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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 107927
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.107927
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.107927
Apparent diffusion coefficient of kidneys with non-contrast magnetic resonance angiography for functional and anatomical assessment in renal artery stenosis
Hira Lal, Surabhi Agarwal, Kaushik Ponmalai, Raghunandan Prasad, Swagata Mandal, Sandeep Kumar, Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Dharmendra S Bhadauria, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Sanjay Gambhir, Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Nuclear Medicine, Lucknow 226014, Uttar Pradesh, India
Priyank Yadav, Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Pinky Jowel, Department of Health and Family Welfare, National Health Mission, Government of Uttar Pradesh, Lucknow 226001, Uttar Pradesh, India
Author contributions: Lal H, Agarwal A, Prasad R, Bhadauria D, Gambhir S, Yadav P designed and coordinated the study; Lal H, Agarwal S, Mandal S, Kumar S performed the examinations, acquired and analyzed data; Lal H, Ponmalai K, Prasad R, Jowel P interpreted the data; Agarwal S, Yadav P wrote the manuscript; Statistical analysis was performed by Agarwal S, Yadav P, Singh A; all authors approved the final version of the article.
Institutional review board statement: The study was reviewed and approved by the institutional review board of SGPGIMS, Lucknow, India (IEC code: 2018-110-MD-EXP; PGI/BE/424/2018).
Informed consent statement: All study participants provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hira Lal, Professor, Department of Radiology, Sanjay Gandhi Postgra
Received: April 2, 2025
Revised: May 25, 2025
Accepted: August 20, 2025
Published online: March 20, 2026
Processing time: 316 Days and 0.8 Hours
Revised: May 25, 2025
Accepted: August 20, 2025
Published online: March 20, 2026
Processing time: 316 Days and 0.8 Hours
Core Tip
Core Tip: Diffusion-weighted magnetic resonance imaging (DW-MRI) provides a non-invasive method to assess renal function in patients with renal artery stenosis (RAS). This study demonstrates that the apparent diffusion coefficient is significantly lower in RAS-affected kidneys, correlating with stenosis severity and split glomerular filtration rate. DW-MRI, in combination with non-contrast magnetic resonance angiography, offers a promising tool for early detection and triage of RAS patients, potentially guiding timely intervention and improving clinical outcomes.