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World J Methodol. Jun 20, 2023; 13(3): 67-78
Published online Jun 20, 2023. doi: 10.5662/wjm.v13.i3.67
IgA nephropathy associated with Crohn's disease
Hiroshi Tamura
Hiroshi Tamura, Department of Pediatrics, Kumamoto University, Kumamoto 8608556, Japan
Author contributions: Tamura H reviewed the patient’s clinical data, wrote the initial draft of the manuscript, contributed to writing the manuscript, and revised the final version of the manuscript.
Conflict-of-interest statement: The author declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroshi Tamura, MD, PhD, Assistant Professor, Department of Pediatrics, Kumamoto University, Chuo-ku Honjo 1-1-1, Kumamoto 8608556, Japan. bohm1905ht@kuh.kumamoto-u.ac.jp
Received: March 24, 2023
Peer-review started: March 24, 2023
First decision: April 3, 2023
Revised: April 16, 2023
Accepted: May 12, 2023
Article in press: May 12, 2023
Published online: June 20, 2023
Processing time: 88 Days and 9.7 Hours
Abstract

The relationship between IgA nephropathy (IgAN) and Crohn’s disease was reported. IgAN is the most common primary glomerulonephritis and one of the leading causes of chronic kidney disease and end-stage renal failure, and up to 50% of cases progressed to end-stage renal disease within 25 years after IgAN diagnosis. However, specific and effective therapeutic strategies are still lacking. In this review, we discuss the possibility of the mechanism involved in IgAN associated with Crohn’s disease based on the findings of basic and clinical studies. Although the etiology of IgAN associated with Crohn’s disease is not permanent and various factors are thought to be involved, the stabilization of the disease condition of Crohn’s disease is believed to help treat IgAN.

Keywords: Crohn’s disease; IgA nephropathy; Immunological abnormalities; Mucosal-associated lymphoid tissue; Gut-associated lymphoid tissue; Nasopharynx-associated lymphoid tissue

Core Tip: The relationship between IgA nephropathy (IgAN) and Crohn’s disease was reported. Crohn's disease (CD) immunological abnormalities may promote and activate the IgAN inflammatory process. Although the etiology of CD-IgAN is not fixed and various factors are thought to be involved, the stabilization of the disease condition of CD is believed to help treat IgAN.