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Copyright ©The Author(s) 2025.
World J Methodol. Dec 20, 2025; 15(4): 102401
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.102401
Table 1 Spinal disorders associated with skeletal dysplasia
Group/name of disorder
Inheritance
Gene
Case-control studies
Cohort studies
Hydroxy
Choline kinase
Atlantoaxial instability
Basilar invagination
Chronic viral B-hepatitis
Thoracolumbar kyphosis
Scoliosis
Lumbar canal stenosis
AchondroplasiaADFibroblast growth factor receptor 3++++++++++
Hypochondroplasia+++++
Thanatophoric dysplasia+++++++++
Diastrophic dysplasiaARSolute carrier 26A+++++++++++++++
Spondyloepiphyseal dysplasia congenitaAD/ARCollagen type alpha 1 chain+++++++++
Kneist syndromeAD+++++++++
PseudoachondroplasiaADCartilage oligomeric matrix protein+++++++++
Metatrophic dysplasiaADTransient receptor potential vanilloid type 4++
Campomelic dysplasiaADSex determining region Y (SRY)-box 9++++++++
MPS IARIduronidase++++++++++++
MPS IVGalactosamine-6-sulfate++++++++++++++
MPS VIArysulfatase B+++++++++
Table 2 List of studies on surgical management of spinal disorders in achondroplasia
Ref.
Spinal disorder
Type of study
Sample size (male/female)
Mean age (years) (SD)
Total surgeries
Surgical levels decompressed
Median follow-up
Indications of primary surgery
Revision surgery indications (early)
Revision surgery indications (late)
Late revision surgery types
Complications
Outcomes
Urbanschitz et al[30], 2024Thoracolumbar spinal stenosisRetrospective15 (8/7)52 (10.4)31 (primary: 12/revision: 19)7924 months (interquartile range: 34 months; range: 4-85 months)Myelopathy: 5; spinal claudication: 4; paraparesis: 2; acute foot drop: 13/19 (complication within 30 days: Dural tear, wound healing disorder, adjacent segment collapse)16/19 (spinal stenosis: 7; hyperkyphosis: 4; adjacent segment disease: 2; pseudoarthrosis: 2; posttraumatic deformity: 1)Decompression: 5; decompression + fusion: 8; alignment correction with osteotomy: 3)Dural tear: 11; implant failure: 2; wound disorder: 2; urosepsis: 1Full recovery: 5; partial recovery: 11; no improvement: 2
Hariharan et al[31], 2024Spinal stenosisRetrospective3318.7 (10.1)33 (24 selected for analysis)---Caudal pseudarthrosis: 8; proximal junctional kyphosis: 7; new neurological symptoms: 7
Tanaka et al[28], 2022TLKRetrospective case series3 (2/1)22.3 3Posterior vertebral column resection9.3 yearsSevere TLK with neurological deficits and urinary disturbanceSurgery: Posterior vertebral column resection with cage and segmental instrumentationRod breakage, surgical site infectionAverage Japanese Orthopedic Association score improved from 8.3/11 to 10.7/11 (mean recovery rate: 83%); 67% kyphotic angle correction
Sciubba et al[29], 2007Spinal stenosis. Surgery: Decompression +/- fusionRetrospective44 (25/19)12.760 decompressive surgeriesThoracolumbar (65.3%), lumbar (20.4%), cervical (8%), cervicothoracic (4%), thoracic (2%)34 monthsNeurogenic claudication (91%), pain (95.4%), cauda equina syndrome (25%), myelopathy (4.5%)Disc herniation at L2-3 within a previous laminectomyProgressive deformity, junctional stenosis, and recurrence of symptomsDural tear: 4, wound breakdown: 2, radicular pain: 332 patients showed improvement in symptoms
Matsumoto et al[32], 2006TLK, surgery: Posterior osteotomy with segmental instrumentationCase report4 (3/1)32.54Thoracolumbar35 monthsSevere TLK with neurologic deficitDural tear and partial nerve root laceration: 2Mean recovery rate: 75%
Table 3 Summary of surgical management of spinal disorders in various skeletal dysplasias
Skeletal dysplasia (incidence)
Common spinal disorders
Nonsurgical management
Surgical management
Achondroplasia (1:20000-1:30000)Foramen magnum stenosis neurological complicationsRegular monitoring with magnetic resonance imaging and X-rays. Physical therapy for posture and strength. Pain management. Ergonomic modificationsDecompression surgery if severe compression or neurological symptoms occur
Hypochondroplasia (1:15000-1:40000)Spinal stenosis: Degenerative disc diseasePhysical therapy. Pain management. Ergonomic modifications. Regular spinal assessmentsSurgical intervention for severe stenosis or radiculopathy. Decompression surgery
Spondyloepiphyseal dysplasia congenita (1:100000)AAI, OH, scoliosisPhysical therapy. Bracing for scoliosis. Regular monitoring. Pain management. Adaptive mobility devicesDecompression (C1 laminectomy) and OC fusion. Deformity correction
Kniest dysplasia (1:1000000)AAI, OH, scoliosisPhysical therapy. Bracing for scoliosis. Regular monitoring. Pain management. Adaptive mobility devicesDecompression (C1 laminectomy) and OC fusion. Deformity correction
Diastrophic dysplasia (1:500000)Cervical kyphosis, kyphoscoliosisEarly orthotic management. Regular monitoring for curve progression. Physical therapy. Pain managementAnterior/posterior correction for severe curves or progressive deformities. Spinal fusion if necessary
Mucopolysaccharidoses (all forms: 1:25000, I: 1:100000, IV: 1:200000-1:300000)Craniovertebral junction stenosis, Thoracolumbar kyphosis, scoliosisRegular monitoring and physical therapy. Management of symptoms and pain. Occupational therapy. Supportive careDeformity correction. Decompression if necessary
Osteogenesis imperfecta (all forms: 1:10000-1:20000)Spinal deformities (kyphosis, scoliosis)Regular spinal evaluations. Bracing and physical therapy. Bisphosphonates for bone strength. Pain managementSurgery for severe curves or spinal instability. Spinal fusion in progressive cases