Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Bassetti M, Eckmann C, Giacobbe DR, Sartelli M, Montravers P. Post-operative abdominal infections: epidemiology, operational definitions, and outcomes. Intensive Care Med 2019;46:163-172. [PMID: 31701205 DOI: 10.1007/s00134-019-05841-5] [Citation(s) in RCA: 36] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/03/2019] [Accepted: 10/23/2019] [Indexed: 12/29/2022]

For:	Bassetti M, Eckmann C, Giacobbe DR, Sartelli M, Montravers P. Post-operative abdominal infections: epidemiology, operational definitions, and outcomes. Intensive Care Med 2019;46:163-172. [PMID: 31701205 DOI: 10.1007/s00134-019-05841-5] [Citation(s) in RCA: 36] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/03/2019] [Accepted: 10/23/2019] [Indexed: 12/29/2022]

Number

Cited by Other Article(s)

Maurer LR, Martin ND. Sepsis management of the acute care surgery patient: What you need to know. J Trauma Acute Care Surg 2025;98:533-540. [PMID: 40122845 DOI: 10.1097/ta.0000000000004467] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/25/2025]

Chen J, Song C, Guo X. Effects of seamless care in the perioperative management of laparoscopic pancreatoduodenectomy on patients' quality of life and postoperative complications. Sci Rep 2025;15:8726. [PMID: 40082622 PMCID: PMC11906768 DOI: 10.1038/s41598-025-92871-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2024] [Accepted: 03/03/2025] [Indexed: 03/16/2025] Open

Li Q, Wei C, Xu L, Zhang J, Li Y, Lu X, Xu R, Guo H, Cao P, Ouyang C, Xu J, Chen W, Wang Z, Wang L. A Smart Semi-Implantable Device Integrating Microchannel-Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification. ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY) 2025;12:e2407868. [PMID: 39741227 PMCID: PMC11848630 DOI: 10.1002/advs.202407868] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/11/2024] [Revised: 12/19/2024] [Indexed: 01/02/2025]

Affiliation(s)

Qilin Li Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Chunyu Wei Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Luming Xu Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Jiao Zhang Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Yuyu Li Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Xiaohuan Lu Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Gastrointestinal SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Rengui Xu Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Honglian Guo Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Peng Cao Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Chenke Ouyang Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Jiarong Xu Department of PharmacologySchool of Basic MedicineState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesTongji‐Rongcheng Center for BiomedicineTongji Medical CollegeHuazhong University of Science and TechnologyHubei Key Laboratory for Drug Target Research and Pharmacodynamic EvaluationHuazhong University of Science and TechnologyWuhan430030China
Wei Chen Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of PharmacologySchool of Basic MedicineState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesTongji‐Rongcheng Center for BiomedicineTongji Medical CollegeHuazhong University of Science and TechnologyHubei Key Laboratory for Drug Target Research and Pharmacodynamic EvaluationHuazhong University of Science and TechnologyWuhan430030China
Zheng Wang Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Gastrointestinal SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China
Lin Wang Department of Clinical LaboratoryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key Laboratory of Regenerative Medicine and Multi‐disciplinary Translational ResearchHubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart EquipmentResearch Center for Tissue Engineering and Regenerative MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Collapse

Xu T, Song S, Zhu K, Yang Y, Wu C, Wang N, Lu S. Systemic inflammatory response index improves prognostic predictive value in intensive care unit patients with sepsis. Sci Rep 2025;15:1908. [PMID: 39809872 PMCID: PMC11732978 DOI: 10.1038/s41598-024-81860-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Accepted: 11/29/2024] [Indexed: 01/16/2025] Open

Hussein IS, El-Manakhly AR, Salama AS, Habib AAED, Marei T, Elkholy JA, Soliman MS, El-Kholy AA. Distribution and Antimicrobial Resistance of Complicated Intraabdominal Infection Pathogens in Two Tertiary Hospitals in Egypt. Surg Infect (Larchmt) 2024;25:682-690. [PMID: 39172656 DOI: 10.1089/sur.2023.375] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/24/2024] Open

Abstract

Background: Management of complicated intraabdominal infections (cIAIs) requires containment of the source and appropriate initial antimicrobial therapy. Identifying the local data is important to guide the empirical selection of antimicrobial therapy. In this study, we aimed to describe the pathogen distribution and antimicrobial resistance of cIAI. Methods: In two major tertiary care hospitals in Egypt, we enrolled patients who met the case definition of cIAI from October 2022 to September 2023. Blood cultures were performed using the BACTAlert system (BioMerieux, Marcy l'Etoile, France). A culture of aspirated fluid, resected material, or debridement of the infection site was performed. Identification of pathogens and antimicrobial susceptibility testing were conducted by the VITEK-2 system (BioMerieux, Marcy l'Etoile, France). Gram-negative resistance genes were identified by PCR and confirmed by whole bacterial genome sequencing using the Nextera XT DNA Library Preparation Kit and sequencing with the MiSeq Reagent Kit 600 v3 (Illumina, USA) on the Illumina MiSeq. Results: We enrolled 423 patients, 275 (65.01%) males. The median age was 61.35 (range 25-72 years). We studied 452 recovered bacterial isolates. Gram-negative bacteria were the vast majority, dominated by E. coli, followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Proteus mirabilis (33.6%, 30.5%, 13.7%, 13%, and 5.4%, respectively). High rates of resistance were detected to third- and fourth-generation cephalosporins and fluoroquinolones. No resistance was detected to colistin. Resistance to amikacin and tigecycline was low among all isolates. Resistance to meropenem and ceftazidime/avibactam was moderate. ESBL genes were common in E. coli and K. pneumoniae. CTX-M15 gene was the most frequent. Among Enterobacterales, blaOXA-48 and blaNDM were the most prevalent carbapenemase genes. Pseudomonas aeruginosa isolates harbored a wide variety of carbapenemase genes (OXA, NDM, VIM, SIM, GIM, SPM, IMP, AIM), dominated by metallo-beta-lactamases. In 20.6% of isolates, we identified two or more resistance genes. Conclusion: High resistance rates were detected to third- and fourth-generation cephalosporins and fluoroquinolones. Amikacin and tigecyclines were the most active antimicrobials. Our data call for urgent implementation of antimicrobial stewardship programs and reinforcement of infection control.

Collapse

Itami T, Kurokawa Y, Yoshioka R, Saito T, Yamamoto K, Takahashi T, Momose K, Yamashita K, Tanaka K, Makino T, Nakajima K, Eguchi H, Doki Y. Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY 2024;50:108564. [PMID: 39089184 DOI: 10.1016/j.ejso.2024.108564] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/14/2024] [Revised: 07/08/2024] [Accepted: 07/22/2024] [Indexed: 08/03/2024]

Roat E, Tosi M, Coloretti I, Bondi F, Chierego G, De Julis S, Talamonti M, Biagioni E, Busani S, Di Sandro S, Franceschini E, Guerrini GP, Meschiari M, Di Benedetto F, Mussini C, Girardis M. Perioperative Use of IgM-Enriched Immunoglobulins in Liver Transplantation Recipients at High Risk for Infections: A Preliminary Study. J Clin Med 2024;13:4965. [PMID: 39201107 PMCID: PMC11355682 DOI: 10.3390/jcm13164965] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2024] [Revised: 08/19/2024] [Accepted: 08/20/2024] [Indexed: 09/02/2024] Open

Affiliation(s)

Erika Roat Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Martina Tosi Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Irene Coloretti Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Filippo Bondi Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Giovanni Chierego Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Stefano De Julis Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Marta Talamonti Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Emanuela Biagioni Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Stefano Busani Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)
Stefano Di Sandro Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (S.D.S.); (G.P.G.); (F.D.B.)
Erika Franceschini Infectious Disease Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (E.F.); (M.M.); (C.M.)
Gian Piero Guerrini Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (S.D.S.); (G.P.G.); (F.D.B.)
Marianna Meschiari Infectious Disease Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (E.F.); (M.M.); (C.M.)
Fabrizio Di Benedetto Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (S.D.S.); (G.P.G.); (F.D.B.)
Cristina Mussini Infectious Disease Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41121 Modena, Italy; (E.F.); (M.M.); (C.M.)
Massimo Girardis Anesthesia and Intensive Care Unit, University Hospital of Modena, University of Modena and Reggio Emilia, L.go del Pozzo 71, 41125 Modena, Italy; (E.R.); (M.T.); (I.C.); (F.B.); (G.C.); (S.D.J.); (M.T.); (E.B.); (S.B.)

Collapse

Zhang FL, Xu J, Jiang YH, Zhu YD, Wu QN, Shi Y, Zhan ZY, Wang H. Special stent for draining the abdominal abscess respectively from colon and duodenum: A case report. World J Clin Cases 2024;12:3931-3935. [PMID: 38994300 PMCID: PMC11235422 DOI: 10.12998/wjcc.v12.i19.3931] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/20/2024] [Revised: 04/22/2024] [Accepted: 05/14/2024] [Indexed: 06/29/2024] Open

Hamel JF, Alves A, Beyer-Bergot L, Zerbib P, Bridoux V, Manceau G, Panis Y, Buscail E, Khaoudy I, Gaillard M, Viennet M, Thobie A, Menahem B, Eveno C, Bonnel C, Mabrut JY, Badic B, Godet C, Eid Y, Duchalais E, Lakkis Z, Cotte E, Laforest A, Defourneaux V, Maggiorri L, Rebibo L, Christou N, Talal A, Mege D, Aubert M, Bonnamy C, Germain A, Mauvais F, Tresallet C, Roudie J, Laurent A, Trilling B, Bertrand M, Massalou D, Romain B, Tranchart H, Ouaissi M, Pellegrin A, Sabbagh C, Venara A. Stenosis of the colorectal anastomosis after surgery for diverticulitis: A national retrospective cohort study. Colorectal Dis 2024;26:1437-1446. [PMID: 38886887 DOI: 10.1111/codi.17076] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/09/2023] [Revised: 05/11/2024] [Accepted: 05/25/2024] [Indexed: 06/20/2024]

Abstract

AIM

The aim of this work was to investigate the association between early postoperative anastomotic leakage or pelvic abscess (AL/PA) and symptomatic anastomotic stenosis (SAS) in patients after surgery for left colonic diverticulitis.

METHOD

This is a retrospective study based on a national cohort of diverticulitis surgery patients carried out by the Association Française de Chirurgie. The assessment was performed using path analyses. The database included 7053 patients operated on for colonic diverticulitis, with surgery performed electively or in an emergency, by open access or laparoscopically. Patients were excluded from the study analysis where there was (i) right-sided diverticulitis (the initial database included all consecutive patients operated on for colonic diverticulitis), (ii) no anastomosis was performed during the first procedure or (iii) missing information about stenosis, postoperative abscess or anastomotic leakage.

RESULTS

Of the 4441 patients who were included in the final analysis, AL/PA occurred in 327 (4.6%) and SAS occurred in 82 (1.8%). AL/PA was a significant independent factor associated with a risk for occurrence of SAS (OR = 3.41, 95% CI = 1.75-6.66), as was the case for diverting stoma for ≥100 days (OR = 2.77, 95% CI = 1.32-5.82), while central vessel ligation proximal to the inferior mesenteric artery was associated with a reduced risk (OR = 0.41; 95% CI = 0.19-0.88). Diverting stoma created for <100 days or ≥100 days was also a factor associated with a risk for AL/PA (OR = 3.08, 95% CI = 2-4.75 and OR = 12.95, 95% CI = 9.11-18.50). Interestingly, no significant association between radiological drainage or surgical management of AL/PA and SAS could be highlighted.

CONCLUSION

AL/PA was an independent factor associated with the risk for SAS. The treatment of AL/PA was not associated with the occurrence of anastomotic stenosis. Diverting stoma was associated with an increased risk of both AL/PA and SAS, especially if it was left for ≥100 days. Physicians must be aware of this information in order to decide on the best course of action when creating a stoma during elective or emergency surgery.

Collapse

Affiliation(s)

Jean-Francois Hamel Faculty of Health, Department of Medicine, University of Angers, Angers, France Department of Biostatistics, University Hospital of Angers, Angers, France
Arnaud Alves Department of Digestive Surgery, University Hospital of Caen, Caen, France
Laura Beyer-Bergot Department of Digestive Surgery Assistance, Publique Hôpitaux de Marseille, North University Hospital, Marseille, France
Philippe Zerbib Department of Digestive Surgery and Transplantation, Huriez Hospital, Université Lille Nord de France, Lille, France
Valérie Bridoux Department of Digestive Surgery, University Hospital of Rouen, Rouen, France
Gilles Manceau Department of Surgery, European Georges Pompidou Hospital, Paris, France
Yves Panis Colorectal Surgery Center, Groupe Hospitalier Privé Ambroise Paré-Hartmann, Neuilly/Seine, France
Etienne Buscail Department of Surgery, CHU Toulouse-Rangueil and Toulouse University, Toulouse, France
Iman Khaoudy Department of Digestive Surgery, Le Havre Hospital, Le Havre, France
Martin Gaillard Department of Digestive Surgery, Cochin Hospital, Paris, France
Manon Viennet Department of General Surgery, University Hospital of Bocage, Dijon, France
Alexandre Thobie Department of Digestive Surgery, Avranches-Granville Hospital, Avranches, France
Benjamin Menahem Department of Digestive Surgery, University Hospital of Caen, Caen, France
Clarisse Eveno Department of Digestive Surgery, University Hospital of Lille, Lille, France
Catherine Bonnel Department of Digestive Surgery, Nord-Essonne Hospital, Longjumeau, France
Jean-Yves Mabrut Department of Digestive Surgery and Transplantation, Croix Rousse University Hospital, Lyon, France
Bodgan Badic Department of General and Digestive Surgery, University Hospital, Brest, France
Camille Godet Department of Digestive Surgery, Memorial Hospital of Saint-Lô, Saint-Lô, France
Yassine Eid Department of Digestive Surgery, Robert Bisson Hospital, Lisieux, France
Emilie Duchalais Department of Oncological, Digestive and Endocrine Surgery, University Hospital of Nantes, Nantes, France
Zaher Lakkis Department of Digestive Surgical Oncology and Liver Transplantation, University Hospital of Besançon, Besançon, France
Eddy Cotte Department of Digestive Surgery, Hôpital Lyon Sud, Lyon, France
Anais Laforest Department of Digestive Surgery, Montsouris Institut, Paris, France
Véronique Defourneaux Department of Digestive Surgery, CHU Rennes, Rennes, France
Léon Maggiorri Department of Digestive Surgery, Hôpital Saint-Louis, Université Paris VII, APHP, Paris, France
Lionel Rebibo Department of Digestive, Esogastric and Bariatric Surgery, Hôpital Bichat-Claude-Bernard, Paris, France
Niki Christou Department of Digestive Surgery, Limoges Hospital, Limoges, France
Ali Talal Department of Digestive Surgery, Argentan Hospital, Argentan, France
Diane Mege Department of Digestive Surgery, Aix Marseille Univ, APHM, Timone University Hospital, Marseille, France
Mathilde Aubert Department of Digestive Surgery, Aix Marseille Univ, APHM, Timone University Hospital, Marseille, France
Cécile Bonnamy Department of Digestive Surgery, Bayeux Hospital, Bayeux, France
Adeline Germain Department of Digestive Surgery, CHRU Nancy, Nancy, France
François Mauvais Department of Digestive Surgery, Beauvais Hospital, Beauvais, France
Christophe Tresallet Department of Digestive Surgical Oncology, Avicenne University Hospital, Sorbonne Paris Nord University, Paris, France
Jean Roudie Department of Digestive Surgery, Martinique Hospital, Fort-de-France, France
Alexis Laurent Department of Digestive Surgery, Créteil Hospital, Créteil, France
Bertrand Trilling Department of Digestive and Emergency Surgery, Grenoble Alpes University Hospital, Grenoble, France
Martin Bertrand Department of Digestive Surgery, University Hospital of Nîmes, Nîmes, France
Damien Massalou Department of Digestive Surgery, Hôpital L'Archet, Nice University, Nice, France
Benoit Romain Department of General and Digestive Surgery, Hautepierre Hospital, Strasbourg University Hospital, Strasbourg, France
Hadrien Tranchart Department of Minimally Invasive Digestive Surgery, Antoine Beclere Hospital, Clamart, France
Mehdi Ouaissi Department of Digestive, Oncological, Endocrine, Hepatobiliary and Liver Transplantation, Trousseau Hospital, University Hospital of Tours, Tours, France
Alexandra Pellegrin Department of Surgery, Amiens University Hospital, Amiens, France
Charles Sabbagh Department of Surgery, Amiens University Hospital, Amiens, France
Aurélien Venara Faculty of Health, Department of Medicine, University of Angers, Angers, France UMR INSERM 1235, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France Department of Surgery, Angers University Hospital, Angers, France

Collapse

Mokart D, Boutaba M, Servan L, Bertrand B, Baldesi O, Lefebvre L, Gonzalez F, Bisbal M, Pastene B, Duclos G, Faucher M, Zieleskiewicz L, Chow-Chine L, Sannini A, Boher JM, Ronflé R, Leone M. Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study. Ann Intensive Care 2024;14:98. [PMID: 38916830 PMCID: PMC11199462 DOI: 10.1186/s13613-024-01333-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/10/2024] [Accepted: 06/10/2024] [Indexed: 06/26/2024] Open

Affiliation(s)

Djamel Mokart Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Mehdi Boutaba Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires De Marseille, Aix Marseille University, Marseille, France
Luca Servan Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Benjamin Bertrand Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Olivier Baldesi Réanimation et Surveillance Continue Médico-Chirurgicales Polyvalentes, Centre Hospitalier du Pays d'Aix, Marseille, Aix-en-Provence, France
Laurent Lefebvre Réanimation et Surveillance Continue Médico-Chirurgicales Polyvalentes, Centre Hospitalier du Pays d'Aix, Marseille, Aix-en-Provence, France
Frédéric Gonzalez Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Magali Bisbal Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Bruno Pastene Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires De Marseille, Aix Marseille University, Marseille, France
Gary Duclos Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires De Marseille, Aix Marseille University, Marseille, France
Marion Faucher Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Laurent Zieleskiewicz Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires De Marseille, Aix Marseille University, Marseille, France
Laurent Chow-Chine Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Antoine Sannini Department of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France
Jean Marie Boher Biostatistics and Methodology Unit, Institut Paoli-Calmettes, Marseille, France Aix Marseille University, INSERM, IRD, SESSTIM, Marseille, France
Romain Ronflé Réanimation et Surveillance Continue Médico-Chirurgicales Polyvalentes, Centre Hospitalier du Pays d'Aix, Marseille, Aix-en-Provence, France
Marc Leone Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires De Marseille, Aix Marseille University, Marseille, France

Collapse

Zhao YS, Lai QP, Tang H, Luo RJ, He ZW, Huang W, Wang LY, Zhang ZT, Lin SH, Qin WJ, Xu F. Identifying the risk factors of ICU-acquired fungal infections: clinical evidence from using machine learning. Front Med (Lausanne) 2024;11:1386161. [PMID: 38784232 PMCID: PMC11112035 DOI: 10.3389/fmed.2024.1386161] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2024] [Accepted: 04/18/2024] [Indexed: 05/25/2024] Open

Abstract

Background

Fungal infections are associated with high morbidity and mortality in the intensive care unit (ICU), but their diagnosis is difficult. In this study, machine learning was applied to design and define the predictive model of ICU-acquired fungi (ICU-AF) in the early stage of fungal infections using Random Forest.

Objectives

This study aimed to provide evidence for the early warning and management of fungal infections.

Methods

We analyzed the data of patients with culture-positive fungi during their admission to seven ICUs of the First Affiliated Hospital of Chongqing Medical University from January 1, 2015, to December 31, 2019. Patients whose first culture was positive for fungi longer than 48 h after ICU admission were included in the ICU-AF cohort. A predictive model of ICU-AF was obtained using the Least Absolute Shrinkage and Selection Operator and machine learning, and the relationship between the features within the model and the disease severity and mortality of patients was analyzed. Finally, the relationships between the ICU-AF model, antifungal therapy and empirical antifungal therapy were analyzed.

Results

A total of 1,434 cases were included finally. We used lasso dimensionality reduction for all features and selected six features with importance ≥0.05 in the optimal model, namely, times of arterial catheter, enteral nutrition, corticosteroids, broadspectrum antibiotics, urinary catheter, and invasive mechanical ventilation. The area under the curve of the model for predicting ICU-AF was 0.981 in the test set, with a sensitivity of 0.960 and specificity of 0.990. The times of arterial catheter (p = 0.011, OR = 1.057, 95% CI = 1.053-1.104) and invasive mechanical ventilation (p = 0.007, OR = 1.056, 95%CI = 1.015-1.098) were independent risk factors for antifungal therapy in ICU-AF. The times of arterial catheter (p = 0.004, OR = 1.098, 95%CI = 0.855-0.970) were an independent risk factor for empirical antifungal therapy.

Conclusion

The most important risk factors for ICU-AF are the six time-related features of clinical parameters (arterial catheter, enteral nutrition, corticosteroids, broadspectrum antibiotics, urinary catheter, and invasive mechanical ventilation), which provide early warning for the occurrence of fungal infection. Furthermore, this model can help ICU physicians to assess whether empiric antifungal therapy should be administered to ICU patients who are susceptible to fungal infections.

Collapse

Prasetiyanti R, Robi'ul Fuadi M, Azmi YA, Wirjopranoto S. Massive subcutaneous abscess: A case report of management and source control. Int J Surg Case Rep 2024;118:109638. [PMID: 38653168 PMCID: PMC11053300 DOI: 10.1016/j.ijscr.2024.109638] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/07/2024] [Revised: 04/03/2024] [Accepted: 04/17/2024] [Indexed: 04/25/2024] Open

Unver Ulusoy T, Karakoç Parlayan HN, Altın N, Sarıkaya B, Öztürk B, Şencan İ. Comparative Analysis of Demographic and Clinical Findings in Spontaneous, Peritoneal Dialysis-Related, and Secondary Bacterial Peritonitis. Cureus 2024;16:e55445. [PMID: 38567242 PMCID: PMC10987013 DOI: 10.7759/cureus.55445] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/03/2024] [Indexed: 04/04/2024] Open

Zhang XP, Wei WT, Huang Y, Miao CH, Zhang XG, Du F. Efficacy and safety of patient-controlled epidural analgesia versus patient-controlled intravenous analgesia following open hepatectomy: A single-center retrospective study. Heliyon 2024;10:e23548. [PMID: 38187245 PMCID: PMC10767150 DOI: 10.1016/j.heliyon.2023.e23548] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/04/2023] [Revised: 12/05/2023] [Accepted: 12/06/2023] [Indexed: 01/09/2024] Open

Abstract

Background

Postoperative analgesia is an essential component of enhanced recovery after surgery following abdominal surgery. Studies comparing the effectiveness of epidural analgesia with that of other analgesic modalities after liver surgery have reported inconsistent results. Consequently, the use of epidural analgesia for open hepatectomy is controversial.

Objective

The present single-center retrospective study aimed to compare the efficacy and safety of patient-controlled epidural analgesia (PCEA) and patient-controlled intravenous analgesia (PCIA) in adults undergoing open hepatectomy.

Methods

Patients who underwent open hepatectomy between January 2018 to December 2019 at Zhongshan Hospital, Fudan University were retrospectively analyzed. Propensity score matching was used to adjust baseline information between the PCEA and PCIA groups. The primary outcome measure was scores of the numeric rating scales (NRSs) for resting, exercise, and nocturnal pain at postoperative 24 h (postoperative day 1 [POD1]) and 48 h (POD2). The secondary outcome indicators included postoperative nausea and vomiting (PONV), hypotension, pruritus, respiratory depression, functional activity score (FAS), effective analgesic pump compression ratio, analgesic relief rate, discontinuation of the analgesic pump, reasons for discontinuation of the analgesic pump, and patient satisfaction with postoperative analgesia.

Results

The NRS scores of the PCEA group on POD1 were significantly lower than those of the PCIA group (P < 0.05). On POD2, the difference between the two groups was significant only for motion NRS scores (P < 0.05). The PCIA group had significantly more patients with lower FAS functional class than the PCEA group (P < 0.001). The effective analgesic pump compression ratio and the analgesic relief rate at 2 days after the surgery were lower in the PCEA group than in the PCIA group (P < 0.001). The incidence of pump discontinuation was higher in the PCEA group than in the PCIA group on POD2 (P = 0.044). Moreover, on POD1 and POD2, the PCEA group showed a higher incidence of pruritus and hypotension than the PCIA group (P < 0.001). Both groups showed no significant difference in PONV incidence.

Conclusion

In patients undergoing open hepatectomy, PCEA was more effective than PCIA in relieving moderate to severe pain on POD1. However, improving the safety and effectiveness of PCEA remains a challenge.

Collapse

De Waele JJ, Coccolini F, Lagunes L, Maseda E, Rausei S, Rubio-Perez I, Theodorakopoulou M, Arvanti K. Optimized Treatment of Nosocomial Peritonitis. Antibiotics (Basel) 2023;12:1711. [PMID: 38136745 PMCID: PMC10740749 DOI: 10.3390/antibiotics12121711] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2023] [Revised: 11/24/2023] [Accepted: 12/01/2023] [Indexed: 12/24/2023] Open

Novy E, Roger C, Roberts JA, Cotta MO. Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis. Crit Care 2023;27:449. [PMID: 37981676 PMCID: PMC10659066 DOI: 10.1186/s13054-023-04742-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2023] [Accepted: 11/14/2023] [Indexed: 11/21/2023] Open

Dettori S, Portunato F, Vena A, Giacobbe DR, Bassetti M. Severe infections caused by difficult-to-treat Gram-negative bacteria. Curr Opin Crit Care 2023;29:438-445. [PMID: 37641512 PMCID: PMC10919274 DOI: 10.1097/mcc.0000000000001074] [Citation(s) in RCA: 12] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/31/2023]

Sid Ahmed MA, Petkar HM, Saleh TM, Albirair M, Arisgado LA, Eltayeb FK, Mahmoud Hamed M, Al-Maslamani MA, Al Khal AL, Alsoub H, Ibrahim EB, Abdel Hadi H. The epidemiology and microbiological characteristics of infections caused by Gram-negative bacteria in Qatar: national surveillance from the Study for Monitoring of Antimicrobial Resistance Trends (SMART): 2017 to 2019. JAC Antimicrob Resist 2023;5:dlad086. [PMID: 37546546 PMCID: PMC10400155 DOI: 10.1093/jacamr/dlad086] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2023] [Accepted: 06/26/2023] [Indexed: 08/08/2023] Open

Abstract

Background

The global Study of Monitoring Antimicrobial Resistance Trends (SMART) is a surveillance program for evaluation of antimicrobial resistance (AMR) in Gram-negative bacteria (GNB) from different regions including Gulf countries.

Objectives

To evaluate AMR in GNB from various clinical specimens including microbiological and genetic characteristics for existing and novel antimicrobials.

Methods

A prospective study was conducted on clinical specimens from Hamad Medical Corporation, Qatar, between 2017 and 2019 according to the SMART protocol. Consecutive GNB from different sites were evaluated including lower respiratory, urinary tract, intrabdominal and bloodstream infections.

Results

Over the 3 years study period, 748 isolates were evaluated from the specified sites comprising 37 different GNB outlining four key pathogens: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia.For the two major pathogens E. coli and K. pneumoniae, phenotypic ESBL was identified in 55.77% (116/208) compared to 39% (73/187), while meropenem resistance was 3.8% compared to 12.8% and imipenem/relebactam resistance was 2.97% compared to 11.76%, respectively. The overall ceftolozane/tazobactam resistance for E. coli was 9.6% (20/208) compared to 14.97% (28/187) for K. pneumoniae while resistance for ceftazidime/avibactam was 3.65% (5/137) and 5.98% (10/117), respectively. Genomic characteristics of 70 Enterobacterales including 48 carbapenem-resistant, revealed prevalence of β-lactamases from all classes, predominated by blaCXM-15 while carbapenem resistance revealed paucity of blaKPC and dominance of blaOXA-48 and blaNDM resistance genes.

Conclusions

Surveillance of GNB from Qatar showed prevalence of key pathogens similar to other regions but demonstrated significant resistance patterns to existing and novel antimicrobials with different underlying resistance mechanisms.

Collapse

Tsigalou C, Paraschaki A, Bragazzi NL, Aftzoglou K, Stavropoulou E, Tsakris Z, Vradelis S, Bezirtzoglou E. Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications. Front Cell Infect Microbiol 2023;13:1191126. [PMID: 37333847 PMCID: PMC10272562 DOI: 10.3389/fcimb.2023.1191126] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2023] [Accepted: 05/23/2023] [Indexed: 06/20/2023] Open

Ganapathy A, Ballard DH, Bishop GL, Hoegger MJ, Abraham N, D’Agostino HB. Pilot Study on the Influence of Incentive Spirometry on Percutaneous Image-Guided Intra-Abdominal Drainage Catheter Pressure: A Potential Method to Enhance Drainage. APPLIED SCIENCES (BASEL, SWITZERLAND) 2023;13:7308. [PMID: 37621554 PMCID: PMC10448541 DOI: 10.3390/app13127308] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Indexed: 08/26/2023]

Yue C, Wu X, Mo Z, Yang Q, Wang W, Zhou H, Gao R, Liang J, Yu P, Zhang Y, Ji G, Li X. Multidrug-resistant Klebsiella Pneumoniae Infection Led to Resection of the Graft in a Small Bowel Transplant Recipient: A Case Report and Review of the Literature. Transplant Proc 2023:S0041-1345(23)00254-3. [PMID: 37225551 DOI: 10.1016/j.transproceed.2023.04.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2023] [Revised: 03/27/2023] [Accepted: 04/11/2023] [Indexed: 05/26/2023]

Méchaï F, Kolakowska A, Carbonnelle E, Bouchaud O, Tresallet C, Jaureguy F. Intra-abdominal abscesses: Microbiological epidemiology and empirical antibiotherapy. Infect Dis Now 2023;53:104604. [PMID: 36067948 DOI: 10.1016/j.idnow.2022.08.005] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2022] [Revised: 07/29/2022] [Accepted: 08/29/2022] [Indexed: 11/29/2022]

Shi J, Wu J, Chen Q, Shen Y, Mi K, Yang H, Mu L. A Frog-Derived Cathelicidin Peptide with Dual Antimicrobial and Immunomodulatory Activities Effectively Ameliorates Staphylococcus aureus-Induced Peritonitis in Mice. ACS Infect Dis 2022;8:2464-2479. [PMID: 36378028 DOI: 10.1021/acsinfecdis.2c00260] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]

Cervicothoracic spine infection of unknown pathogens: A case report. Asian J Surg 2022;46:1965-1966. [PMID: 36509595 DOI: 10.1016/j.asjsur.2022.12.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/11/2022] [Accepted: 12/01/2022] [Indexed: 12/13/2022] Open

Ventura F, Gasche Y, Rached AKB, Pugin D, Mollard F, Vora S, Charbonnet P, Bühler L. Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis. J Surg Case Rep 2022;2022:rjac497. [PMID: 36389436 PMCID: PMC9659425 DOI: 10.1093/jscr/rjac497] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2022] [Accepted: 10/05/2022] [Indexed: 12/29/2022] Open

Li X, Xie L, Huang H, Li Z, Li G, Liu P, Xiao D, Zhang X, Xiong W, Zeng Z. Prevalence of Livestock-Associated MRSA ST398 in a Swine Slaughterhouse in Guangzhou, China. Front Microbiol 2022;13:914764. [PMID: 35814703 PMCID: PMC9260045 DOI: 10.3389/fmicb.2022.914764] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2022] [Accepted: 05/17/2022] [Indexed: 01/01/2023] Open

Abstract

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an important zoonotic microorganism that is increasingly causing public health concern worldwide. The objective of this study was to determine the transmission and occurrence of MRSA in a slaughterhouse environment and evaluate its antimicrobial resistance and genetic characterization. In this study, we conducted a comprehensive epidemiological survey of S. aureus by spa typing and whole-genome sequencing (WGS) of samples obtained from the pork production chain, the environment, and community residents. To clarify the evolutionary relationships of MRSA sequence type (ST) 398 in this study and global isolates, 197 published whole-genome sequences data of MRSA ST398 strains were downloaded from the GenBank database and included in the phylogenetic analysis. A total of 585 porcine samples (snout and carcass swabs), 78 human nasal samples, and 136 environmental samples were collected. The MRSA isolates were detected at higher frequencies in samples from swine (15.0%) than carcasses (10.0%), slaughterhouse workers (8.0%), community residents (0%), and environment samples (5.9%). The spa typing results showed that t571 accounted for a higher proportion than other spa types. Closely related isolates from the samples of swine, slaughterhouse workers, carcasses, carrier vehicle, and surrounding fishpond water indicate that MRSA ST398 strains may spread among swine, humans, and the environment. MRSA ST398-t571 isolates were genetically different from global strains, except for two Korean isolates, which showed genetic closeness with it. In addition, a MRSA ST398 isolate recovered from an infected patient in Europe differed by only 31 SNPs from the airborne dust-associated strain isolated in this study, thereby suggesting potential transmission among different countries. Antimicrobial susceptibility testing results demonstrated that 99.0% (96/97) of MRSA and 95.1% (231/243) of methicillin-sensitive S. aureus (MSSA) showed multidrug-resistant (MDR) phenotypes. According to WGS analysis, the poxtA-carrying segment (IS431mec-optrA-IS1216-fexB-IS431mec) was reported in MRSA ST398 isolates for the first time. The coexistence of cfr and optrA in a plasmid was first detected in MRSA ST398. The potential transmission of MRSA among humans, animals, and the environment is a cause for concern. The emergence and transmission of LA-MRSA ST398 with high levels of resistance profiles highlight the urgent need for LA-MRSA surveillance.

Collapse

Affiliation(s)

Xiaoshen Li Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Longfei Xie Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Honghao Huang Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Zhi Li Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Guihua Li Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Peng Liu College of Veterinary Medicine, China Agricultural University, Beijing, China
Danyu Xiao Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Xucai Zhang Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China
Wenguang Xiong Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China *Correspondence: Wenguang Xiong,
Zhenling Zeng Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China Zhenling Zeng,

Collapse

Gabriel PÉ, Siebert M, Le Fouler A, Van Glabeke E, Trésallet C. Management of gastro-intestinal emergencies in patients with ileal conduit ureteral diversion. J Visc Surg 2022;159:399-408. [PMID: 35690581 DOI: 10.1016/j.jviscsurg.2022.05.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]

Emeli TO, Serrao R. Delayed perihepatic abscess caused by Cutibacterium acnes following right partial hepatectomy. BMJ Case Rep 2022;15:e247279. [PMID: 35414576 PMCID: PMC9006826 DOI: 10.1136/bcr-2021-247279] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/01/2022] [Indexed: 11/04/2022] Open

Lederer AK, Chikhladze S, Kohnert E, Huber R, Müller A. Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery-A Narrative Review. Diagnostics (Basel) 2021;11:diagnostics11112099. [PMID: 34829446 PMCID: PMC8625751 DOI: 10.3390/diagnostics11112099] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2021] [Revised: 10/26/2021] [Accepted: 11/10/2021] [Indexed: 12/19/2022] Open

Lebedev NV, Agrba SB, Popov VS, Klimov AE, Svanadze GT. New System For Predicting The Outcome Of Secondary Peritonitis. RUSSIAN OPEN MEDICAL JOURNAL 2021. [DOI: 10.15275/rusomj.2021.0315] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022] Open

Abstract Despite improvements in the methods of diagnostics, surgical interventions and intensive care, the problem of treating patients with diffuse peritonitis remains relevant. Diffuse peritonitis is a major contributor to mortality in all urgent care settings and the second leading cause of sepsis in critically ill patients. At the same time, even in developed countries, the number of patients with peritonitis does not tend to decrease, and mortality rates remain high, reaching 90-93% with the development of abdominal sepsis and toxic shock syndrome. One of the ways to reduce mortality in peritonitis is the use of objective systems for prognosis of the peritonitis outcome, allowing to compare the results of patient treatment and to choose the optimal treatment tactics for each particular patient. The objective — To develop a new system for predicting the outcome of secondary peritonitis (survival or death) focused on the criteria of abdominal sepsis and multiple organ dysfunction syndrome (associated or not associated with peritonitis), and to analyze its accuracy versus the most common comparable systems. Material and Methods — Our study was based on analyzing the treatment outcomes in 352 patients with secondary diffuse peritonitis. On admission, sepsis was diagnosed in 15 (4.3%), and toxic shock in 4 (1.1%) patients. The main causes of death were purulent intoxication and/or sepsis (51 cases or 87.9%), cancer intoxication (4 cases or 6.9%), and acute cardiac failure (3 cases or 5.2%). We analyzed the effectiveness of several systems of predicting the peritonitis outcomes: the Mannheim’s Peritoneal Index (MPI), World Society for Emergency Surgery Sepsis Severity Score (WSES SSS), Acute Physiology and Chronic Health Evaluation II (APACHE II) system, general Sequential Organ Failure Assessment Score (gSOFA), as well as the Peritonitis Prognosis System (PPS) developed by the authors. The probability of the effect of 40 clinical and laboratory parameters on the outcome of patients with secondary peritonitis was analyzed via using parametric and nonparametric methods of statistical analysis (Fisher’s test, Mann-Whitney U test, Chi-squared test with Yates’s continuity correction). The criteria were selected that had a predictive power for the lethal outcome (p <0.05), and they were included in the PPS system. To compare the predictive value of the PPS, ROC analysis was conducted with construction of receiver operating characteristic curves for each analyzed system of predicting the peritonitis outcome. The STATISTICA 8 software was used for performing the statistical analysis. Results — The following criteria were of greatest importance in predicting the lethal outcome: a patient’s age, a presence of a malignant neoplasm, a nature of the exudate, the development of sepsis (toxic shock), as well as multiple organ dysfunction not associated with the developed peritonitis. PPS exhibited the greatest accuracy in terms of predicting mortality in patients with secondary diffuse peritonitis (AUC=0.942) versus minimal in APACHE II (AUC=0.840). Conclusion — APACHE II, MPI, WSES SSS and PPS can be considered reliable in terms of mortality prognosis in peritonitis patients. PPS has the greatest accuracy of predicting the mortality in patients with secondary diffuse peritonitis (94%). Collapse

Pan J, Zhu Q, Zhang X, Xu J, Pan L, Mao X, Wu X. Factors Influencing the Prognosis of Patients with Intra-Abdominal Infection and Its Value in Assessing Prognosis. Infect Drug Resist 2021;14:3425-3432. [PMID: 34466008 PMCID: PMC8402985 DOI: 10.2147/idr.s325386] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2021] [Accepted: 08/17/2021] [Indexed: 01/08/2023] Open

Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes. PLoS One 2021;16:e0250818. [PMID: 33939725 PMCID: PMC8092803 DOI: 10.1371/journal.pone.0250818] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/07/2020] [Accepted: 04/14/2021] [Indexed: 01/01/2023] Open

Abstract

Background

Postoperative abdominal infections belong to the most common triggers of sepsis and septic shock in intensive care units worldwide. While monocytes play a central role in mediating the initial host response to infections, sepsis-induced immune dysregulation is characterized by a defective antigen presentation to T-cells via loss of Major Histocompatibility Complex Class II DR (HLA-DR) surface expression. Here, we hypothesized a sepsis-induced differential occupancy of the CCCTC-Binding Factor (CTCF), an architectural protein and superordinate regulator of transcription, inside the Major Histocompatibility Complex Class II (MHC-II) region in patients with postoperative sepsis, contributing to an altered monocytic transcriptional response during critical illness.

Results

Compared to a matched surgical control cohort, postoperative sepsis was associated with selective and enduring increase in CTCF binding within the MHC-II. In detail, increased CTCF binding was detected at four sites adjacent to classical HLA class II genes coding for proteins expressed on monocyte surface. Gene expression analysis revealed a sepsis-associated decreased transcription of (i) the classical HLA genes HLA-DRA, HLA-DRB1, HLA-DPA1 and HLA-DPB1 and (ii) the gene of the MHC-II master regulator, CIITA (Class II Major Histocompatibility Complex Transactivator). Increased CTCF binding persisted in all sepsis patients, while transcriptional recovery CIITA was exclusively found in long-term survivors.

Conclusion

Our experiments demonstrate differential and persisting alterations of CTCF occupancy within the MHC-II, accompanied by selective changes in the expression of spatially related HLA class II genes, indicating an important role of CTCF in modulating the transcriptional response of immunocompromised human monocytes during critical illness.

Collapse

Bassetti M, Azoulay E, Kullberg BJ, Ruhnke M, Shoham S, Vazquez J, Giacobbe DR, Calandra T. EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group. Clin Infect Dis 2021;72:S121-S127. [PMID: 33709127 DOI: 10.1093/cid/ciaa1751] [Citation(s) in RCA: 148] [Impact Index Per Article: 37.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022] Open

Priorities in peritonitis. Curr Opin Crit Care 2021;27:201-207. [PMID: 33395082 DOI: 10.1097/mcc.0000000000000805] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]

Protocol for the pBDG2 Study: Prospective Evaluation of 1.3-β-D-Glucan in the Peritoneal Fluid for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients. MICROBIOLOGY RESEARCH 2021. [DOI: 10.3390/microbiolres12010015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open

Neri A, Fusario D, Marano L, Savelli V, Bartalini Cinughi de Pazzi A, Cassetti D, Roviello F, Marrelli D. Clinical evaluation of the Mannheim Prognostic Index in post-operative peritonitis: a prospective cohort study. Updates Surg 2020;72:1159-1166. [PMID: 32578039 DOI: 10.1007/s13304-020-00831-5] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2020] [Accepted: 06/10/2020] [Indexed: 12/29/2022]

Bassetti M, Vena A, Pincino R, Briano F, Giacobbe DR. Role of Antifungal Therapy in Complicated Intra-abdominal Infections. Curr Infect Dis Rep 2020. [DOI: 10.1007/s11908-020-00731-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022]