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World J Methodol. Jun 26, 2014; 4(2): 99-108
Published online Jun 26, 2014. doi: 10.5662/wjm.v4.i2.99
Published online Jun 26, 2014. doi: 10.5662/wjm.v4.i2.99
Adult stem cell-based apexogenesis
Yao Li, Li-Hong Shu, Ming Yan, Wen-Yong Dai, Jun-Jun Li, Guang-Dong Zhang, Jin-Hua Yu, Institute of Stomatology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Yao Li, Department of Stomatology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing 210014, Jiangsu Province, China
Li-Hong Shu, Department of Stomatology, Children’s Hospital of Changzhou, Changzhou 213003, Jiangsu Province, China
Ming Yan, Guang-Dong Zhang, Jin-Hua Yu, Endodontic Department, Dental School of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Li Y, Shu LH, Yan M, Dai WY, Li JJ, Zhang GD and Yu JH contributed to this paper.
Supported by National Natural Science Foundation of China, No. 81371144; Natural Science Foundation of Jiangsu Province, No. BK20131392; and the Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD, No. 2011-137
Correspondence to: Jin-Hua Yu, PhD, DDS, Professor, Vice Director, Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. yuziyi_yjh@hotmail.com
Telephone: +86-25-86862843 Fax: +86-25-86862823
Received: November 23, 2013
Revised: January 1, 2014
Accepted: March 13, 2014
Published online: June 26, 2014
Processing time: 270 Days and 2.9 Hours
Revised: January 1, 2014
Accepted: March 13, 2014
Published online: June 26, 2014
Processing time: 270 Days and 2.9 Hours
Core Tip
Core tip: Compared with traditional root canal therapy, stem cell-based therapies initiate a new approach to treating dental pulp diseases. The development of teeth depends on many kinds of stem cells and some of which still exist after the formation of the root, creating a chance for the tooth to regenerate itself when it stops developing due to infection or trauma. This article provides an interesting view on the benchtop and clinical regeneration of root apex mediated by adult stem cells. Moreover, current strategies for infected pulp therapy are also discussed.