Clinical efficacy of Danggui Sini Decoction for treatment of lower limb arteriosclerosis obliterans: A randomized controlled trial

doi:10.5662/wjm.v16.i2.115003

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Jun 20, 2026 (publication date) through Apr 23, 2026

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Methodol. Jun 20, 2026; 16(2): 115003
Published online Jun 20, 2026. doi: 10.5662/wjm.v16.i2.115003

Table 1 Comparison of baseline characteristics between the two groups, n (%)/mean ± SD

		Experimental group	Control group	t/χ²	P value
Age (years)		66.84 ± 7.98	66.32 ± 10.87	0.17	0.87
Gender	Male	12 (63.16)	10 (52.63)	0.43	0.51
Gender	Female	7 (36.84)	9 (47.37)	0.43	0.51
Smoking		7 (36.84)	6 (31.58)	0.12	0.73
Comorbidities	Hypertension	8 (42.11)	7 (36.84)	0.11	0.74
	Diabetes	7 (36.84)	6 (31.58)	0.12	0.73
	Coronary heart disease	5 (26.32)	4 (21.05)	0.15	0.70
	Chronic renal insufficiency	8 (42.11)	5 (26.32)	1.05	0.31
Fontaine stage	Stage I	0	0
	Stage II	6 (31.58)	5 (26.32)	0.13	0.72
	Stage III	8 (42.11)	10 (52.63)	0.42	0.52
	Stage IV	5 (26.32)	4 (21.05)	0.15	0.70
Ankle-brachial-pressure-index		0.26 ± 0.22	0.30 ± 0.23	-0.54	0.59
Lesion location	Iliac artery	4 (21.05)	7 (36.84)	1.15	0.28
	Femoropopliteal artery	13 (68.42)	7 (36.84)	3.8	0.051
	Infrapopliteal artery	9 (47.37)	13 (68.42)	1.73	0.19

Full Size Table

Table 2 Comparison of clinical effectiveness rate, complications, and VascuQol scores between the two groups at 1 month postoperatively, n (%)/mean ± SD

	Experimental group	Control group	χ²	P value
Clinical effectiveness rate	15 (78.95)	16 (84.21)	0.18	0.67
Complications	1 (5.26)	2 (10.53)	0.36	0.55
Change in VascuQol score (postoperative - preoperative)	46.11 ± 17.07	24.74 ± 8.61	4.87	0.001

Full Size Table

Table 3 Comparison of clinical effectiveness rate, limb salvage rate, and freedom from target lesion revascularization between the two groups at 6 months postoperatively, n (%)

	Experimental group	Control group	χ²	P value
Clinical effectiveness rate	18 (94.74)	14 (73.68)	4.38	0.04
Limb salvage rate	19 (100)	19 (100)
Freedom from target lesion revascularization	19	16 (84.21)	3.26	0.07

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Citation: Fu YB, Yan F, Zhu HJ, Wang C. Clinical efficacy of Danggui Sini Decoction for treatment of lower limb arteriosclerosis obliterans: A randomized controlled trial. World J Methodol 2026; 16(2): 115003
URL: https://www.wjgnet.com/2222-0682/full/v16/i2/115003.htm
DOI: https://dx.doi.org/10.5662/wjm.v16.i2.115003