Molecular and serology methods in the diagnosis of COVID-19: An overview

Table 1 Coronavirus disease 2019 main diagnostic methods characteristics

Ref.	Diagnostic method	Sensitivity	Specificity	Time to result
Liu et al[23]	ELISA (IgM/IgG)	57.9%-90.7%	No cross-reactivity observed	About 100 min
Cai et al[24]	CLIA (IgM/IgG/IgM and IgG)	57.2%-81.5%	No cross-reactivity observed	ND
Montesinos et al[25]	LFA (IgM/IgG/IgM and IgG)	~70.0%	95.8%-100%	About 10 min
Scohy et al[52]	Antigen detection	30.2%	100%	About 15 min
Porte et al[54]	Antigen detection	93.9%	100%	About 15 min
Suo et al[19]	RT-PCR	94.0%	100%	ND
Österdahl et al[26]	RT-LAMP	80.0%	73%–100%	About 25 min
Dao Thi et al[27]	RT-LAMP	97.5%	99.7%	About 30 min
Ai et al[28]	Chest CT	97.0%	25%	ND

ELISA: Enzyme-linked immunosorbent assay; IgA: Immunoglobulin A; IgM: Immunoglobulin M; IgG: Immunoglobulin G; LFA: Lateral flow assay; CLIA: Chemiluminescence immunoassay; RT-PCR: Reverse transcription-polymerase chain reaction; RT-LAMP: Reverse transcription loop-mediated isothermal amplification; CT: Computed tomography; ND: Not described.