|
1
|
Bălan DC, Drăghici R, Găiculescu I, Rusu A, Stan AE, Stan P. An Optimal Beneficiary Profile to Ensure Focused Interventions for Older Adults. Geriatrics (Basel) 2025; 10:59. [PMID: 40277858 PMCID: PMC12026497 DOI: 10.3390/geriatrics10020059] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2025] [Revised: 03/19/2025] [Accepted: 04/09/2025] [Indexed: 04/26/2025] Open
Abstract
Background: Aging is a lifelong process, and many chronic diseases and geriatric syndromes are influenced by lifestyle factors. For active aging and maintaining functional capacity facilitate health, there are essential aspects in geriatric care. Our objective was to create a specific profile focusing on the characteristics of a possible optimal beneficiary of a newly developed program that is meant to increase the social inclusion and participation in social life of older adults. Methods: The profile was built based on a mixed design, a quantitative and qualitative analysis that identified the typology of an optimal beneficiary of a newly developed yoga program. The quantitative analysis (50 subjects from NIGG "Ana Aslan" Bucharest) identified the main predictors impacting subjects' willingness to participate in a yoga program based on their pathologies at a mental and/or physical level. The main materials used for this were the Clinical Assessment Scales for the Elderly (CASE-SF) and the Quality-of-Life Assessment Questionnaire (WHOQOL-BREF). The qualitative analysis consisted of four focus groups (10 subjects from NIGG "Ana Aslan" and 7 subjects from GNSPY), aiming to provide the in-depth reasons for participating in a yoga program. Results: The results showed that a diagnosed physical impairment was correlated with an increased willingness to participate in yoga classes, while a mental pathology was associated with a decreased willingness to participate in such a program. Five main themes emerged from the qualitative analysis. Conclusions: The profile provides answers related to the specifics of the beneficiary based on their motivation, limits, and personality traits.
Collapse
Affiliation(s)
| | - Rozeta Drăghici
- Research Laboratory of Social Gerontology and GerontoPsychology, “Ana Aslan” National Institute of Gerontology and Geriatrics, 011241 Bucharest, Romania; (D.-C.B.); (I.G.); (A.R.); (A.-E.S.); (P.S.)
| | | | | | | | | |
Collapse
|
|
2
|
Vallazhath A, Thimmappa PY, Joshi HB, Hebbar KR, Nayak A, Umakanth S, Saoji AA, Manjunath NK, Hadapad BS, Joshi MB. A comprehensive review on the implications of Yogic/Sattvic diet in reducing inflammation in type 2 diabetes. Nutr Diabetes 2025; 15:14. [PMID: 40216734 PMCID: PMC11992243 DOI: 10.1038/s41387-025-00371-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/23/2024] [Revised: 03/25/2025] [Accepted: 03/28/2025] [Indexed: 04/14/2025] Open
Abstract
Chronic inflammation in type 2 diabetes (T2D), characterized by constitutively activated immune cells and elevated pro-inflammatory mediators along with hyperglycaemia and increased free fatty acids and branched chain amino acid levels, significantly alters the immuno-metabolic axis. Over the years, dietary intervention has been explored as an effective strategy for managing T2D. Evidence from experimental and clinical studies indicates that various diets, including Mediterranean, Nordic, Palaeolithic and ketogenic diets, increase insulin sensitivity, decrease gluconeogenesis, and adiposity, and exert anti-inflammatory effects, thus preserving immuno-metabolic homeostasis in individuals with T2D. Indian dietary sources are categorized as Sattvic, Rajasic, and Tamasic, depending on their impact on health and behaviour. The Yogic diet, commonly recommended during yoga practice, is predominantly Sattvic, emphasizing plant-based whole foods while limiting processed and high-glycaemic-index items. Yogic diet is also recommended for Mitahara, emphasizing mindful eating, which is attributed to calorie restriction. Adopting a Yogic diet, featuring low-fat vegetarian principles, strongly reduces inflammatory mediator levels. This diet not only ameliorates insulin resistance and maintains a healthy body weight but also regulates immunomodulation, enhances gut microbiome diversity and provides essential phytonutrients, collectively preventing inflammation. Although, preliminary studies show aforementioned beneficial role of Yogic diet in improving diabetes associated metabolic and inflammatory changes, precise cellular and molecular mechanisms are not yet understood. Hence, further studies are warranted to decipher the mechanisms. This review summarizes the multiple roles of Yogic diet and related dietary components in mitigating inflammation and enhancing glycaemic control in T2D.
Collapse
Affiliation(s)
- Anupama Vallazhath
- Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India
| | - Pooja Yedehalli Thimmappa
- Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India
| | - Harshit B Joshi
- Division of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, 576104, India
| | - Krishna Raghava Hebbar
- Division of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, 576104, India
| | - Anupama Nayak
- Division of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, 576104, India
| | | | - Apar Avinash Saoji
- Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, 560105, Karnataka, India
| | | | - Basavaraj S Hadapad
- Division of Ayurveda, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, 576104, India
| | - Manjunath B Joshi
- Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
- Centre for Ayurveda Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
| |
Collapse
|
|
3
|
Pandey S, Pandey AC, Kotecha VR. Yoga-A complementary and traditional medicine for human health. JOURNAL OF INTEGRATIVE MEDICINE 2025; 23:93-105. [PMID: 39855918 DOI: 10.1016/j.joim.2025.01.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/26/2024] [Accepted: 06/07/2024] [Indexed: 01/27/2025]
Abstract
Yoga is a therapeutic practice renowned for its multifaceted benefits across the body's systems. Its positive impact spans the physical, mental and emotional realms, fostering harmony and well-being. Through a combination of postures, breathing techniques and meditation, yoga offers profound effects, enhancing flexibility, strength and balance while simultaneously promoting relaxation and reducing stress. This integrative approach not only cultivates physical resilience but also supports mental clarity, emotional balance and overall vitality, showcasing yoga as a comprehensive and impactful system for holistic health. The review delved into the multifaceted ways in which yoga exerts a positive influence on the body's various systems. It highlights how yoga serves as a beneficial tool in addressing and counteracting the underlying factors associated with different diseases. By examining yoga's effects on these systems and its potential in combating illness, the paper sheds light on the comprehensive therapeutic benefits that yoga offers. Please cite this article as: Pandey S, Pandey AC, Kotecha VR. Yoga-A complementary and traditional medicine for human health. J Integr Med. 2025; 23(2): 93-105.
Collapse
Affiliation(s)
- Saurabh Pandey
- Inter University Centre for Yogic Science, Aruna Asaf Ali Marg, New Delhi 110067, India; Ministry of Ayush, Ayush Bhawan, New Delhi 110023, India.
| | - Avinash C Pandey
- Inter University Centre for Yogic Science, Aruna Asaf Ali Marg, New Delhi 110067, India
| | | |
Collapse
|
|
4
|
Blanchette JE, Paquin F, Dobbs BN, Kiely RL, Hatipoglu B. Incorporating Complementary Therapies Into Diabetes Care. J Clin Endocrinol Metab 2025; 110:S137-S146. [PMID: 39998922 DOI: 10.1210/clinem/dgae587] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/06/2024] [Indexed: 02/27/2025]
Abstract
CONTEXT Current diabetes care and education programs and expert clinical diabetes management guidelines focus on diabetes self-care behaviors and have yet to incorporate complementary therapies. Complementary therapies, such as music therapy, yoga, mindfulness, and art therapy, have been used globally for centuries and have positive metabolic and glycemic outcomes. In this mini-review, we describe complementary therapies successfully used in diabetes, identify current evidence-based practice gaps, and provide recommendations for incorporating complementary therapies into diabetes care. EVIDENCE ACQUISITION We thoroughly searched relevant PubMed and Google Scholar studies from 2004 to 2024. Our inclusion criteria were clinical trial studies using the search terms "diabetes self-management" OR "metabolic outcomes" OR "diabetes" OR "type of complementary therapy (music therapy, mindfulness, yoga or art therapy) OR population (type 1 diabetes, type 2 diabetes, prediabetes, diabetes)." EVIDENCE SYNTHESIS We synthesized the evidence to determine complementary therapies (music therapy, mindfulness, yoga, or art therapy) that benefit individuals with diabetes. Findings showed that complementary therapies support diabetes-related psychological and cardiometabolic outcomes and enhance the Association of Diabetes Care and Education Specialists 7 Self-Care Behaviors for diabetes self-management, specifically healthy coping, monitoring, reducing risks, and problem-solving. Critical gaps included the lack of large-scale randomized controlled trials in North American diabetes self-management education programs. CONCLUSION Complementary therapies have positive psychological and physiological health benefits for people living with diabetes, yet more randomized controlled trials are needed to assess their effectiveness on a large scale. In the interim, complementary therapies can be integrated into diabetes education, specifically as adjunctive hands-on therapies to enhance self-management behaviors and meet self-management goals.
Collapse
Affiliation(s)
- Julia E Blanchette
- Diabetes and Metabolic Care Center, Division of Endocrinology, Department of Medicine, University Hospitals, Cleveland, OH 44106, USA
- School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
| | - Forrest Paquin
- Connor Whole Health, University Hospitals, Cleveland, OH 44106, USA
| | - Brandi N Dobbs
- Diabetes and Metabolic Care Center, Division of Endocrinology, Department of Medicine, University Hospitals, Cleveland, OH 44106, USA
| | - Rebecca L Kiely
- Connor Whole Health, University Hospitals, Cleveland, OH 44106, USA
| | - Betul Hatipoglu
- Diabetes and Metabolic Care Center, Division of Endocrinology, Department of Medicine, University Hospitals, Cleveland, OH 44106, USA
- School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
| |
Collapse
|
|
5
|
Balkrishna A, Katiyar P, Upreti J, Chauhan M, Sharma D, Kumar S, Arya V. Investigating Ayurvedic Strategies: An In-Depth Examination of Managing Diabetes across Different Types. Curr Diabetes Rev 2025; 21:79-93. [PMID: 38468519 DOI: 10.2174/0115733998284193240227041720] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/23/2023] [Revised: 01/23/2024] [Accepted: 01/31/2024] [Indexed: 03/13/2024]
Abstract
In light of the escalating global concern surrounding diabetes mellitus, contemporary medical practices predominantly hinge on pharmaceutical interventions, accompanied by inherent side effects and enduring limitations. This investigation accentuates a discernible research void regarding the amalgamation of Ayurvedic principles an age-old traditional medical system with prevalent approaches to diabetes management. Despite Ayurveda's promising potential in furnishing a comprehensive and personalized strategy for diabetes treatment, the imperative for further research and collaboration between Ayurvedic practitioners and contemporary healthcare professionals becomes evident. Existing scholarly works underscore the potential advantages of Ayurveda in delivering holistic diabetes care, encompassing not only glycemic control but also fostering overall well-being. Nevertheless, a closer examination reveals specific limitations, challenges, and gaps in current research, necessitating targeted efforts to enable a more exhaustive exploration of Ayurvedic interventions within diabetes management. This comprehensive review scrutinizes Ayurvedic recommendations pertaining to dietary practices, lifestyle adjustments, and herbal therapeutics, shedding light on their plausible efficacy. It serves as a clarion call for heightened research endeavors, aiming to bridge existing gaps and carve a pathway toward an integrated, patientcentric paradigm in diabetes care. In summary, as diabetes prevalence continues to rise globally, the study underscores the limitations of current pharmaceutical-centric approaches and highlights the need for extensive research and collaboration to unlock the full potential of Ayurvedic principles in providing a more holistic and personalized framework for diabetes management. The review navigates through Ayurvedic recommendations, emphasizing the urgency for intensified research efforts to fill existing gaps and pave the way for a seamlessly integrated, patient-focused approach to diabetes care.
Collapse
Affiliation(s)
- Acharya Balkrishna
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
- Department of Applied and Allied Sciences, University of Patanjali, Haridwar, 249405, Uttarakhand, India
| | - Prashant Katiyar
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
| | - Jaya Upreti
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
| | - Muskan Chauhan
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
| | - Dushyant Sharma
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
| | - Sandeep Kumar
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
| | - Vedpriya Arya
- Herbal Research Division, Patanjali Research Foundation, Haridwar, 249405, Uttarakhand, India
- Department of Applied and Allied Sciences, University of Patanjali, Haridwar, 249405, Uttarakhand, India
| |
Collapse
|
|
6
|
Subramani P, Mohan AR, Satish L, Karthikeyan S, Ravi P, Ulagamathesan V, Kannikan V, Viswanathan M. The Impact of Yoga Intervention on Physical and Mental Health of Adults with Type 2 Diabetes. Int J Yoga 2025; 18:67-73. [PMID: 40365367 PMCID: PMC12068464 DOI: 10.4103/ijoy.ijoy_219_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/27/2024] [Revised: 12/04/2024] [Accepted: 12/06/2024] [Indexed: 05/15/2025] Open
Abstract
Aim To assess the impact of a yoga intervention on the physical and mental health of adults with type 2 diabetes. Methods This study was conducted at Madras Diabetes Research Foundation, Chennai, for 6 months. Participants aged 18-65 years, diagnosed with type 2 diabetes mellitus (T2DM), and glycated hemoglobin (HbA1c) levels ranging from ≥7.0% to ≤10.5% were recruited. One hundred and fifty-two participants were randomized in 1:1 ratio to either the intervention or control arm by simple random method. The intervention included structured yoga practice for 35 min, every 2 weeks for a period of 12 weeks, and followed up for 3 months. Participants in the control arm received the standard care for diabetes. Sociodemographic data, anthropometric measurements, and blood samples were collected at baseline and final visit. Standard questionnaires were administered for assessing mental health parameters. Results 53 of 76 (70%) participants from the intervention arm and 70 of 76 (92%) participants from the control arm completed the study. The mean age of the participants was 53 ± 7.5 years. The mean duration of diabetes of the participants was 10 ± 6.9 years. HbA1c showed reduction postintervention, but this was not statistically significant compared to control. The intervention group showed statistically significant improvements in depression, stress, cognitive function, and mindfulness compared to the control arm. Conclusion Yoga is helpful in reducing depression and stress and enhancing mindfulness and cognitive function in patients with T2DM.
Collapse
Affiliation(s)
- Poongothai Subramani
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| | - Anjana Ranjit Mohan
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| | - Latha Satish
- Krishnamacharya Yoga Mandiram, KYM Research Advisory Board, Chennai, Tamil Nadu, India
| | - Swetha Karthikeyan
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| | - Pavithra Ravi
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| | | | - Viswanathan Kannikan
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| | - Mohan Viswanathan
- Department of Clinical Trials, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India
| |
Collapse
|
|
7
|
Tripathi P, Tiwari D, Raizada MK, Kadam N. Type 2 diabetes remission through lifestyle intervention in a geriatric patient with long-standing diabetes and at thirty-three-months follow-up. Endocrinol Diabetes Metab Case Rep 2025; 2025:e240089. [PMID: 39922185 PMCID: PMC11825170 DOI: 10.1530/edm-24-0089] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/01/2024] [Revised: 01/13/2025] [Accepted: 01/24/2025] [Indexed: 02/10/2025] Open
Abstract
Summary Type 2 diabetes (T2D) is a chronic metabolic disorder that affects millions of people worldwide, particularly the elderly population. Remission of T2D in elderly patients through lifestyle modifications has been well documented, especially in newly diagnosed patients with good glycemic control and without obesity. It is also common in patients with obesity undergoing bariatric surgery. In this report, we present the case of a 66-year-old male patient with a 30-year history of T2D and mild obesity who achieved remission of T2D through customized integrated intensive lifestyle modifications, including a vegan diet, exercise and psychological support. The patient showed an improvement in HbA1c (7.7 to 5.3%) and insulin resistance (HOMA-IR; 6.2 to 1.8) and a shift in BMI (25.3 to 23.7 kg/m2) through weight loss (73 to 67 kg). The patient remains in remission 33 months after the completion of the intervention. This case suggests the possibility of long-term remission with lifestyle changes in patients with advanced age, a longer duration of diabetes and mild obesity. Learning points Long-term sustained remission is possible in a geriatric patient with long-standing type 2 diabetes (T2D) of more than 30 years. Customized integrated intensive lifestyle intervention can lead to a significant improvement in glycemic control and insulin resistance in elderly patients with T2D. Integrated lifestyle interventions, including a vegan diet, exercise and psychological support, have the potential to stop the usage of oral hypoglycemic agents and insulin in an elderly patient with a prolonged history of T2D and mild obesity.
Collapse
Affiliation(s)
- Pramod Tripathi
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, India
| | - Diptika Tiwari
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, India
| | - Milanjeet Kaur Raizada
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, India
| | - Nidhi Kadam
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, India
| |
Collapse
|
|
8
|
Tripathi P, Kadam N, Sharma B, Shah M, Vijayakumar V, Kuppusamy M. Diabetes Remission After Radical Nephrectomy in a Geriatric Patient With Obesity and Type 2 Diabetes-34 Months' Follow-Up. JCEM CASE REPORTS 2024; 2:luae210. [PMID: 39544889 PMCID: PMC11561905 DOI: 10.1210/jcemcr/luae210] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/17/2024] [Indexed: 11/17/2024]
Abstract
Diabetes mellitus significantly affects survival in patients with renal cell carcinoma undergoing nephrectomy, requiring personalized care. This case involved a 64-year-old man with type 2 diabetes (T2D) who underwent radical nephrectomy for renal cell carcinoma. He consented to a 1-year intensive lifestyle intervention (ILI), including a vegan diet (to lower calorie intake, reduce uric acid, support renal health, and promote weight loss), intermittent fasting, regular exercise, psychological support, and medical management. Quarterly biochemical assessments and monthly adherence evaluations were conducted. Post intervention, the patient achieved diabetes remission, maintaining glycated hemoglobin A1c (HbA1c) below 6.5% (48 mmol/mol) (reference range, <6.5%; <48 mmol/mol) without medication. He lost 36 kg (79.37 lb), reducing his body mass index from 35.3 to 25.1. His lipid profile normalized (total cholesterol, 175 to 127 mg/dL (4.53 to 3.29 mmol/L) (reference range, <200 mg/dL; <5.18 mmol/L); triglycerides, 155 to 73 mg/dL (1.75 to 0.82 mmol/L) (reference range, <150 mg/dL; <1.69 mmol/L), allowing the discontinuation of statins. Improvements in serum creatinine and high-sensitivity C-reactive protein levels were also observed. The patient exhibited normal glucose tolerance, consecutively passing an oral glucose tolerance test for 2 years. This case highlights the potential of lifestyle modifications in managing T2D in patients with a history of nephrectomy.
Collapse
Affiliation(s)
- Pramod Tripathi
- Department of Research, Freedom From Diabetes Research Foundation, Pune, Maharashtra 411004, India
| | - Nidhi Kadam
- Department of Research, Freedom From Diabetes Research Foundation, Pune, Maharashtra 411004, India
| | - Baby Sharma
- Department of Research, Freedom From Diabetes Research Foundation, Pune, Maharashtra 411004, India
| | - Manisha Shah
- Department of Research, Freedom From Diabetes Research Foundation, Pune, Maharashtra 411004, India
| | - Venugopal Vijayakumar
- Department of Yoga, Government Yoga and Naturopathy Medical College and Hospital, Chennai, Tamil Nadu 600106, India
| | - Maheshkumar Kuppusamy
- Department of Physiology, Government Yoga and Naturopathy Medical College and Hospital, Arumbakkam, Chennai, Tamil Nadu 600106, India
| |
Collapse
|
|
9
|
Saboo N, Rao A, Kacker S. A study to compare and correlate the effect of a yogic lifestyle on Framingham, Q RISK 3, and WHO risk scores among high-risk cardiovascular subjects. Niger Med J 2024; 65:911-924. [PMID: 39877499 PMCID: PMC11770659 DOI: 10.60787/nmj.v65i6.531] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2025] Open
Abstract
Background Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels. Yoga is a low-cost, easily accessible lifestyle modification program that holds as an approach to decreasing cardiometabolic risk factors and increasing exercise self-efficacy among high-risk subjects. This study aimed to assess the impact of the yogic lifestyle (including diet) on cardiovascular risk scores by using the Framingham (FRS), QRISK3 score, and World Health Organization (WHO) CVD risk prediction charts at baseline, three months, and six months. The present study compares and correlates FRS, QRISK3, and WHO cardiovascular risk scores. Methodology The experimental interventional study was conducted among the high-risk population at RUHS College of Medical Sciences and Associated Group of Hospitals, Jaipur. Framingham risk Score, QRISK3 score, and WHO CVD risk prediction charts were used as a method of measurement for the outcome of interest at baseline, three months, and six months in the study and control group. Randomization and allocation in yoga and control groups were performed using computer-generated random numbers. The statistical analysis was done using advanced SPSS-22 software at significant level tests as p≤0.05, ensuring the highest level of accuracy. Data were analyzed using a one-way variance ANOVA test analysis at baseline, three, and six months. Pearson correlation analysis was done to compare different risk scores. Results Participants had a mean age of 48.43 ± 6.4 years. Baseline values (mean±SD) of FRS, Qrisk3, WHO were 24.59±10.15,28.59±10.11,15.71±6.07. After six months of yogic lifestyle, these values decreased significantly to 15.1±7.05, 20.09±7.08, and 13.85±4.96. The decrease in cardiovascular scores was statistically significant (p<0.0001), providing strong evidence for the effectiveness of the yogic lifestyle. Pearson correlation analysis results depict that FRS and Q risk 3 (r=0.840, p<0.0001), FRS and WHO risk chart (r=0.768, p<0.0001), Q risk3 and WHO risk chart (r=0.778, p<0.0001) have a statistically significant strong positive correlation. Conclusion This study's findings suggest that a 24-week yogic lifestyle intervention (including diet) significantly decreased FRS, Q RISK 3, and WHO CVD risk scores among high-risk subjects compared to the control group.
Collapse
Affiliation(s)
- Neha Saboo
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, India
| | - Aayusheee Rao
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, India
| | - Sudhanshu Kacker
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, India
| |
Collapse
|
|
10
|
Tripathi P, Sharma B, Kadam N, Tiwari D, Kathrikolly T, Vyawahare A, Biswas MD, Vijayakumar V, Kuppusamy M, Ganla M, Saboo B. Improvement in symptoms of anxiety and depression in individuals with type 2 diabetes: retrospective analysis of an intensive lifestyle modification program. BMC Psychiatry 2024; 24:714. [PMID: 39438811 PMCID: PMC11520180 DOI: 10.1186/s12888-024-06130-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/17/2024] [Accepted: 09/30/2024] [Indexed: 10/25/2024] Open
Abstract
BACKGROUND Type 2 diabetes (T2D) is a chronic metabolic disorder that has a notable influence on mental well-being, contributing to elevated morbidity and mortality rates. Depression and anxiety disorders are the most common mental health concerns among patients with T2D worldwide. Therefore, the present study aimed to assess the impact of an online intensive lifestyle intervention (ILI) on mental health outcomes (depression and anxiety) in patients with T2D in India. MATERIALS AND METHODS This retrospective pre-post analysis included adult patients (aged > 18 years) diagnosed with T2D who were enrolled in a diabetes management program in India between June 2021 and June 2023. The intervention consisted of lifestyle modifications such as a customized plant-based diet, regular physical activity, psychological support through group and individual therapy, and medical management. Data were extracted from the electronic database of the clinic, including anthropometry, medical history, biochemical parameters, symptoms of depression, and anxiety (assessed using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorders-7 (GAD-7) scale) at the start and end of the six-month intervention period. RESULTS Of the 1061 eligible patients (177 with prediabetes), 40.3% were female. The mean age, duration of diabetes, and HbA1c levels were 52 ± 10.4 years, 9.8 ± 7.8 years, and 8 ± 1.7%, respectively. The prevalence of symptoms of depression and anxiety (ranging from mild to severe) was 46% and 44.3%, respectively, which reduced to 28.7% and 29.2%, respectively, post-intervention. CONCLUSION Integrated ILI successfully improved the symptoms of anxiety and depression, highlighting the importance of a multidisciplinary approach that includes diet, physical activity, psychological support, and medical management in enhancing mental health outcomes among patients with T2D. Future prospective studies are needed to explore the long-term effects of such interventions and develop effective strategies for promoting mental health in diverse populations. TRIAL REGISTRATION The study was approved by the Freedom from Diabetes Research Foundation Institutional Ethics Committee (approval number FFDRF/IEC/2024/7) and registered in the Clinical Trials Registry of India (CTRI/2024/03/064596, registered on March 21, 2024).
Collapse
Affiliation(s)
- Pramod Tripathi
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India
- Freedom from Diabetes Clinic, Pune, Maharashtra, India
| | - Baby Sharma
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India
| | - Nidhi Kadam
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India.
| | - Diptika Tiwari
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India
| | - Thejas Kathrikolly
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India
| | - Anagha Vyawahare
- Department of Research, Freedom from Diabetes Research Foundation, Pune, Maharashtra, 411004, India
| | | | - Venugopal Vijayakumar
- Department of Yoga, Government Yoga and Naturopathy Medical College and Hospital, Chennai, Tamil Nadu, India
| | - Maheshkumar Kuppusamy
- Department of Physiology, Government Yoga and Naturopathy Medical College and Hospital, Arumbakkam, Chennai, Tamil Nadu, India
| | - Malhar Ganla
- Freedom from Diabetes Clinic, Pune, Maharashtra, India
| | - Banshi Saboo
- Department of Medicine, Dia Care- Diabetes Care and Hormone Clinic, Diabetology, Ahmedabad, Gujarat, India
| |
Collapse
|
|
11
|
Warad VG, Kankanala AR, Kadagud AM, Khodnapur JP. Role of Yoga in Modulating Vascular Aging in Type 2 Diabetes Mellitus. Cureus 2024; 16:e72507. [PMID: 39606504 PMCID: PMC11599163 DOI: 10.7759/cureus.72507] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 10/27/2024] [Indexed: 11/29/2024] Open
Abstract
BACKGROUND Diabetes is one of the top 10 global causes of mortality, with considerable contributions to cardiovascular disease (CVD), respiratory illness, and cancer. Yoga is a traditional Indian mind-body practice that has been linked to improved cardiovascular health, diabetic management, and reduced stress. OBJECTIVE The purpose of this study was to assess the effect of yoga on vascular aging in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS From September 2021 to July 2024, Shri B M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), in Vijayapura carried out hospital-based prospective research. Two groups of 70 T2DM patients were created: 35 patients in Group Y (yoga practice) and 35 patients in Group NY (routine without yoga). Age, gender distribution, and baseline glycemic control were similar in both groups. HbA1c, postprandial and fasting blood glucose, and vascular aging using a periscope were determined at baseline and three months later as part of the data-gathering process. RESULTS Three months later, Group Y's mean random blood sugar (RBS) and HbA1c levels were considerably lower than those of Group NY (p<0.05). Furthermore, there were notable declines in the brachial-ankle pulse wave velocity and the carotid-femoral pulse wave velocity in Group Y, suggesting a decreased arterial stiffness (p<0.05). CONCLUSION The study concludes that yoga practice significantly improves glycemic control and reduces arterial stiffness in patients with T2DM.
Collapse
Affiliation(s)
- Vijaykumar G Warad
- General Medicine, Shri B M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND
| | - Akhil Reddy Kankanala
- General Medicine, Shri B M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND
| | - Anuja M Kadagud
- General Medicine, Shri B M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND
| | - Jyoti P Khodnapur
- Physiology, Shri B M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND
| |
Collapse
|
|
12
|
Sonwane BP, Raut P, Chitalkar J, Godbole S, Sabnis S, Gupta J, Santhakumari B, Deshpande MV, Kulkarni MJ. Yoga Therapy Attenuates the Progression of Diabetes - Insights from Proteomics and Metabolomics Analysis. Int J Yoga 2024; 17:163-174. [PMID: 39959515 PMCID: PMC11823562 DOI: 10.4103/ijoy.ijoy_178_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2024] [Revised: 10/18/2024] [Accepted: 10/18/2024] [Indexed: 02/18/2025] Open
Abstract
Objective Diabetes management remains challenging despite advancements in therapeutics, with many subjects developing complications. Yoga has been shown to aid diabetes management. This study investigates the impact of yoga therapy on diabetes progression, utilizing proteomics and metabolomics analyses to explore underlying molecular mechanisms. Methodology A 3-month longitudinal study involving healthy subjects with prediabetes and diabetes was conducted. Blood glucose, glycated hemoglobin (HbA1c), lipid profile, and malondialdehyde (MDA) levels were measured before and after the yoga intervention. Results and Conclusion Healthy subjects showed no significant changes in blood glucose, lipid profile, HbA1c, or MDA levels. However, subjects with prediabetes and diabetes experienced positive changes, with decreases in HbA1c and MDA levels. Proteomics and metabolomics analyses provided insights into the molecular mechanisms by which yoga attenuates diabetes progression in subjects with prediabetes and diabetes. This study is a pioneering effort to understand the molecular basis of yoga's beneficial effects on diabetes management.
Collapse
Affiliation(s)
- Babasaheb P. Sonwane
- Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
- Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
| | - Pooja Raut
- Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - Jyotsna Chitalkar
- Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - Smita Godbole
- Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - Shanta Sabnis
- Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - Jyoti Gupta
- Medical Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - B. Santhakumari
- Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
| | - Mukund V. Deshpande
- Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
- Director and Heads, Greenvention Biotech Private Limited, Pune, Maharashtra, India
| | - Mahesh J. Kulkarni
- Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India
- Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
| |
Collapse
|
|
13
|
Kumari S, Tubaki BR, Patil RS, Laxmikant SD. Reversal of type 2 diabetes mellitus through integrated Ayurveda dietary protocol - A case report. J Ayurveda Integr Med 2024; 15:100946. [PMID: 39047599 PMCID: PMC11321381 DOI: 10.1016/j.jaim.2024.100946] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2022] [Revised: 04/10/2024] [Accepted: 04/13/2024] [Indexed: 07/27/2024] Open
Abstract
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder of hyperglycemia has close link with obesity and insulin resistance. Standard approaches in T2DM management are lifestyle management and Pharmacotherapy. Dietary management in T2DM was found to be safe and effective. In India, studies on reversal of T2DM through diet were less found. Presenting a case of female aged 31 years with T2DM (HbA1c-13.5) was successfully reversed diabetes with dietary principles of Indian traditional medicine (Ayurveda diet) and therapeutic yoga practices. Pre and post assessment of Glycaemic parameters (HbA1C, FBS, and PPBS), Lipid profiles, Insulin resistance parameter (HOMA IR) were done. Major outcome of this case is greater reduction of HbA1c from inadequate control to near normal. Marked changes observed in weight, BMI and Waist circumference. A change in Homa IR indicates improvement in insulin resistance. Ayurveda dietary management training include Therapeutic fasting [Two meal method], meals include nutrient dense wholesome food, Indian millet based diet, herbal recipes [therapeutic food/herbal drinks, smoothies and plant juices] and eat only when hungry method. Yoga include complete sequel of body loosening practices, surya namaskara, yogic postures and breathing and meditative techniques practiced for specified period [60 min].This case showed effectiveness of Ayurveda diet and Yoga practices in reversing the insulin resistance, help to maintain the glycemic parameters .In addition, patient was able to loose body weight, waist circumference & serum triglyceride levels. Patient can able to withstand her diabetic profile in normal without any pharmacotherapy intervention.
Collapse
Affiliation(s)
- Suketha Kumari
- Department of Kayachikitsa, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, India, 590003
| | - Basavaraj R Tubaki
- Department of Kayachikitsa, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, India, 590003.
| | - Rekha S Patil
- Department of Medicine, KAHER's Jawaharlal Nehru Medical College, Nehru Nagar, Belagavi, Karnataka, India, 590003
| | - S D Laxmikant
- Department of Shalyatantra, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, India, 590003
| |
Collapse
|
|
14
|
Dhawan V, Malhotra N, Singh N, Dadhwal V, Dada R. Yoga and its effect on sperm genomic integrity, gene expression, telomere length and perceived quality of life in early pregnancy loss. Sci Rep 2024; 14:11711. [PMID: 38777848 PMCID: PMC11111444 DOI: 10.1038/s41598-024-62380-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2023] [Accepted: 05/16/2024] [Indexed: 05/25/2024] Open
Abstract
Achieving successful pregnancy outcomes is a delicate interplay between the maternal and the fetal counterparts. Paternal factors play a critical role in health and disease of offspring. Early pregnancy loss (EPL) is a psychologically devastating condition affecting the quality of life (QOL). Thus, it needs to be managed by a mind body integrated approach like yoga.The prospective single arm exploratory studyincluded male partners of couples experiencing recurrent pregnancy loss (RPL, n = 30), and recurrent implantation failure (RIF, n = 30) and semen samples wereassessed at the beginning and completion of yoga (6 weeks) (WHO 2010).A significant increase in the sperm concentration, motility, decrease in seminal ROS, DFI and increase in relative sperm telomere length was found at the end of yoga. The relative expression of genes critical for early embryonic developmentnormalized towards the levels of controls. WHOQOL-BREF questionnaire scores to assess QOL also showed improvement.Integration of regular practice yoga into our lifestyle may help in improving seminal redox status, genomic integrity, telomere length, normalizing gene expression and QOL, highlighting the need to use an integrated, holistic approach in management of such cases. This is pertinent for decreasing the transmission of mutation and epimutation load to the developing embryo, improving pregnancy outcomes and decreasing genetic and epigenetic disease burden in the next generation.
Collapse
Affiliation(s)
- Vidhu Dhawan
- Department of Anatomy, Laboratory of Molecular Reproduction and Genetics, All India Institute of Medical Sciences, New Delhi, 110029, India
| | - Neena Malhotra
- Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
| | - Neeta Singh
- Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
| | - Vatsla Dadhwal
- Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
| | - Rima Dada
- Department of Anatomy, Laboratory of Molecular Reproduction and Genetics, All India Institute of Medical Sciences, New Delhi, 110029, India.
| |
Collapse
|
|
15
|
Gupta P. Yoga at Primary Health Centers - A Pathway to Holistic Health: Narrative Review. Int J Yoga 2024; 17:93-100. [PMID: 39444671 PMCID: PMC11495301 DOI: 10.4103/ijoy.ijoy_106_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/24/2024] [Revised: 06/18/2024] [Accepted: 07/01/2024] [Indexed: 10/25/2024] Open
Abstract
There is a global rise of noncommunicable diseases (NCDs), causing significant morbidity and mortality. Risk factors of NCDs commonly include drinking alcohol, smoking, eating unhealthy diet, and sedentary lifestyle. The current health-care system faces challenges dealing with them. In order to deal with this pandemic, the strengthening of primary health centers (PHCs) at community level is required, which supports the principles of promotion, prevention, and treatment of NCDs. Yoga is an ancient practice encompassing physical, mental, social, and spiritual techniques to obtain health. Numerous studies have proven the potential benefits of Yoga in reducing chronic physical and mental health issues, making it a cost-effective method to enhance overall well-being and reduce health-care costs. This review paper aims to explore the profound impact of integrating yoga in PHCs, focusing on its benefits in enhancing patient outcomes, supporting overall health and wellness. The study searched PubMed and Google for scholarly articles on yoga in primary care, public health care, promotion of health, rehabilitation care, cancer, wellness, prevention, health care, etc. By examining the role of yoga in PHCs, this paper seeks to provide insights into the potential of yoga as a complementary approach to conventional treatments. The paper concludes that the burden of NCDs can be addressed by increasing human resources and promoting preventive health care through Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy personnel. Integrating yoga in PHCs will raise awareness about lifestyle management and ultimately reduce the prevalence of diseases.
Collapse
Affiliation(s)
- Priya Gupta
- Department of Yoga, Sant Hirdaram Medical College of Naturopathy and Yogic Sciences for Women, Bhopal, Madhya Pradesh, India
| |
Collapse
|
|
16
|
Sharma T, Goyal B, Ahmed KAM, Deo G, Kaushik I, Malik R, Jain V, Singh D, Kohli S, Chandra K. Efficacy of Standardized Yoga Asanas as Add-on Therapy in the Management of Hypothyroidism: A Randomized, Open-label, Controlled Clinical Study. Int J Yoga 2024; 17:124-131. [PMID: 39444676 PMCID: PMC11495305 DOI: 10.4103/ijoy.ijoy_89_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/05/2024] [Revised: 06/19/2024] [Accepted: 07/01/2024] [Indexed: 10/25/2024] Open
Abstract
Background Hypothyroidism is an endocrine disorder in which the thyroid gland does not produce an adequate amount of thyroid hormones. This study aimed to determine the efficacy of yoga asanas as an add-on therapy for the management of hypothyroidism. Materials and Methods For this interventional clinical study, a total of 450 study participants were screened for eligibility. Out of this, 170 study participants were found fit for preliminary eligibility following stringent inclusion and exclusion criteria. Further, 58 participants were excluded before randomization. A total of 112 hypothyroidism patients (57 in the control group and 55 in the yoga group) participated in this study. The study participants were further followed up for 8 weeks in both the yoga practice (yoga+ standard care of treatment) and control group (standard care of treatment only). The markers of oxidative stress, inflammation, and thyroid hormones were assessed at baseline and after 8 weeks of follow-up/intervention. Results After 8 weeks, the study participants in yoga group showed a significant reduction in serum thyroid-stimulating hormone and malondialdehyde levels as compared to baseline (P < 0.05). There was also a positive trend of improvement in other oxidative markers (catalase, superoxide dismutase, and glutathione), and a significant reduction in interleukin-6 levels (P < 0.05) was found in the yoga group as compared to the baseline. However, there was no significant change found in the control group of subjects. Conclusion Frequent yoga practice can be an effective lifestyle intervention for hypothyroidism, reducing oxidative stress, inflammation, and potentially improving overall well-being.
Collapse
Affiliation(s)
- Tanu Sharma
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Bhavy Goyal
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Khan Afreen Mustaq Ahmed
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Guru Deo
- Department of Yoga Therapy, Morarji Desai National Institute of Yoga, New Delhi, India
| | - Ishita Kaushik
- Department of Yoga Therapy, Morarji Desai National Institute of Yoga, New Delhi, India
| | - Rohit Malik
- Department of Yoga Therapy, Morarji Desai National Institute of Yoga, New Delhi, India
| | - Vineet Jain
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Dharmander Singh
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Sunil Kohli
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| | - Kailash Chandra
- Department of Biochemistry and Medicine, Hamdard Institute of Medical Sciences and Research and Associated HAHC Hospital, New Delhi, India
| |
Collapse
|
|
17
|
Saboo N, Kacker S. A Study on Yoga-Based Lifestyle Intervention versus Dietary Intervention Alone on Cardiometabolic Risk Factors among People with Prediabetes. Ann Afr Med 2024; 23:202-212. [PMID: 39028170 PMCID: PMC11210738 DOI: 10.4103/aam.aam_56_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2023] [Revised: 10/08/2023] [Accepted: 10/11/2023] [Indexed: 07/20/2024] Open
Abstract
BACKGROUND Prediabetes is presented as a metabolic state that predisposes persons to a greater risk of diabetes progression in the future. Prediabetes is an intervening stage between normoglycemia and diabetes with impaired fasting glucose and impaired glucose tolerance. This study aimed to compare the effect of the yoga-based lifestyle intervention (including diet) versus dietary intervention (DI) alone on cardiometabolic parameters namely fasting blood glucose (FBG), glycated hemoglobin (HbA1C), lipid profile; triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), heart rate variability (HRV), and carotid intima-media thickness (CIMT) among people with prediabetes. METHODS A randomized controlled study was conducted on 250 people with prediabetes who were randomly allocated by computer-generated methods to the yoga-based lifestyle intervention (including diet) (n = 125) and DI alone (n = 125) groups. Yoga sessions were approximately 45 min 6 days a week over a period of 6 months. Assessments were made at baseline and after 6 months of intervention. RESULTS Post-intervention comparison of cardiometabolic parameters in yoga-based lifestyle intervention (including diet) versus DI alone showed a significant decline in body mass index (P = 0.0002), waist-hip ratio (P = 0.0001), systolic blood pressure (P = 0.0001), diastolic blood pressure (P = 0.0001), perceived stress score (P = 0.0001), FBG (P = 0.0001), HbA1C (P = 0.0001), lipid profile; TG (P = 0.008), LDL (P = 0.0001), VLDL (P = 0.0001), HRV (P = 0.0001), CIMT (P = 0.02) and a nonsignificant decline in, TC (P = 0.22), HDL (P = 0.211), FFQ (P = 0.164). CONCLUSION The finding of this study suggests that a 24-week yoga-based lifestyle intervention which includes diet significantly decreased cardiometabolic parameters compared to DI alone among people with prediabetes.
Collapse
Affiliation(s)
- Neha Saboo
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| | - Sudhanshu Kacker
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| |
Collapse
|
|
18
|
Joshi AM, Raveendran AV, Arumugam M. Therapeutic role of yoga in hypertension. World J Methodol 2024; 14:90127. [PMID: 38577206 PMCID: PMC10989416 DOI: 10.5662/wjm.v14.i1.90127] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/23/2023] [Revised: 12/19/2023] [Accepted: 01/16/2024] [Indexed: 03/07/2024] Open
Abstract
Systemic hypertension is an established risk factor for coronary artery disease and cerebrovascular accident and control of blood pressure reduces the risk of a major cardiovascular event. Both non-pharmacological and pharmacological treatment options are available to treat hypertension. Yoga, recently received more attention as a treatment modality for various lifestyle disorders, even though practiced in India since ancient times. In this review, we are analyzing the role of yoga in the treatment of systemic hypertension.
Collapse
Affiliation(s)
- Anjali Mangesh Joshi
- Department of Psycho-Oncology, HCG NCHRI Cancer Center, Nagpur 440026, Maharashtra, India
| | - Arkiath Veettil Raveendran
- Department of Internal Medicine, Former Assistant Professor of Medicine, Govt. Medical College, Kozhikode 673010, Kerala, India
| | - Muruganathan Arumugam
- Department of Internal Medicine, Past president API Past Governor American College of Physicians Past President Hypertension Society of India Past Dean Indian College of Physicians, Tirupur 641602, Tamilnadu, India
| |
Collapse
|
|
19
|
Cota E Souza LA, Gouvea TM, Fernandes FC, Carrillo MRGG, Veloso VM, Santos Filho AF, Lima AA. Yoga practice can reduce metabolic syndrome and cardiovascular risk in climacteric women. J Behav Med 2024; 47:94-101. [PMID: 37294473 DOI: 10.1007/s10865-023-00420-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2022] [Accepted: 03/20/2023] [Indexed: 06/10/2023]
Abstract
To evaluate the effect of yoga on the frequency of MetS and its impact on cardiovascular risk markers in climacteric women. We recruited 84 sedentary women between 40 and 65 years diagnosed with MetS. Participants were randomly assigned to a 24-week yoga intervention or control group. We evaluated the frequency of MetS and changes in the individual components of MetS at baseline and after 24 weeks. We also assessed the impact of yoga practices on cardiovascular risk through the following markers: High-sensitivity C-reactive Protein (hs-CRP), Lipid Accumulation Product (LAP), Visceral Adiposity Index (VAI), and Atherogenic Index of Plasma (AIP). The frequency of MetS reduced significantly after 24 weeks of yoga practice (- 34.1%; p < 0.001). Statistical analysis showed that the frequency of MetS was significantly lower in the yoga group (65.9%; n = 27) than in the control group (93.0%; n = 40) after 24 weeks (p = 0.002). Regarding the individual components of MetS, yoga practitioners had statistically lower waist circumference, systolic blood pressure, triglycerides, HDLc, and glucose serum concentrations than the control group after 24 weeks. Yoga practitioners also had a significant decrease in hs-CRP serum concentrations (3.27 ± 2.95 mg/L vs. 2.52 ± 2.14 mg/L; p = 0.040) and a lower frequency of moderate or high cardiovascular risk (48.8% vs. 34.1%; p = 0.001) after 24 weeks of practice. The yoga group had LAP values significantly lower than the control group after the intervention period (55.8 ± 38.04 vs. 73.9 ± 40.7; p = 0.039). Yoga practice demonstrated to be an effective therapeutic to manage MetS and reduce cardiovascular risk in climacteric women.
Collapse
Affiliation(s)
- Laura Alves Cota E Souza
- Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
| | - Thiago Magalhães Gouvea
- Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
| | - Francielle Caroline Fernandes
- Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
| | | | - Vanja Maria Veloso
- Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
- Departamento de Farmácia (DEFAR), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
| | | | - Angélica Alves Lima
- Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
- Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil
| |
Collapse
|
|
20
|
Grover S, Avasthi A, Majid A. Clinical Practice Guidelines for mental health and well-being in patients with chronic medical illnesses. Indian J Psychiatry 2024; 66:S338-S352. [PMID: 38445289 PMCID: PMC10911329 DOI: 10.4103/indianjpsychiatry.indianjpsychiatry_603_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/13/2023] [Revised: 12/03/2023] [Accepted: 12/04/2023] [Indexed: 03/07/2024] Open
Affiliation(s)
- Sandeep Grover
- Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India E-mail:
| | - Ajit Avasthi
- Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India E-mail:
| | - Abdul Majid
- Department of Psychiatry, SKIMS, Srinagar, Jammu and Kashmir, India
| |
Collapse
|
|
21
|
Dmello MM, Bhagwat G. Novel Approaches to Control Diabetes. Curr Diabetes Rev 2024; 20:e090823219599. [PMID: 37559237 DOI: 10.2174/1573399820666230809152742] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/20/2022] [Revised: 06/20/2023] [Accepted: 07/04/2023] [Indexed: 08/11/2023]
Abstract
Diabetes is a chronic, long-term, incurable, but controllable condition. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia that results from defects in insulin secretion, insulin action, or both. People who have diabetes often experience a variety of symptoms, including blurry vision, excessive thirst, fatigue, frequent urination, hunger, and weight loss. This review article includes a discussion on diabetes types, symptoms, diagnostic tests, and various therapies for treating, controlling, and managing blood glucose levels, with a focus on its most recent innovation of therapies and medications. Diabetes management will also be reviewed, along with clinical pharmacodynamics, bioavailability, advantages, and complications of combined drugs/medications.
Collapse
Affiliation(s)
- Malissa Mathew Dmello
- Department of MES's, H. K. College of Pharmacy, Jogeshwari (West), Mumbai, 400102, Maharashtra, India
| | - Geeta Bhagwat
- Department of Pharmaceutics, DY Patil University School of Pharmacy, Nerul, Navi-Mumbai 400607, India
| |
Collapse
|
|
22
|
Srivastava SP, Upadhyay P, Das S, Tiwari N, Mishra S, Tripathi SM. Managing Diabetic Complications with Alternative Therapeutic Strategies. Curr Diabetes Rev 2024; 20:e070923220791. [PMID: 37691189 DOI: 10.2174/1573399820666230907112430] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/03/2023] [Revised: 07/02/2023] [Accepted: 07/27/2023] [Indexed: 09/12/2023]
Abstract
Diabetes is a chronic metabolic disease affecting millions worldwide. It is characterized by a lack of insulin production or impaired insulin function, leading to elevated blood glucose levels. Conventional treatment methods for diabetes management typically include lifestyle changes and medications. However, alternative therapies have gained attention in recent years, including traditional medicine containing bioactive compounds, supplements like vitamin D and Omega-3 fatty acids, aromatherapy, and homeopathy. Diabetic complications are common in patients with uncontrolled diabetes and can lead to serious health problems, including diabetic retinopathy, impaired wound healing, kidney disease, nerve damage, and cardiovascular disease. Alternative remedies, such as traditional medicine containing bioactive compounds, supplements, and aromatherapy, have been studied for their potential benefits in managing these complications. Traditional medicines like bitter melon, cinnamon, and fenugreek have been shown to have anti-diabetic effects due to their bioactive compounds. Similarly, supplements like vitamin D and Omega-3 fatty acids have been found to improve glycemic control in patients with diabetes. Aromatherapy, which involves the use of essential oils, has also been explored for its potential benefits in diabetes management. Homeopathy, which uses highly diluted substances to stimulate the body's natural healing abilities, has been used to treat diabetes-related symptoms like neuropathy and wounds. Personalized care is essential in natural diabetes management because each person's body and health needs are unique. A holistic approach that addresses the individual's physical, emotional, and spiritual well-being is essential. As research in this field continues to expand, a more comprehensive understanding of diabetes management will lead to improved outcomes for those living with this condition.
Collapse
Affiliation(s)
| | - Pawan Upadhyay
- Department of Pharmacy, Maharishi University of Information Technology, Lucknow, India
| | - Shibu Das
- Department of Pharmacy, Maharishi University of Information Technology, Lucknow, India
| | - Neha Tiwari
- Khyati College of Pharmacy, Palodia, Ahmedabad, India
| | - Sudhanshu Mishra
- Department of Pharmaceutical Science and Technology, Madan Mohan Malaviya University of Technology, Gorakhpur, India
| | - Shivendra Mani Tripathi
- Department of Pharmaceutical Science and Technology, Madan Mohan Malaviya University of Technology, Gorakhpur, India
| |
Collapse
|
|
23
|
Muangritdech N, Promsrisuk T, Kongsui R, Sriraksa N, Thongrong S, Srithawong A. Exploring the Impact of Combined Thai Yoga and Elastic Band Exercise on Physical Fitness and Exercise Capacity in Older Patients with Type 2 Diabetes. PHYSICAL EDUCATION THEORY AND METHODOLOGY 2023; 23:894-901. [DOI: 10.17309/tmfv.2023.6.11] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/06/2025]
Abstract
Study purpose. Although it is acknowledged that exercise can positively affect both physical and biochemical markers in older individuals with type 2 diabetes (T2DM), there are still uncertainties about the specific impacts of combining Thai yoga with an elastic band exercise in this population. The objective of the study was to assess the impact of a 12-week program involving Thai yoga combined with an elastic band exercise on the physical fitness and functional exercise capacity among older individuals with T2DM.
Materials and methods. A total of 42 participants, consisting of 20 men and 22 women with T2DM and a mean age of 64.6±3.6 years, were randomly assigned to two groups: the control group and the exercise group. The exercise group engaged in a daily regimen of Thai yoga combined with an elastic band exercise for 40 minutes, 5 days a week, over a 12-week period. In contrast, the control group maintained their regular routines. Physical fitness and functional exercise capacity were assessed both before and after the 12-week intervention.
Results. The exercise group showed significant reductions in body weight (58.7±11.9 vs. 58.0±12.0 kg), body mass index (24.2±3.0 vs. 23.9±3.0 kg/m2), waist circumference (33.6±3.6 vs. 33.1±3.6 in), and waist-hip ratio (0.90±0.06 vs. 0.89±0.06) (p < 0.001). Additionally, there were notable improvements in physical fitness parameters, including hand grips, back strength, leg strength (p < 0.01), and trunk flexibility (p < 0.001). Functional exercise capacity, indicated by the 6-minute walk test and estimated peak oxygen consumption (p < 0.01), also improved significantly.
Conclusions. Thai yoga combined with an elastic band exercise enhances physical fitness and functional exercise capacity in older individuals with T2DM. This improvement has the potential to enhance their cardiopulmonary performance. Consequently, this exercise regimen is considered a health alternative for older individuals with T2DM.
Collapse
|
|
24
|
James DL, Larkey LK, Evans B, Sebren A, Goldsmith K, Ahlich E, Hawley NA, Kechter A, Sears DD. Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model. Menopause 2023; 30:1114-1123. [PMID: 37788427 DOI: 10.1097/gme.0000000000002262] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/05/2023]
Abstract
OBJECTIVES Weight gain and unfavorable body composition are prevalent among midlife/older women throughout menopause. These shifts may negatively impact health, well-being, and longevity. Efforts to attenuate weight and body composition changes are traditionally driven by manipulation of diet and/or exercise; however, sustained results are limited, possibly because the full spectrum of biobehavioral systems is not addressed by diet and exercise alone. We propose a biobehavioral model detailing mechanisms of body composition decline among perimenopausal women and the associated components of Meditative Movement (ie, tai chi, qigong, yoga) that address each of these factors. METHODS Based on our previous work and extensive review of the literature, we developed a multifactorial and multidimensional biobehavioral model including factors that most directly relate to body composition among perimenopausal women: 1) psychological (ie, stress and mood, mindfulness and self-compassion, body awareness), 2) behavioral (ie, sleep, physical activity, eating behaviors), and 3) physiological (ie, cortisol, estrogen). Relationships between each factor, Meditative Movement practice components, and predicted effects on body composition were explored in detail. RESULTS Our model describes select psychological, behavioral, and physiological factors, and potential mechanistic pathways of Meditative Movement practice driving improved changes in body composition and weight outcomes for perimenopausal women. CONCLUSIONS The proposed model details a novel, evidence-supported means to reduce the risk of deleterious shifts in body composition throughout perimenopause and menopause thereafter. We suggest that these changes may occur directly and/or indirectly through psychological, behavioral, and physiological mechanisms that facilitate the desired changes in body composition.
Collapse
Affiliation(s)
| | - Linda K Larkey
- From the Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ
| | - Bronwynne Evans
- From the Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ
| | - Ann Sebren
- College of Health Solutions, Arizona State University, Phoenix, AZ
| | - Kimberley Goldsmith
- Department of Biostatistics & Informatics, Institute of Psychiatry, King's College London, London, United Kingdom
| | - Erica Ahlich
- Department of Psychology, University of South Alabama, Mobile, AL
| | - Nanako A Hawley
- Department of Psychology, University of South Alabama, Mobile, AL
| | | | - Dorothy D Sears
- College of Health Solutions, Arizona State University, Phoenix, AZ
| |
Collapse
|
|
25
|
Wu S, Wang L, He Y, Shi F, Zhuang H, Mei L, Qian Y. Effects of different mind-body exercises on glucose and lipid metabolism in patients with type 2 diabetes: A network meta-analysis. Complement Ther Clin Pract 2023; 53:101802. [PMID: 37769432 DOI: 10.1016/j.ctcp.2023.101802] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2023] [Revised: 09/10/2023] [Accepted: 09/22/2023] [Indexed: 09/30/2023]
Abstract
BACKGROUND This study aims to compare the relative effectiveness of different forms of mind-body exercise in improving glycolipid metabolism in patients with T2DM using a network meta-analysis. METHODS The relevant literature was systematically searched in Cochrane Library, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang database and VIP Chinese Science. A network meta-analysis was conducted using a random-effects model within a frequentist framework. RESULTS A total of 52 studies with 6 modalities of mind-body exercise involving 4024 patients were included. Compared with controls, all exercise modalities except Yijinjing significantly improved patients' fasting blood glucose (MDs ranged from -0.72(95% CI: -1.20,-0.25) in dance to -2.06(95% CI: -2.59,-1.54) in yoga), glycated hemoglobin (MDs ranged from -0.62 (95% CI: -0.96) in taijiquan to -0.27,-0.27) in Pilates to -1.18(95% CI: 1.80,-0.57)), total cholesterol (MDs ranged from -0.73(95% CI: -1.29,-0.17) in Pilates to -0.41(95% CI: -0.62,-0.19) in Tai Chi), triglycerides (MDs ranged from -0.56 in Pilates (95% CI: -1.07,-0.04) for Pilates to -0.38 (95% CI: -0.67,-0.10)) for dance; only Tai Chi Chuan (MD:0.12 95% CI:0.04,0.20) and Baduanjin (MD:0.14 95% CI:0.06,0.22) significantly increased high-density lipoprotein cholesterol levels in patients; only yoga(MD: 0.78 95%CI: 1.20,-0.37) and Tai Chi Chuan(MD: 0.32 95%CI: 0.60,-0.04) significantly decreased high-density lipoprotein cholesterol levels in patients. CONCLUSION All mind-body exercises help to improve blood glucose and lipid levels in T2DM patients, but the ranking of relative effectiveness needs to be rationalized. Our study suggests that T2DM patients should choose appropriate mind-body exercises according to their conditions and stick to them for a long time under their healthcare professionals' guidance to achieve effective diabetes control.
Collapse
Affiliation(s)
- Sijun Wu
- School of Physical Education, Wuhan University of Technology, Wuhan, 430070, China.
| | - Lin Wang
- School of Physical Education, Wuhan University of Technology, Wuhan, 430070, China.
| | - Yuxuan He
- School of Physical Education, Wuhan University of Technology, Wuhan, 430070, China.
| | - Fengrui Shi
- School of Physical Education, Wuhan University of Technology, Wuhan, 430070, China.
| | - Huiqi Zhuang
- School of Physical Education, Wuhan University of Technology, Wuhan, 430070, China.
| | - Linqi Mei
- School of Physical Education, Hubei University, Wuhan, 430062, China.
| | - Youling Qian
- School of Physical Education, Hubei Minzu University, Enshi, 445000, China.
| |
Collapse
|
|
26
|
McVoy M, Miller D, Bransteter I, Gubitosi-Klug R, Segal T, Surdam J, Sajatovic M, Dusek JA. A self-management plus mind body intervention for adolescents and young adults with type 2 diabetes: Trial design and methodological report. Contemp Clin Trials 2023; 133:107317. [PMID: 37625585 DOI: 10.1016/j.cct.2023.107317] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2023] [Revised: 07/25/2023] [Accepted: 08/22/2023] [Indexed: 08/27/2023]
Abstract
BACKGROUND The onset of type 2 diabetes (T2D) is increasingly common in adolescents and young adults (AYAs). Improving self-management skills and the mental health of this population is important, but understudied. METHODS The goal of this research was to develop a mind-body intervention which could serve as an adjunctive therapy to support AYAs with T2D (INTEND intervention). Toward that end, we used an iterative process, including use of focus groups, advisory board, and cognitive semi-structured interviews with patients, parents of patient and clinical providers, to understand the gaps in the current information provided to AYAs with T2D. Based on the data gathered from the focus groups and interviews, we enhanced an existing self-management intervention for adults with T2D to include an additional mind body intervention for AYAs with T2D. The INTEND intervention will be piloted in a group of AYAs with T2D. RESULTS This report describes the methodology and design of the InterveNTion for Early oNset type 2 Diabetes (INTEND) study. The details of this single arm pre-post pilot feasibility trial are described. DISCUSSION If successful, the INTEND approach has the potential to advance care for vulnerable youth with T2D.
Collapse
Affiliation(s)
- Molly McVoy
- Case Western Reserve University School of Medicine (CWRU SOM), USA; University Hospitals Cleveland Medical Center (UHCMC), USA; Rainbow Babies and Children, UHCMC, USA.
| | | | | | - Rose Gubitosi-Klug
- Case Western Reserve University School of Medicine (CWRU SOM), USA; Rainbow Babies and Children, UHCMC, USA
| | - Tracy Segal
- University Hospitals Connor Whole Health, USA
| | | | - Martha Sajatovic
- Case Western Reserve University School of Medicine (CWRU SOM), USA; University Hospitals Cleveland Medical Center (UHCMC), USA
| | - Jeffery A Dusek
- Case Western Reserve University School of Medicine (CWRU SOM), USA; University Hospitals Connor Whole Health, USA
| |
Collapse
|
|
27
|
Dhali B, Chatterjee S, Sundar Das S, Cruz MD. Effect of Yoga and Walking on Glycemic Control for the Management of Type 2 Diabetes: A Systematic Review and Meta-analysis. J ASEAN Fed Endocr Soc 2023; 38:113-122. [PMID: 38045671 PMCID: PMC10692414 DOI: 10.15605/jafes.038.02.20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2023] [Accepted: 04/18/2023] [Indexed: 12/05/2023] Open
Abstract
Background A daily habit of yogic practice or walking, along with an oral hypoglycemic agent (OHA) could be beneficial for better control of type 2 diabetes mellitus (T2DM). We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to find out the efficiency of yoga or walking on glycemic control in T2DM. Methodology The present systematic review and meta-analysis were completed according to the PRISMA guidelines. The risk of bias in included studies was evaluated, by using the revised Cochrane risk-of-bias tool for randomized trials. Meta-analysis was implemented using RevMan software. Forest plots were used to illustrate the study findings and meta-analysis results. Results Sixteen studies were included in this systematic review, where 1820 participants were allocated to one of the following interventions: yoga, walking, and without any regular exercise (control group). Participants were between 17-75 years of age. Compared to the control group, the yoga group had a significant reduction in fasting blood glucose (FBG) by 31.98 mg/dL (95% CI = -47.93 to -16.03), postprandial blood glucose (PPBG) by 25.59 mg/dL (95% CI = -44.00 to -7.18], glycosylated hemoglobin (HbAlc) by 0.73% (95% CI = -1.24 to -0.22), fasting insulin by 7.19 μIU/mL (95% CI = -12.10 to -2.28), and homeostatic model assessment for insulin resistance (HOMA-IR) by 3.87 (95% CI = -8.40 to -0.66). Compared to the control group, the walking group had a significant reduction in FBG by 12.37 mg/dL (95% CI = -20.06 to -4.68) and HbA1c by 0.35% (95% CI = -0.70 to -0.01). Compared to the walking group, the yoga group had a significant reduction in FBG by 12.07 mg/dL (95% CI = -24.34 to - 0.20), HbA1c by 0.20% (95% CI = -0.37 to -0.04), fasting insulin by 10.06 μIU/mL (95% CI = -23.84 to 3.71) and HOMA-IR by 5.97 (95% CI = -16.92 to 4.99). Conclusions Yoga or walking with OHA has positive effects on glycemic control. For the management of T2DM, yoga has relatively more significant effects on glycemic control than walking.Review registration number: PROSPERO registration number CRD42022310213.
Collapse
Affiliation(s)
- Biswajit Dhali
- Department of Physical Education, Jadavpur University, Kolkata, India
| | - Sridip Chatterjee
- Department of Physical Education, Jadavpur University, Kolkata, India
| | - Sudip Sundar Das
- Department of Physical Education, Jadavpur University, Kolkata, India
| | | |
Collapse
|
|
28
|
Yadav U, Kumar Bhatted S. A comparative analysis of Vamana and ShamanaChikitsa in prediabetes management: A randomized clinical trial. J Ayurveda Integr Med 2023; 14:100764. [PMID: 37738856 PMCID: PMC10518475 DOI: 10.1016/j.jaim.2023.100764] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/19/2021] [Revised: 06/28/2023] [Accepted: 07/03/2023] [Indexed: 09/24/2023] Open
Abstract
BACKGROUND Prediabetes is a condition before manifestation of diabetes. It is associated with biochemical change in body due to disturbances in food habits, sleep patterns and sedentary lifestyle. Conventional system of medicine has limitations, however Ayurvedic medicines can be effective for management of this condition. OBJECTIVE To compare the efficacy of Vamana Karma (∼therapeutic emesis) followed by Darvyadi Kwatha (∼herbal decoction) with that of oral medication of Darvyadi Kwatha with lifestyle modification in reducing HbA1c of the prediabetic participants. METHODOLOGY After approval of IEC and registration under clinical trial registry of India, 40 patients were registered in two groups suffering from prediabetes in the trial. The primary criteria were HBA1c, FBS & PPBS along with secondary criterias like Agnibala (∼strength of digestion and metabolism), Dehabala (physical strength) and Satvabala (mental strength) relief in signs & symptoms of Prameha and quality of life (SF-36 Score). RESULTS Statistically significant results were observed in both the parameters: (primary & secondary) within the group [VM group (HbA1c (<0.001), FBS (<0.001) & PPBS (<0.001) and SM group (HbA1c (<0.001), FBS (<0.001) & PPBS (<0.001)] and between the group [HbA1c (P < 0.01), FBS (P < 0.01), SF-36 score (P < 0.001) as well. CONCLUSION The present clinical study suggests that there is significant improvement between the groups. On comparision, it was found that treating prediabete.s Shodhana was more safe & effective than Shamana.
Collapse
Affiliation(s)
- Uttamram Yadav
- Department of Panchakarma, Vijyashree Ayurveda Medical College & Hospital Jabalpur, India.
| | | |
Collapse
|
|
29
|
Saboo N, Kacker S. A Study to Assess and Correlate Metabolic Parameters with Carotid Intima-Media Thickness after Combined Approach of Yoga Therapy among Prediabetics. Adv Biomed Res 2023; 12:145. [PMID: 37434919 PMCID: PMC10331556 DOI: 10.4103/abr.abr_146_22] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/03/2022] [Revised: 02/07/2023] [Accepted: 02/13/2023] [Indexed: 07/13/2023] Open
Abstract
Background Prediabetes is an intermediate hyperglycemia in which the fasting blood glucose (FBG) level is greater than normal (100-125 mg/dl) but lower than diabetic levels (more than 125 mg/dl). The aim of the present study was to evaluate and correlate the impact of the combined approach of yoga therapy (CAYT) on carotid intima-media thickness (CIMT) and metabolic parameters including FBG, glycated hemoglobin (HbA1C), and lipid profile-like triglyceride (TG), total cholesterol (TC), and high-density lipoprotein (HDL). Materials and Methods Experimental Interventional study was conducted on a total of 250 prediabetics divided into the control (n = 125) and study group (n = 125) at "RUHS College of Medical Sciences and associated hospitals." Assessments were made at baseline and after six months of the CAYT. The study group (n = 125) was engaged in the CAYT, which consists of yoga, dietary modification, counseling, and follow-up. The control group not participated in CAYT. Result Mean age of participants was 45.3 ± 5.4 years. Pearson correlation analysis of CIMT and metabolic parameters which were fasting blood sugar, HbA1C, and lipid parameters (TC, TG, and HDL) showed that significant positive correlation with FBG (r =.880), HbA1C (r =.514), TC (r =.523), TG (r =.832), and negative correlation with HDL (r = -0.591) after six months of CAYT. Conclusion This study demonstrated that after six months of CAYT metabolic parameters, CIMT were significantly decreased. We have observed a significant correlation exists between CIMT and metabolic parameters. Therefore, regular CIMT measurement might be beneficial for the assessment of cardiovascular disease (CVD) risk and facilitate better use of treatment modalities in prediabetics.
Collapse
Affiliation(s)
- Neha Saboo
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| | - Sudhanshu Kacker
- Department of Physiology, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| |
Collapse
|
|
30
|
Giridharan S. Beyond the Mat: Exploring the Potential Clinical Benefits of Yoga on Epigenetics and Gene Expression: A Narrative Review of the Current Scientific Evidence. Int J Yoga 2023; 16:64-71. [PMID: 38204768 PMCID: PMC10775846 DOI: 10.4103/ijoy.ijoy_141_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2023] [Revised: 08/28/2023] [Accepted: 08/29/2023] [Indexed: 01/12/2024] Open
Abstract
Yoga, an ancient practice rooted in Indian philosophy, has gained widespread popularity for its numerous physical and mental health benefits. In the recent years, there has been growing interest in understanding how yoga influences gene expression and epigenetic modifications. This narrative review investigates the molecular mechanisms, by which yoga influences gene expression, focusing on deoxyribonucleic acid (DNA) methylation, and histone modifications. Research literature was sourced from various databases to select randomized clinical trials and comparative cohort studies examining yoga's impact on gene expression and epigenetic changes. Our findings suggest that yoga could exert anti-inflammatory effects, as it downregulates pro-inflammatory cytokines, soluble interleukin IL-2 receptor gene expression, and transcription factors. Yoga also boosts the innate antiviral response and brain health by enhancing natural defense genes and microRNA-29c expression. Notably, it activates telomerase, linked with cellular longevity, and promotes nitric oxide synthetase and neuroprotective gene expression, implying benefits for ocular health. In addition, yoga fosters DNA repair and cellular integrity maintenance by increasing oxoguanine glycosylase one protein and p53 gene expression. However, the diversity of yoga interventions in these studies complicates direct comparisons and broader application. The current research primarily focuses on short-term outcomes, offering a limited understanding of yoga's long-term epigenetic impacts. Future research should address these gaps by studying the enduring effects of Yoga, personalizing interventions, and contrasting techniques.
Collapse
|
|
31
|
Li M, Jeeyavudeen MS, Arunagirinathan G, Pappachan J. Is Type 2 Diabetes Mellitus a Behavioural Disorder? An Evidence Review for Type 2 Diabetes Mellitus Prevention and Remission through Lifestyle Modification. TOUCHREVIEWS IN ENDOCRINOLOGY 2023; 19:7-15. [PMID: 37313234 PMCID: PMC10258624 DOI: 10.17925/ee.2023.19.1.7] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 09/07/2023] [Accepted: 10/27/2023] [Indexed: 06/15/2023]
Abstract
The prevalence of type 2 diabetes mellitus (T2DM) is steadily rising worldwide due to an increasingly sedentary lifestyle combined with unhealthy food habits. Currently, the burden of diabetes on healthcare systems is unprecedented and rising daily. Several observational studies and randomized controlled trials provide clinical evidence that T2DM remission is possible by adopting dietary interventions and a strict exercise training protocol. Notably, these studies provide ample evidence for remission in patients with T2DM or for prevention in those with risk factors for the disease through various non-pharmacological behavioural interventions. In this article, we present two clinical cases of individuals who showed remission from T2DM/prediabetes via behavioural changes, especially through the adoption of a low-energy diet and exercise. We also discuss the recent advances in T2DM and obesity research, focusing on nutritional interventions and exercise and their benefits for weight loss, improved metabolic profile, enhanced glycaemic control and remission of diabetes.
Collapse
Affiliation(s)
- Matthias Li
- The University of Manchester Medical School, Manchester, UK
| | | | | | - Joseph Pappachan
- The University of Manchester Medical School, Manchester, UK
- Lancashire Teaching Hospitals NHS Trust and Manchester Metropolitan University, Manchester, UK
| |
Collapse
|
|
32
|
Barman P, Das M, Verma M. Epidemiology of type 2 diabetes mellitus and treatment utilization patterns among the elderly from the first wave of Longitudinal Aging study in India (2017-18)using a Heckman selection model. BMC Public Health 2023; 23:699. [PMID: 37059974 PMCID: PMC10103042 DOI: 10.1186/s12889-023-15661-4] [Citation(s) in RCA: 7] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/04/2022] [Accepted: 04/11/2023] [Indexed: 04/16/2023] Open
Abstract
INTRODUCTION Unmanaged Type 2 diabetes mellitus (T2DM) substantially contributes to the multi-morbidity of the elderly. Fewer research has concentrated on understanding the determinants of treatment utilization among older people, with even lesser concerns about missing data in outcome variables leading to biased estimates. The present study intends to evaluate the epidemiology of T2DM in the elderly in India and explore the socioeconomic and behavioral risk factors determining the treatment utilization among the elderly > 60 years in India by addressing the missing data to generate robust estimates. METHODS The secondary analysis used data from the Longitudinal Ageing Study in India. The key dependent variables were the presence or absence of T2DM and treatment utilization. Descriptive statistics were used to understand the differences in the prevalence of diabetes and the utilization of treatment across various socio-demographic characteristics. Heckman's statistical technique evaluated the predictors of T2DM and treatment utilization. Analysis was done using STATA software version 14.0. RESULTS Almost 14% elderly reported to be living with T2DM. The odds of living with T2DM increased with non-working status, a sedentary lifestyle, and a higher BMI. A higher proportion of the elderly was on oral drugs than insulin and had been practicing lifestyle modifications to control their disease. The probability of developing T2DM was lower among females than males, but females had better odds for treatment utilization of health medication than males. Lastly, treatment utilization was significantly affected by socio-demographic characteristics like education and monthly per capita expenditure. CONCLUSIONS Treatment utilization by the elderly living with T2DM is significantly affected by socio-demographic characteristics. Keeping in mind the increasing proportion of the geriatric population in our country, it is pertinent to tailor-made counseling sessions for the elderly to improve medication utilization and adherence and realize our goals concerning non-communicable diseases.
Collapse
Affiliation(s)
- Papai Barman
- International Institute for Population Sciences (IIPS), Mumbai, India
| | - Milan Das
- International Institute for Population Sciences (IIPS), Mumbai, India
| | - Madhur Verma
- Department of community & Family medicine, All India institute of medical sciences Bathinda, Bathinda, India
| |
Collapse
|
|
33
|
Sharma S, Bhardwaj S, Gupta A, Katoch VM, Sharma KK, Gupta R. Influence of 24-Week Yoga Intervention on Cardiovascular Risk Factors and Inflammatory Markers in Type 2 Diabetes. Int J Yoga 2023; 16:27-33. [PMID: 37583542 PMCID: PMC10424277 DOI: 10.4103/ijoy.ijoy_176_22] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2022] [Revised: 03/27/2023] [Accepted: 04/04/2023] [Indexed: 08/17/2023] Open
Abstract
Background and Aims Persistent hyperglycemia, dyslipidemia, inflammation, and oxidative stress are important in cardiovascular risk in type-2 diabetes mellitus (DM). To evaluate the effect of 24-week yoga intervention on anthropometry and biochemical markers in DM patients, we performed a study. Methods A hospital-based prospective randomized study in 104 participants with DM divided into control (n = 52) and intervention (n = 52) groups was performed. Patients in the intervention group performed 40 min of multifaceted individualized yoga exercises 5 days/week for 24 weeks. Anthropometric measurements and biochemical analysis were performed at baseline and after 24 weeks in both groups. Descriptive statistics are reported. Results Baseline characteristics were similar in both groups. At 24 weeks, participants in the intervention versus controls had lower body mass index (25.6 ± 2.9 vs. 28.0 ± 3.2 kg/m2), waist-hip ratio (0.94 ± 0.06 vs. 0.99 ± 0.05), systolic blood pressure (121.2 ± 11.7 vs. 139.3 ± 19.1 mmHg), fasting glucose (142.7 ± 45.3 vs. 175.7 ± 45.4 mg/dL), glycated hemoglobin (7.2 ± 1.8 vs. 9.4 ± 1.9%), low-density lipoprotein cholesterol (167.5 ± 38.1 vs. 192.2 ± 51.4 mg/dL), nonhigh-density lipoprotein cholesterol (136.8 ± 35.3 vs. 158.6 ± 47.2 mg/dL), interleukin-6 (32.0 ± 21.5 vs. 43.5 ± 34.3 pg/mL), and high-sensitivity C-reactive protein (5.1 ± 3.7 vs. 9.5 ± 15.6 mg/L) (P ≤ 0.05). In the intervention group, higher levels of high-density lipoprotein cholesterol (49.2 ± 15.0 vs. 40.4 ± 7.2 mg/dL) and serum total antioxidants (1.9 ± 0.4 vs. 1.4 ± 0.4 mmol/L) were observed (P < 0.001). Conclusion A short-term yoga intervention led to reduced glycemia, dyslipidemia, and inflammatory markers and increased antioxidant status in patients with type-2 DM.
Collapse
Affiliation(s)
- Sonali Sharma
- Department of Biochemistry, RUHS College of Medical Sciences, Jaipur, Rajasthan, India
| | - Sonal Bhardwaj
- Department of Biochemistry, RUHS College of Medical Sciences, Jaipur, Rajasthan, India
| | - Arvind Gupta
- Department of Medicine, Rajasthan Hospital, Jaipur, Rajasthan, India
| | - Vishwa Mohan Katoch
- Public Health Research, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| | | | - Rajeev Gupta
- Academic Research Development Unit, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
| |
Collapse
|
|
34
|
Effect of Yoga intervention on Skeletal Muscle linked Glucose Homeostasis in Pre-diabetic individuals: study protocol for a randomized controlled trial. ADVANCES IN INTEGRATIVE MEDICINE 2022. [DOI: 10.1016/j.aimed.2022.11.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
|
|
35
|
Anjana K, Archana R, Mukkadan JK. Effect of om chanting and yoga nidra on blood pressure and lipid profile in hypertension - A randomized controlled trial. J Ayurveda Integr Med 2022; 13:100657. [PMID: 36375220 PMCID: PMC9663516 DOI: 10.1016/j.jaim.2022.100657] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2022] [Revised: 09/28/2022] [Accepted: 10/07/2022] [Indexed: 11/13/2022] Open
Abstract
BACKGROUND Hypertension (HTN) is a major public health concern, and elevated blood pressure (BP) is a distinct risk factor for all - causes of morbidity and mortality. OBJECTIVES Considering the growing evidence of yoga interventions in the management of hypertension, the objective of the current randomized controlled study is to assess the effect of OM chanting and Yoga nidra (Relaxation technique) on BP and lipid profile in individuals with HTN. MATERIALS AND METHODS Eighty patients with diagnosed HTN were recruited and randomized equally to either the experimental group or the control group. Patients in the experimental group received a combination of OM chanting and Yoga nidra, five days a week for a period of 2 months and patients in the control group continued with their regular conventional medications. BP and lipid profile parameters were assessed at baseline, 30th day and 60th day for both the groups. RESULTS After 2 months of intervention, a significant (p < 0.05) reduction in the BP and lipid profile was observed in the intervention group when compared to the control group. The reduction in systolic and diastolic BP and LDL were significantly (p < 0.001) higher in the experimental group. In addition, there is a significant increase in HDL levels in the experimental group. No adverse events were reported during the trial period. CONCLUSION The current study demonstrates the efficacy of Om chanting and Yoga nidra in reducing blood pressure and improving lipid profiles in patients with HTN. These particular yoga interventions could thus be considered a safer form of complementary therapy in the management of HTN, alongside conventional management. REGISTRATION Clinical trial identifier- CTRI/2020/02/023400.
Collapse
Affiliation(s)
- K Anjana
- Department of Physiology, Little Flower Medical Research Center, Angamaly 683572, Kerala, India
| | - R Archana
- Department of Physiology, Saveetha Medical College, Saveetha Institute of Technical and Medical Sciences (SIMATS), Thandalam, Chennai 602105 Tamil Nadu, India.
| | - J K Mukkadan
- Department of Physiology, Little Flower Medical Research Center, Angamaly 683572, Kerala, India
| |
Collapse
|
|
36
|
Lin WY. The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants. Front Nutr 2022; 9:944028. [PMID: 36211487 PMCID: PMC9539558 DOI: 10.3389/fnut.2022.944028] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/14/2022] [Accepted: 09/08/2022] [Indexed: 11/13/2022] Open
Abstract
Regular physical exercise is recommended to reduce the risk of obesity. However, it remains unclear which activities are more effective in preventing obesity. In this study, five obesity indices and lifestyle factors of 33,731 Taiwan Biobank adults were measured/collected twice with a mean time interval of 4.06 years. A linear mixed effects model was fitted to assess the associations of exercises with obesity indices, in which a random intercept term was used to account for individual differences. The five obesity indices included body mass index (BMI), body fat percentage (BFP), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR). Among 23 exercises, jogging and yoga were consistently the most effective choices across all five obesity indices. One more weekly hour to jog was associated with a 0.093 kg/m2 decrease in BMI (p = 4.2E-20), a 0.297% decrease in BFP (p = 3.8E-36), a 0.398 cm decrease in WC (p = 1.6E-21), and a 2.9E-3 decrease in WHR (p = 1.3E-17). One more weekly hour to perform yoga was associated with a 0.225 cm decrease in HC (p = 6.4E-14). Jogging is an exercise for the entire body. Arms swing, waist turn, legs and feet run, and shoulders and abdomen are also involved in this act. By contrast, many yoga poses use muscles around the hips and pelvis, and therefore yoga is the most effective exercise to reduce HC.
Collapse
Affiliation(s)
- Wan-Yu Lin
- Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
- Master of Public Health Degree Program, College of Public Health, National Taiwan University, Taipei, Taiwan
- Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
| |
Collapse
|
|
37
|
Kumar S, Kant R, Yadav P, Kumar B. Effect of non-pharmacological interventions on adults with cardiovascular risk in a rural community. J Family Med Prim Care 2022; 11:5521-5526. [PMID: 36505636 PMCID: PMC9730992 DOI: 10.4103/jfmpc.jfmpc_2472_21] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/24/2021] [Revised: 06/10/2022] [Accepted: 06/20/2022] [Indexed: 12/15/2022] Open
Abstract
Background Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide, with three-fourth of deaths occurring in low- and middle-income countries (LMICs) like India. Currently, three out of the top five causes of morbidity and mortality in the country are NCDs. Objective This study evaluated the impact of non-pharmacological interventions as a comprehensive approach toward adults with cardiovascular risk in Indian rural communities. Material and Methods It was a quasi-experimental study conducted in Rishikesh, a holy city of Uttarakhand known as the world's yoga capital at the foothills of Himalaya. Out of 87 villages, four villages were randomly selected. Eighty-eight participants were enrolled (22 from each village and household). It was a multi-stage random sampling. All the participants with cardiovascular risk and age >30 years were recruited. Pregnant, severely ill, and unwilling to consent were excluded. Non-pharmacological intervention as a comprehensive approach, including yoga, meditation, mental health counseling, dietary counseling, tobacco, and alcohol cessation counseling has been provided to cardiovascular risk participants. Results Data of 76 participants were analyzed as the per-protocol analysis method. The drop-out rate was 13.63%. Male and female participants were 52 (68.4%) and 24 (31.6%) in number. Mean age of the participants was 55.28 ± 13.64 years. Diastolic blood pressure or DBP (P = 0.017*), systolic blood pressure or SBP (P = 0.008**), waist circumference (WC) (P = 0.000**), waist-to-hip ratio (P = 0.000**) and waist-to-height ratio (P = 0.000**) significantly improved in the post intervention group. Conclusion Non-pharmacological interventions as a comprehensive approach can significantly reduce modifiable risk factors for cardio-metabolic disease.
Collapse
Affiliation(s)
- Santosh Kumar
- Department of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| | - Ravi Kant
- Department of Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| | - Poonam Yadav
- College of Nursing, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India,Address for correspondence: Mrs. Poonam Yadav, Ph. D. Scholar, College of Nursing, All India Institute of Medical Sciences, Rishikesh, Uttrakhand, India. E-mail:
| | - Barun Kumar
- Department of Cardiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| |
Collapse
|
|
38
|
Verma MR, Langade DG, Rao RD, Shivangi S, Khedkar S, Kanchibhotla D. An Observational Study on the Effect of Yoga and Sudarshan Kriya in Type 2 Diabetes Mellitus Patients. Cureus 2022; 14:e27951. [PMID: 36120271 PMCID: PMC9464970 DOI: 10.7759/cureus.27951] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/11/2022] [Indexed: 11/14/2022] Open
Abstract
Introduction One of the major health problems in many countries including India is type 2 diabetes. Yoga is being explored as an alternative therapy for the management of diabetes. Methods Among the total of 137 participants who successfully completed the ‘Living Well’ workshop by the Art of Living, 84 with type 2 diabetes were assessed for change in random blood sugar levels, systolic and diastolic blood pressure levels (SBP/DBP), and pulse rate over seven days. In the Living Well workshop, the participants performed a comprehensive Yogic Breathing Program that included yogic movements and postures (Asana), relaxation practice, three-stage Pranayama, Sudarshan Kriya Yoga (SKY), breathing techniques, and discussion of stress relieving principles over those seven days. The parameters were recorded at the time of enrollment and after the completion of seven days of the workshop. Results There was a greater (p<0.05) percent reduction in the mean blood sugar level in diabetics as compared to non-diabetic individuals. However, the reduction in SBP and DBP were similar (p>0.05) in diabetics and non-diabetics. The percent reduction in the pulse rate however was greater (p<0.05) in diabetics than non-diabetics. Conclusion Comprehensive yogic breathing practices comprising SKY may be beneficial in patients with type 2 diabetes mellitus.
Collapse
|
|
39
|
Mangala Gowri M, Rajendran J, Srinivasan AR, Bhavanani AB, Meena R. Impact of an Integrated Yoga Therapy Protocol on Insulin Resistance and Glycemic Control in Patients with Type 2 Diabetes Mellitus. Rambam Maimonides Med J 2022; 13:RMMJ.10462. [PMID: 35089124 PMCID: PMC8798588 DOI: 10.5041/rmmj.10462] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
Abstract
OBJECTIVE Diabetes mellitus (DM), characterized by chronic hyperglycemia, is attributed to relative insulin deficiency or resistance, or both. Studies have shown that yoga can modulate parameters of insulin resistance. The present study explored the possible beneficial effects of integrated yoga therapy with reference to glycemic control and insulin resistance (IR) in individuals with diabetes maintained on standard oral medical care with yoga therapy, compared to those on standard oral medical care alone. METHODS In this study, the subjects on yoga intervention comprised 35 type 2 diabetics, and an equal number of volunteers constituted the control group. Subjects ranged in age from 30 to 70 years, with hemoglobin A1c (HbA1c) test more than 7%, and were maintained on diabetic diet and oral hypoglycemic agents. Blood samples were drawn prior to and after 120 days of integrated yoga therapy intervention. Fasting blood glucose (FBG), post-prandial blood glucose (PPBG), HbA1c, insulin, and lipid profile were assessed in both the intervention and control groups. RESULTS The intervention group revealed significant improvements in body mass index (BMI) (0.7 kg/m2 median decrease; P=0.001), FBG (20 mg/dL median decrease; P<0.001), PPBG (33 mg/dL median decrease; P<0.001), HbA1c (0.4% median decrease; P<0.001), homeostatic model assessment for insulin resistance (HOMA-IR) (1.2 median decrease; P<0.001), cholesterol (13 mg/dL median decrease, P=0.006), triacylglycerol (22 mg/dL median decrease; P=0.027), low-density lipoprotein (6 mg/dL median decrease; P=0.004), and very-low-density lipoprotein levels (4 mg/dL median decrease; P=0.032). Increases in high-density lipoprotein after 120 days were not significant (6 mg/dL median increase; P=0.15). However, when compared to changes observed in patients in the control group, all these improvements proved to be significant. CONCLUSION Administration of integrated yoga therapy to individuals with diabetes leads to a significant improvement in glycemic control, insulin resistance, and key biochemical parameters.
Collapse
Affiliation(s)
- Manoharan Mangala Gowri
- Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry, India
| | - Jayanthi Rajendran
- Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry, India
| | - Abu Raghavan Srinivasan
- Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry, India
- To whom correspondence should be addressed. E-mail:
| | - Ananda Balayogi Bhavanani
- Centre for Yoga Therapy Education and Research, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry, India
| | - Ramanathan Meena
- Centre for Yoga Therapy Education and Research, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry, India
| |
Collapse
|
|
40
|
Kumari S, S D L, B S, Khanal S. Efficacy of Integrated Ayurveda treatment protocol in type 2 diabetes mellitus - A case report. J Ayurveda Integr Med 2021; 13:100512. [PMID: 34903437 PMCID: PMC8728054 DOI: 10.1016/j.jaim.2021.08.005] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2021] [Revised: 08/05/2021] [Accepted: 08/06/2021] [Indexed: 11/19/2022] Open
Abstract
Type 2 Diabetes Mellitus (T2DM) is a growing global concern having reached the epidemic proportion in most countries. Achieving glycaemic control decreases the risk of macrovascular and microvascular complications in T2D. To achieve and maintain good glycaemic control, lifestyle changes and pharmacological treatment is necessary. Pharmacological management of T2DM have some limitations as it may lead to vit-B12 deprivation, hypoglycemia, increased cardiovascular risk etc. Treatment algorithm that include integration of Ayurvedic treatment & diet, Panchakarma therapies and Yoga will ensure good glycaemic control and reduce the progression of complications. Diagnosed cases of T2DM without intervention of conventional pharmacological drugs will be safe and beneficial. A female patient aged about 52 years visited to diabetic specialty OPD with the following complaints: increased micturation frequency, vaginal itching, fatigue and increased thirst. Patient reported weight gain in past 1 year, was not on any conventional antidiabetic medication. Her HbA1c status confirmed diagnosis of T2DM. Patient was treated with a course of nityavirechana (medicated purgation) and Sarwanga Udwartana (Dry medicated powder rubbing whole body) for the duration of 7 days along with ayurveda medicines for 1 year. Patient was prescribed Ayurvedic diet and Yoga practices throughout the intervention. This case report reveals the protocol based integrated Ayurveda and Yoga practices for diagnosed case of T2DM without causing any untoward effect along with reversal of the diabetes.
Collapse
Affiliation(s)
- Suketha Kumari
- Department of Kayachikitsa, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, 590003, India.
| | - Laxmikant S D
- Department of Shalyatantra, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, 590003, India
| | - Sonika B
- Department of Kayachikitsa, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, 590003, India
| | - Suman Khanal
- Department of Kayachikitsa, KAHER's Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi, Karnataka, 590003, India
| |
Collapse
|
|
41
|
Patil SS, Raghuram N, Singh A, Rajesh SK, Ahmed S, Hongasandra N. A Prospective Study on Type-2 Diabetic Complications and Efficacy of Integrated Yoga: A Pan India 2017. Ann Neurosci 2021; 28:21-28. [PMID: 34733051 PMCID: PMC8558979 DOI: 10.1177/09727531211016271] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/23/2020] [Accepted: 03/30/2021] [Indexed: 11/17/2022] Open
Abstract
Background Type 2 diabetes (T2DM) contributes to high mortality and morbidity because of its major complications related to kidney, heart, brain, and eyes. It also poses a high risk for mortality because of COVID-19. Studies suggest the possible implications of Yoga in delaying or attenuating such complications. Methodology This was a pan-India multi centered cluster-randomized (4 level) two-armed trial in the rural and urban population of all populous states of India. Data were obtained using mobile app in all adults in the household of the selected clusters. Results We report the diabetes related complications in 16623 adults (48% males, 52% females) from 65 districts (1 in 10 districts, 2011 census) of 29 (out of 35) states and Union Territories of India; mean age was 48.2 ± 12.46 years. Out of this 40% lived in rural and 62% in urban locations. In high risk diabetes individuals (scored ≥ 60 points on Indian diabetes risk score key), 18.0% had self-reported history of (peripheral neuropathy, 6.1% had h/o major strokes, 5.5% had minor strokes (transient ischemic episodes), 18.1% had lower limb claudication, 20.5% leg ulcers, 4.4% had h/o cardiac surgery, 4.8% angioplasty, and 15.1% had diabetes retinopathy. Complications were higher in rural than in urban areas, higher in people with extended duration of diabetes. Integrated yoga module for three months (one hour daily) showed significantly better reduction in symptoms related to complications as compared to control group (P < .001). Conclusion The alarming high prevalence of complications in diabetes population calls for urgent action, where yoga may show the benefits in reduction of symptoms of complications.
Collapse
Affiliation(s)
- Suchitra S Patil
- Department of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| | - Nagarathna Raghuram
- Department of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| | - Amit Singh
- Department of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| | - S K Rajesh
- Department of Yoga and Physical Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| | - Sabzar Ahmed
- Department of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| | - Nagendra Hongasandra
- Department of Yoga and Life Science, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India
| |
Collapse
|
|
42
|
Yuniartika W, Sudaryanto A, Muhlisin A, Hudiyawati D, Pribadi DRA. Effects of Yoga Therapy and Walking Therapy in Reducing Blood Sugar Levels on Diabetes Mellitus Patients in the Community. Open Access Maced J Med Sci 2021. [DOI: 10.3889/oamjms.2021.7104] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
BACKGROUND: The increasing of diabetes mellitus cases in Indonesia may be due to changes in people’s lifestyles, which is lack of exercise. Factors that may contribute to the high prevalence of diabetes mellitus sufferers other than genetics are exacerbated by environmental factors. Exercise interventions have been effective in counterbalancing diabetes complications. Yoga exerts a beneficial effect on insulin kinetics and the resulting lipid profile. Yoga helps redistribute body fat and reduces obesity which may lead to insulin resistance. In addition, other types of physical activity that can be done by diabetes mellitus patients are adequate morning walking while having scenery leisure for 30 min or more.
AIM: This study was conducted to determine the effect of yoga therapy and walking therapy on diabetes mellitus patients in the community.
METHODS: Quantitative research using randomized control trial, conducted in Gedongan Village, Baki Subdistrict, Sukoharjo Regency, involving 54 samples divided into three groups. Inclusion criteria: Patients with type 2 diabetes mellitus, fasting glucose levels of 126 mg/dl, no complication, and no insulin therapy or diabetes medication. The outcome measured was fasting blood sugar levels. The intervention group performed therapy for 12 weeks with a duration of 3 times a week.
RESULTS: The average fasting sugar levels in the yoga group pre (217.00) post (187.72) p (0.001), the walking group averaged pre (209.89) post (193.83) p (0.001), and the control group averaged pre (221.50) post (225.17) p (0.067).
CONCLUSION: There was an effect of yoga therapy and walking therapy on reducing fasting glucose levels.
Collapse
|
|
43
|
Nagarathna R, Kumar S, Anand A, Acharya IN, Singh AK, Patil SS, Latha RH, Datey P, Nagendra HR. Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population-A Community Based Multicenter Randomized Controlled Trial. MEDICINES 2021; 8:medicines8070037. [PMID: 34357153 PMCID: PMC8303653 DOI: 10.3390/medicines8070037] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/01/2021] [Revised: 06/13/2021] [Accepted: 06/29/2021] [Indexed: 01/09/2023]
Abstract
Background: Dyslipidemia poses a high risk for cardiovascular disease and stroke in Type 2 diabetes (T2DM). There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Methods: Here, we report the results of lipid profile values of 11,254 (yoga 5932 and control 5322) adults (20–70 years) of both genders with high risk (≥60 on Indian diabetes risk score) for diabetes from a nationwide rural and urban community-based two group (yoga and conventional management) cluster randomized controlled trial. The yoga group practiced a validated integrated yoga lifestyle protocol (DYP) in nine day camps followed by daily one-hour practice. Biochemical profiling included glycated hemoglobin and lipid profiles before and after three months. Results: There was a significant difference between groups (p < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. Further, the regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Conclusion: Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities.
Collapse
Affiliation(s)
- Raghuram Nagarathna
- Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA), Bengaluru 560105, India; (A.K.S.); (S.S.P.); (H.R.N.)
- Correspondence: (R.N.); (A.A.)
| | - Saurabh Kumar
- Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India;
| | - Akshay Anand
- Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India;
- Centre for Mind Body Medicine, PGIMER, Chandigarh 160012, India
- Centre for Cognitive Science and Phenomenology, Panjab University, Chandigarh 160014, India
- Correspondence: (R.N.); (A.A.)
| | - Ishwara N. Acharya
- Central Council for Research in Yoga & Naturopathy (CCRYN), Delhi 110058, India;
| | - Amit Kumar Singh
- Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA), Bengaluru 560105, India; (A.K.S.); (S.S.P.); (H.R.N.)
| | - Suchitra S. Patil
- Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA), Bengaluru 560105, India; (A.K.S.); (S.S.P.); (H.R.N.)
| | | | | | | |
Collapse
|
|
44
|
Abstract
Yoga, one of the world’s oldest health systems is receiving new attention for claims that it can contribute to healthy aging. Until recently, scientific evidence for its efficacy has relied heavily on small and poorly-designed research, but this is changing. Multiple, well-designed studies provide data showing that yoga practice has positive effects on cellular aging, mobility, balance, mental health, and prevention of cognitive decline—all areas of concern for older adults. Since the cost of implementing yoga-based community and home-based interventions is low—policymakers are also eyeing yoga practice as a cost-effective way to reduce medical costs and improve outcomes among a growing aging population. This commentary reviews the evidence for both physical and mental health benefits from yoga, as well as concerns about injuries that have been associated with certain types of yoga practice. It reveals a surprising range of yoga programs and difficulty levels that provide opportunities for almost anyone to participate and gain health benefits with practice.
Collapse
|
|
45
|
Ramu R, Patil SM. A Perspective on the Effective Conduction of Functional-based Coaching Program on Diabetic Indonesian Communities. Oman Med J 2021; 36:e281. [PMID: 34267953 PMCID: PMC8254870 DOI: 10.5001/omj.2021.80] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2020] [Accepted: 10/08/2020] [Indexed: 12/04/2022] Open
Affiliation(s)
- Ramith Ramu
- Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Karnataka, India
| | - Shashank M Patil
- Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Karnataka, India
| |
Collapse
|
|
46
|
Nair RG, Vasudev MM, Mavathur R. Role of Yoga and Its Plausible Mechanism in the Mitigation of DNA Damage in Type-2 Diabetes: A Randomized Clinical Trial. Ann Behav Med 2021; 56:235-244. [PMID: 34180500 DOI: 10.1093/abm/kaab043] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/22/2023] Open
Abstract
BACKGROUND Although yoga is found to be beneficial in the management of type 2 diabetes (T2D), its mechanism of action is poorly understood. T2D is also known to be associated with increased oxidative stress (OS) and DNA damage. PURPOSE This study examines how yoga modulates OS-induced DNA damage and the efficiency of DNA repair in T2D conditions. METHODS In this assessor-masked randomized clinical trial, T2D subjects (n = 61), aged (Mean ± SD, 50.3 ± 4.2) were randomly allocated into Yoga group (31) that received 10 weeks of yoga intervention and Control (30) with routine exercises. Molecular and biochemical assessments were done before and after the intervention period. Structural Equation Modeling using "R" was used for mediation analysis. RESULTS At the end of the 10th week, Yoga group showed significant reduction in DNA damage indicators like Tail Moment (-5.88[95%CI: -10.47 to -1.30]; P = .013) and Olive Tail Moment (-2.93[95%CI: -4.87 to -1.00]; P < .01), oxidative DNA damage marker 8-OHdG (-60.39[95%CI: -92.55 to -28.23]; P < .001) and Fasting Blood Sugar (-22.58[95%CI: -44.33 to -0.83]; P = .042) compared to Control. OGG1 protein expression indicating DNA repair, improved significantly (17.55[95%CI:1.37 to 33.73]; P = .034) whereas Total Antioxidant Capacity did not (5.80[95%CI: -0.86 to 12.47]; P = 0.086). Mediation analysis indicated that improvements in oxidative DNA damage and DNA repair together played a major mediatory role (97.4%) in carrying the effect of yoga. CONCLUSION The beneficial effect of yoga on DNA damage in T2D subjects was found to be mediated by mitigation of oxidative DNA damage and enhancement of DNA repair. CLINICAL TRIAL INFORMATION (www.ctri.nic.in) CTRI/2018/07/014825.
Collapse
Affiliation(s)
- Rajesh G Nair
- Molecular Bioscience Lab, Anvesana Research Labs, S-VYASA, Bangalore, India
| | - Mithila M Vasudev
- Molecular Bioscience Lab, Anvesana Research Labs, S-VYASA, Bangalore, India
| | - Ramesh Mavathur
- Molecular Bioscience Lab, Anvesana Research Labs, S-VYASA, Bangalore, India
| |
Collapse
|
|
47
|
Dutta D, Bhattacharya S, Sharma M, Khandelwal D, Surana V, Kalra S. Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis. J Diabetes Metab Disord 2021; 20:349-367. [PMID: 34178843 PMCID: PMC8212260 DOI: 10.1007/s40200-021-00751-0] [Citation(s) in RCA: 12] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/22/2020] [Accepted: 01/24/2021] [Indexed: 10/22/2022]
Abstract
PURPOSE Prior systematic reviews on yoga and diabetes have given conflicting results. They have been limited by inclusion of uncontrolled unblinded single group observational studies. No reviews are available which have used the Cochrane methodology and GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach. This meta-analysis evaluated the efficacy of yoga on glycaemia and lipids in T2DM using the Cochrane methodology and GRADE approach. METHODS Major repositories were searched to pick randomized controlled trials involving T2DM patients receiving yoga. Primary outcome was to evaluate changes in fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c). Secondary outcomes were to evaluate changes in post-prandial plasma glucose (PPG), total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Sub-group analysis involving people undergoing structured exercise regimen (SER) versus those undergoing standard diabetes care in controls was done. RESULTS Data from 13 studies involving 1440 patients were analysed. Compared to controls, individuals doing yoga had significantly lower FPG [mean difference (MD) -17.22 mg/dl (95% CI: -26.19 - -8.26 mg/dl); p < 0.01; considerable heterogeneity (CH); low certainty of evidence (LCE)], PPG [MD -27.77 mg/dl (95% CI: -35.73 - -19.81 mg/dl); p < 0.01; low heterogeneity; moderate certainty of evidence (MCE)], TC [MD -19.48 mg/dl (95% CI: -31.97 - -6.99 mg/dl); p < 0.01; CH; LCE], triglycerides [MD -12.99 mg/dl (95% CI: -23.74 - -2.25 mg/dl); p < 0.01; CH; LCE], LDL-C [MD -11.71 mg/dl (95% CI: -17.49 - -5.93 mg/dl); p < 0.01; I2 = 69% CH; LCE] and significantly higher HDL-C [MD 4.58 mg/dl (95% CI: 3.98-5.18 mg/dl); p < 0.01; low heterogeneity; MCE]. On sub-group analysis, where yoga was compared to SER, FPG was significantly lower in yoga group. CONCLUSION Yoga improves glycaemia and lipid parameters in T2DM with additional benefits seen both in people doing/not doing structured exercise. SUPPLEMENTARY INFORMATION The online version contains supplementary material available at 10.1007/s40200-021-00751-0.
Collapse
Affiliation(s)
- Deep Dutta
- Department of Endocrinology, Center for Endocrinology, Diabetes, Arthritis & Rheumatism (CEDAR) Super-speciality Clinics, Dwarka, New Delhi, 110075 India
| | | | - Meha Sharma
- Department of Rheumatology, CEDAR Superspeciality Clinics, Dwarka, New Delhi, India
| | - Deepak Khandelwal
- Department of Endocrinology, Maharaj Agrasen Hospital, New Delhi, India
| | - Vineet Surana
- Department of Endocrinology, Manipal Hospitals, Dwarka, New Delhi, India
| | - Sanjay Kalra
- Department of Endocrinology, Bharti Hospitals, Karnal, India
| |
Collapse
|
|
48
|
Rajput R, Yadav K, Rajput M, Yadav J, Saini N. Effect of Yoga on Glucose Control and Quality of Life in Patients of Prediabetes. Metab Syndr Relat Disord 2021; 19:417-421. [PMID: 34037489 DOI: 10.1089/met.2020.0040] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022] Open
Abstract
Objective: The objective of this study was to evaluate effect of yoga on fasting plasma glucose (FPG), postprandial plasma glucose, and hemoglobin A1C (HbA1C) and also on quality of life (QoL). Research Design and Methods: This was a cohort study in which 100 diagnosed cases of prediabetes were recruited for doing specific yoga, and they themselves act as control for the study. The measurement and comparison of FPG, prandial plasma glucose (PPG), and HbA1C were done at three different time intervals, that is, baseline, 3 months, and at 6 months. The assessment of QoL was done using SF-36 scale. Results: One hundred prediabetic cases were selected for the study in which impaired fasting glucose (IFG) was present more in younger population compared to impaired glucose tolerance (IGT) and IFG plus IGT both of which are more prevalent in middle age group. The yoga therapy was found to have favorable effect on FPG, PPG, and HbA1C along with various anthropometry measures studied in this study. After adjusting correlation coefficient for various anthropometry measures, yoga was found to be effective for controlling glycemic parameters in prediabetics. Conclusions: Yoga is a type of exercise known to improve glycemic control by changing anthropometry measures, but our study aids in knowledge about the beneficial effect beyond this known fact through other mechanisms yet to be explored.
Collapse
Affiliation(s)
- Rajesh Rajput
- General Medicine, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, Haryana, India
| | - Karamvir Yadav
- General Medicine, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, Haryana, India
| | - Meena Rajput
- General Medicine, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, Haryana, India
| | - Jyoti Yadav
- General Medicine, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, Haryana, India
| | - Neharika Saini
- General Medicine, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, Haryana, India
| |
Collapse
|
|
49
|
Datta K, Tripathi M, Verma M, Masiwal D, Mallick HN. Yoga nidra practice shows improvement in sleep in patients with chronic insomnia: A randomized controlled trial. THE NATIONAL MEDICAL JOURNAL OF INDIA 2021; 34:143-150. [PMID: 34825538 DOI: 10.25259/nmji_63_19] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/04/2022]
Abstract
Background Yoga nidra is practised by sages for sleep. The practice is simple to use and has been clearly laid out, but its role in the treatment of chronic insomnia has not been well studied. Methods In this randomized parallel-design study conducted during 2012-16, we enrolled 41 patients with chronic insomnia to receive conventional intervention of cognitive behavioural therapy for insomnia (n=20) or yoga nidra (n=21). Outcome measures were both subjective using a sleep diary and objective using polysomnography (PSG). Salivary cortisol levels were also measured. PSG was done before the intervention in all patients and repeated only in those who volunteered for the same. Results Both interventions showed an improvement in subjective total sleep time (TST), sleep efficiency, wake after sleep onset, reduction in total wake duration and enhancement in subjective sleep quality. Objectively, both the interventions improved TST and total wake duration and increased N1% of TST. Yoga nidra showed marked improvement in N2% and N3% in TST. Salivary cortisol reduced statistically significantly after yoga nidra (p=0.041). Conclusion Improvement of N3 sleep, total wake duration and subjective sleep quality occurred following yoga nidra practice. Yoga nidra practice can be used for treatment of chronic insomnia after supervised practice sessions.
Collapse
Affiliation(s)
- Karuna Datta
- Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
| | - Manjari Tripathi
- Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
| | - Mansi Verma
- Department of Sports Medicine, Armed Forces Medical College, Pune, Maharashtra, India
| | - Deepika Masiwal
- Department of Sports Medicine, Armed Forces Medical College, Pune, Maharashtra, India
| | - Hruda Nanda Mallick
- Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
| |
Collapse
|
|
50
|
Kim KS, Choi YK, Kim MJ, Hwang JW, Min K, Jung SY, Kim SK, Choi YS, Cho YW. Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell. Diabetes Metab J 2021; 45:260-269. [PMID: 32662257 PMCID: PMC8024157 DOI: 10.4093/dmj.2019.0191] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/18/2019] [Accepted: 03/08/2020] [Indexed: 12/17/2022] Open
Abstract
BACKGROUND Umbilical cord-mesenchymal stem cell-conditioned medium (UC-MSC-CM) has emerged as a promising cell-free therapy. The aim of this study was to explore the therapeutic effects of UC-MSC-CM on insulin resistance in C2C12 cell. METHODS Insulin resistance was induced by palmitate. Effects of UC-MSC-CM on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 (GLUT4) translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell. RESULTS Glucose uptake was improved by UC-MSC-CM. UC-MSC-CM treatment increased only in membranous GLUT4 expression, not in cytosolic GLUT4 expression. It restored the insulin-signaling pathway in insulin receptor substrate 1 and protein kinase B. Mitochondrial contents evaluated by mitochondrial transcription factor A, mitochondrial DNA copy number, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha were increased by UC-MSC-CM. In addition, UC-MSC-CM significantly decreased mitochondrial reactive oxygen species and increased fatty acid oxidation and mitochondrial membrane potential. There was no improvement in adenosine triphosphate (ATP) contents, but ATP synthesis was improved by UC-MSC-CM. Cytokine and active factor analysis of UC-MSC-CM showed that it contained many regulators inhibiting insulin resistance. CONCLUSION UC-MSC-CM improves insulin resistance with multiple mechanisms in C2C12 cell.
Collapse
Affiliation(s)
- Kyung-Soo Kim
- Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
| | - Yeon Kyung Choi
- Department of Biotechnology, CHA University, Seongnam, Korea
| | - Mi Jin Kim
- Department of Biotechnology, CHA University, Seongnam, Korea
| | - Jung Wook Hwang
- Department of Biotechnology, CHA University, Seongnam, Korea
| | - Kyunghoon Min
- Department of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
| | - Sang Youn Jung
- Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
| | - Soo-Kyung Kim
- Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
| | - Yong-Soo Choi
- Department of Biotechnology, CHA University, Seongnam, Korea
| | - Yong-Wook Cho
- Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
| |
Collapse
|