Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Sep 20, 2022; 12(5): 428-437
Published online Sep 20, 2022. doi: 10.5662/wjm.v12.i5.428
Role of the circulatory interleukin-6 in the pathogenesis of gliomas: A systematic review
Manish Singh, Alok Raghav, Kirti Amresh Gautam
Manish Singh, Alok Raghav, Department of Neurosurgery, GSVM Medical College, Kanpur 208001, India
Kirti Amresh Gautam, Department of Basic and Applied Science, GD Goenka University, Gurugram 122103, Haryana, India
Author contributions: Singh M conceptualized this manuscript; Gautam KG and Raghav A performed the literature search and scrutiny of eligible studies; Gautam KG and Raghav A wrote the manuscript; all authors have read and approved the final draft of the manuscript.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kirti Amresh Gautam, BSc, MSc, PhD, Assistant Professor, Department of Basic and Applied Science, GD Goenka University, Sohna Road, Gurugram 122103, Haryana, India. emails2kirti@gmail.com
Received: December 13, 2021
Peer-review started: December 13, 2021
First decision: March 24, 2022
Revised: April 1, 2022
Accepted: July 24, 2022
Article in press: July 24, 2022
Published online: September 20, 2022
Processing time: 277 Days and 4.2 Hours
Core Tip

Core Tip: In spite of extensive research in the field of brain oncology, the overall survival is not much improved. There is an urgent need to explore the circulatory markers for diagnosis and prognosis. This systematic review focused on the role of interleukin-6 in brain cancer development and progression and its utility as a diagnostic or prognostic biomarker.