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World J Methodol. Dec 20, 2025; 15(4): 107305
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.107305
Endoscopic ultrasound-guided radiofrequency ablation of pancreatic tumors: Current status and future perspectives
Hussein H Okasha, Eyad Gadour, Abdullah Zuhair Alyouzbaki, Hossam E Shaaban
Hussein H Okasha, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kasr Al-Aini School of Medicine, Cairo University, Cairo 11562, Egypt
Eyad Gadour, Multiorgan Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia
Eyad Gadour, Department of Medicine, Faculty of Medicine, Zamzam University College, Khartoum 11113, Sudan
Abdullah Zuhair Alyouzbaki, Department of Internal Medicine, College of Medicine, University of Mosul, Mosul 41002, Nīnawá, Iraq
Hossam E Shaaban, Department of Internal Medicine and Gastroenterology, NHTMRI, Cairo 11796, Egypt
Hossam E Shaaban, Department of Gastroenterology, Barking Havering and Redbridge University Hospital NHS Trust, London RM7 0AG, United Kingdom
Author contributions: Shaaban HE wrote the original draft; Okasha HH revised it and added modifications and the figure; Alyouzbaki AZ and Gadour E revised the modified version; All the authors revised and agreed to the final manuscript prior to submission.
Conflict-of-interest statement: The authors declare that there are no commercial, personal, political, intellectual, or religious conflicts of interest related to this work. All authors have reviewed and approved the final manuscript and confirm that there are no financial or non-financial interests that could be perceived to influence the content presented in this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hossam E Shaaban, PhD, Consultant, FACG, FASGE, Department of Internal Medicine and Gastroenterology, NHTMRI, 10 Kasr Alan st., Cairo 11796, Egypt. hsshaaban@aol.com
Received: March 20, 2025
Revised: April 20, 2025
Accepted: June 17, 2025
Published online: December 20, 2025
Processing time: 137 Days and 19.3 Hours
Core Tip

Core Tip: Endoscopic ultrasound-guided radiofrequency ablation has emerged as a promising minimally invasive approach for managing pancreatic tumors, providing a valuable alternative for patients who are poor surgical candidates. It effectively achieves significant tumor size reduction, symptom relief, and, in selected cases, prolonged survival, especially in pancreatic neuroendocrine tumors and cystic lesions. Despite a favorable safety profile, including low rates of major complications, standardization of protocols and further technological advancements such as artificial intelligence integration and combination therapies are essential for optimizing treatment outcomes and broadening clinical applicability.