Review
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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Dec 26, 2015; 5(4): 185-195
Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.185
Table 1 Performance of hydatid cyst fluid in diagnosis of cystic echinococcosis in different serological assays
Antigen No. of subjects Test Sensitivity (%) Specificity (%) Cross reactions Year Ref. CE patients Other disease Healthy control SHCF 78 24 15 IgG ELISA 72.4 NR 2001 [71] BHCF 129 65 203 IgG ELISA 77.6 96.6 Cysts, Toxoc. 2003 [44] CHCF 26 35 10 Dipstick assay 100 91.4 Cysts, AE, Trichinosis, Schist., Fascio 2004 [6] CHCF 26 35 10 EITB 100 91.4 Cysts, AE, trichinosis, Schist, Fascio 2004 [6] CHCF 26 30 10 IgG ELISA 96.2 100 None 2004 [6] SHCF 102 68 95 IgG ELISA 88.2 80.9 AE, Cysts, Schist, Fascio, Taeniasis, Dirofilariasis 2008 [72] SHCF 120 Casoni’s skin test 88.2 80.9 NR 2005 [73] SHCF 120 Casoni’s skin test 70 87 NR 2005 [73] SHCF 120 Casoni’s skin test 62 85 NR 2005 [73] SHCF 120 IHA 56 84 NR 2005 [73] SHCF 25 15 25 ELISA on serum 72 76 Cysts, Ascaris, Ambs liver abscess 2007 [74] SHCF 25 15 25 ELISA on urine 84 76 Cysts, Ascaris, Ambs liver abscess 2007 [74] SHCF 25 15 25 ELISA on saliva 56 76 Cysts, Ascaris, Ambs liver abscess 2007 [74] SHCF 40 40 70 CCIEP 97.5 58.1 Fascio, Toxoc, Taenia, 2007 [10] Malignancies SHFF 204 53 90 IEP 31 100 None 2000 [75] SHFF 204 53 90 IHA 54 100 None 2000 [75] SHFF 204 53 90 IB 80 96 Cysts, Serous cysts 2000 [75] SHCF 35 12 25 Dot-ELISA 100 89.1 Ascaris, Taenia, 2010 [1] Strogyl SHCF 35 12 25 CCIEP 80 62 Ascaris, Strogyl, 2010 [1] Toxop SHCF 59 60 39 IgG ELISA 91.5 96 Clonorchiasis 2013 [76] hHCF 50 15 20 IB 83 98 None 2014 [28] hHCF 50 15 20 IgG IB 83 98 None 2014 [28] SHCF 50 40 20 IgG ELISA 92 85 Ascaris, Ambs, 2014 [67] Malignancy, Toxop SHCF 50 40 20 IgM ELISA 70 93.33 Ascaris, Ambs, 2014 [67] Malignancy, Toxop SHCF 50 40 20 IgE ELISA 86 96.66 Ascaris, Ambs, 2014 [67] Malignancy, Toxop SHCF 50 40 20 IgG1 ELISA 82 98.33 Ascaris, Ambs, Malignancy, Toxop 2014 [67] SHCF 50 40 20 IgG2 ELISA 74 95 Ascaris, Ambs, 2014 [67] Malignancy, Toxop SHCF 50 40 20 IgG3 ELISA 52 36 Ascaris, Ambs, Malignancy, Toxop 2014 [67] SHCF 50 40 20 IgG4 ELISA 86 28 Ascaris, Ambs, 2014 [67] Malignancy, Toxop Psx Ag 113 112 121 DIGFA 87.6 90.90 Hd, Cysts, 2015 [48] HCC, HH CPsx extract 147 88 60 IgG ELISA 90 57 AE, Trypanosomiasis 2002 [76] Emwl Ag 50 154 WB IgG 98 NCC 2000 [14] Emwl Ag 50 154 IHA > 80 94.3 NR 2000 [14] Emwl Ag 50 154 IHA > 320 80 NR 2000 [14] Emwl Ag 50 154 IgG ELISA 79.4 NR 2000 [14]
Table 2 Performances of antigen 5 for immunodiagnosis of cystic echinococcosis in different serological assays
No. of subjects Test Sensitivity (%) Specificity (%) Cross reaction Year Ref. CE patient Other disease Healthy control Ag5 39 51 29 IgG ELISA 54 89 AE 2000 [9] Ag5 58 36 40 IgG ELISA 100 70.17 Leish, Toxop, Fascio 2006 [39] Ag5 58 36 40 IgG1 ELISA 100 70.17 Leish, Toxop, Fascio 2006 [38] Ag5 58 36 40 IgG4 ELISA 75.8 93.02 Toxop, Fascio 2006 [38] Ag5 58 36 40 IgE ELISA 70.1 100 None 2006 [38] rAg5 34 36 18 IgG ELISA 65 89 AE, Cysts 2005 [77] rAg5-38s 34 36 18 IgG ELISA 21 97 AE 2005 [77]
Table 3 Performances of antigen B in diagnosis of cystic echinococcosis
Antigen No. of subjects Test Sensitivity (%) Specificity (%) Cross reactions Year Ref. CE patients Other disease Healthy control nAg B 204 21 90 IB 66 100 None 2000 [75] nAg B 59 55 15 IgG ELISA 80 77 AE, NCC 2005 [77] nAg B 90 86 27 IgG ELISA 77 85 AE, RA 2000 [9] nAg B 204 21 90 IgG ELISA 74 100 None 2000 [75] nAg B 31 87 29 IgG ELISA 77.41 81.9 AE, Ev, Schist, Toxoc 2000 [78] nAg B 78 24 15 IgG ELISA 93.5 89.7 Distomatosis, Schist 2001 [71] nAg B 129 65 203 IgG ELISA 60.3 92.6 Cysts,Toxoc 2003 [44] nAg B 22 12 4 WB 77 100 Toxoc, Other cestodes 2010 [30] nAg B 40 40 70 IgG ELISA 92.5 97.3 Fascio 2007 [10] nAg B 40 40 70 CCIEP 97.5 58.2 Fascio, Toxoc, Taenia, Malignancy 2007 [10] nAg B 204 53 90 IB 66 100 None 2000 [75] nAg B 204 53 90 IgG ELISA 74 100 None 2000 [75] nAg B 35 29 25 IgG ELISA 94.2 81.6 NR 2009 [16] nAg B 55 72 50 IgG ELISA 96.4 97.2 None 2014 [68] nAg B 113 112 121 DIGFA 92.9 81 HD, Cysts, HCC, HH 2015 [48] Goat liver Ag B 47 30 40 IgG ELISA 91.4 92.8 NR 2011 [49] Human liver Ag B 47 30 40 IgG ELISA 97.8 97.1 NR 2011 [49] Bovine lung Ag B 47 30 40 IgG ELISA 78.7 85.7 NR 2011 [49] Sheep lung Ag B 47 30 40 IgG ELISA 93.6 88.5 NR 2011 [49] Camel lung Ag B 47 30 40 IgG ELISA 93.6 90 NR 2011 [49] Sheep liver Ag B 47 30 40 IgG ELISA 95.7 92.8 NR 201 [49] rAgB 204 21 90 IB 72 100 None 2000 [75] rAgB 113 112 121 DIGFA 77.9 98.3 None 2015 [48] rAgB8/1 31 87 29 IgG ELISA 54.84 80.17 AE, Schist, Toxoc 2000 [78] rAgB8/1 129 65 203 IgG4 ELISA 91.4 91.7 Cysts 2003 [44] rAgB8/1 59 55 15 IgG ELISA 68 88 AE, NCC 2005 [80] rAgB8/2 31 87 29 IgG ELISA 83.87 98.28 Schist, Toxoc 2000 [78] rAgB8/2 129 65 203 IgG ELISA 93.1 99.5 Cysts, Toxoc 2003 [45] rAgB8/2 129 65 203 IgG4 ELISA 69 87.5 Cysts 2003 [45] rAgB8/2 59 55 15 IgG ELISA 45 86 AE, NCC 2005 [77] rAgB8/1 129 65 203 IgG4 ELISA 91.4 91.7 Cysts 2003 [44] rAgB8/1 59 55 15 IgG ELISA 68 88 AE, NCC 2005 [77] rAgB8/2 31 87 29 IgG ELISA 83.87 98.28 Schist, Toxoc 2000 [78] rAgB8/2 129 65 203 IgG ELISA 93.1 99.5 Cysts, Toxoc 2003 [44] rAgB8/2 129 65 203 IgG4 ELISA 69 87.5 Cysts 2003 [44] rAgB8/2 59 55 15 IgG ELISA 45 86 AE, NCC 2005 [77] B1t 102 68 95 IgG ELISA 83.3 87.5 AE, Schist, Cysts, Fascio, 2008 [9] B2t 102 68 95 IgG ELISA 91.2 93 Cysts, Schist, Fascio 2008 [9] 2B2t 186 174 110 IgG ELISA 87.6 99.1 AE, NCC, Hepatitis 2012 [9] rEgAFFPt 129 65 203 IgG ELISA 58.6 95.6 Cysts, Toxoc 2003 [44] rEgCaBP2 129 65 203 IgG ELISA 84.5 96.6 Cysts, Toxoc 2003 [44] rEgcMDH 129 65 203 IgG ELISA 89.7 95.1 Cysts 2003 [44] rEgAFFPf 129 65 203 IgG ELISA 69 89.7 Cysts, Toxoc 2003 [44] rEpC1-GST 324 502 70 IgG IB 92.2 95.6 AE, NCC, Schist, 2003 [79] Liver cancer rTPxEg 100 218 20 IgG IB 39 69.3 AE, NCC 2004 [78] rEgG5 23 138 20 IgG IB 61 70 AE, Cysts 2004 [79] E14t 102 68 95 IgG ELISA 35.3 91.7 Schist 2008 [9] C317 102 68 95 IgG ELISA 58.8 80.9 AE, Cysts, Taeniasis, Schist, 2008 [9] p65 90 86 27 IgG ELISA 44 96 AE, Schist, Toxoc 2000 [9] p175 90 86 27 IgG ELISA 49 94 AE, Schist, Toxoc 2000 [9] p176 90 86 27 IgG ELISA 80 93 AE, Schist, Toxoc, 2000 [9] Syph, Chagas p177 90 86 27 IgG ELISA 38 92 AE, Toxoc, Syph, 2000 [9] Chagas pGu4 90 86 27 IgG ELISA 18 98 AE 2000 [9]
Table 4 Performances of antigen detection assays in immunodiagnosis of cystic echinococcosis
Antigen No. of subjects Test Sensitivity (%) Specificity (%) Cross reaction (%) Year Ref. CE patient Other disease Healthy control Urinary antigen 40 24 25 Co-A 50 89.09 12.5 2000 [62] Serum antigen 40 24 25 Co-A 73.08 94.23 12.5 2000 [62] Serum antigen 35 29 25 IgG ELISA 25.7 98 3.4 2009 [16] Serum antigen 141 25 25 LAT 72 98 4 2003 [7] Serum antigen 40 24 25 CIEP 45 100 None 1997 [80] Urinary antigen (ucon) 40 24 25 CIEP 22.5 95.91 8.33 1997 [80] Urinary antigen (con) 40 24 25 CIEP 47.5 95.91 None 1997 [80]