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Dec 26, 2015 (publication date) through Feb 13, 2026
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World Journal of Methodology
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2222-0682
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Dec 26, 2015; 5(4): 185-195
Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.185
Immunodiagnosis of human hydatid disease: Where do we stand?
Bahador Sarkari, Zahra Rezaei
Bahador Sarkari, Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz 71345-1735, Iran
Zahra Rezaei, Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-1735, Iran
Author contributions: Sarkari B performed the literature search, wrote the first draft of the manuscript, edited and approved the final version; Rezaei Z performed the literature and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Correspondence to: Bahador Sarkari, PhD, Professor of Immunoparasitology, Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Zand Street, Building No. 3, Shiraz 71345-1735, Iran. sarkarib@sums.ac.ir
Telephone: +98-71-32305291 Fax: +98-71-32305291
Received: August 4, 2015
Peer-review started: August 6, 2015
First decision: September 22, 2015
Revised: October 26, 2015
Accepted: November 13, 2015
Article in press: November 17, 2015
Published online: December 26, 2015
Processing time: 132 Days and 19.4 Hours
Core Tip

Core tip: Cystic echinococcosis (CE) (hydatid cyst) is one of the most important parasitic diseases, causing tremendous morbidity and mortality for the human patients. Diagnosis of CE mainly relies on ultrasound images of the cyst along with serological testing. So far, there is no highly specific and sensitive immunodiagnostic test for diagnosis of CE and performances of the currently available tests are not satisfactory. Different antigenic sources including hydatid cyst fluid, antigen B and 5, excretory-secretory antigens of larval stage or adult worm have widely been used for development of serological assays for diagnosis of CE. Utilizing of antigen B subunits in immunodiagnostic tests and detection of IgG subclasses, as a good marker, opened a promising perspective in diagnosis of this debilitating disease.
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