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©The Author(s) 2025.
World J Methodol. Dec 20, 2025; 15(4): 102401
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.102401
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.102401
Table 1 Spinal disorders associated with skeletal dysplasia
Group/name of disorder | Inheritance | Gene | Case-control studies | Cohort studies | Hydroxy | Choline kinase | Atlantoaxial instability | Basilar invagination | Chronic viral B-hepatitis | Thoracolumbar kyphosis | Scoliosis | Lumbar canal stenosis |
Achondroplasia | AD | Fibroblast growth factor receptor 3 | +++ | + | +++ | +++ | ||||||
Hypochondroplasia | ++ | +++ | ||||||||||
Thanatophoric dysplasia | +++ | +++ | +++ | |||||||||
Diastrophic dysplasia | AR | Solute carrier 26A | ++ | +++ | +++ | +++ | ++ | ++ | ||||
Spondyloepiphyseal dysplasia congenita | AD/AR | Collagen type alpha 1 chain | +++ | +++ | +++ | |||||||
Kneist syndrome | AD | + | + | ++ | + | ++ | ++ | |||||
Pseudoachondroplasia | AD | Cartilage oligomeric matrix protein | +++ | +++ | ++ | + | ||||||
Metatrophic dysplasia | AD | Transient receptor potential vanilloid type 4 | + | + | ||||||||
Campomelic dysplasia | AD | Sex determining region Y (SRY)-box 9 | ++ | ++ | ++ | ++ | ||||||
MPS I | AR | Iduronidase | ++ | ++ | ++ | ++ | +++ | + | ||||
MPS IV | Galactosamine-6-sulfate | +++ | + | +++ | +++ | ++ | ++ | |||||
MPS VI | Arysulfatase B | ++ | + | ++ | ++ | ++ |
Table 2 List of studies on surgical management of spinal disorders in achondroplasia
Ref. | Spinal disorder | Type of study | Sample size (male/female) | Mean age (years) (SD) | Total surgeries | Surgical levels decompressed | Median follow-up | Indications of primary surgery | Revision surgery indications (early) | Revision surgery indications (late) | Late revision surgery types | Complications | Outcomes |
Urbanschitz et al[30], 2024 | Thoracolumbar spinal stenosis | Retrospective | 15 (8/7) | 52 (10.4) | 31 (primary: 12/revision: 19) | 79 | 24 months (interquartile range: 34 months; range: 4-85 months) | Myelopathy: 5; spinal claudication: 4; paraparesis: 2; acute foot drop: 1 | 3/19 (complication within 30 days: Dural tear, wound healing disorder, adjacent segment collapse) | 16/19 (spinal stenosis: 7; hyperkyphosis: 4; adjacent segment disease: 2; pseudoarthrosis: 2; posttraumatic deformity: 1) | Decompression: 5; decompression + fusion: 8; alignment correction with osteotomy: 3) | Dural tear: 11; implant failure: 2; wound disorder: 2; urosepsis: 1 | Full recovery: 5; partial recovery: 11; no improvement: 2 |
Hariharan et al[31], 2024 | Spinal stenosis | Retrospective | 33 | 18.7 (10.1) | 33 (24 selected for analysis) | - | - | - | Caudal pseudarthrosis: 8; proximal junctional kyphosis: 7; new neurological symptoms: 7 | ||||
Tanaka et al[28], 2022 | TLK | Retrospective case series | 3 (2/1) | 22.3 | 3 | Posterior vertebral column resection | 9.3 years | Severe TLK with neurological deficits and urinary disturbance | Surgery: Posterior vertebral column resection with cage and segmental instrumentation | Rod breakage, surgical site infection | Average Japanese Orthopedic Association score improved from 8.3/11 to 10.7/11 (mean recovery rate: 83%); 67% kyphotic angle correction | ||
Sciubba et al[29], 2007 | Spinal stenosis. Surgery: Decompression +/- fusion | Retrospective | 44 (25/19) | 12.7 | 60 decompressive surgeries | Thoracolumbar (65.3%), lumbar (20.4%), cervical (8%), cervicothoracic (4%), thoracic (2%) | 34 months | Neurogenic claudication (91%), pain (95.4%), cauda equina syndrome (25%), myelopathy (4.5%) | Disc herniation at L2-3 within a previous laminectomy | Progressive deformity, junctional stenosis, and recurrence of symptoms | Dural tear: 4, wound breakdown: 2, radicular pain: 3 | 32 patients showed improvement in symptoms | |
Matsumoto et al[32], 2006 | TLK, surgery: Posterior osteotomy with segmental instrumentation | Case report | 4 (3/1) | 32.5 | 4 | Thoracolumbar | 35 months | Severe TLK with neurologic deficit | Dural tear and partial nerve root laceration: 2 | Mean recovery rate: 75% |
Table 3 Summary of surgical management of spinal disorders in various skeletal dysplasias
Skeletal dysplasia (incidence) | Common spinal disorders | Nonsurgical management | Surgical management |
Achondroplasia (1:20000-1:30000) | Foramen magnum stenosis neurological complications | Regular monitoring with magnetic resonance imaging and X-rays. Physical therapy for posture and strength. Pain management. Ergonomic modifications | Decompression surgery if severe compression or neurological symptoms occur |
Hypochondroplasia (1:15000-1:40000) | Spinal stenosis: Degenerative disc disease | Physical therapy. Pain management. Ergonomic modifications. Regular spinal assessments | Surgical intervention for severe stenosis or radiculopathy. Decompression surgery |
Spondyloepiphyseal dysplasia congenita (1:100000) | AAI, OH, scoliosis | Physical therapy. Bracing for scoliosis. Regular monitoring. Pain management. Adaptive mobility devices | Decompression (C1 laminectomy) and OC fusion. Deformity correction |
Kniest dysplasia (1:1000000) | AAI, OH, scoliosis | Physical therapy. Bracing for scoliosis. Regular monitoring. Pain management. Adaptive mobility devices | Decompression (C1 laminectomy) and OC fusion. Deformity correction |
Diastrophic dysplasia (1:500000) | Cervical kyphosis, kyphoscoliosis | Early orthotic management. Regular monitoring for curve progression. Physical therapy. Pain management | Anterior/posterior correction for severe curves or progressive deformities. Spinal fusion if necessary |
Mucopolysaccharidoses (all forms: 1:25000, I: 1:100000, IV: 1:200000-1:300000) | Craniovertebral junction stenosis, Thoracolumbar kyphosis, scoliosis | Regular monitoring and physical therapy. Management of symptoms and pain. Occupational therapy. Supportive care | Deformity correction. Decompression if necessary |
Osteogenesis imperfecta (all forms: 1:10000-1:20000) | Spinal deformities (kyphosis, scoliosis) | Regular spinal evaluations. Bracing and physical therapy. Bisphosphonates for bone strength. Pain management | Surgery for severe curves or spinal instability. Spinal fusion in progressive cases |
- Citation: Tsirikos AI, Jain A, Ahuja K. Challenges and solutions in the treatment of spinal disorders in patients with skeletal dysplasia: A comprehensive review. World J Methodol 2025; 15(4): 102401
- URL: https://www.wjgnet.com/2222-0682/full/v15/i4/102401.htm
- DOI: https://dx.doi.org/10.5662/wjm.v15.i4.102401