Laboratory evaluation in rheumatic diseases

doi:10.5662/wjm.v7.i1.1

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World Journal of Methodology

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World J Methodol. Mar 26, 2017; 7(1): 1-8
Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.1

Laboratory evaluation in rheumatic diseases

Murat Birtane, Selçuk Yavuz, Nurettin Taştekin

Murat Birtane, Selçuk Yavuz, Nurettin Taştekin, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Edirne 22040, Turkey

Author contributions: All authors equally contributed to this paper with literature review, drafting, critical revision, editing, and final approval of the final version.

Conflict-of-interest statement: All authors declare no potential conflicts of interests for this paper and no financial support.

Correspondence to: Selçuk Yavuz, MD, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Balkan Campus, Edirne 22040, Turkey. selcukyavuz@trakya.edu.tr

Telephone: +90-505-4876184 Fax: +90-284-2357641

Received: August 26, 2016
Peer-review started: August 26, 2016
First decision: November 29, 2016
Revised: January 6, 2017
Accepted: January 16, 2017
Article in press: January 18, 2017
Published online: March 26, 2017
Processing time: 210 Days and 8.1 Hours

Core Tip

Core tip: Serological and proteomic biomarkers are useful in confirming clinically suspected preliminary diagnosis, monitoring the treatment response and prognosis of autoimmune diseases. Tests for acute phase proteins, rheumatoid factor, anti-citrullinated peptide antibodies and antinuclear antibodies, may support the diagnoses of rheumatic diseases. But these biomarkers should be used beside a careful anamnesis and detailed physical examination. Improper using of these tests may cause false-positive results and unnecessary harmful treatments. The sensitivity, specificity and likelihood ratios of the test must be known. If the test is highly specific, the diagnosis can be confirmed in case of positivity and if it is highly sensitive, the possible diagnosis can be excluded in case of negativity.