional Sciences, University of Toronto, Toronto, Canada
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15
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Das SS, Krishnan S, Mandhane NK, Shalak HS. Intentional Ingestion of Foreign Bodies: A Physician's Agony. Cureus 2023; 15:e37677. [PMID: 37206521 PMCID: PMC10189832 DOI: 10.7759/cureus.37677] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/17/2023] [Indexed: 05/21/2023] Open
Abstract
Intentional foreign body ingestion is the phenomenon wherein one swallows a non-digestible object with the intent to cause self-injury. It is intentional in adult patients with a positive psychiatric history and can be a recurrent issue. Although the incidence of this condition is increasing, there are few existing articles on the subject that highlight its importance. This case report aims to present a unique patient encounter to emphasize the multispecialty approach required for management and provide an overview of the literature available on the subject regarding types of objects swallowed, selection of appropriate imaging modalities, and plans of management.
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16
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Eckharter C, Gass JM, Kremo V. Intra-Abdominal Abscess of Unusual Origin. PRAXIS 2023; 112:117-119. [PMID: 36722104 DOI: 10.1024/1661-8157/a003968] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/18/2023]
Abstract
This article describes the case of a woman who unknowingly swallowed several fishbones, one of which perforated the intestinal wall and subsequently formed an intra-abdominal abscess due to the foreign body reaction.
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Affiliation(s)
- Christoph Eckharter
- Department of General and Visceral Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland
| | - Jörn-Markus Gass
- Department of General and Visceral Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland
| | - Valerie Kremo
- Department of General and Visceral Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland
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17
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Soga M, Tanaka T, Ueda T, Kirihataya Y, Yamaguchi Y, Okura Y, Sawai M, Yoshimura A. Accidental duodenal foreign body of toothbrush removed laparoscopically: a case report. Surg Case Rep 2022; 8:141. [PMID: 35895183 PMCID: PMC9329496 DOI: 10.1186/s40792-022-01501-x] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2022] [Accepted: 07/20/2022] [Indexed: 11/13/2022] Open
Abstract
Background Foreign body ingestion is a common case in daily medical care, and it usually passes through the entire gastrointestinal tract naturally and is excreted in the feces. However, long and sharp foreign bodies may be difficult to pass naturally due to their shape. Here, we present a rare case of a duodenal foreign body, a toothbrush, that required laparoscopic surgical removal after a failed endoscopic attempt. Case presentation A 51-year-old male with intellectual disability presented to our hospital due to fever. Initially, he was diagnosed with aspiration pneumonia by chest X-ray and blood examination. However, abdominal X-ray examination suggested a foreign body, and a computed tomography scan revealed a toothbrush in the duodenum. Therefore, upper gastrointestinal endoscopy was immediately attempted to remove it, but it could not be safely removed because the handle part of the toothbrush seemed deeply embedded in the duodenal mucosa. Therefore, this case was diagnosed as duodenal incarceration of the toothbrush, and it was removed by laparoscopic surgery. The operation was performed safely, and the patient’s postoperative course was good without any complications. The extracted toothbrush was 15 cm in length. Conclusion We experienced a rare case of a duodenal foreign body, which was a toothbrush. The duodenal foreign body was safely removed by laparoscopic surgery for the first time.
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18
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Goh SLL, Steen C, Wong E, Scott M. Small bowel obstruction secondary to a plastic bezoar. BMJ Case Rep 2022; 15:e251438. [PMID: 36446472 PMCID: PMC9710328 DOI: 10.1136/bcr-2022-251438] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/14/2022] [Indexed: 12/03/2022] Open
Abstract
We present a case of a small bowel obstruction secondary to a rare plastic bezoar. A man in their early 20s with autism and an intellectual disability presented with symptoms of small bowel obstruction. CT revealed very subtle signs and, despite passage of gastrografin, ongoing clinical suspicion led to operative management which confirmed the diagnoses of plastic bezoar.
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Affiliation(s)
| | | | - Enoch Wong
- General Surgery, Eastern Health, Box Hill, Victoria, Australia
| | - Monique Scott
- Department of Pscyhology, Swinburne University of Technology, Hawthorn, Victoria, Australia
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19
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Large Chicken Bone Impacted in Colonic Diverticulum Mimicking Diverticulitis. ACG Case Rep J 2022; 9:e00917. [DOI: 10.14309/crj.0000000000000917] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/30/2022] [Accepted: 10/21/2022] [Indexed: 11/24/2022] Open
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20
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Barry H, Abusaleh R, Mazin L, Elmasry S, Chuang KY. Successful endoscopic removal of foreign body lacerating into the duodenum. VideoGIE 2022; 7:408-409. [DOI: 10.1016/j.vgie.2022.07.014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
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21
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Roman L, Hardesty BD, Schuyler Q. A systematic review and risk matrix of plastic litter impacts on aquatic wildlife: A case study of the Mekong and Ganges River Basins. THE SCIENCE OF THE TOTAL ENVIRONMENT 2022; 843:156858. [PMID: 35772547 DOI: 10.1016/j.scitotenv.2022.156858] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/16/2022] [Revised: 06/15/2022] [Accepted: 06/17/2022] [Indexed: 06/15/2023]
Abstract
Plastic litter is a pollutant of aquatic environments worldwide, with some of the world's highest litter densities occurring in freshwater ecosystems. Little information about the risk that plastic litter poses to aquatic wildlife is available across the world's most polluted waterways. To help assess the risk to aquatic species where empirical data is lacking, our review presents i) a risk assessment methodology for predicting plastic litter impacts on aquatic wildlife in data poor environments, ii) a case study demonstrating this risk assessment methodology for wildlife across two heavily polluted river basins in Asia, the Mekong and Ganges River Basins; and iii) a broad review summarising common trends in litter interactions and risk to freshwater fish, aquatic birds, cetaceans and raptors. This risk analysis unites a systematic review approach with risk matrices following International Standards Organization's risk assessment criteria, evaluating the risk of plastic entanglement and ingestion and the potential for harm to the animal. In the Mekong and Ganges River Basins, we found that the risk of litter entanglement is higher than litter ingestion. Four species were forecast to be at high risk of entanglement: Ganges River dolphin, Gharial, Mekong giant catfish and Irrawaddy dolphin. The eastern imperial eagle and greater spotted eagle were noted to be at moderate risk of entanglement. Both the Ganges River dolphin and Irrawaddy dolphin were predicted to have a moderate risk of plastic ingestion. Interestingly, cranes, waterfowl and wading birds were deemed at low or negligible risk from plastic litter. This risk matrix methodology can be applied to other waterways and taxa to assess the risk posed by plastic. It can also be readily updated as more information becomes available. This review enables decision makers to bridge a data gap by providing a tool for conservation and management before comprehensive empirical data is available.
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Affiliation(s)
- Lauren Roman
- CSIRO Oceans and Atmosphere, Hobart, Tasmania, Australia.
| | - Britta Denise Hardesty
- CSIRO Oceans and Atmosphere, Hobart, Tasmania, Australia; Centre for Marine Socioecology, Hobart, Tasmania, Australia
| | - Qamar Schuyler
- CSIRO Oceans and Atmosphere, Hobart, Tasmania, Australia
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22
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Pesky Pesce: A Forgettable Fish Dinner with a Late Surprise, a Perianal Abscess. Dig Dis Sci 2022; 67:4369-4372. [PMID: 35857242 DOI: 10.1007/s10620-022-07625-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 07/06/2022] [Indexed: 12/09/2022]
Abstract
Clinical presentation after ingestion of foreign body is a common finding in surgical practice. Perianal sepsis due to a foreign body is, usually, secondary to introduction via the trans-anal route. The case here reported is extremely rare since an ingested fishbone passed asymptomatically through most of the gastrointestinal tract, with resultant late-onset ischiorectal abscess. Moreover, clinical evidence of the perianal abscess manifested one month after the fishbone had been ingested. The final localization of the fishbone-lying anterior to the sacrum-complicated the preoperative and intraoperative detection of the ingested foreign body.
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23
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Kaffash E, Ali Shahbazi M, Hatami H, Nokhodchi A. An insight into gastrointestinal macromolecule delivery using physical oral devices. Drug Discov Today 2022; 27:2309-2321. [PMID: 35460891 DOI: 10.1016/j.drudis.2022.04.014] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2021] [Revised: 02/25/2022] [Accepted: 04/13/2022] [Indexed: 11/03/2022]
Abstract
Oral delivery is preferred over other routes of drug administration by both patients and physicians. The bioavailability of some therapeutics that are delivered via the oral route is restricted due to the protease- and bacteria-rich environment in the gastrointestinal tract, and by the pH variability along the delivery route. Given these harsh environments, the oral delivery of therapeutic macromolecules is complicated and remains challenging. Various formulation approaches, including the use of permeation enhancers and nanosized carriers, as well as chemical alteration of the drug structure, have been studied as ways to improve the oral absorption of macromolecular drugs. Nevertheless, the bioavailability of marketed oral peptide medicines is often relatively poor. This review highlights the most recent and promising physical methods for improving the oral bioavailability of macromolecules such as peptides. These methods include microneedle injections, high-speed stream injectors, magnetic drug targeting, expandable hydrogels, and iontophoresis. We highlight the potential and challenges of these new technologies, which may impact the future approaches used by pharmaceutical companies to create more efficient and safer orally administered macromolecules. Teaser: Despite substantial effort, the oral delivery of macromolecules remains challenging due to their low bioavailability. This review discusses the potential, challenges, and safety concerns associated with new technologies and devices for oral macromolecule delivery.
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Affiliation(s)
- Ehsan Kaffash
- Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
| | - Mohammad Ali Shahbazi
- Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands; Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.
| | - Hooman Hatami
- Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
| | - Ali Nokhodchi
- Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton, UK.
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24
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Yamazaki H, Matsubara M, Kato H, Imagawa K, Murakami T, Mathis BJ, Hiramatsu Y. Pediatric cardiac tamponade caused by metallic wire penetration into the heart: A case report and literature review. J Card Surg 2022; 37:1069-1071. [DOI: 10.1111/jocs.16263] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2022] [Revised: 01/13/2022] [Accepted: 01/13/2022] [Indexed: 11/26/2022]
Affiliation(s)
- Hajime Yamazaki
- Department of Cardiovascular Surgery University of Tsukuba Tsukuba Japan
| | - Muneaki Matsubara
- Department of Cardiovascular Surgery University of Tsukuba Tsukuba Japan
| | - Hideyuki Kato
- Department of Cardiovascular Surgery University of Tsukuba Tsukuba Japan
| | - Kazuo Imagawa
- Department of Pediatrics University of Tsukuba Tsukuba Japan
| | | | - Bryan J. Mathis
- Department of Cardiovascular Surgery University of Tsukuba Tsukuba Japan
| | - Yuji Hiramatsu
- Department of Cardiovascular Surgery University of Tsukuba Tsukuba Japan
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25
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Ekwunife CN, Ogbue UN, Kaduru CO. Spontaneous Partial Percutaneous Extrusion of Swallowed Metallic long Spoon: A Case Report. Niger J Clin Pract 2022; 25:118-120. [PMID: 35046206 DOI: 10.4103/njcp.njcp_512_20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022]
Abstract
Foreign body ingestion is a commonly encountered clinical challenge. Most of these objects pass spontaneously, but long objects could be retained leading to uncommon complications. There seem to be no record of percutaneous extrusion of ingested spoon in literature. We report a case of 20 year old lady who swallowed a long metallic spoon. It got retained in the stomach for a month without obstructive symptoms, until the tail end of it eroded onto the skin. It was retrieved through an open gastrotomy. Patient had an uneventful postoperative recovery. Clinicians should be mindful that ingested large foreign bodies may be delayed in presentation. Whereas our index patient had open surgery, minimally invasive retrieval approaches could be considered when comparable cases are encountered.
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Affiliation(s)
- C N Ekwunife
- Department of Surgery, Imo State University Teaching Hospital, Orlu, Imo State, Nigeria
| | - U N Ogbue
- Department of Surgery, Imo State University Teaching Hospital, Orlu, Imo State, Nigeria
| | - C O Kaduru
- Department of Surgery, Imo State University Teaching Hospital, Orlu, Imo State, Nigeria
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26
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Endoscopic foreign body retrieval from the caecum - A case report and push for intervention guidelines. Int J Surg Case Rep 2022; 90:106755. [PMID: 34998265 PMCID: PMC8741470 DOI: 10.1016/j.ijscr.2022.106755] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/27/2021] [Revised: 12/31/2021] [Accepted: 01/01/2022] [Indexed: 11/23/2022] Open
Abstract
INTRODUCTION AND IMPORTANCE Endoscopic foreign body retrieval in the upper gastrointestinal tract is well established, however indications for endoscopy for retained foreign bodies in the lower gastrointestinal tract and specifically the right colon is still being navigated [3]. A PubMed and Google Scholar search discovered a variety of case reports detailing various methods and indications for endoscopic retrieval of right sided colonic foreign bodies. This case report endeavors to supplement the literature so that guidelines can one day be established for colonoscopic retrieval of right-sided foreign bodies. CASE PRESENTATION 36-year-old male prisoner swallowed 6.5 cm nail clippers with a long-standing history of intentional foreign body ingestion (FBI) including multiple laparotomies for foreign body retrievals. Computerized tomography (CT) was used initially to confirm the position of the nail clippers. After almost two weeks of failure of the foreign body (FB) to move beyond the caecum as demonstrated on plain abdominal X-rays, the patient had a colonoscopy with successful retrieval of the FB. CLINICAL DISCUSSION This case report hopes to encourage the consideration of colonoscopy for retrieval of right sided colonic foreign bodies that have failed to pass on their own and where an operation may come with increased risk (multiple laparotomies, multiple comorbidities, and higher anaesthetic risk for a general anaesthetic). Colonoscopy/endoscopy still has inherent risk and this patient did have an episode of temporary laryngospasm that required intubation and monitoring in the intensive care unit post operatively. Despite this the patient recovered and was discharged day one post procedure without further complication. The case report has been reported in line with the SCARE 2020 criteria (Agha et al., 2020 [2]). CONCLUSION Indications for consideration of endoscopic retrieval of foreign bodies in the right colon have not been entirely detailed as endoscopy is for upper gastrointestinal foreign bodies. This case report documents the indications for endoscopy in the clinical context of a recurrent FBI and a history of multiple laparotomies with failure of the FB to move beyond the caecum.
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27
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Koroljov M, Antipova M, Drobjazgin E, Zaharenko A, Meshkov A, Mihin A, Panfilova V, Pinigin A, Sinicyn V, Razumovskij A, Fedorov E, Shavrov A, Shhjogolev A. A foreign body in the digestive tract. Age group: adults and children. The main positions of the national clinical recommendations approved by the Ministry of Health in December 2021. ENDOSKOPICHESKAYA KHIRURGIYA 2022; 28:5. [DOI: 10.17116/endoskop2022280315] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/04/2025]
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28
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Balogun O, Jeje E, Fatuga A, Atoyebi O. An unusual cause of pyogenic liver abscess. The conundrum of broom splinter. Report of two cases. NIGERIAN JOURNAL OF MEDICINE 2022. [DOI: 10.4103/njm.njm_2_22] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
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29
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Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Nat Biotechnol 2022; 40:103-109. [PMID: 34462588 PMCID: PMC8766875 DOI: 10.1038/s41587-021-01024-0] [Citation(s) in RCA: 61] [Impact Index Per Article: 20.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2020] [Accepted: 07/16/2021] [Indexed: 02/07/2023]
Abstract
Oral administration provides a simple and non-invasive approach for drug delivery. However, due to poor absorption and swift enzymatic degradation in the gastrointestinal tract, a wide range of molecules must be parenterally injected to attain required doses and pharmacokinetics. Here we present an orally dosed liquid auto-injector capable of delivering up to 4-mg doses of a bioavailable drug with the rapid pharmacokinetics of an injection, reaching an absolute bioavailability of up to 80% and a maximum plasma drug concentration within 30 min after dosing. This approach improves dosing efficiencies and pharmacokinetics an order of magnitude over our previously designed injector capsules and up to two orders of magnitude over clinically available and preclinical chemical permeation enhancement technologies. We administered the capsules to swine for delivery of clinically relevant doses of four commonly injected medications, including adalimumab, a GLP-1 analog, recombinant human insulin and epinephrine. These multi-day dosing experiments and oral administration in awake animal models support the translational potential of the system.
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30
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Williams TR, Okoli J. Spontaneous resolution of gastric perforation caused by an ingested foreign body: a case report. J Surg Case Rep 2021; 2021:rjab506. [PMID: 34868547 PMCID: PMC8634504 DOI: 10.1093/jscr/rjab506] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/19/2021] [Revised: 10/12/2021] [Accepted: 10/20/2021] [Indexed: 11/13/2022] Open
Abstract
Foreign body ingestions are commonly seen and are usually uneventful. Very rarely, ingested foreign bodies will cause perforation of the gastrointestinal tract, which can lead to peritonitis, abscesses or fistulation. This is the case of a patient with vague abdominal pain after voluntary ingestion of bleach and an ink pen. The ink pen was found lodged in the gastric antral wall on esophagogastroduodenoscopy. The foreign body spontaneously migrated into the gastric lumen and was successfully removed with endoscopy.
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Affiliation(s)
| | - Joel Okoli
- Department of Surgery, Morehouse School of Medicine, Atlanta, GA, USA
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31
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Kaur A, Zivari K, Sharma N. What Happens When the Digested Screw Does Not Come Out of Ileum? Cureus 2021; 13:e20169. [PMID: 35003996 PMCID: PMC8724225 DOI: 10.7759/cureus.20169] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 12/04/2021] [Indexed: 11/05/2022] Open
Abstract
Adults with foreign body ingestion are mainly secondary to psychiatric disorders, alcoholic intoxication, and secondary gains. Conservative management without any intervention is successful in 80% of the ingested foreign bodies. Risk factors for complication include sharp objects, objects larger than 6 mm, recurrent ingestion, and previous gastrointestinal tract surgeries. Sharp objects specifically account for 35% perforation rates and impactions, most commonly at the ileocecal valve. There is limited evidence on the role of colonoscopy after the distal migration of foreign bodies into the ileum and colon. In our case report, we present a case of a 53-year-old-male with a history of recurrent foreign body ingestion secondary to a multitude of psychiatric disorders. It describes multiple foreign body ingestions, leading to failure of a screw at the ileocecal valve at day 5 of ingestion, despite conservative management with serial bowel preparations and abdominal radiographs. There is limited evidence on the management of foreign bodies after distal migration to the ligament of Trietz. Existing literature and guidelines suggest surgically managing the sharp foreign bodies after the failure of conservative management for three to five days. In the case report, we have attempted to emphasize the noninvasive, colonoscopic approach as initial management in removing impacted foreign bodies. This abstract has been presented and accepted at the American college of gastroenterology meeting held from October 22, 2021, to October 27, 2021, in Las Vegas as a poster.
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32
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Masood M. Intentional Foreign Body Ingestions: A Complex, Recurrent and Costly Issue. AMERICAN JOURNAL OF CASE REPORTS 2021; 22:e934164. [PMID: 34780394 PMCID: PMC8607049 DOI: 10.12659/ajcr.934164] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/03/2022]
Abstract
Patient: Male, 23-year-old
Final Diagnosis: Foreign body ingestion
Symptoms: Abdominal pain • nausea
Medication: —
Clinical Procedure: —
Specialty: Gastroenterology and Hepatology • General and Internal Medicine • Psychiatry • Toxicology
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Affiliation(s)
- Muaaz Masood
- Department of Internal Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA
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33
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Alemu S, Bayileyegn NS, Arefayine MB. Swallowed Metallic Spoon Causing Doudeno-Jejunal Junction Perforation in a 13-Year-Old Child: Case Report. Int Med Case Rep J 2021; 14:731-734. [PMID: 34675692 PMCID: PMC8521338 DOI: 10.2147/imcrj.s331039] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/25/2021] [Accepted: 09/23/2021] [Indexed: 11/29/2022] Open
Abstract
Background A child swallowing a long metallic spoon is an extremely rare phenomenon. Foreign bodies longer than 6 cm are unlikely to pass through the gastrointestinal tract spontaneously and require endoscopic or surgical removal in order to avoid associated complications, such as visceral perforations. Case Details A 13-year-old child presented with accidental swallowing of a metallic spoon 10 days prior to hospital admission. He had history of loss of appetite, epigastric and left upper quadrant abdominal pain and started to have high grade intermittent fever 11 days after swallowing the spoon. A plain abdominal radiograph revealed a metallic spoon in the mid-abdomen. An exploratory laparotomy revealed an 11 cm long metallic spoon impacted at the duodeno-jejunal junction with walled off perforation and erosion of the mesentery of the colon. The metallic spoon was removed and the perforated site was repaired. The surgery was smooth and the patient recovered fully and was discharged seven days post-operation. Conclusion A swallowed long metallic spoon is unlikely to pass spontaneously and should be removed as soon as possible in order to avoid associated complications like impaction, perforation and subsequent peritonitis.
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Affiliation(s)
- Seifu Alemu
- Department of Surgery, Jimma University, Jimma, Ethiopia
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34
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Byrne J, Huang HW, McRae JC, Babaee S, Soltani A, Becker SL, Traverso G. Devices for drug delivery in the gastrointestinal tract: A review of systems physically interacting with the mucosa for enhanced delivery. Adv Drug Deliv Rev 2021; 177:113926. [PMID: 34403749 DOI: 10.1016/j.addr.2021.113926] [Citation(s) in RCA: 27] [Impact Index Per Article: 6.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/23/2021] [Revised: 07/14/2021] [Accepted: 08/09/2021] [Indexed: 12/14/2022]
Abstract
The delivery of macromolecules via the gastrointestinal (GI) tract remains a significant challenge. A variety of technologies using physical modes of drug delivery have been developed and investigated to overcome the epithelial cell layer of the GI tract for local and systemic delivery. These technologies include direct injection, jetting, ultrasound, and iontophoresis, which have been largely adapted from transdermal drug delivery. Direct injection of agents using needles through endoscopy has been used clinically for over a century. Jetting, a needle-less method of drug delivery where a high-speed stream of fluid medication penetrates tissue, has been evaluated pre-clinically for delivery of agents into the buccal mucosa. Ultrasound has been shown to be beneficial in enhancing delivery of macromolecules, including nucleic acids, in pre-clinical animal models. The application of an electric field gradient to drive drugs into tissues through the technique of iontophoresis has been shown to deliver highly toxic chemotherapies into GI tissues. Here in, we provide an in-depth overview of these physical modes of drug delivery in the GI tract and their clinical and preclinical uses.
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Affiliation(s)
- James Byrne
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Harvard Radiation Oncology Program, Boston, MA 02114, USA; Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA; Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52240, USA
| | - Hen-Wei Huang
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
| | - James C McRae
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
| | - Sahab Babaee
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
| | - Amin Soltani
- Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
| | - Sarah L Becker
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
| | - Giovanni Traverso
- Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Smart pills for gastrointestinal diagnostics and therapy. Adv Drug Deliv Rev 2021; 177:113931. [PMID: 34416311 DOI: 10.1016/j.addr.2021.113931] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/31/2021] [Revised: 08/03/2021] [Accepted: 08/13/2021] [Indexed: 12/13/2022]
Abstract
Ingestible smart pills have the potential to be a powerful clinical tool in the diagnosis and treatment of gastrointestinal disease. Though examples of this technology, such as capsule endoscopy, have been successfully translated from the lab into clinically used products, there are still numerous challenges that need to be overcome. This review gives an overview of the research being done in the area of ingestible smart pills and reports on the technical challenges in this field.
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36
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Vaz-Pereira R, Ferreira C, Monteiro A, Guidi G, Martins D, Pinto-de-Sousa J. Intestinal perforation on an incarcerated incisional hernia secondary to an ingested foreign body. Report of a rare case. J Surg Case Rep 2021; 2021:rjab348. [PMID: 34408841 PMCID: PMC8364787 DOI: 10.1093/jscr/rjab348] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/13/2021] [Accepted: 07/22/2021] [Indexed: 11/21/2022] Open
Abstract
Ingestion of foreign bodies (FBs) is common and rarely has consequences for the patient, but sometimes it can originate gastrointestinal perforation and lead to devastating consequences if unrecognized. Therefore, whenever present, bowel perforation demands immediate surgical treatment. An 89-year-old woman with an incarcerated incisional hernia, whose imaging study was consistent with intestinal occlusion and perforation within the hernia sac was treated at our hospital. A segmental enterectomy and direct correction of the hernial defect were performed. A perforation in the mesenteric border due to a FB, which seemed to be a toothpick, was identified in the surgical specimen. Nine months after surgery, the patient was without complaints, with adequate healing, and without evidence of hernial recurrence. To the best of our knowledge, this is the first case of intestinal perforation on an incarcerated incisional hernia, due to an ingested FB, reported in the literature.
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Affiliation(s)
- Ricardo Vaz-Pereira
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
| | - Cátia Ferreira
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
| | - Ana Monteiro
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
| | - Gonçalo Guidi
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
| | - Daniela Martins
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
| | - João Pinto-de-Sousa
- Department of General Surgery, Centro Hospitalar De Trás-Os-Montes E Alto Douro, E.P.E, Av. Noruega, 5000-508 Vila Real, Portugal
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Kumar D, Venugopalan Nair A, Nepal P, Alotaibi TZ, Al-Heidous M, Blair Macdonald D. Abdominal CT manifestations in fish bone foreign body injuries: What the radiologist needs to know. Acta Radiol Open 2021; 10:20584601211026808. [PMID: 34377536 PMCID: PMC8330480 DOI: 10.1177/20584601211026808] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2021] [Accepted: 06/02/2021] [Indexed: 01/08/2023] Open
Abstract
Fish bone is one of the most common foreign body ingestions encountered in the emergency department. Fish bone perforations occur most commonly in segments with acute angulation like the ileocecal region and rectosigmoid junction and can present acutely with obstruction and free air or with chronic complications like abscess and sepsis. Radiologists should be familiar with the high-risk clinical scenarios, the CT appearance of radiopaque fishbones, and the spectrum of imaging findings related to gastrointestinal (GI) tract so as to direct management and timely referral to GI endoscopists and surgeons.
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Affiliation(s)
- Devendra Kumar
- Department of Clinical Imaging, Al Wakra Hospital, Hamad Medical Corporation, Doha, Qatar
| | | | - Pankaj Nepal
- Department of Radiology, St Vincent's Medical Center, Bridgeport, CT, USA
| | - Tariq Za Alotaibi
- Department of medical imaging, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
| | - Mahmoud Al-Heidous
- Department of Clinical Imaging, Al Wakra Hospital, Hamad Medical Corporation, Doha, Qatar
| | - David Blair Macdonald
- Department of Radiology, University of Ottawa, Ottawa, ON, Canada.,Department of Medical Imaging, The Ottawa Hospital Research Institute, Ottawa, ON, Canada
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Sunnapwar A, Ojili V, Katre R, Shah H, Nagar A. Multimodality imaging of adult gastric emergencies: A pictorial review. Indian J Radiol Imaging 2021; 27:13-22. [PMID: 28515579 PMCID: PMC5385768 DOI: 10.4103/0971-3026.202957] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022] Open
Abstract
Acute gastric emergencies require urgent surgical or nonsurgical intervention because they are associated with high morbidity and mortality. Imaging plays an important role in diagnosis since the clinical symptoms are often nonspecific and radiologist may be the first one to suggest a diagnosis as the imaging findings are often characteristic. The purpose of this article is to provide a comprehensive review of multimodality imaging (plain radiograph, fluoroscopy, and computed tomography) of various life threatening gastric emergencies.
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Affiliation(s)
- Abhijit Sunnapwar
- Department of Body Imaging, University of Texas Health Science Center, San Antonio, Texas, USA
| | - Vijayanadh Ojili
- Department of Body Imaging, University of Texas Health Science Center, San Antonio, Texas, USA
| | - Rashmi Katre
- Department of Body Imaging, University of Texas Health Science Center, San Antonio, Texas, USA
| | - Hardik Shah
- Department of Body Imaging, University of Texas Health Science Center, San Antonio, Texas, USA
| | - Arpit Nagar
- Department of Body Imaging, Ohio State University Wexner Medical Center, Ohio, USA
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39
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Masaoka R, Masaoka R, Hayashi K, Suzuki Y, Katayama Y, Tamano M. Two cases of gastric penetration by fish bones with differing courses. Oxf Med Case Reports 2021; 2021:omab060. [PMID: 34306725 PMCID: PMC8297643 DOI: 10.1093/omcr/omab060] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/27/2021] [Revised: 06/04/2021] [Accepted: 06/16/2021] [Indexed: 11/13/2022] Open
Abstract
Most foreign bodies swallowed accidentally are naturally excreted. Gastric penetration by a fish bone is rare due to anatomical and physiological features such as the thick stomach wall, wide lumen and gastric acid. The most common penetration site is the antral region. The clinical course of fish bone penetration of the gastric antrum may differ depending on the direction of penetration. In this report, two cases of gastric perforation by fish bones that followed different courses are presented. One case was treated conservatively with antibiotics alone, and another case was considered for surgery, due to increased hematoma and penetration of the fish bone into the pancreas. However, the patient's comorbidities were so severe that surgery was not possible, resulting in meticulous follow-up. Diagnostic imaging was important in these cases.
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Affiliation(s)
- Ryo Masaoka
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
| | - Rion Masaoka
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
| | - Kazunori Hayashi
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
| | - Yuto Suzuki
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
| | - Yasumi Katayama
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan.,Endoscopy Center, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
| | - Masaya Tamano
- Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Koshigaya City, Japan
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40
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Than DJ, Seak JCK, Bolong MF, Hayati F. Bucket of nails: Foreign body ingestion in a young adult. ANZ J Surg 2021; 92:563-565. [PMID: 34270176 DOI: 10.1111/ans.17073] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/09/2021] [Revised: 07/05/2021] [Accepted: 07/05/2021] [Indexed: 11/29/2022]
Affiliation(s)
- Da Jun Than
- Department of Surgery, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia
| | - Jonathan Chen Ken Seak
- Department of Surgery, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia
| | - Mohd Firdaus Bolong
- Department of Emergency Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia
| | - Firdaus Hayati
- Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia
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41
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Wood ML, Potnuru PP, Nair S. Inpatient Pediatric Foreign Body Ingestion: National Estimates and Resource Utilization. J Pediatr Gastroenterol Nutr 2021; 73:37-41. [PMID: 33797450 DOI: 10.1097/mpg.0000000000003143] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/08/2023]
Abstract
OBJECTIVE We generated national estimates of patient and hospitalization characteristics for pediatric inpatient admissions for foreign body ingestion (FBI) and compared these to admissions for other reasons. We further identified characteristics that were independently associated with length of stay (LOS). Finally, we hypothesized that endoscopy within 24 hours of admission was independently associated with a shorter LOS in patients admitted for FBI. METHODS In this retrospective study, we used data from the Kids' Inpatient Database for 2016. Admissions for FBI were identified and national estimates of patient and hospitalization characteristics were generated. Patients admitted for FBI were compared to patients admitted for other causes. Data were analyzed for independent associations with LOS. Subgroup analysis was performed to determine whether early endoscopy was associated with a shorter LOS. RESULTS A total of 2464 admissions for FBI were identified in the database. The median (interquartile range) patient age was 4 (1-11) years with a slight male predominance. Most patients (82.6%) had an endoscopy performed during admission. Independent factors associated with increased LOS included: airway procedures, intra-abdominal surgery, psychiatric diagnosis, esophageal disorder, and developmental delay. Among patients who required endoscopy, 56.7% were performed early (within 24 hours). Early endoscopy was independently associated with a 35% shorter LOS (incidence rate ratio = 0.65, 95% confidence interval 0.54-0.80; P=0.009). CONCLUSIONS Inpatient admissions for FBI frequently require endoscopy and have a short LOS. In patients who require endoscopy during the admission, early endoscopy (within 24 hours of admission) may be associated with a shorter LOS.
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Affiliation(s)
- Mary L Wood
- Division of Gastroenterology, Department of Pediatrics
| | - Paul P Potnuru
- Department of Anesthesiology, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX
| | - Supriya Nair
- Division of Gastroenterology, Department of Pediatrics
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42
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Tavallaei M, Bahadorinia M, Haj Mohamad Ebrahim Ketabforoush A. Intentional Ingestion of a Metallic Wire Causing Perforation and Retroperitoneal Abscess: A Case Report. CLINICAL MEDICINE INSIGHTS-CASE REPORTS 2021; 14:11795476211025919. [PMID: 34262387 PMCID: PMC8252360 DOI: 10.1177/11795476211025919] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/08/2021] [Accepted: 05/30/2021] [Indexed: 12/11/2022]
Abstract
Foreign body ingestion is a frequent condition, with the majority of foreign bodies (FBs) tending to spontaneously proceed along the gastrointestinal tract without any major complications. A wide range of procedures are available to remove FBs; however, a real challenge exists in managing sharp, rigid, and long foreign objects, which are related to higher rates of complications. A 34-year-old man who intentionally swallowed a metallic wire of 20 cm length, presented to our ED with abdominal pain 2 weeks after the ingestion. The FB had migrated to the stomach and duodenum. Complications included perforation of the duodenum and ascending colon and a retroperitoneal abscess. FB removal was done via laparotomy, followed by the repair of perforations and damaged tissues. This case highlights the complications of a FB presence in the gastrointestinal tract for 14 days and emphasizes the importance of urgent and appropriate management of such conditions.
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Affiliation(s)
- Mehdi Tavallaei
- Department of Surgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
| | - Mahsa Bahadorinia
- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
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43
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Hoff JW, Castrisos G, Sivasuthan G, Renwick C. Laparoscopic Management of Hepatic Abscess From Ingested Chicken Bone. Cureus 2021; 13:e13403. [PMID: 33758700 PMCID: PMC7978156 DOI: 10.7759/cureus.13403] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/02/2023] Open
Abstract
A 68-year-old man presented to the hospital with severe right upper abdominal pain, fevers, nausea and lethargy. He deteriorated into septic shock and was found to have a hepatic abscess on computer tomography imaging. After multiple investigations and continual deterioration, he underwent an exploratory laparoscopy which revealed a chicken bone within the liver parenchyma resulting in a large hepatic abscess. The patient required a second laparoscopic washout and prolonged antibiotics, subsequently recovering well. This rare case highlights the difficulty in diagnosing hepatic abscesses caused by gastrointestinal foreign bodies, and successful management with laparoscopic surgery.
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Affiliation(s)
- Jai W Hoff
- General Surgery, Rockhampton Hospital, Rockhampton, AUS
| | | | | | - Clay Renwick
- General Surgery, Rockhampton Hospital, Rockhampton, AUS
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44
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Khuroo S, Wani AA, Kaur I, Razdan A, Gupta G. Unusual Richter's Hernia: Impacted foreign body leading to incarceration and perforation - A rare clinical entity. Int J Surg Case Rep 2021; 79:492-495. [PMID: 33757269 PMCID: PMC7889443 DOI: 10.1016/j.ijscr.2021.01.088] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/01/2021] [Revised: 01/18/2021] [Accepted: 01/18/2021] [Indexed: 11/16/2022] Open
Abstract
The knowledge about this type of hernia has especially gained importance in the context of laparoscopic surgery as majority of the laparoscopic port site hernias are characteristically Richter’s type in configuration. Clinical suspicion, prompt radiological diagnosis and timely surgery can lead to an uneventful recovery. Surgery is the only treatment, but timely surgery remains the golden opportunity. Introduction & Importance Richter’s hernia is a clinically deceiving entity as is particularly associated with high morbidity and mortality which can be can be abated by timely diagnosis and surgery. Direct inguinal hernias having a wide neck have lesser chances of incarceration and strangulation when compared to indirect inguinal hernias. The knowledge about this type of hernia is especially important in the context of laparoscopy as majority of the laparoscopic port site hernias are characteristically Richter’s type in configuration. The objective of this report is to highlight the unusual presentation of the case and sine quo non of prompt diagnosis and timely surgery remains the cornerstone of management. Case presentation We report a case of Richter’s hernia incarcerated due to an impacted foreign body (match stick) through a direct inguinal hernia. Patient presented with a painful, non-expansile, tender swelling in left groin. Patient was diagnosed with a complicated inguinal hernia and underwent exploration with resection of involved bowel segment and primary repair of hernia. Clinical discussion Richter’s hernia is a rare abdominal wall hernia specifically known for its unusual and delayed presentation leading to high rates of morbidity and mortality. Direct inguinal hernias are less prone to complications like obstruction, strangulation and incarceration owing to presence of a wide neck. Clinical suspicion, prompt radiological diagnosis and timely surgery can lead to an uneventful recovery. Conclusion Surgery is the only treatment, but timely surgery remains the golden opportunity. Critical in repair is the evaluation of intestinal viability.
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Affiliation(s)
- Suhail Khuroo
- Department of Surgical Gastroenterology, Shri Mata Vaishno Devi Narayana Super-Specialty Hospital, Kakryal, Jammu and Kashmir, 182320, India.
| | - Ajaz Ahmed Wani
- Department of Surgical Gastroenterology, Shri Mata Vaishno Devi Narayana Super-Specialty Hospital, Kakryal, Jammu and Kashmir, 182320, India
| | - Ishmeet Kaur
- Department of Radiodiagnosis, Shri Mata Vaishno Devi Narayana Super-Specialty Hospital, Kakryal, Jammu and Kashmir, 182320, India
| | - Avinash Razdan
- Department of Radiodiagnosis, Shri Mata Vaishno Devi Narayana Super-Specialty Hospital, Kakryal, Jammu and Kashmir, 182320, India
| | - Geetanjali Gupta
- Department of Radiodiagnosis, Shri Mata Vaishno Devi Narayana Super-Specialty Hospital, Kakryal, Jammu and Kashmir, 182320, India
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45
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Abstract
Ingestion of foreign bodies is common within the pediatric population; in adults, it occurs more commonly in those with a psychiatric background. Diagnosis of such cases can be readily made based on plain abdominal X-rays. As reported, many foreign bodies pass through the gastrointestinal tract without complications, obstruction, bleeding, and perforation. The ultimate decision of the best management approach for such cases should be made based on the available expertise as well as the patient's specific factors. Observation, endoscopic removal, and surgical intervention are all acceptable approaches in cases of metal foreign body ingestion. We report a case of a 29-year-old male patient brought to the emergency department following ingestion of multiple sharp nails. He underwent surgical exploration, which resulted in the retrieval of 73 metallic nails.
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Affiliation(s)
- Ahmed M AlMuhsin
- Department of General Surgery, Security Forces Hospital, Dammam, SAU
| | - Fatima Alsalman
- Department of General Surgery, Security Forces Hospital, Dammam, SAU
| | - Ahmad Bubshait
- Department of General Surgery, Security Forces Hospital, Dammam, SAU
| | - Rami O Abu Hajar
- Department of General Surgery, Security Forces Hospital, Dammam, SAU
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46
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Intestinal Perforation by Ingested Foreign Bodies. Int Surg 2021. [DOI: 10.9738/intsurg-d-15-00303.1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
The aim of our article is to study the incidence, diagnosis, and treatment of bowel perforation by foreign body ingestion. Bowel perforation by foreign body ingestion has been believed to be relatively rare, and most commonly caused by fish bones, chicken bones, and toothpicks. Our clinical experience, however, suggests such perforations may be more common than previously thought, and caused by various other objects as well. Medical records of all patients diagnosed with foreign body–induced intestinal perforation, from the Department of General Surgery at Tonji Hospital, from January 2000 to June 2015, were retrospectively analyzed. A total of 17 men and 8 women suffered intestinal perforations by ingestion of dietary foreign bodies. Among the 25 total patients, 4 ingested foreign bodies intentionally, whereas the other 21 cases were accidental. The foreign bodies were identified by plain X-ray film in 2 patients (2 cases of needles) and by multidetector computed tomography (MDCT) in 11 patients (6 cases of date stones, 3 cases of metallic objects, and 2 cases of bone fragments), thus supporting the correct preoperative diagnosis (13 cases; 52%). The most common location of the perforation was the terminal ileum (n = 17). The offending objects were date stones (n = 13), bones (n = 7), and metallic objects (n = 5). The most common treatment was removal of the foreign body and closure of the perforation with simple suture (n = 22). Ten patients were treated laparoscopically. The present study shows that the most common foreign bodies causing intestinal perforation are date stones and bones. Although about 50% of the foreign bodies could be identified by MDCT, definite diagnosis remained preoperatively difficult. Consequently, because of high misdiagnosis rates, laparoscopy may be the optimal choice for diagnosis and treatment of bowel perforation by foreign bodies.
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47
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Shnaydman I, Ferrantella A, Kaufman J. Appendicostomy for Removal of Foreign Bodies of the Small Bowel. Am Surg 2020:3134820972991. [PMID: 33345549 DOI: 10.1177/0003134820972991] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Affiliation(s)
- Ilya Shnaydman
- Department of Surgery, 23215Jackson Memorial Hospital, Miami, FL, USA
| | | | - Joyce Kaufman
- Department of Surgery, 23215Jackson Memorial Hospital, Miami, FL, USA
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48
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Multidisciplinary Management of an Aorto-esophageal Injury Caused by Foreign Body Ingestion. Ann Vasc Surg 2020; 72:668.e1-668.e4. [PMID: 33333195 DOI: 10.1016/j.avsg.2020.10.039] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/25/2020] [Revised: 10/21/2020] [Accepted: 10/27/2020] [Indexed: 11/23/2022]
Abstract
A 37-year-old incarcerated male ingested a complex "X-shaped" foreign body that resulted in a penetrating aorto-esophageal injury. A primary esophagotomy with retrieval of the foreign body and muscle flap closure was performed simultaneously with thoracic endovascular aortic repair. This multidisciplinary surgical approach controls for both immediate exsanguination and postoperative complications to improve patient outcome.
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49
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Traynor P, Stupalkowska W, Mohamed T, Godfrey E, Bennett JMH, Gourgiotis S. Fishbone perforation of the small bowel mimicking internal herniation and obstruction in a patient with previous gastric bypass surgery. J Surg Case Rep 2020; 2020:rjaa369. [PMID: 33005325 PMCID: PMC7515512 DOI: 10.1093/jscr/rjaa369] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/30/2020] [Accepted: 08/18/2020] [Indexed: 11/21/2022] Open
Abstract
Intestinal perforation following the ingestion of fishbone is unusual and rarely diagnosed preoperatively, as clinical and radiological findings are non-specific. We report a case of a female patient post Roux-en-Y gastric bypass (RYGBP) for obesity, who presented with severe abdominal pain and guarding in left iliac fossa. Computed tomography (CT) suggested internal herniation with compromised vascular supply to the bowel. Exploratory laparotomy identified a perforation site in the blind loop of the RYGBP due to a protruding fishbone. After extraction, primary suture repair was performed. In retrospect, the fishbone was identified on CT but misinterpreted as suture line at the enteroenterostomy site. This case emphasizes that although rare, the ingestion of fishbone can lead to severe complications and should therefore be included in the differential for an acute abdomen. On CT, it should be noted that fishbone may simulate suture line within the bowel if the patient has history of previous surgery.
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Affiliation(s)
- Paul Traynor
- Department of Surgery, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
| | - Weronika Stupalkowska
- Department of Surgery, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
| | - Tahira Mohamed
- Department of Surgery, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
| | - Edmund Godfrey
- Department of Radiology, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
| | - John M H Bennett
- Department of Surgery, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
| | - Stavros Gourgiotis
- Department of Surgery, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge, UK
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50
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Shahid F, Abdalla SO, Elbakary T, Elfaki A, Ali SM. Fish Bone Causing Perforation of the Intestine and Meckel's Diverticulum. Case Rep Surg 2020; 2020:8887603. [PMID: 33014507 PMCID: PMC7525315 DOI: 10.1155/2020/8887603] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2020] [Revised: 08/14/2020] [Accepted: 09/09/2020] [Indexed: 01/29/2023] Open
Abstract
Perforation of small bowel due to ingested fish bone is rare, the most common site is ileum and occasionally, it can involve the appendix and/or Meckel diverticulum. We report six patients who, developed bowel perforation after fish bone ingestion, four of them found to have rent in the ileum and two through Meckel's diverticulum and presented with abdominal pain and localized peritonitis. All underwent surgical exploration and removal of the fish bone and closure of the small intestine/excision of the diverticulum. Foreign body ingestion should be kept in mind in suspicious cases, and laparoscopy is very important to diagnose such rare cases as they may commonly be missed by imaging.
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Affiliation(s)
- Fakhar Shahid
- Department of Surgery, Hamad Medical Corporation, Doha, Qatar
| | | | - Tamer Elbakary
- Department of Surgery, Al-Wakra Hospital, HMC, Al-Wakra, Qatar
| | - Ahmad Elfaki
- Department of Surgery, Al-Wakra Hospital, HMC, Al-Wakra, Qatar
| | - Syed Muhammad Ali
- Department of Acute Care Surgery, Hamad Medical Corporation, Doha, Qatar
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