©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 108291
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.108291
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.108291
Is elevated serum homocysteine in isolated ischemic cranial nerve palsies a predictor of stroke?
Pallikkara Divya Ravindran, Sharanya Rajendra, Karthik Kumar, Virna M Shah, Department of Neuro Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nadu, India
Author contributions: Shah VM and Ravindran PD designed the study; the study was conducted by Rajendra S and Kumar K; Shah VM and Ravindran PD analyzed the data and wrote the paper; Shah VM supervised the study.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Aravind Eye Hospital, Madurai, India.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to use of anonymous patient data for research at the time of registration in the outpatient department. We applied the Opt-out method to obtain consent for this study by using a poster. The poster was approved by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at virna@aravind.org.
Corresponding author: Virna M Shah, Chief Physician, Department of Neuro Ophthalmology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641014, Tamil Nadu, India.
Received: April 11, 2025
Revised: May 21, 2025
Accepted: August 8, 2025
Published online: March 20, 2026
Processing time: 306 Days and 8.1 Hours
Revised: May 21, 2025
Accepted: August 8, 2025
Published online: March 20, 2026
Processing time: 306 Days and 8.1 Hours
Core Tip
Core Tip: This retrospective study of 66 patients with isolated ischemic cranial nerve palsies found elevated serum homocysteine in over half the cases, including those without traditional vascular risk factors. The findings suggest homocysteine may be an independent risk factor for stroke, supporting routine testing in such patients which may help identify stroke risk early and guide preventive care.