Observational Study
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World J Methodol. Mar 20, 2025; 15(1): 98482
Published online Mar 20, 2025. doi: 10.5662/wjm.v15.i1.98482
Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis
Chinmay Mahatme, Madhurima Kaushik, Veerappan Rathinasabapathy Saravanan, Karthik Kumar, Virna M Shah
Chinmay Mahatme, Department of General Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Madhurima Kaushik, Karthik Kumar, Virna M Shah, Department of Neuro-ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Veerappan Rathinasabapathy Saravanan, Department of Vitreoretina, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Author contributions: Kaushik M and Kumar K conducted the study; Shah VM and Saravanan VR designed the study; Mahatme C analyzed the data and wrote the paper; Shah VM supervised the study.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Aravind Eye Hospital, Madurai, India.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to use of anonymous patient data for research at the time of registration in the outpatient department. We applied the opt-out method to obtain consent for this study by using a poster.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at virna@aravind.org.
STROBE statement: The authors have read the STROBE Statement—checklist of items—and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Virna M Shah, DO, Chief Physician, Department of Neuro-ophthalmology, Aravind Eye Hospital, Tamilnadu, Coimbatore 641014, India. virna@aravind.org
Received: June 27, 2024
Revised: August 1, 2024
Accepted: August 13, 2024
Published online: March 20, 2025
Processing time: 94 Days and 3.5 Hours
Core Tip

Core Tip: Our observational study shows that although there are microvascular and structural changes seen on optical coherence tomography angiography in atypical optic neuritis, these changes could not help in differentiating between neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody disorder cases.