Meta-Analysis
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World J Methodol. Jun 20, 2025; 15(2): 99300
Published online Jun 20, 2025. doi: 10.5662/wjm.v15.i2.99300
Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section: A meta-analysis
Rishi Anand, Deb Sanjay Nag, Roushan Patel, Prashant Sharma, Vamsi Krishna Uppalapati, Umesh Kumar Singh
Rishi Anand, Deb Sanjay Nag, Roushan Patel, Prashant Sharma, Vamsi Krishna Uppalapati, Umesh Kumar Singh, Department of Anaesthesiology, Tata Main Hospital, Jamshedpur 831001, Jhārkhand, India
Author contributions: Anand R, Nag DS designed the overall concept and outline of the manuscript; Patel R, Sharma P, Uppalapati VK, Singh UK contributed to the discussion and design of the manuscript; Anand R, Nag DS, Patel R, Sharma P, Uppalapati VK, Singh UK contributed to this paper, the writing, and editing the manuscript and review of literature; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deb Sanjay Nag, MD, Doctor, Department of Anaesthesiology, Tata Main Hospital, C Road West, Northern Town, Bistupur, Jamshedpur 831001, Jhārkhand, India. ds.nag@tatasteel.com
Received: July 19, 2024
Revised: October 11, 2024
Accepted: November 15, 2024
Published online: June 20, 2025
Processing time: 131 Days and 6.4 Hours
Core Tip

Core Tip: Hyperbaric bupivacaine had been the standard local anesthetic drug for spinal anesthesia in caesarean sections. Its drawbacks include high incidences of adverse events (hypotension, nausea) and delayed ambulation. Ropivacaine, a newer local anesthetic agent, offers potential advantages such as improved safety and shorter motor blockade duration. Recent marketing of heavy ropivacaine has reignited interest in this. This meta-analysis compares the hyperbaric preparation of ropivacaine and bupivacaine in the context of spinal anesthesia for cesarean sections. This analysis aims to shed light on the comparative benefits of these agents, paving the way for informed decision-making in obstetric anesthesia practices.