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For: Yang SY, Castellani CA, Longchamps RJ, Pillalamarri VK, O'Rourke B, Guallar E, Arking DE. Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease. Genome Res 2021;31:349-358. [PMID: 33441415 PMCID: PMC7919448 DOI: 10.1101/gr.269381.120] [Citation(s) in RCA: 65] [Impact Index Per Article: 16.3] [Reference Citation Analysis] [What about the content of this article? (0)] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2020] [Accepted: 01/06/2021] [Indexed: 12/12/2022]
Number Cited by Other Article(s)
1
Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. World J Methodol 2025;15:102709. [DOI: 10.5662/wjm.v15.i3.102709] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/26/2024] [Revised: 01/21/2025] [Accepted: 02/08/2025] [Indexed: 03/06/2025]  Open
2
Qin P, Chen X, Ma P, Li X, Lin Y, Liu X, Liang X, Qin T, Liang J, Ouyang J. Mitochondrial DNA copy number and Alzheimer's disease and Parkinson disease. Mitochondrion 2025;83:102032. [PMID: 40157623 DOI: 10.1016/j.mito.2025.102032] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2024] [Revised: 01/22/2025] [Accepted: 03/26/2025] [Indexed: 04/01/2025]
3
Fukunaga H, Fukunaga M. Mitochondrial DNA copy numbers in gastric cancer tissues: a possible biomarker for estimating cancer progression. Jpn J Clin Oncol 2025:hyaf066. [PMID: 40263745 DOI: 10.1093/jjco/hyaf066] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/21/2025] [Revised: 04/02/2025] [Accepted: 04/04/2025] [Indexed: 04/24/2025]  Open
4
Shin EH, Le Q, Barboza R, Morin A, Singh SM, Castellani CA. Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling. Mitochondrion 2025;84:102042. [PMID: 40254118 DOI: 10.1016/j.mito.2025.102042] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2025] [Revised: 03/24/2025] [Accepted: 04/16/2025] [Indexed: 04/22/2025]
5
Xia H, Wang ZH, Wang XB, Gao MR, Jiang S, Du XY, Yang XL. Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases. BMC Neurol 2025;25:160. [PMID: 40240969 PMCID: PMC12001617 DOI: 10.1186/s12883-025-04176-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/13/2024] [Accepted: 04/03/2025] [Indexed: 04/18/2025]  Open
6
Yates J, Kraft A, Boeva V. Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studies. Genome Biol 2025;26:91. [PMID: 40205439 PMCID: PMC11983838 DOI: 10.1186/s13059-025-03559-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2024] [Accepted: 03/25/2025] [Indexed: 04/11/2025]  Open
7
Jo S, Oh JH, Lee EJ, Choi M, Lee J, Lee S, Kim TW, Sung CO, Chung SJ. Mitochondrial DNA Copy Number as a Potential Biomarker for the Severity of Motor Symptoms and Prognosis in Parkinson's Disease. Mov Disord 2025;40:502-510. [PMID: 39760477 DOI: 10.1002/mds.30098] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/12/2024] [Revised: 11/24/2024] [Accepted: 12/11/2024] [Indexed: 01/07/2025]  Open
8
Liu YJ, Sulc J, Auwerx J. Mitochondrial genetics, signalling and stress responses. Nat Cell Biol 2025;27:393-407. [PMID: 40065146 DOI: 10.1038/s41556-025-01625-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2023] [Accepted: 01/22/2025] [Indexed: 03/15/2025]
9
Zheng N, Cao RL, Liu DY, Liu P, Zhao XY, Zhang SX, Huang M, Zheng ZH, Chen GL, Zou LB. OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells. Free Radic Biol Med 2025;228:360-378. [PMID: 39793907 DOI: 10.1016/j.freeradbiomed.2025.01.014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/02/2024] [Revised: 12/22/2024] [Accepted: 01/07/2025] [Indexed: 01/13/2025]
10
Tian Q, Zweibaum DA, Qian Y, Oppong RF, Pilling LC, Casanova F, Atkins JL, Melzer D, Ding J, Ferrucci L. Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty. GeroScience 2025;47:825-835. [PMID: 39313624 PMCID: PMC11872790 DOI: 10.1007/s11357-024-01355-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/06/2024] [Accepted: 09/13/2024] [Indexed: 09/25/2024]  Open
11
Seino R, Kubo H, Nishikubo K, Fukunaga H. Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability. ENVIRONMENT INTERNATIONAL 2025;196:109315. [PMID: 39914081 DOI: 10.1016/j.envint.2025.109315] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/03/2024] [Revised: 01/23/2025] [Accepted: 02/01/2025] [Indexed: 02/23/2025]
12
Meloni A, Paribello P, Pinna M, Contu M, Ardau R, Chillotti C, Congiu D, Gennarelli M, Minelli A, Buson L, Severino G, Pisanu C, Manchia M, Squassina A. Mitochondrial DNA copy number is significantly increased in bipolar disorder patients and is correlated with long-term lithium treatment. Eur Neuropsychopharmacol 2025;91:37-44. [PMID: 39612728 DOI: 10.1016/j.euroneuro.2024.10.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/11/2024] [Revised: 10/18/2024] [Accepted: 10/25/2024] [Indexed: 12/01/2024]
13
Risi B, Imarisio A, Cuconato G, Padovani A, Valente EM, Filosto M. Mitochondrial DNA (mtDNA) as fluid biomarker in neurodegenerative disorders: A systematic review. Eur J Neurol 2025;32:e70014. [PMID: 39831374 PMCID: PMC11744304 DOI: 10.1111/ene.70014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Accepted: 12/09/2024] [Indexed: 01/22/2025]
14
Stocker H, Gentiluomo M, Trares K, Beyer L, Stevenson-Hoare J, Rujescu D, Holleczek B, Beyreuther K, Gerwert K, Schöttker B, Campa D, Canzian F, Brenner H. Mitochondrial DNA abundance in blood is associated with Alzheimer's disease- and dementia-risk. Mol Psychiatry 2025;30:131-139. [PMID: 39009700 DOI: 10.1038/s41380-024-02670-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/27/2023] [Revised: 06/22/2024] [Accepted: 07/08/2024] [Indexed: 07/17/2024]
15
Tsai TH, Wu CY, Chang CC, Lin TT, Liu CS, Chen PS. Mitochondrial DNA copy number as a mediator of the relationship between insulin resistance and cognitive function in patients with euthymic bipolar disorder. Kaohsiung J Med Sci 2025;41:e12914. [PMID: 39579049 PMCID: PMC11724167 DOI: 10.1002/kjm2.12914] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2024] [Revised: 11/11/2024] [Accepted: 11/12/2024] [Indexed: 11/25/2024]  Open
16
Tian Q, Greig EE, Davatzikos C, Landman BA, Resnick SM, Ferrucci L. Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade. Nat Commun 2024;15:10786. [PMID: 39737971 PMCID: PMC11686348 DOI: 10.1038/s41467-024-55009-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2024] [Accepted: 11/25/2024] [Indexed: 01/01/2025]  Open
17
Qin L, Huang T, Zhang D, Wei L, Li G, Zhu Q, Tong Q, Ding G, Liu J. The mitochondrial function of peripheral blood cells in cognitive frailty patients. Front Aging Neurosci 2024;16:1503246. [PMID: 39723155 PMCID: PMC11669044 DOI: 10.3389/fnagi.2024.1503246] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/28/2024] [Accepted: 11/25/2024] [Indexed: 12/28/2024]  Open
18
Zehra Z, Zia MA, Siddiqui SN, von Bartheld CS, Azam M, Qamar R. Increase in blood derived mitochondrial DNA copy number in strabismus patients. J AAPOS 2024;28:104042. [PMID: 39542418 DOI: 10.1016/j.jaapos.2024.104042] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/31/2024] [Revised: 07/24/2024] [Accepted: 08/05/2024] [Indexed: 11/17/2024]
19
Wang L, Han J, Fearnley LG, Milton M, Rafehi H, Reid J, Gerring ZF, Masaldan S, Lang T, Speed TP, Bahlo M. Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson's disease. NPJ Parkinsons Dis 2024;10:219. [PMID: 39543161 PMCID: PMC11564539 DOI: 10.1038/s41531-024-00831-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/01/2024] [Accepted: 10/30/2024] [Indexed: 11/17/2024]  Open
20
Tong T, Zhu C, Farrell JJ, Khurshid Z, Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther 2024;16:234. [PMID: 39444005 PMCID: PMC11515778 DOI: 10.1186/s13195-024-01601-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/23/2024] [Accepted: 10/10/2024] [Indexed: 10/25/2024]
21
Liu F, Sun X, Wei C, Ji L, Song Y, Yang C, Wang Y, Liu X, Wang D, Kang J. Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice. Aging Cell 2024;23:e14242. [PMID: 39422985 PMCID: PMC11488324 DOI: 10.1111/acel.14242] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/26/2023] [Revised: 05/10/2024] [Accepted: 05/15/2024] [Indexed: 10/19/2024]  Open
22
Kim M, Gorelick AN, Vàzquez-García I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Boscenco S, O'Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP, Reznik E. Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes. Nat Genet 2024;56:889-899. [PMID: 38741018 PMCID: PMC11096122 DOI: 10.1038/s41588-024-01724-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2022] [Accepted: 03/20/2024] [Indexed: 05/16/2024]
23
Tian Q, Greig EE, Walker KA, Fishbein KW, Spencer RG, Resnick SM, Ferrucci L. Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function. Age Ageing 2024;53:afae079. [PMID: 38615247 PMCID: PMC11484644 DOI: 10.1093/ageing/afae079] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Indexed: 04/15/2024]  Open
24
Nguyen J, Win PW, Nagano TS, Shin EH, Newcomb C, Arking DE, Castellani CA. Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2024:2024.01.29.577835. [PMID: 38352513 PMCID: PMC10862824 DOI: 10.1101/2024.01.29.577835] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 02/22/2024]
25
Tian Q, Lee PR, Yang Q, Moore AZ, Landman BA, Resnick SM, Ferrucci L. The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility. J Cachexia Sarcopenia Muscle 2024;15:138-148. [PMID: 38116708 PMCID: PMC10834332 DOI: 10.1002/jcsm.13413] [Citation(s) in RCA: 9] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/30/2023] [Revised: 10/24/2023] [Accepted: 11/20/2023] [Indexed: 12/21/2023]  Open
26
Calarco CA, Keppetipola SM, Kumar G, Shipper AG, Lobo MK. Whole blood mitochondrial copy number in clinical populations with mood disorders: A meta-analysis: Blood mitochondrial copy number and mood disorders. Psychiatry Res 2024;331:115662. [PMID: 38118327 DOI: 10.1016/j.psychres.2023.115662] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/13/2023] [Revised: 12/01/2023] [Accepted: 12/02/2023] [Indexed: 12/22/2023]
27
Liu X, Sun X, Zhang Y, Jiang W, Lai M, Wiggins KL, Raffield LM, Bielak LF, Zhao W, Pitsillides A, Haessler J, Zheng Y, Blackwell TW, Yao J, Guo X, Qian Y, Thyagarajan B, Pankratz N, Rich SS, Taylor KD, Peyser PA, Heckbert SR, Seshadri S, Boerwinkle E, Grove ML, Larson NB, Smith JA, Vasan RS, Fitzpatrick AL, Fornage M, Ding J, Carson AP, Abecasis G, Dupuis J, Reiner A, Kooperberg C, Hou L, Psaty BM, Wilson JG, Levy D, Rotter JI, Bis JC, TOPMed mtDNA Working Group in NHLBI Trans‐Omics for Precision Medicine (TOPMed) Consortium, Satizabal CL, Arking DE, Liu C. Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk. J Am Heart Assoc 2023;12:e029090. [PMID: 37804200 PMCID: PMC10757530 DOI: 10.1161/jaha.122.029090] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/09/2023] [Accepted: 09/08/2023] [Indexed: 10/09/2023]
28
Gorham IK, Barber RC, Jones HP, Phillips NR. Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer's disease. Alzheimers Res Ther 2023;15:171. [PMID: 37821944 PMCID: PMC10566158 DOI: 10.1186/s13195-023-01322-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/06/2023] [Accepted: 09/28/2023] [Indexed: 10/13/2023]
29
Ortega-Vázquez A, Sánchez-Badajos S, Ramírez-García MÁ, Alvarez-Luquín D, López-López M, Adalid-Peralta LV, Monroy-Jaramillo N. Longitudinal Changes in Mitochondrial DNA Copy Number and Telomere Length in Patients with Parkinson's Disease. Genes (Basel) 2023;14:1913. [PMID: 37895262 PMCID: PMC10606744 DOI: 10.3390/genes14101913] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2023] [Revised: 09/30/2023] [Accepted: 10/05/2023] [Indexed: 10/29/2023]  Open
30
Calarco CA, Keppetipola SM, Kumar G, Shipper AG, Lobo MK. Whole blood mitochondrial copy number in clinical populations with mood disorders: a meta-analysis. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2023:2023.09.13.557572. [PMID: 37745411 PMCID: PMC10515896 DOI: 10.1101/2023.09.13.557572] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/26/2023]
31
Volobaev VP, Kunizheva SS, Uralsky LI, Kupriyanova DA, Rogaev EI. Quantifying human genome parameters in aging. Vavilovskii Zhurnal Genet Selektsii 2023;27:495-501. [PMID: 37808212 PMCID: PMC10551942 DOI: 10.18699/vjgb-23-60] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2022] [Revised: 02/07/2023] [Accepted: 02/07/2023] [Indexed: 10/10/2023]  Open
32
Wang W, Jia T, Liu Y, Deng H, Chen Z, Wang J, Geng Z, Wei R, Qiao J, Ma Y, Jiang X, Xu W, Shao J, Zhou K, Li Y, Pan Q, Yang W, Weng J, Guo L. Data-driven subgroups of newly diagnosed type 2 diabetes and the relationship with cardiovascular diseases at genetic and clinical levels in Chinese adults. Diabetes Metab Syndr 2023;17:102850. [PMID: 37683311 DOI: 10.1016/j.dsx.2023.102850] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/05/2023] [Revised: 08/20/2023] [Accepted: 08/29/2023] [Indexed: 09/10/2023]
33
Liu Y, Pan Y, Tian Z, Wang J, Chen F, Geng Z, Li Q, Liu Z, Zhou X, Zhou K. Association of mitochondrial DNA copy number with chronic kidney disease in older adults. BMC Geriatr 2023;23:514. [PMID: 37620817 PMCID: PMC10463711 DOI: 10.1186/s12877-023-04203-7] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/22/2023] [Accepted: 07/29/2023] [Indexed: 08/26/2023]  Open
34
Gupta R, Kanai M, Durham TJ, Tsuo K, McCoy JG, Kotrys AV, Zhou W, Chinnery PF, Karczewski KJ, Calvo SE, Neale BM, Mootha VK. Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. Nature 2023;620:839-848. [PMID: 37587338 PMCID: PMC10447254 DOI: 10.1038/s41586-023-06426-5] [Citation(s) in RCA: 72] [Impact Index Per Article: 36.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/29/2022] [Accepted: 07/11/2023] [Indexed: 08/18/2023]
35
Al-Kafaji G, Jahrami HA, Alwehaidah MS, Alshammari Y, Husni M. Mitochondrial DNA copy number in autism spectrum disorder and attention deficit hyperactivity disorder: a systematic review and meta-analysis. Front Psychiatry 2023;14:1196035. [PMID: 37484684 PMCID: PMC10361772 DOI: 10.3389/fpsyt.2023.1196035] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/29/2023] [Accepted: 06/21/2023] [Indexed: 07/25/2023]  Open
36
Gaylord A, Cohen A, Kupsco A. Biomarkers of aging through the life course: A Recent Literature Update. CURRENT OPINION IN EPIDEMIOLOGY AND PUBLIC HEALTH 2023;2:7-17. [PMID: 38130910 PMCID: PMC10732539 DOI: 10.1097/pxh.0000000000000018] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/23/2023]
37
Zhang Y, Liu X, Wiggins KL, Kurniansyah N, Guo X, Rodrigue AL, Zhao W, Yanek LR, Ratliff SM, Pitsillides A, Aguirre Patiño JS, Sofer T, Arking DE, Austin TR, Beiser AS, Blangero J, Boerwinkle E, Bressler J, Curran JE, Hou L, Hughes TM, Kardia SLR, Launer LJ, Levy D, Mosley TH, Nasrallah IM, Rich SS, Rotter JI, Seshadri S, Tarraf W, González KA, Ramachandran V, Yaffe K, Nyquist PA, Psaty BM, DeCarli CS, Smith JA, Glahn DC, González HM, Bis JC, Fornage M, Heckbert SR, Fitzpatrick AL, Liu C, Satizabal CL. Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts. Neurology 2023;100:e1930-e1943. [PMID: 36927883 PMCID: PMC10159770 DOI: 10.1212/wnl.0000000000207157] [Citation(s) in RCA: 18] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2022] [Accepted: 01/20/2023] [Indexed: 03/18/2023]  Open
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Ma J, Guo J, Fan Z, Zhao W, Zhou X. CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM. Biomolecules 2023;13:767. [PMID: 37238637 PMCID: PMC10216626 DOI: 10.3390/biom13050767] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/18/2023] [Revised: 04/20/2023] [Accepted: 04/25/2023] [Indexed: 05/28/2023]  Open
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Genetic correlation and gene-based pleiotropy analysis for four major neurodegenerative diseases with summary statistics. Neurobiol Aging 2023;124:117-128. [PMID: 36740554 DOI: 10.1016/j.neurobiolaging.2022.12.012] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/10/2021] [Revised: 03/25/2022] [Accepted: 12/27/2022] [Indexed: 01/02/2023]
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Kupsco A, Bloomquist TR, Hu H, Reddam A, Tang D, Goldsmith J, Rundle AG, Baccarelli AA, Herbstman JB. Mitochondrial DNA copy number dynamics and associations with the prenatal environment from birth through adolescence in a population of Dominican and African American children. Mitochondrion 2023;69:140-146. [PMID: 36804466 PMCID: PMC10006332 DOI: 10.1016/j.mito.2023.02.008] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/24/2022] [Revised: 01/17/2023] [Accepted: 02/13/2023] [Indexed: 02/18/2023]
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Wang J, Liang H, Huang R, Weng X, Zheng L, Wang Y, Zheng X, Gu Z, Chen F, Shao J, Geng Z, Pearson ER, Weng J, Yang W, Xu T, Zhou K. Higher mitochondrial DNA copy number is associated with metformin-induced weight loss. COMMUNICATIONS MEDICINE 2023;3:29. [PMID: 36806755 PMCID: PMC9938854 DOI: 10.1038/s43856-023-00258-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/11/2022] [Accepted: 02/09/2023] [Indexed: 02/20/2023]  Open
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Gupta R, Kanai M, Durham TJ, Tsuo K, McCoy JG, Chinnery PF, Karczewski KJ, Calvo SE, Neale BM, Mootha VK. Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES 2023:2023.01.19.23284696. [PMID: 36711677 PMCID: PMC9882621 DOI: 10.1101/2023.01.19.23284696] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Indexed: 01/21/2023]
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Pillalamarri V, Shi W, Say C, Yang S, Lane J, Guallar E, Pankratz N, Arking DE. Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy number. HGG ADVANCES 2023;4:100147. [PMID: 36311265 PMCID: PMC9615038 DOI: 10.1016/j.xhgg.2022.100147] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/06/2022] [Accepted: 09/23/2022] [Indexed: 10/14/2022]  Open
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Wu IC, Liu CS, Cheng WL, Lin TT, Chen HL, Chen PF, Wu RC, Huang CW, Hsiung CA, Hsu CC. Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study. Immun Ageing 2022;19:62. [PMID: 36494677 PMCID: PMC9733307 DOI: 10.1186/s12979-022-00322-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/19/2022] [Accepted: 12/02/2022] [Indexed: 12/13/2022]
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Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases. Sci Rep 2022;12:20167. [PMID: 36424512 PMCID: PMC9686236 DOI: 10.1038/s41598-022-24611-w] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2022] [Accepted: 11/17/2022] [Indexed: 11/27/2022]  Open
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Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, Swerdlow RH, Andrews SJ. The role of mitochondrial genome abundance in Alzheimer's disease. Alzheimers Dement 2022;19:2069-2083. [PMID: 36224040 DOI: 10.1002/alz.12812] [Citation(s) in RCA: 14] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/1912] [Revised: 12/12/1912] [Accepted: 12/12/1912] [Indexed: 11/05/2022]
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Wang Y, Guo X, Hong X, Wang G, Pearson C, Zuckerman B, Clark AG, O'Brien KO, Wang X, Gu Z. Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism. Nat Commun 2022;13:3790. [PMID: 35778412 PMCID: PMC9249801 DOI: 10.1038/s41467-022-30805-7] [Citation(s) in RCA: 24] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/26/2021] [Accepted: 05/19/2022] [Indexed: 12/30/2022]  Open
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Torres-Gonzalez E, Makova KD. Exploring the Effects of Mitonuclear Interactions on Mitochondrial DNA Gene Expression in Humans. Front Genet 2022;13:797129. [PMID: 35846132 PMCID: PMC9277102 DOI: 10.3389/fgene.2022.797129] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2021] [Accepted: 05/30/2022] [Indexed: 11/13/2022]  Open
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Martens LG, Luo J, Wermer MJ, Willems van Dijk K, Hägg S, Grassmann F, Noordam R, van Heemst D. The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyse. Atherosclerosis 2022;354:1-7. [PMID: 35793595 DOI: 10.1016/j.atherosclerosis.2022.06.1012] [Citation(s) in RCA: 12] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2021] [Revised: 06/09/2022] [Accepted: 06/10/2022] [Indexed: 11/02/2022]
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A model to predict a risk of allergic rhinitis based on mitochondrial DNA copy number. Eur Arch Otorhinolaryngol 2022;279:4997-5008. [DOI: 10.1007/s00405-022-07341-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2021] [Accepted: 03/07/2022] [Indexed: 11/26/2022]
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