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World J Methodol. Sep 20, 2026; 16(3): 121596
Published online Sep 20, 2026. doi: 10.5662/wjm.v16.i3.121596
Published online Sep 20, 2026. doi: 10.5662/wjm.v16.i3.121596
Salivary glutathione peroxidase-1 levels in periodontitis
Leonardo Lorente, Intensive Care Unit, Hospital Universitario de Canarias, San Cristóbal de La Laguna 38320, Tenerife, Spain
Esther Hernández Marrero, María José Marrero González, Carmen Hernández Marrero, Olga Hernández Marrero, Cándido Manuel Hernández Padilla, Department of Periodontology, Clínica Dental Cándido, San Cristóbal de La Laguna 38204, Tenerife, Spain
Pedro Abreu-Gonzalez, Department of Basic Medical Sciences, University of La Laguna, La Laguna 38320, Tenerife, Spain
Angel Daniel Lorente Martín, Department of Odontology, CEU San Pablo University, Madrid 28660, Spain
Marina Lorente Martín, Department of Nursing, Salus Infirmorum-Universidad Pontificia de Salamanca, Madrid 28015, Spain
Alejandro Jiménez, Research Unit, Hospital Universitario de Canarias, San Cristóbal de La Laguna 38320, Tenerife, Spain
Author contributions: Lorente L conceived, designed and coordinated the study, participated in acquisition and interpretation of data, and drafted the manuscript. Hernández Marrero E, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, and Hernández Padilla CM participated in acquisition of data; Abreu-Gonzalez PA participated in salivary levels determinations; Jiménez A participated in the interpretation of data; and all authors revised the manuscript critically for important intellectual content and made the final approval of the version to be published.
Institutional review board statement: This study was initiated after obtaining approval from the Clinical Research Ethics Committee of the Hospital Universitario de Canarias (CHUC_2023_138; November 30, 2023).
Informed consent statement: Prior to inclusion, all participants provided written informed consent.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets generated during the current study are available from the corresponding author on reasonable request.
Corresponding author: Leonardo Lorente, MD, PhD, Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, San Cristóbal de La Laguna 38320, Tenerife, Spain.
Received: March 30, 2026
Revised: April 29, 2026
Accepted: May 18, 2026
Published online: September 20, 2026
Processing time: 104 Days and 22.4 Hours
Revised: April 29, 2026
Accepted: May 18, 2026
Published online: September 20, 2026
Processing time: 104 Days and 22.4 Hours
Core Tip
Core Tip: Periodontitis consists of a chronic inflammatory disease of periodontal tissue. In addition to inflammation, oxidation is also involved in periodontitis. Glutathione peroxidase (GPx)-1 is an antioxidant enzyme. Novel findings of our study were that salivary GPx-1 levels were able to diagnose periodontitis and were independently associated with periodontitis.