Popescu FD, Vieru M. Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules. World J Methodol 2018; 8(3): 17-36 [PMID: 30519536 DOI: 10.5662/wjm.v8.i3.17]
Corresponding Author of This Article
Florin-Dan Popescu, MD, PhD, Associate Professor, Chief Doctor, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Sos Vergului 12, Sector 2, Bucharest 022441, Romania. florindanpopescu@ymail.com
Research Domain of This Article
Anatomy & Morphology
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Editorial
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Popescu FD, Vieru M. Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules. World J Methodol 2018; 8(3): 17-36 [PMID: 30519536 DOI: 10.5662/wjm.v8.i3.17]
World J Methodol. Nov 29, 2018; 8(3): 17-36 Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules
Florin-Dan Popescu, Mariana Vieru
Florin-Dan Popescu, Mariana Vieru, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, Bucharest 022441, Romania
Florin-Dan Popescu, Mariana Vieru, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Bucharest 022441, Romania
Author contributions: Popescu FD and Vieru M conceived the editorial and drafted the manuscript; both authors approved the final version of the article.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Corresponding author to: Florin-Dan Popescu, MD, PhD, Associate Professor, Chief Doctor, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Sos Vergului 12, Sector 2, Bucharest 022441, Romania. florindanpopescu@ymail.com
Telephone: +40-212-555405 Fax: + 40-212-555275
Received: July 9, 2018 Peer-review started: July 9, 2018 First decision: August 2, 2018 Revised: August 9, 2018 Accepted: October 9, 2018 Article in press: October 9, 2018 Published online: November 29, 2018 Processing time: 143 Days and 11.6 Hours
Core Tip
Core tip: Allergic respiratory diseases affect many people of all ages worldwide, showing increased prevalence, severity and complexity. New generation immunoassays using allergenic molecules represent a great precision medicine approach in research and clinical practice, allowing in vitro assessment of the immunoglobulin E (IgE) sensitization pattern at the molecular level, with favorable impact on allergy diagnosis and treatment, especially in selected patients with multiple aeroallergen sensitizations. The choice for a specific IgE immunoassay (singleplex, multiparameter or multiplex) for the allergenic extracts and molecular specificities, and the correct interpretation of the results, require optimal knowledge of the tests’ methodologies and characteristics, and good clinical judgments.
