©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Jun 26, 2017; 7(2): 37-45
Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.37
Published online Jun 26, 2017. doi: 10.5662/wjm.v7.i2.37
Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?
George Vaos, Nick Zavras, Department of Paediatric Surgery, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, School of Medicine, 12462 Haidari, Athens, Greece
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Correspondence to: George Vaos, MD, PhD, FEBPS, Professor, Department of Paediatric Surgery, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, School of Medicine, 1 Rimini Street, 12462 Haidari, Athens, Greece. gvaos@med.uoa.gr
Telephone: +30-210-5831299 Fax: +30-210-5326411
Received: January 28, 2017
Peer-review started: February 8, 2017
First decision: March 28, 2017
Revised: April 21, 2017
Accepted: May 12, 2017
Article in press: May 15, 2017
Published online: June 26, 2017
Processing time: 142 Days and 12.4 Hours
Peer-review started: February 8, 2017
First decision: March 28, 2017
Revised: April 21, 2017
Accepted: May 12, 2017
Article in press: May 15, 2017
Published online: June 26, 2017
Processing time: 142 Days and 12.4 Hours
Core Tip
Core tip: Testicular torsion is an emergency condition, most commonly seen in newborns and adolescents, which can be considered as an ischemia-reperfusion injury. We provide an overview of the molecular pathogenesis of the disease, and the current evidence of antioxidants use in the experimental torsion-detorsion situation. Possible adaptation of the experimental factors in the clinical practice is discussed.