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World J Methodol. Sep 20, 2025; 15(3): 102703
Published online Sep 20, 2025. doi: 10.5662/wjm.v15.i3.102703
Table 1 The adverse events in gastrointestinal endoscopy classification
Grading
Definition
No adverse eventA telephone contact with the general practitioner, outpatient clinic, or endoscopy service without any intervention or extended observation of the patient after the procedure, < 3 hours, without any intervention
Grade IAdverse events with any deviation of the standard postprocedural course, without the need for pharmacologic treatment or endoscopic, radiologic, or surgical interventions
Presentation at the emergency ward, without any intervention
Hospital admission (< 24 hours), without any intervention
Allowed therapeutic regimens are drugs as antiemetics, antipyretics, analgesics, and electrolytes
Allowed diagnostic tests: Radiology and laboratory tests
Grade IIAdverse events requiring pharmacologic treatment with drugs other than those allowed for grade I adverse events (i.e., antibiotics, antithrombotics, etc.)
Blood or blood product transfusions
Hospital admission for more than 24 hours
Grade IIIAdverse events requiring endoscopic, radiologic, or surgical intervention
Grade IIIaEndoscopic or radiologic intervention
Grade IIIbSurgical intervention
Grade IVAdverse events requiring intensive care unit/critical care unit admission
Grade IVaSingle-organ dysfunction (including dialysis)
Grade IVbMultiorgan dysfunction
Grade VDeath
Table 2 Classification of adverse events of third space endoscopy[18]
Category
Type of adverse event
SevereAny events requiring prolongation of hospital for > 10 days and ICU admission > 1 night
Insufflation related events
Causing hemodynamic instability
Requiring premature termination of procedure ± drainage
Mucosal injury (during or after)
Requiring special closure techniques (stenting/sponge/surgery/drainage)
Bleeding (during or after)
Requiring blood transfusion
Causing hemodynamic instability
Endoscopic reintervention or surgery
Post procedure leak
Requiring endoscopic reintervention, drainage or surgery
Cardiopulmonary events
Causing hemodynamic instability
Requiring premature termination of procedure
Infection
Causing hemodynamic instability requiring antibiotics ± drainage or surgery
ModerateAny events requiring prolongation of hospital for 4-10 days and ICU admission for 1 day
Insufflation related events with high probability of hemodynamic compromise requiring prolonged withholding of procedure (15 minutes) ± immediate drainage
Capno-pericardium
Mediastinal emphysema
Tension pneumothorax
Pleural effusion (during or after)
Requiring drainage ± antibiotics
MildInsufflation related events requiring temporary withholding of procedure ± drainage
Retroperitoneum
Pneumothora
Capno-peritoneum
Mucosal injury (during or after) which can closed endoscopically
Bleeding (during or after) not requiring blood transfusion or additional endoscopic intervention
Infection requiring prolonged antibiotics
Not an adverse eventInsufflation related events not requiring any measures and accidently detected during fluoroscopy
Small pneumothorax
Small pneumoperitoneum
Retroperitoneum
Mild mediastinal emphysema
Subcutaneous emphysema