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Muthu S, Vadranapu S. Variations in quantifying patient reported outcome measures to estimate treatment effect. World J Methodol 2025; 15:97078. [DOI: 10.5662/wjm.v15.i2.97078] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/22/2024] [Revised: 10/13/2024] [Accepted: 11/06/2024] [Indexed: 11/27/2024] Open
Abstract
In the practice of healthcare, patient-reported outcomes (PROs) and PRO measures (PROMs) are used as an attempt to observe the changes in complex clinical situations. They guide us in making decisions based on the evidence regarding patient care by recording the change in outcomes for a particular treatment to a given condition and finally to understand whether a patient will benefit from a particular treatment and to quantify the treatment effect. For any PROM to be usable in health care, we need it to be reliable, encapsulating the points of interest with the potential to detect any real change. Using structured outcome measures routinely in clinical practice helps the physician to understand the functional limitation of a patient that would otherwise not be clear in an office interview, and this allows the physician and patient to have a meaningful conversation as well as a customized plan for each patient. Having mentioned the rationale and the benefits of PROMs, understanding the quantification process is crucial before embarking on management decisions. A better interpretation of change needs to identify the treatment effect based on clinical relevance for a given condition. There are a multiple set of measurement indices to serve this effect and most of them are used interchangeably without clear demarcation on their differences. This article details the various quantification metrics used to evaluate the treatment effect using PROMs, their limitations and the scope of usage and implementation in clinical practice.
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Affiliation(s)
- Sathish Muthu
- Department of Orthopaedics, Orthopaedic Research Group, Coimbatore 641045, Tamil Nadu, India
- Department of Orthopaedics, Government Medical College, Karur 639004, Tamil Nadu, India
- Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India
| | - Srujun Vadranapu
- Department of Orthopaedics, Royal Care Super Speciality Hospital, Coimbatore 641062, Tamil Nadu, India
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Passias PG, Dave P, Smith JS, Lafage R, Onafowokan OO, Tretiakov P, Mir J, Line B, Diebo B, Daniels AH, Gum JL, Eastlack R, Hamilton DK, Chou D, Klineberg EO, Kebaish KM, Lewis S, Gupta MC, Kim HJ, Lenke LG, Ames CP, Shaffrey CI, Schwab FJ, Lafage V, Bess S, Hostin R, Burton DC. Cause and effect of revisions in adult spinal deformity surgery: a multicenter study on outcomes based on etiology. Spine J 2025; 25:1229-1235. [PMID: 39706345 DOI: 10.1016/j.spinee.2024.12.023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/31/2024] [Revised: 11/26/2024] [Accepted: 12/14/2024] [Indexed: 12/23/2024]
Abstract
BACKGROUND CONTEXT While the treatment of adult spinal deformity (ASD) has increasingly favored surgical correction, the incidence of revision surgery remains high. Yet, little has been explored on the association between the etiology of reoperation and patient outcomes. PURPOSE To assess the impact of the etiology of revision surgery on postoperative outcomes. STUDY DESIGN/SETTING Retrospective cohort analysis. PATIENT SAMPLE A total of 891 ASD patients. OUTCOME MEASURES Complications, radiographic parameters, disability metrics. METHODS Operative ASD patients with at least 1 revision stratified by etiology (mechanical [Mech] -pseudarthrosis, thoracic decompensation without junctional failure, X-ray malalignment, implant failure, implant malposition, PJK ± major malalignment; infection [Infx]-early vs late onset, major vs minor; wound [Wound]; SI pain [SI Pain]). Excluded multiple etiologies, and intraoperative or medical complications. Data from the immediate visit prior to the final revision was used as baseline (rBL). Follow-up based on visits best aligned to time points after final revision. Radiographic parameters SVA, PI-LL, and PT were used to assess alignment postrevision via ANOVA. Multivariate analysis controlling for relevant covariates assessed outcome differences after final revision surgery. RESULTS In total, 891 met inclusion (Age: 60.40±14.17, 77% F, BMI: 27.97±5.87 kg/m2, CCI: 1.80±1.73). Etiology groups were as follows: Mech: 432; Infx: 296; Wound: 65; SI Pain: 98. Surgically, Infx had lower rates of osteotomy, interbody fusion, and decompression (p<.05). Infx and SI Pain demonstrated similar correction in radiographics SVA, PI-LL, and PT (p>.05), whereas Mech had significantly less improvement by 2 years (p<.003) that improved by 5 years. Compared to without revision, the odds of MCID in ODI were 48.6% lower across groups (OR: 0.514 [.280, .945], p=.032). Indications of X-ray malalignment were 93.0% less likely to reach MCID (OR: 0.071, [.006, .866], p=.038). Similarly, implant failure negatively impacted rates of MCID (40% vs 15.2%, p=.029). Those with PJK had 57% lower odds of MCID (33% vs 54%, OR: .43, [0.2, 0.9] p= .023), further negated by major malalignment (OR: 0.05, [.07, .97], p=.02). Indications of pseudarthrosis, thoracic decompensation, implant malposition were not significant. Major sepsis had lower rates of MCID compared to minor (6.4% vs 21.2%), and early onset infection improved compared to late (OR: 1.43, [1.17, 2.98], p<.001). In the early follow-up period, the Mech group has significantly worse SRS Pain and Mental Health scores compared to other groups (1-year: Mech 1.56 vs Infx 0.83 vs SI Pain 0.72, p<.001; 2-year: 1.88 vs 0.71 vs 0.76, p=.034). Complication rates increased with the number of revisions and with mechanical indication (all p<.05). At 5 years, patient satisfaction was significantly more likely to improve compared to early follow-up (OR: 1.22, p=.011), along with improved pain score, in Mech group (0.89 vs 0.49 vs 0.56, p=.081). CONCLUSIONS This study focused on the impact of revision as it varies with etiology and time of occurrence postoperatively. Compared to other etiologies, revision surgery due to mechanical complications had less radiographic improvement and worsening patient-reported scores in the early postoperative period despite stabilization at 5 years. The depth of impact of mechanical complication, particularly with the addition of malalignment, merits greater focus during surgical planning. LEVEL OF EVIDENCE III.
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Affiliation(s)
- Peter G Passias
- Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA.
| | - Pooja Dave
- Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA
| | - Justin S Smith
- Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA
| | - Renaud Lafage
- Department of Orthopaedics, Hospital for Special Surgery, New York, NY, USA
| | - Oluwatobi O Onafowokan
- Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA
| | - Peter Tretiakov
- Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA
| | - Jamshaid Mir
- Division of Spinal Surgery/Departments of Orthopaedic and Neurosurgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA
| | - Breton Line
- Department of Spine Surgery, Denver International Spine Clinic, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver, CO, USA
| | - Bassel Diebo
- Department of Orthopaedic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI, USA
| | - Alan H Daniels
- Department of Orthopaedic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI, USA
| | - Jeffrey L Gum
- Department of Orthopaedic Surgery, Norton Leatherman Spine Center, Louisville, KY, USA
| | - Robert Eastlack
- Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California, USA
| | - D Kojo Hamilton
- Departments of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
| | - Dean Chou
- Department of Neurological Surgery, University of California, San Francisco, CA, USA; Department of Neurological Surgery, Columbia University, NY, USA
| | | | - Khaled M Kebaish
- Department of Orthopaedic Surgery, Johns Hopkins Medical Center, Baltimore, MD, USA
| | - Stephen Lewis
- Division of Orthopaedic Surgery, University of Toronto, Canada
| | - Munish C Gupta
- Department of Orthopaedic Surgery, Washington University, St. Louis, MO
| | - Han Jo Kim
- Department of Orthopaedics, Hospital for Special Surgery, New York, NY, USA
| | - Lawrence G Lenke
- Department of Orthopaedic Surgery, Columbia University, New York, NY
| | - Christopher P Ames
- Department of Neurological Surgery, University of California San Francisco, San Francisco, CA
| | | | - Frank J Schwab
- Department of Orthopaedics, Lenox Hill Hospital, Northwell Health, New York, NY
| | - Virginie Lafage
- Department of Orthopaedics, Lenox Hill Hospital, Northwell Health, New York, NY
| | - Shay Bess
- Department of Spine Surgery, Denver International Spine Clinic, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver, CO, USA
| | - Robert Hostin
- Department of Orthopaedic Surgery, Southwest Scoliosis Center, Dallas, TX, USA
| | - Douglas C Burton
- Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, MI, USA; Rocky Mountain Scoliosis and Spine, Denver, CO, USA
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Djurasovic M, Carreon LY, Bisson EF, Chan AK, Bydon M, Mummaneni PV, Foley KT, Shaffrey CI, Potts EA, Shaffrey ME, Coric D, Knightly JJ, Park P, Wang MY, Fu KM, Slotkin JR, Asher AL, Virk MS, Chou D, Haid RW, Glassman SD. Predictors of Delayed Clinical Benefit Following Surgical Treatment for Low-grade Spondylolisthesis. Spine (Phila Pa 1976) 2025; 50:E213-E218. [PMID: 39087454 DOI: 10.1097/brs.0000000000005115] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Accepted: 07/24/2024] [Indexed: 08/02/2024]
Abstract
STUDY DESIGN Retrospective review of prospectively collected data. OBJECTIVE The aim of this study was to investigate what factors predict delayed improvement after surgical treatment of low-grade spondylolisthesis. SUMMARY OF BACKGROUND DATA Lumbar surgery leads to clinical improvement in the majority of patients with low-grade spondylolisthesis. Most patients improve rapidly after surgery, but some patients demonstrate a delayed clinical course. METHODS The Quality and Outcomes Database (QOD) was queried for grade 1 spondylolisthesis patients who underwent surgery who had patient-reported outcome measures (PROMs) collected at baseline, 3, 6, and 12 months, including back and leg pain Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and EuroQol-5D (EQ-5D). Patients were stratified as "early responders" reaching MCID at 3 months and maintaining improvement through 12 months and "delayed responders" not reaching MCID at 3 months but ultimately reaching MCID at 12 months. These two groups were compared with respect to factors which predicted delayed improvement. RESULTS Of 608 patients enrolled, 436 (72%) met inclusion criteria for this study. Overall, 317 patients (72.7%) reached MCID for ODI at 12 months following surgery. Of these patients, 249 (78.5%) exhibited a rapid clinical improvement trajectory and had achieved ODI MCID threshold by the 3-month postoperative follow-up. Sixty-eight patients (21.4%) showed a delayed trajectory, and had not achieved ODI MCID threshold at 3 months, but did ultimately reach MCID at 12-month follow-up. Factors associated with delayed improvement included impaired preoperative ambulatory status, better baseline back and leg pain scores, and worse 3-month leg pain scores ( P <0.01). CONCLUSIONS The majority of patients undergoing surgery for low-grade spondylolisthesis reach ODI MCID threshold rapidly, within the first 3 months after surgery. Factors associated with a delayed clinical course include impaired preoperative ambulation status, relatively better preoperative back and leg pain, and persistent leg pain at 3 months.
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Affiliation(s)
| | | | - Erica F Bisson
- University of Utah Health, Clinical Neurosciences Center, Salt Lake City, UT
| | - Andrew K Chan
- Department of Neurological Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY
| | - Mohamad Bydon
- Department of Neurologic Surgery, Mayo Clinic College of Medicine and Science, Rochester, MN
| | - Praveen V Mummaneni
- Department of Neurological Surgery, University of California, San Francisco, University of California, San Francisco, San Francisco, CA
| | - Kevin T Foley
- Semmes-Murphey Neurologic and Spine Institute, University of Tennessee, Memphis, TN
| | | | | | - Mark E Shaffrey
- Department of Neurosurgery, University of Virginia, Charlottesville, VA
| | - Domagoj Coric
- Carolina Neurosurgery and Spine Associates, Charlotte, NC
| | - John J Knightly
- Atlantic Neurosurgical Specialists and Altair Health, Cedar Knolls, NJ
| | - Paul Park
- Semmes-Murphey Neurologic and Spine Institute, University of Tennessee, Memphis, TN
| | - Michael Y Wang
- Department of Neurological Surgery, University of Miami, Miami, FL
| | - Kai-Ming Fu
- Department of Neurosurgery, NewYork-Presbyterian Och Spine Hospital, New York, NY
| | | | | | - Michael S Virk
- Department of Neurosurgery, NewYork-Presbyterian Och Spine Hospital, New York, NY
| | - Dean Chou
- Department of Neurosurgery, NewYork-Presbyterian Och Spine Hospital, New York, NY
| | - Regis W Haid
- Carolina Neurosurgery and Spine Associates, Charlotte, NC
- Atlanta Brain and Spine Care, Atlanta, GA
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Adindu E, Singh D, Geck M, Stokes J, Eeric Truumees. The impact of obesity on postoperative and perioperative outcomes in lumbar spine surgery: a systematic review and meta-analysis. Spine J 2025; 25:1081-1095. [PMID: 39672205 DOI: 10.1016/j.spinee.2024.12.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Revised: 11/12/2024] [Accepted: 12/03/2024] [Indexed: 12/15/2024]
Abstract
BACKGROUND CONTEXT Obesity is increasingly prevalent globally and is associated with various health issues, including spine-related disorders. Previous studies have shown mixed results regarding the impact of obesity on spine surgery outcomes. PURPOSE This meta-analysis aims to evaluate the effects of obesity on perioperative and postoperative outcomes in spine surgery patients. STUDY DESIGN/SETTING We performed a systematic review and meta-analysis of prospective and retrospective studies comparing outcomes between obese and nonobese spine surgery patients. PATIENT SAMPLE The meta-analysis included 35,639 patients, of which 9,369 were obese (BMI≥30 kg/m²) and 26,270 were nonobese (BMI<30 kg/m²). OUTCOME MEASURES Primary outcomes included patient-reported outcome measures (PROMs) such as the Oswestry Disability Index (ODI) and the Visual Analog Scale (VAS) for leg and back pain. Secondary outcomes involved perioperative measures like estimated blood loss (EBL), operative time, and length of stay (LOS), as well as complication and reoperation rates. METHODS Following PRISMA guidelines, four databases were searched for relevant studies. The quality of included studies was assessed using the Cochrane Risk of Bias tool. Mean differences were used to quantify the differences in PROMs and perioperative outcomes. Odds ratios were used to analyze differences in complication rates. RESULTS Obese patients had similar PROMs compared to nonobese patients, with differences not exceeding the minimal clinically important difference (MCID). However, obese patients experienced longer operative times, greater EBL, and extended hospital stays. They also had higher rates of postoperative complications such as Dural tears, infections, and reoperations. CONCLUSIONS While obesity is associated with certain perioperative challenges, the postoperative recovery in terms of pain and disability appears comparable between obese and nonobese patients. Spine surgeons should be aware of the increased perioperative risks but can reassure obese patients of similar long-term outcomes postsurgery.
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Affiliation(s)
- Ebubechi Adindu
- The University of Texas Dell Medical School, Department of Surgery and Perioperative Care, Austin, TX, USA
| | | | - Matthew Geck
- The University of Texas Dell Medical School, Ascension Texas Spine and Scoliosis, Austin, TX, USA
| | - John Stokes
- Ascension Texas Spine and Scoliosis, Austin TX, USA
| | - Eeric Truumees
- The University of Texas Dell Medical School, Ascension Texas Spine and Scoliosis, Austin, TX, USA.
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Hirai T, Okawa A, Takahashi H, Shiosakai K, Yoshii T. Efficacy and Safety of Mirogabalin in Patients with Neuropathic Pain Due to Cervical Spondylotic Radiculopathy: Miro-Cens, A Randomized, Controlled, Interventional Study. Pain Ther 2025; 14:1063-1079. [PMID: 40216732 PMCID: PMC12085725 DOI: 10.1007/s40122-025-00722-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/29/2024] [Accepted: 03/04/2025] [Indexed: 05/18/2025] Open
Abstract
INTRODUCTION There are few studies of pharmacotherapy of neuropathic pain in cervical spondylotic radiculopathy (CSR). Miro-Cens aimed to examine the efficacy and safety of mirogabalin for treating pain in patients with CSR on non-steroidal anti-inflammatory drugs (NSAIDs), compared with NSAIDs alone. METHODS Miro-Cens was a 12-week, multicenter, randomized, controlled, open-label, interventional study in Japan. Eligible patients with CSR having upper limb pain (visual analog scale score ≥ 40 mm) were randomly assigned in a 1:1 ratio to the mirogabalin add-on to NSAIDs group and the NSAIDs alone group. The primary endpoint was the change in the weekly average numerical rating scale (NRS) score for upper limb pain from baseline at Week 12. RESULTS The mirogabalin add-on group and NSAIDs alone group included 72 and 70 patients, respectively. The mirogabalin add-on group had a significantly greater reduction in the NRS score for upper limb pain than the NSAIDs alone group: estimated changes from baseline at Week 12, - 2.63 [95% confidence interval (CI) - 3.14, - 2.11] in the mirogabalin add-on group; - 1.07 (- 1.62, - 0.53) in the NSAIDs alone group; intergroup difference, - 1.55 (- 2.31, - 0.80; p < 0.001). The responder rate on the NRS score at Week 12 was significantly higher in the mirogabalin add-on group than in the NSAIDs alone group: ≥ 30% improvement, 71.7% vs. 39.6%; ≥ 50% improvement, 58.3% vs. 22.6% (both p < 0.001). The frequent treatment-emergent adverse drug reactions in the mirogabalin add-on group were the known ones (somnolence and dizziness), with most being mild or moderate in severity. CONCLUSION In patients with CSR, combination therapy with mirogabalin and NSAIDs significantly improved neuropathic pain compared with NSAID monotherapy. No new safety concerns were identified, although caution should be exercised regarding somnolence and dizziness. These findings suggest that concomitant use of mirogabalin with NSAIDs could be tolerable and a novel treatment option for CSR patients with insufficient analgesic effects on NSAIDs. TRIAL REGISTRATION NUMBER jRCTs031210629.
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Affiliation(s)
- Takashi Hirai
- Department of Orthopedic Surgery, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
| | - Atsushi Okawa
- Department of Orthopedic Surgery, Yokohama City Minato Red Cross Hospital, Yokohama, Japan
| | - Hiroshi Takahashi
- Primary Medical Science Department, Medical Affairs Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan
| | - Kazuhito Shiosakai
- Data Intelligence Department, Global DX, Daiichi Sankyo Co., Ltd., Tokyo, Japan
| | - Toshitaka Yoshii
- Department of Orthopedic Surgery, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
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Carmichael J, Stuber K, Pohlman KA, Ferguson A, Maiers M. Where are the chiropractic clinical outcomes registries? A scoping review. Chiropr Man Therap 2025; 33:22. [PMID: 40414990 PMCID: PMC12103756 DOI: 10.1186/s12998-025-00583-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2024] [Accepted: 05/09/2025] [Indexed: 05/27/2025] Open
Abstract
OBJECTIVE This scoping review maps chiropractic-specific clinical outcomes registries. INTRODUCTION Clinical outcomes registries track patient outcomes to improve evidence-based practice and quality of care; however, their role in chiropractic remains unclear. METHODS This research adhered to Joanna Briggs Institute's scoping review outline and methodology, as well as the PRISMA-ScR guidelines. Five databases were searched on January 9, 2025, with subsequent search of grey literature and citation tracking. Sources were included if they described chiropractic-specific registries that reported clinical outcomes data. Two reviewers independently screened 604 citations, extracting data into Excel. Variables included registry characteristics and clinical outcomes collected. RESULTS Only one dedicated chiropractic clinical outcomes registry was identified: Spine IQ, launched in 2016 in the US with approximately 50 chiropractors submitting data on over 2000 low back pain patients. Spine IQ collected patient-reported outcome measures including the Oswestry Disability Index, Bournemouth Questionnaire, and the PROMIS physical function measure. By 2018, Spine IQ had completed its pilot phase and planned expansion to 100 clinics. Three sources were excluded: one spine registry not collecting chiropractic outcomes and two databases that included chiropractic data in publications but did not qualify as registries. CONCLUSIONS This review identified only Spine IQ as a dedicated chiropractic clinical outcomes registry, revealing a significant gap in registry infrastructure within the profession globally. The profession should explore the development of registries to enhance care quality, societal impact, and opportunities for collaborative research.
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Affiliation(s)
- Joel Carmichael
- Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado Anschutz Medical Campus, 13121 E 17th Ave, Mail Stop C244, Aurora, CO, 80045, USA.
- School of Chiropractic, Universidad Central del Caribe, P.O. Box 60327, Bayamón, 00960-6032, Puerto Rico.
- , Lone Tree, USA.
| | - Kent Stuber
- Parker Research Center, Parker University, 2540 Walnut Hill Lane, Dallas, TX, 75229, USA
- Department of Research and Innovation, Canadian Memorial Chiropractic College, 6100 Leslie St, Toronto, ON, M2H 3J1, Canada
| | - Katherine A Pohlman
- Department of Research and Innovation, Canadian Memorial Chiropractic College, 6100 Leslie St, Toronto, ON, M2H 3J1, Canada
| | - Amy Ferguson
- Evidence Search Lab, 2008 Fairmeadow Drive, Richardson, TX, 75080, USA
| | - Michele Maiers
- Center for Research and Innovation, Northwestern Health Sciences University, 2501 W. 84th Street, Bloomington, MN, 55431, USA
- RAND Research Across Complementary and Integrative Health Institutions (REACH) Center, RAND, 1776 Main Street, Santa Monica, CA, 90401-2138, USA
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Charron B, Ross M, Thornley P. Patient-Reported Outcomes Measures in Spine Surgery. Curr Rev Musculoskelet Med 2025:10.1007/s12178-025-09981-8. [PMID: 40381171 DOI: 10.1007/s12178-025-09981-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 05/09/2025] [Indexed: 05/19/2025]
Abstract
PURPOSE OF REVIEW Patient-reported outcome measures (PROMs) represent a valuable means of assessing the impact of spine surgery on various aspects of patient function and quality of life. This review highlights the most common and contemporary PROMs used in degenerative cervical and lumbar spine conditions, adolescent idiopathic scoliosis, and adult spinal deformity. RECENT FINDINGS Available PROMs differ in their comprehensiveness, flexibility, and ease of use, as well as their ability to provide prognostic information. Condition-specific PROMs such as the Scoliosis Research Society-22 and Modified Japanese Orthopedic Association offer the benefit of prompts tailored to capture the unique considerations for a particular disease state, while more generalized metrics such as the Short-Form 36 facilitate widespread PROM standardization permitting comparison between disease states and interventions. Newer PROMS such as the Patient Reported Outcomes Measurement Information System and the Patient Generated Index offer benefits due to their generalizable yet adaptable format, conferring them the potential to capture condition-specific factors while still permitting comparison between diseases. However, these instruments require further adaptations and validation prior to widespread implementation to fully realize these advantages. Many PROMs are available for use in the spine surgery population, each with unique benefits and drawbacks, necessitating careful evaluation when selecting PROMs for research use.
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Affiliation(s)
- Brynn Charron
- Division of Orthopedic Surgery, Department of Surgery, Western University, London, ON, Canada
| | - Maia Ross
- Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
| | - Patrick Thornley
- Division of Orthopedic Surgery, Department of Surgery, Western University, London, ON, Canada.
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Chang MS, Adeniyi B, Crandall DG. Spinal Cord Stimulators Adversely Affect Outcomes in Spinal Deformity Surgery. A Retrospective Case-Control Study. Global Spine J 2025:21925682251334987. [PMID: 40315348 PMCID: PMC12048398 DOI: 10.1177/21925682251334987] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 05/04/2025] Open
Abstract
Study DesignRetrospective comparative analysis of prospective cohort.ObjectiveTo examine clinical outcomes of patients with preexisting SCS after adult spinal deformity surgery.MethodsA total of 94 patients with and without a previous history of spinal cord stimulator placement undergoing surgery for ASD with minimum 2-year follow-up. Thirty-three patients with SCS undergoing ASD surgery with minimum 2-year follow-up were compared with a matched cohort of 61 ASD patients without SCS.ResultsDespite similar baseline ODI (56 vs 50, P = .11) and back VAS (6.8 vs 6.6, P = .52), SCS patients did worse at all post-op time intervals. At 6 months, the SCS cohort had higher ODI (48 vs 31, P < .001) and VAS (4.8 vs 3.5, P = .01). This difference persisted at 1 year for ODI (46 vs 30, P < .001) but not for VAS (4.7 vs 4.0, P = .19). At 2 years, ODI remained significantly worse in the SCS cohort (49 vs 38, P = .004). Both cohorts had significant improvement at 2 years compared to baseline (SCS: -1.6 VAS, P < .001, -7 ODI, P = .03; Control: -2.5 VAS, P < .001, -13 ODI, P < .001). Radiographic parameters such as curve magnitude, curve correction, and balance were similar between the 2 groups.ConclusionDespite having substantial improvement after ASD surgery, patients with previous SCS placement did significantly worse in both back VAS and ODI postop compared with controls. They also did not experience a decrease in narcotic use at 2 years despite having similar overall radiographic results and complication rates.
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Affiliation(s)
- Michael S. Chang
- Sonoran Spine in Collaboration with HonorHealth, Tempe, AZ, USA
- Department of Orthopaedic Surgery, Mayo Clinic Phoenix, Phoenix, AZ, USA
- Department of Orthopaedic Surgery, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA
| | - Biodun Adeniyi
- Sonoran Spine in Collaboration with HonorHealth, Tempe, AZ, USA
- Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
| | - Dennis G. Crandall
- Sonoran Spine in Collaboration with HonorHealth, Tempe, AZ, USA
- Department of Orthopaedic Surgery, Mayo Clinic Phoenix, Phoenix, AZ, USA
- Department of Orthopaedic Surgery, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA
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Subramanian T, Shahi P, Hirase T, Kazarian GS, Boddapati V, Kaidi AC, Asada T, Singh S, Mai E, Simon CZ, Akosman I, Zhao ER, Song J, Amen TB, Araghi K, Korsun MK, Zhang J, Kwas CT, Vaishnav AS, Tuma O, Kim ET, Singh N, Allen MRJ, Bay A, Sheha ED, Lovecchio FC, Dowdell JE, Qureshi SA, Iyer S. Outcomes of One Versus Two Level MIS Decompression With Adjacent Level Stenosis. Global Spine J 2025; 15:2458-2466. [PMID: 39581893 PMCID: PMC11586935 DOI: 10.1177/21925682241303104] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/26/2024] Open
Abstract
Study DesignRetrospective cohort study.ObjectiveDecompression for the treatment of lumbar spinal stenosis (LSS) has shown excellent clinical outcomes. In patients with symptomatic single level stenosis and asymptomatic adjacent level disease, it is unknown whether decompressing only the symptomatic level is sufficient. The objective of this study is to compare outcomes between single level and dual level minimally invasive (MIS) decompression in patients with adjacent level stenosis.MethodsThe current study is a retrospective review of patients undergoing primary single or dual level MIS decompression for LSS. Radiographic stenosis severity was graded using the Schizas grading. Patients undergoing single level decompression (SLD) with moderate stenosis at the adjacent level were compared with patients undergoing dual level decompression (DLD) for multi-level LSS. Clinical outcomes, complications, and reoperations were compared. Subgroup analysis was performed on patients with the same Schizas grade at the adjacent level in the SLD group and the second surgical level in the DLD group.Results148 patients were included (126 SLD, 76 DLD). There were no significant differences in patient reported outcomes between the two groups at any timepoint up to 2 years postoperatively, including in the matched stenosis severity subgroups. Operative time was longer in the DLD cohort (P < 0.001). There were no significant differences in complications or reoperation rates.ConclusionIn patients with single level symptomatic LSS and adjacent level stenosis, decompression of only the symptomatic level provided equivalent clinical outcomes compared to dual level decompression. The additional operative time and potential incremental risk of dual level surgery may not be justified.
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Affiliation(s)
- Tejas Subramanian
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Pratyush Shahi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Takashi Hirase
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Gregory S. Kazarian
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Venkat Boddapati
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Austin C. Kaidi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Tomoyuki Asada
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Sumedha Singh
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Eric Mai
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Chad Z. Simon
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Izzet Akosman
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Eric R. Zhao
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Junho Song
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Troy B. Amen
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Kasra Araghi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | | | - Joshua Zhang
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Cole T. Kwas
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Avani S. Vaishnav
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Olivia Tuma
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Eric T. Kim
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Nishtha Singh
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Myles R. J. Allen
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Annika Bay
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Evan D. Sheha
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | | | - James E. Dowdell
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Sheeraz A. Qureshi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Sravisht Iyer
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
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10
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Park SM, Song KS, Ham DW, Kang MS, You KH, Park CK, Kim JS, Park HJ. Comparing the efficacy and safety of biportal endoscopic discectomy with microscopic discectomy for lumbar herniated intervertebral disc: a multicentre, prospective, assessor-blinded, randomized controlled trial. Bone Joint J 2025; 107-B:529-539. [PMID: 40306720 DOI: 10.1302/0301-620x.107b5.bjj-2024-1560.r1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 05/02/2025]
Abstract
Aims The aim of this study was to compare the efficacy and safety of biportal endoscopic discectomy (BED) with microdiscectomy (MD) in patients with a single-level lumbar disc herniation, and to determine whether BED gives similar clinical outcomes to MD but with potential additional benefits. Methods Included in this multicentre, prospective, assessor-blind, randomized controlled trial were patients with a single-level lumbar disc herniation requiring surgical intervention. These were recruited from six hospitals between 13 July 2021 and 16 September 2022, and followed up for 12 months. The interventions were either BED (n = 50) or MD (n = 50). The primary outcome was the Oswestry Disability Index (ODI) at 12 months postoperatively. Results In total, 100 patients were randomized into the BED and MD groups based on computer-generated allocation. The analysis included 41 and 46 patients from the MD and BED groups, respectively. At 12 months, the mean ODI scores were comparable between the BED (10.92; SD 12.93) and MD (10.32; SD 12.55) groups (mean difference 0.61 (95% CI -4.47 to 5.68); p = 0.816). No serious adverse event was seen in either group. Compared to the MD group, the BED group showed slightly lower surgical site pain at 24 (p = 0.004) and 48 hours postoperatively (p = 0.014), lower serum creatine phosphokinase (CPK) (p = 0.003), better scar quality at three (p = 0.002) and six months (p = 0.007), and a significantly lower rate of wound dehiscence (p = 0.018). Conclusion BED is as effective as MD in treating single-level lumbar disc herniation but has distinct advantages in terms of postoperative wound complications. Additionally, BED may offer potential benefits in terms of early postoperative surgical site pain, scar aesthetics, and muscle preservation as indicated by CPK levels. These findings suggest that BED is a safe and effective alternative to MD, offering the benefits of minimal invasiveness while maintaining clinical efficacy.
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Affiliation(s)
- Sang-Min Park
- Department of Orthopaedic Surgery, Spine Center, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea
| | - Kwang-Sup Song
- Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, South Korea
| | - Dae-Woong Ham
- Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, South Korea
| | - Min-Seok Kang
- Department of Orthopaedics Surgery, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, South Korea
| | - Ki-Han You
- Department of Orthopaedic Surgery, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, South Korea
| | - Choon-Keun Park
- Department of Neurosurgery, The Leon Wiltse Memorial Hospital, Suwon, South Korea
| | - Jin-Sung Kim
- Department of Neurosurgery, The Catholic University College of Medicine, Seoul St. Mary's Hospital, Seoul, South Korea
| | - Hyun-Jin Park
- Department of Orthopaedic Surgery, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, South Korea
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11
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Bond M, Charest-Morin R, Street J, Fisher C, Dea N, Singh S, Paquet J, Abraham E, Bailey C, Weber M, Nataraj A, Attabib N, Kelly A, Rampersaud R, Manson N, Phan P, Thomas K, Soroceanu A, LaRue B, Ahn H, Marion T, Christie S, Glennie A, Zhi W, Hall H, Sutherland JM. The Influence of Wait Time on Surgical Outcomes in Elective Lumbar Degenerative Spine Conditions: A Retrospective Multicentre Cohort Study. Global Spine J 2025; 15:2118-2128. [PMID: 39322408 PMCID: PMC11559814 DOI: 10.1177/21925682241287463] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 09/27/2024] Open
Abstract
Study DesignRetrospective cohort study.ObjectivesThe impact of delayed access to operative treatment on patient reported outcomes (PROs) for lumbar degenerative conditions remains unclear. The goal of this study is to evaluate the association between wait times for elective lumbar spine surgery and post-operative PROs.MethodsThis study is a retrospective analysis of patients surgically treated for a degenerative lumbar conditions. Wait times were calculated from primary care referral to surgery, termed the cumulative wait time (CWT). CWT benchmarks were created at 3, 6 and 12 months. A multivariable logistic regression model was used to measure the associations between CWT and meeting the minimally clinically important difference (MCID) for the Oswestry Disability Index (ODI) score at 12 months post-operatively.ResultsA total of 2281 patients were included in the study cohort. The average age was 59.4 years (SD 14.8). The median CWT was 43.1 weeks (IQR 17.8 - 60.6) and only 30.9% had treatment within 6 months. Patients were more likely achieve the MCID for the ODI at 12 months post-operatively if they had surgery within 6 months of referral from primary care (OR 1.22; 95% CI 1.11 - 1.34). This relationship was also found at a benchmark CWT time of 3 months (OR 1.33; 95% CI 1.15 - 1.54) though not at 12 months (OR 1.08; 95% CI 0.97 - 1.20).ConclusionsPatients who received operative treatment within a 3- and 6-month benchmark between referral and surgery were more likely to experience noticeable improvement in post-operative function.
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Affiliation(s)
- Michael Bond
- Centre for Health Services and Policy Research, University of British Columbia, Vancouver, Canada
| | - Raphaële Charest-Morin
- Combined Neurosurgical and Orthopaedic Spine Program, Vancouver General Hospital, Vancouver, Canada
| | - John Street
- Combined Neurosurgical and Orthopaedic Spine Program, Vancouver General Hospital, Vancouver, Canada
| | - Charles Fisher
- Combined Neurosurgical and Orthopaedic Spine Program, Vancouver General Hospital, Vancouver, Canada
| | - Nicolas Dea
- Combined Neurosurgical and Orthopaedic Spine Program, Vancouver General Hospital, Vancouver, Canada
| | - Supriya Singh
- London Health Science Centre Combined Neurosurgical and Orthopaedic Spine Program, Schulich School of Medicine, Western University, London, ON, Canada
| | - Jerome Paquet
- Centre de Recherche CHU de Quebec, CHU de Quebec-Universite Laval, Quebec, QC, Canada
| | - Edward Abraham
- Division of Orthopaedics, Canada East Spine Centre, Saint John, NB, Canada
| | - Christopher Bailey
- London Health Science Centre Combined Neurosurgical and Orthopaedic Spine Program, Schulich School of Medicine, Western University, London, ON, Canada
| | - Michael Weber
- Department of Surgery, Division of Orthopaedics, Montreal General Hospital, McGill University, Montreal, QC, Canada
| | - Andrew Nataraj
- Division of Neurosurgery, University of Alberta, Edmonton, AB, Canada
| | - Najmedden Attabib
- Division of Neurosurgery, Canada East Spine Centre, Saint John, NB, Canada
| | - Adrienne Kelly
- Sault Area Hospital, Northern Ontario School of Medicine, Thunder Bay, ON, Canada
| | - Raja Rampersaud
- Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada
| | - Neil Manson
- Division of Orthopaedics, Canada East Spine Centre, Saint John, NB, Canada
| | - Phillippe Phan
- Division of Orthopaedic Surgery, University of Ottawa, Ottawa Hospital, Ottawa, ON, Canada
| | - Ken Thomas
- University of Calgary Spine Program, University of Calgary, Calgary, AB, Canada
| | - Alex Soroceanu
- University of Calgary Spine Program, University of Calgary, Calgary, AB, Canada
| | - Bernard LaRue
- Départment de chirurgie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada
| | - Henry Ahn
- Division of Orthopaedic Surgery, St. Michael’s Hospital, Toronto, ON, Canada
| | - Travis Marion
- Department of Surgery, Thunder Bay Regional Health Science Centre, Thunder Bay, ON, Canada
| | - Sean Christie
- Department of Surgery, Dalhousie University, Halifax, NS, Canada
| | - Andrew Glennie
- Department of Surgery, Dalhousie University, Halifax, NS, Canada
| | - Wang Zhi
- Department of Orthopedic Surgery, University of Montreal Health Center, Montreal, QC, Canada
| | - Hamilton Hall
- Department of Surgery, University of Toronto, Toronto, ON, Canada
| | - Jason M. Sutherland
- Centre for Health Services and Policy Research, University of British Columbia, Vancouver, Canada
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12
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Wheeler PC, Tattersall C, Calver R. Radial Extracorporeal Shockwave Therapy (rESWT) Is Not Superior to "Minimal-Dose" rESWT for Patients With Chronic Noninsertional Achilles Tendinopathy: A Double-Anonymized Randomized Controlled Trial. Foot Ankle Int 2025:10711007251327421. [PMID: 40263964 DOI: 10.1177/10711007251327421] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 04/24/2025]
Abstract
BACKGROUND Outcomes following radial extracorporeal shockwave therapy (rESWT) in patients with chronic noninsertional Achilles tendinopathy are investigated. METHODS Patients with chronic noninsertional Achilles tendinopathy were recruited from a single National Health Services clinic, randomized equally to either "therapeutic" or "minimal-dose" ("presumed sham") rESWT (3 sessions at weekly intervals). Both groups had an identical structured home rehabilitation program of progressive loading, balance, and stretching exercises. RESULTS Fifty-seven patients were recruited; mean age 49.7±7.2 years, 60% female, symptom duration: 22.2±19.5 months. No between-group differences were identified at the final or any interim time points. Clinically and statistically significant within-group improvements were identified in pain/local function patient-reported outcome measures for both groups, with "average pain" improving by 34% at 6 months. No consistent benefits were seen in global function, activity levels, or mood. CONCLUSION "Recommended-dose" rESWT is not superior to "minimal-dose" rESWT and may be ineffective for patients with chronic noninsertional Achilles tendinopathy.
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Affiliation(s)
- Patrick C Wheeler
- Department of Musculoskeletal, Sport & Exercise Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
- School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom
- National Centre of Sport and Exercise Medicine, Loughborough, United Kingdom
| | - Chloe Tattersall
- Department of Musculoskeletal, Sport & Exercise Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
| | - Rachel Calver
- Department of Musculoskeletal, Sport & Exercise Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
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13
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Dandurand C, Dvorak MF, Öner CF, Hauri D, Schnake K, Vaccaro AR, Benneker LM, Schroeder GD, Rajasekaran S, El-Skarkawi M, Kanna RM, Popescu EC, Tee JW, Joaquim AF, Chhabra HS, Spiegl U, Bransford RJ. Gender Differences in Outcomes in Patients Treated for Thoracolumbar Burst Fractures Without Neurological Deficits: Prospective International Multicenter Study. Neurosurgery 2025:00006123-990000000-01563. [PMID: 40183559 DOI: 10.1227/neu.0000000000003408] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/18/2024] [Accepted: 11/28/2024] [Indexed: 04/05/2025] Open
Abstract
BACKGROUND AND OBJECTIVES Exploring gender differences in outcomes after spinal surgery is essential. We aimed to assess gender differences in patients treated for thoracolumbar burst fractures without neurological deficit regarding Oswestry Disability Index (ODI) improvement. Secondarily, we assessed baseline characteristics, treatment selection, and other patient-reported outcomes. METHODS Data were prospectively collected. The primary end point was defined as time to achieve minimal clinically important difference (MCID) in ODI. In an exploratory analysis, we defined improvement in ODI as reaching minimal disability. RESULTS Genders had similar baseline characteristics, injury characteristics, and treatment selection and timing.Surgically treated women showed a faster achievement of MCID in ODI (14 days, 95% CI 14.0-28.0 vs 28 days, 95% CI 15.0-34.0, P = .009). On multivariable modeling, nonoperatively treated women had a lower chance of achieving improvement in the ODI than nonoperatively treated men (hazard ratio 0.55, 95% CI: 0.32-0.96, P = .036).Women had a longer median time to achieve minimal disability (102.0 days, 95% CI: 76.0; 131.0 vs 62.0 days, 95% CI: 51.0; 72.0, P = .008). Nonoperative women had a longer median time to achieve minimal disability (130.0 days, 95% CI: 82.0-185.0 vs 61.0 days, 95% CI: 47.0-76.0, P = .048). On multivariable modeling, nonoperative women had a lower chance for achieving minimal disability than nonoperatively treated men (hazard ratio 0.55, 95% CI 0.31-0.98 P = .042). CONCLUSION This novel study reports gender differences in thoracolumbar burst fractures in neurologically intact patient. Women do worse with nonoperative management than men. In addition, women do better with operative than nonoperative management in achieving MCID, whereas this was not observed in men. Thus, women benefit to a greater extent from surgical management than do men. These results highlight the importance of personalized treatment that incorporates gender. Future studies should assess gender differences in other traumatic spinal pathologies.
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Affiliation(s)
- Charlotte Dandurand
- Combined Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
| | - Marcel F Dvorak
- Combined Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
| | - Cumhur F Öner
- University Medical Centers, Utrecht, the Netherlands
| | - Dimitri Hauri
- Clinical Operations, AO Innovation Translation Center, AO Foundation, Davos, Switzerland
| | - Klaus Schnake
- Center for Spinal and Scoliosis Surgery, Malteser Waldkrankenhaus St. Marien Erlangen, Erlangen, Germany
- Department of Orthopedics and Traumatology, Paracelsus Private Medical University Nuremberg, Nuremberg, Germany
| | - Alexander R Vaccaro
- Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
| | - Lorin M Benneker
- Spine Unit, Sonnenhof Spital, University of Bern, Bern, Switzerland
| | - Gregory D Schroeder
- Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
| | | | - Mohammad El-Skarkawi
- Department of Orthopaedic and Trauma Surgery, Faculty of Medicine, Assiut University, Asyut, Egypt
| | - Rishi M Kanna
- Spine Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India
| | | | - Jin Wee Tee
- Department of Neurosurgery, National Trauma Research Institute (NTRI), The Alfred Hospital, Melbourne, Victoria, Australia
| | | | - Harvinder Singh Chhabra
- Department of Spine & Rehabilitation Centre, Sri Balaji Action Medical Institute, Sri Balaji Action Medical Institute, New Delhi, India
| | - Ulrich Spiegl
- Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University of Leipzig, Leipzig, Germany
| | - Richard J Bransford
- Department of Orthopaedics and Sports Medicine, Harborview Medical Center, University of Washington, Seattle, Washington, USA
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14
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Asada T, Simon CZ, Durbas A, Allen MRJ, DiSilvestro KJ, Hirase T, Singh N, Bovonratwet P, Bay A, Subramanian T, Mai E, Kim YE, Korsun MK, Tuma OC, Araghi K, Zhang J, Kim ET, Kwas CT, Lu AZ, Vaishnav AS, Dowdell JE, Sheha ED, Qureshi SA, Iyer S. Short-segment fusion versus isolated decompression in lumbar spinal canal stenosis patients with Cobb angles over 20°. Spine J 2025; 25:669-678. [PMID: 39505012 DOI: 10.1016/j.spinee.2024.10.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/03/2024] [Revised: 09/19/2024] [Accepted: 10/27/2024] [Indexed: 11/08/2024]
Abstract
BACKGROUND CONTEXT Lumbar decompression and short-segment lumbar fusion are standard procedures for short-segment lumbar canal stenosis, even in patients with moderate Cobb angles. Adult degenerative scoliosis is diagnosed at a threshold of 10°, and patients with coronal Cobb angles over 30° are recommended for long fusion due to global spinal deformity. However, there is a lack of research on clinical outcomes in patients with moderate coronal deformity, such as Cobb angles between 20° and 30°. PURPOSE This study aims to investigate the radiographic and clinical outcome differences between isolated decompression and short-segment interbody fusion for lumbar spinal canal stenosis in patients with moderate coronal deformity. STUDY DESIGN A retrospective analysis of a prospectively collected registry. PATIENT SAMPLE Patients with Cobb angle exceeding 20° who underwent 1- or 2- levels of lumbar surgery for lumbar canal stenosis. Patients diagnosed as spinal deformity were excluded. OUTCOME MEASURES Patient-reported outcomes included Oswestry Disability Index (ODI), VAS back, VAS leg, Short form 12 physical component score (SF-12 PCS) and Mental Component Score (SF-12 MCS), and patient-reported outcomes measurement information system physical function (PROMIS-PF) at preoperative, 12-week postoperative, and 1-year postoperative timepoints. Preoperative and postoperative spinopelvic alignment was assessed using Cobb angle, pelvic tilt, sacral slope, pelvic incidence, lumbar lordosis and PI minus LL. METHODS A propensity score-matched analysis with the overlap weighting was utilized to investigate patient-reported outcomes at 12-week and 1-year postoperatively between the surgery groups. Spinopelvic alignments were compared between preoperative and 1-year postoperative timepoint using a linear mixed-effect model. RESULTS Before overlap weighting, the two surgery groups showed significant differences in age and diagnosis. No obvious sagittal malalignment was observed (PI minus LL: decompression, 7.4° vs fusion, 11.5°). After propensity score weighting, the fusion groups exhibited significantly better ODI and VAS back at the 1-year timepoint (ODI: fusion, 16.6 vs decompression, 28.1, p=.013; VAS back: fusion, 1.5±2.1 vs decompression, 3.7±1.9, p<.001). Radiographic assessment showed that the fusion group achieved better PI minus LL compared to decompression group (15° vs 10°, p=.008). CONCLUSION In patients with degenerative scoliosis and a Cobb angle greater than 20°, short-segment lumbar fusion surgery may result in enhanced improvement for short-segment lumbar pathology compared to isolated decompression.
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Affiliation(s)
- Tomoyuki Asada
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Chad Z Simon
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Atahan Durbas
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Myles R J Allen
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | | | - Takashi Hirase
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Nishtha Singh
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | | | - Annika Bay
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Tejas Subramanian
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
| | - Eric Mai
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
| | - Yeo Eun Kim
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
| | | | - Olivia C Tuma
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Kasra Araghi
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Joshua Zhang
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Eric T Kim
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Cole T Kwas
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Amy Z Lu
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
| | | | - James E Dowdell
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | - Evan D Sheha
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA
| | | | - Sravisht Iyer
- Hospital for Special Surgery, 535 E 70th St, New York, NY, USA.
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15
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Garufi G, Conti A, Collufio D, Messineo F, Morabito A, Ricciardo G, Cardali S. The Early Clinical and Radiographic Outcomes of Robotic-Assisted Midline Lumbar Interbody Fusion (MIDLIF) With Expandable Interbody Spacers: A Case Series. Cureus 2025; 17:e82802. [PMID: 40406778 PMCID: PMC12097802 DOI: 10.7759/cureus.82802] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/22/2025] [Indexed: 05/26/2025] Open
Abstract
OBJECTIVE To assess the early clinical and radiological outcomes of the midline lumbar interbody fusion (MIDLIF) approach with the use of robotic assistance and expandable spacers. METHODS A retrospective case series was performed on patients who underwent MIDLIF procedures for the treatment of degenerative spinal diseases, with a minimum of three months postoperative follow-up. Demographic (age, gender, body mass index [BMI], comorbidities, and diagnoses), surgical data (operative time, blood loss, hospital stay, intraoperative complications), patient-reported outcomes (PROs) (visual analogue scale [VAS] back pain and disability (Oswestry disability index [ODI]), and radiographic data were collected. RESULTS In total, 42 patients were included, with an average age of 53.6 years and a BMI of 28 kg/m². Surgical data showed the mean total operative time was 98.8 minutes, and the mean blood loss was 17.1 mL with no intraoperative complications. At three-month follow-up, all mean PROs showed statistically significant improvement (p<0.05) when compared with baseline. VAS back pain improved from 7.5 (standard deviation (stdev) 7.5±0.7) preoperatively to 3.0 (stdev 1.0) at three months postoperative, while ODI improved from 58.7 (stdev 7.2) to 26.3 (stdev 10.3) at the same time points. Radiographic data showed that using robotic assistance for planning and placing cortical screws yielded high accuracy, as evidenced by a mean tip deviation of 1.2 mm (stdev 0.6 mm), mean tail deviation of 1.1 mm (stdev 0.4 mm) and a mean angular offset of 1.4 mm (stdev 0.7). Two (4.8%) patients had postoperative complications at three-month follow-up, including a wound infection and one report of wound dehiscence. CONCLUSION MIDLIF is an efficient, reproducible surgical procedure with a low complication rate that resulted in significant improvements in early PROs. Robotic assistance for planning and placing cortical screws in MIDLIF was highly accurate. These initial findings suggest that using robotic assistance adds value to MIDLIF procedures and is a viable alternative to traditional posterior fusion procedures.
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Affiliation(s)
- Giada Garufi
- Neurosurgery, Papardo Hospital, University of Messina, Messina, ITA
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Ells B, Canizares M, Charest-Morin R, Nataraj A, Bailey C, Wai E, Soroceanu A, Marion T, Dvorak M, Rampersaud YR, Fisher C, Wang Z, Attabib N, Christie S, Dea N, Kelly A, Singh S, Larue B, Weber M, Small C, Hall H, Glennie RA. Surgical Outcomes and Patient Expectations and Satisfaction in Spine Surgery Stratified by Surgeon Age. JAMA Netw Open 2025; 8:e255984. [PMID: 40257796 PMCID: PMC12013352 DOI: 10.1001/jamanetworkopen.2025.5984] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/09/2024] [Accepted: 02/12/2025] [Indexed: 04/22/2025] Open
Abstract
Importance There is a paucity of data comparing patient-reported outcomes across surgeon age. Prior work has focused on adverse event rates for surgeon age across a variety of surgical procedures. Objective To compare patient-reported outcomes, expectation fulfillment, and satisfaction measures after spine surgery across surgeon age categories. Design, Setting, and Participants This retrospective cohort study was conducted at multicentered tertiary referral centers across Canada. Patients with degenerative conditions of the spine were enrolled in a national research network from January 2015 to August 2020. Patients were linked to a demographic survey distributed to spine surgeons who enrolled the patients. Elective surgery for degenerative spine conditions were followed up for a minimum of 1 year after operation. The data were analyzed in January 2024. Exposure Surgeons were classified according to their age: younger (age 35-44 years), middle age (45-59 years), and older (≥60 years). Main Outcome and Measures The primary outcomes were the Ostwestry Disability Index (ODI) and Neck Disability Index (NDI), numerical pain scores, expectation fulfillment, and overall satisfaction with spine surgery. Baseline demographic and clinical data and surgical procedure complexity were collected. Multivariate logistic regression models were employed, using generalized estimating equations to account for clustering within surgeons, to compare patient outcomes, expectation fulfillment, and satisfaction by surgeon age. Results A total of 3421 patients (1236 [36.1%] aged 65 years or older; 1603 female [46.9%]) were included in the study for analysis, with 811 (23.7%) treated by younger surgeons, 1643 (48.0%) by middle-age surgeons, and 967 (28.3%) by older surgeons. There were 2857 procedures of the lumbar spine (83.5%). After accounting for patient demographic, clinical, surgical, and surgeon characteristics, there were no significant differences in disability and pain (ODI and NDI or pain score) at 12 months among younger (mean ODI and NDI score, 25.6; 95% CI, 24.3-26.9; mean pain score, 3.4; 95% CI, 3.2-3.6), middle-age (mean ODI and NDI score, 25.8; 95% CI, 24.9-26.8; mean pain score, 3.3; 95% CI, 3.2-3.4), and older (mean ODI and NDI score, 24.6; 95% CI, 23.4-25.8; mean pain score, 3.4; 95% CI, 3.2-3.6) surgeons. Patients treated by younger (adjusted odds ratio [aOR], 1.57; 95% CI, 1.02-2.40) and middle-age (aOR, 1.41; 95% CI, 1.06-1.86) surgeons reported having all their expectations fulfilled compared with older surgeons. Additionally, patients treated by younger surgeons reported higher satisfaction levels (aOR, 1.29; 95% CI, 1.01-1.69) compared with middle-aged and older surgeons. Conclusions and Relevance In this retrospective cohort study of patients who underwent elective spine surgery, there was no difference in outcomes by surgeon age at 1 year, but patients treated by younger surgeons reported higher levels of satisfaction and expectation fulfillment. These findings suggest that spine surgeons of all ages are a valuable resource given similar patient outcomes for all groups.
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Affiliation(s)
- Brett Ells
- Dalhousie University, Halifax, Nova Scotia, Canada
| | | | | | | | | | - Eugene Wai
- University of Ottawa, Ottawa, Ontario, Canada
| | | | | | - Marcel Dvorak
- University of British Columbia, Vancouver, British Columbia, Canada
| | | | - Charles Fisher
- University of British Columbia, Vancouver, British Columbia, Canada
| | - Zhi Wang
- Universite de Montreal, Montreal, Quebec, Canada
| | - Naj Attabib
- Horizon Health New Brunswick, New Brunswick, Canada
| | | | - Nicholas Dea
- University of British Columbia, Vancouver, British Columbia, Canada
| | | | | | - Bernard Larue
- University de Sherbrooke, Sherbrooke, Quebec, Canada
| | | | - Chris Small
- Horizon Health New Brunswick, New Brunswick, Canada
| | - Hamilton Hall
- University Health Network Toronto, Toronto, Ontario, Canada
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Klukowska AM, Ciobanu-Caraus O, Germans MR, Vandertop WP, Schröder ML, Staartjes VE. Measurement properties of the 5-repetition sit-to-stand test in patients with lumbar degenerative disorders: COSMIN systematic review. Spine J 2025; 25:696-718. [PMID: 39647639 DOI: 10.1016/j.spinee.2024.10.027] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/07/2024] [Revised: 10/28/2024] [Accepted: 10/31/2024] [Indexed: 12/10/2024]
Abstract
BACKGROUND CONTEXT There has been no recent updated comprehensive review of measurement properties focused on the 5-repetition sit-to-stand test (5R-STS) in patients with lumbar degenerative disorders (LDD) that could aid in better understanding of its clinical and research applicability. PURPOSE The aim of this systematic review was to summarize evidence on measurement properties of the 5R-STS in patients with LDD according to COnsensus Based Standards for the Selection of Health Measurement INstruments (COSMIN) guidelines. DESIGN Systematic review and meta-analysis. PATIENT SAMPLE In Step 1 and 2, 3,363 and 1,287 adult patients with suspected or diagnosed either clinically and/or radiologically LDD were included, respectively. Step 2 involved screening studies from Step 1 that passed the full text-stage and including only those that assessed at least 1 COSMIN measurement property. OUTCOME MEASURES Functional Measures (5R-STS, Timed Up and Go Test). Self-report Measures (including Oswestry Disability Index (ODI), Roland Morris Disability Questionnaire, pain scores eg, Visual Analogue Scale) and healthcare quality of life questionnaires (eg, EQ-5D-3L)). METHODS In December 2022 Embase, PubMed/Medline, Web of Science and Scopus were searched for studies of 5R-STS of patients with LDD (PROSPERO: CRD42022383095). Quality of evidence was assessed using GRADE and COSMIN Checklist. Results for measurement error were pooled using the weighted mean method. Random effect meta-analysis was performed for studies on reliability and criterion validity. RESULTS Thirty-eight full-text articles were included in Step 1 and 19 in Step 2. The overall intraclass correlation coefficient (ICC) of test-retest reliability and inter-rater reliability of the 5R-STS was 0.93 (95% CI 0.37-1.00) and 0.99 (95% CI 0.83-1.00), respectively. The weighted standard error of measurement (SEM) mean value was 2.8s. Estimated r of 5R-STS and ODI, reflecting insufficient criterion validity (since r <0.70), was 0.53 (95% CI 0.17-0.88). Hypothesis testing for construct validity was confirmed for 40% of predefined hypothesis (graded as insufficient since overall, not >70% hypothesis confirmed). Accounting for limited evidence, responsiveness of the test was adequate. CONCLUSION This COSMIN systematic review summarizes 5R-STS measurement properties in patients with LDD, including pooled estimates of ICC for reliability, SEM, and correlation between 5R-STS and ODI. The 5R-STS is a reliable and responsive instrument reflecting a new dimension of functional impairment in patients with LDD.
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Affiliation(s)
- Anita M Klukowska
- Department of Neurosurgery, Park Medical Center, Rotterdam, The Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Neurosurgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands; Department of Neurosurgery, Medical University of Bialystok, Bialystok, Poland
| | - Olga Ciobanu-Caraus
- Department of Neurosurgery, Park Medical Center, Rotterdam, The Netherlands; Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
| | - Menno R Germans
- Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland
| | - W Peter Vandertop
- Amsterdam UMC, Vrije Universiteit Amsterdam, Neurosurgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands
| | - Marc L Schröder
- Department of Neurosurgery, Park Medical Center, Rotterdam, The Netherlands
| | - Victor E Staartjes
- Department of Neurosurgery, Park Medical Center, Rotterdam, The Netherlands; Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
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18
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Shahi P, Subramanian T, Araghi K, Korsun MK, Singh S, Singh N, Tuma OC, Asada T, Bay A, Zhao ER, Ehrlich AM, Halayqeh S, Harhash T, Pezzi A, Lui A, Sheha ED, Dowdell JE, Qureshi S, Iyer S. Class 2/3 obesity leads to worse outcomes following minimally invasive transforaminal lumbar interbody fusion. Spine J 2025:S1529-9430(25)00167-6. [PMID: 40154631 DOI: 10.1016/j.spinee.2025.03.020] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/24/2024] [Revised: 02/08/2025] [Accepted: 03/22/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND CONTEXT There is lack of evidence regarding the impact of class 2/3 obesity (body mass index [BMI] ≥35) on outcomes following minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). PURPOSE To analyze clinical outcomes, return to activities, fusion rates, and complication/reoperation rates following MI-TLIF in class 2/3 obese patients and compare them with other BMI groups. STUDY DESIGN Retrospective cohort. PATIENT SAMPLE Patients who underwent primary single-level tubular MI-TLIF for degenerative conditions of lumbar spine and had a minimum of 1-year follow-up were included. Patients were divided into 4 cohorts based on their BMI: normal (BMI 18.5 to <25), overweight (25 to <30), class 1 obesity (30 to <35), and class 2/3 obesity (BMI ≥35). OUTCOME MEASURES (1) operative variables: operative time, estimated blood loss (EBL), postoperative length of stay (LOS); (2) patient reported outcome measures (PROMs) (Oswestry Disability Index [ODI]; Visual Analog Scale [VAS] back and leg; 12-Item Short Form Survey Physical Component Score, SF-12 PCS); (3) global rating change (GRC), minimal clinically important difference (MCID), and patient acceptable symptom state (PASS) achievement rates; (4) return to activities; (5) fusion rates; and (6) complication and reoperation rates. Two postoperative timepoints were defined: early (<6 months) and late (≥6 months). METHODS Differences between the 4 BMI cohorts in demographics and outcome measures were analyzed with appropriate statistical tests. Subgroup analyses were performed to compare outcomes between (1) class 2 and class 3 obesity groups and (2) patients with and without metabolic syndrome. Regression analyses were performed to analyze the relationship of BMI groups and metabolic syndrome with PASS achievement. RESULTS Three hundred and ninety patients were included (119 normal, 160 overweight, 67 class 1 obesity, 44 class 2/3 obesity). There was no significant difference in intraoperative variables. Although no significant difference was seen between the groups in PROMs at <6 months, class 2/3 obesity group had significantly worse PROMs, lower PASS achievement rates, and lower MCID achievement rates in VAS leg and SF-12 PCS at ≥6 months. There were no significant differences in the MCID achievement rates in ODI and VAS back and responses on the GRC scale. Although class 2/3 obesity group had a lower fusion rate (67% vs. >87% in other groups), this difference was not statistically significant. Class 2/3 obesity group had significantly higher postoperative LOS (62 hours vs. <50 hours in other groups) and took significantly greater number of days to return to driving (74 days vs. <40 days in other groups). No significant difference was found in return to work and discontinuation of narcotics. The groups had similar complication and reoperation rates. On subgroup analysis, postoperative PROMs did not show any difference between (1) class 2 and class 3 obesity groups and (2) patients with and without metabolic syndrome. On regression analysis, class 2 and class 3 obesity groups showed a significant negative relationship with PASS achievement. Class 2 obese patients were 3.7 times and class 3 obese groups were 5 times less likely to achieve PASS. CONCLUSIONS Class 2/3 obese patients undergoing MI-TLIF had significantly worse PROMs and lower MCID and PASS achievement rates at ≥6 months. They took longer to be discharged from the hospital and return to driving following surgery. Class 2 obese patients were 3.7 times and class 3 obese groups were 5 times less likely to achieve an acceptable symptom state after surgery.
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Affiliation(s)
- Pratyush Shahi
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Tejas Subramanian
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
| | - Kasra Araghi
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | | | - Sumedha Singh
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Nishtha Singh
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Olivia C Tuma
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Tomoyuki Asada
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Annika Bay
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Eric R Zhao
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Adin M Ehrlich
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Sereen Halayqeh
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Tarek Harhash
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Andrea Pezzi
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Adrian Lui
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Evan D Sheha
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - James E Dowdell
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Sheeraz Qureshi
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA
| | - Sravisht Iyer
- Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA.
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Eif M, Forster T, Fleege C, Kilian F, Schmitt AD, Daentzer D. Lumbar fusion using a carbon-fiber PEEK pedicle screw system combined with a carbon-fiber PEEK TLIF cage: a prospective, multicenter study. BMC Musculoskelet Disord 2025; 26:224. [PMID: 40050812 PMCID: PMC11883982 DOI: 10.1186/s12891-025-08457-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/23/2023] [Accepted: 02/19/2025] [Indexed: 03/10/2025] Open
Abstract
BACKGROUND Carbon-fiber-reinforced polyether ether ketone (CF-PEEK) is a radiolucent, non-metallic implant material used for instrumented lumbar spondylodesis. Clinical studies of pedicle screw systems employing this material, especially for degenerative indications, are scant. METHODS We conducted a multicenter, prospective clinical study to assess clinical and radiographic outcomes in patients with symptomatic degenerative lumbar disk disease, including degenerative spondylolisthesis treated with a CF-PEEK pedicle screw and a transforaminal lumbar interbody fusion (TLIF) cage system. We followed up the participants for two years postoperatively to collect clinical data (via the Oswestry Disability Index, Core Outcome Measures Index, and Visual Analog Scale), radiographic parameters (functional X-rays) to assess fusion status, and any complications. RESULTS In total, 86 patients were recruited. During the study, 21 patients (24.4%) dropped out, including 5 (5.8%) who underwent explantation of the study device(s). At the final follow-up, the fusion rate was 98.6% (95% confidence interval, 92.7-100.0%). All clinical parameters improved significantly. There were no complications potentially attributed to the implant material. CONCLUSIONS The results demonstrate a fusion rate similar to that of metallic implant systems with the use of a CF-PEEK pedicle screw and a TLIF cage system. Further studies with larger samples are needed to substantiate this finding. TRIAL REGISTRATION The study was registered at ClinicalTrials.gov (NCT02087267). Date of registration: March 12, 2014.
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Affiliation(s)
- Marcus Eif
- Städtisches Klinikum Görlitz gGmbH, Klinik für Neurochirurgie, Girbigsdorfer Straße 1-3, 02828, Görlitz, Germany
| | - Thomas Forster
- Kantonsspital St. Gallen, Ostschweizer Wirbelsäulenzentrum, Rorschacher Strasse 95, St. Gallen, 9007, Switzerland
| | - Christoph Fleege
- Orthopädische Universitätsklinik Friedrichsheim gGmbH, Marienburgstrasse 2, 60528, Frankfurt am Main, Germany
| | - Francis Kilian
- Katholisches Klinikum Brüderhaus Koblenz, Klinik für Wirbelsäulenchirurgie, Kardinal- Krementz-Str. 1-5, 56073, Koblenz, Germany
| | - Anne Dorothée Schmitt
- Klinik für Neurochirurgie, UK S-H, Campus Kiel, Arnold-Heller-Str. 3, Haus 41, 24105, Kiel, Germany
| | - Dorothea Daentzer
- Orthopedic Department, Spine Section, Hannover Medical School, DIAKOVERE Annastift, Anna-von-Borries-Str. 1-7, 30625, Hannover, Germany.
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20
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Klukowska AM, Dol MG, Vandertop WP, Schröder ML, Staartjes VE. Estimating the minimum clinically important difference (MCID) of the five-repetition sit-to-stand test in patients with lumbar disc herniation. EUROPEAN SPINE JOURNAL : OFFICIAL PUBLICATION OF THE EUROPEAN SPINE SOCIETY, THE EUROPEAN SPINAL DEFORMITY SOCIETY, AND THE EUROPEAN SECTION OF THE CERVICAL SPINE RESEARCH SOCIETY 2025; 34:1107-1114. [PMID: 39680122 DOI: 10.1007/s00586-024-08582-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/26/2024] [Revised: 10/06/2024] [Accepted: 11/18/2024] [Indexed: 12/17/2024]
Abstract
BACKGROUND The impact of surgical interventions on lumbar disc herniation (LDH) is often assessed using objective functional impairment (OFI) tests like the five-repetition sit-to-stand (5R-STS) test. This study calculates the minimum clinically important difference (MCID) for 5R-STS improvement in patients with LDH one year after surgery. METHODS Adult patients with LDH scheduled for surgery were prospectively recruited from a Dutch short-stay spinal clinic. The 5R-STS time, Oswestry Disability Index (ODI), Roland-Morris Disability Questionnaire (RMDQ), Numeric Rating Scale for back and leg pain, EQ-5D-3L health-related quality of life questionnaire and EQ5D-VAS were recorded preoperatively, at 6-weeks and 1-year post-operatively. The MCID was calculated using anchor-based methods (within-patient change; between-patient change; and receiver-operating characteristic approaches) and distribution-based methods (0.5 standard deviation (SD); effect size; standard error of measurement; standardized response mean; and 95% minimum detectable change (MDC)). The final MCID value was based on the "gold standard": an averaging of the anchor-based methods using ODI and RMDQ as the closest available anchors. RESULTS We prospectively recruited 134 patients. One-year follow-up was completed by 103 (76.8%) of patients. The MCID values derived using different methods varied from 0.7 to 5.1 s (s). The final, averaged, anchor-based MCID for improvement was 3.6 s. Within distribution-based methods, 95% MDC and 0.5SD approach, yielded an MCID of 3.0 and 3.8 s, respectively, aligning closely with the overall anchor-derived MCID for 5R-STS. CONCLUSION In a patient with LDH, an improvement in 5R-STS performance of at least 3.6 s can be regarded as a clinically relevant improvement.
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Affiliation(s)
- Anita M Klukowska
- Department of Neurosurgery, Bergman Clinics, Amsterdam, The Netherlands
- Amsterdam UMC, Neurosurgery, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
- Department of Neurosurgery, Medical University of Bialystok, Bialystok, Poland
| | - Manon G Dol
- Department of Neurosurgery, Bergman Clinics, Amsterdam, The Netherlands
| | - W Peter Vandertop
- Amsterdam UMC, Neurosurgery, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
| | - Marc L Schröder
- Department of Neurosurgery, Bergman Clinics, Amsterdam, The Netherlands
| | - Victor E Staartjes
- Machine Intelligence in Clinical Neuroscience and Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
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Goh GS, Tay AYW, Zeng GJ, Soh RCC. Long-Term Results of Minimally Invasive Transforaminal Lumbar Interbody Fusion in Elderly Patients: A 5-Year Follow-Up Study. Global Spine J 2025; 15:838-845. [PMID: 37942769 PMCID: PMC11877569 DOI: 10.1177/21925682231214067] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/10/2023] Open
Abstract
STUDY DESIGN Retrospective review of prospective data. OBJECTIVES Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) may be beneficial for elderly patients due to decreased surgical morbidity and faster postoperative recovery. This study compared the clinical and radiological outcomes of MIS-TLIF in elderly patients and younger controls at minimum 5-year follow-up. METHODS There were 120 patients who underwent single-level MIS-TLIF for degenerative spondylolisthesis. Elderly patients (≥70 years; n = 30) and controls (<70 years; n = 90) were matched 1:3 for demographics, comorbidities and preoperative patient-reported outcomes (PROs). The Oswestry Disability Index (ODI), 36-Item Short-Form Physical (SF-36 PCS) and Mental Component Summary (SF-36 MCS), Visual Analogue Scale (VAS) back pain, and VAS leg pain were compared at 6 months, 2 years and 5 years. Radiographic fusion, adjacent segment degeneration (ASD) and revision rates were assessed at mean 7.2 ± 2.0 years. RESULTS Elderly patients had longer length of stay (4.7 ± 5.8 vs 3.3 ± 1.4 days, P = .035) and more readmissions (10% vs 1%, P = .019), but there was no difference in operative time, transfusions, complications or discharge disposition. All PROs were comparable at 5 years and satisfaction rates were similar (93% elderly vs 91% controls, P = .703). The rates of radiographic fusion in the control group and elderly group were similar (94% vs 97%, P = .605), as were the rates of ASD (40% vs 33%, P = .503). There were 3 revisions (3.3%) in the control group (2 for ASD, 1 for screw loosening) but none in the elderly group (P = .311). CONCLUSIONS Elderly patients undergoing MIS-TLIF achieved similar improvements in pain, disability and quality of life that were sustained at 5 years.Level of Evidence: Level III, retrospective cohort study.
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Affiliation(s)
- Graham S. Goh
- Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore
| | - Adriel You Wei Tay
- Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore
| | - Gerald J. Zeng
- Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore
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22
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Shahi P, Subramanian T, Singh S, Araghi K, Asada T, Korsun M, Singh N, Tuma O, Simon C, Vaishnav A, Mai E, Zhang J, Kwas C, Allen M, Kim E, Heuer A, Sheha E, Dowdell J, Qureshi S, Iyer S. Morbidly Obese Patients Have Similar Clinical Outcomes and Recovery Kinetics After Minimally Invasive Decompression. Spine (Phila Pa 1976) 2025; 50:318-325. [PMID: 38756000 DOI: 10.1097/brs.0000000000005045] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/12/2024] [Accepted: 05/05/2024] [Indexed: 05/18/2024]
Abstract
STUDY DESIGN Retrospective cohort. OBJECTIVE To study the impact of class 2/3 obesity (body mass index, BMI ≥35) on outcomes following minimally invasive decompression. SUMMARY OF BACKGROUND DATA No previous study has analyzed the impact of class 2/3 obesity on outcomes following minimally invasive decompression. MATERIALS AND METHODS Patients who underwent primary minimally invasive decompression were divided into four cohorts based on their BMI: normal (BMI: 18.5-<25), overweight (25-<30), class 1 obesity (30-<35), and class 2/3 obesity (BMI ≥35). Outcome measures were: 1) intraoperative variables: operative time, estimated blood loss (EBL); 2) patient-reported outcome measures (PROMs) (Oswestry disability index, ODI; visual analog scale, VAS back and leg; 12-Item Short Form Survey Physical Component Score, SF-12 PCS); 3) global rating change (GRC), minimal clinically important difference (MCID), and patient acceptable symptom state (PASS) achievement rates; 4) return to activities; and 5) complication and reoperation rates. RESULTS Totally, 838 patients were included (226 normal, 357 overweight, 179 class 1 obesity, and 76 class 2/3 obesity). Class 1 and 2/3 obesity groups had significantly greater operative times compared with the other groups. Class 2/3 obesity group had worse ODI, VAS back and SF-12 PCS preoperatively, worse ODI, VAS back, VAS leg and SF-12 PCS at below six months, and worse ODI and SF-12 PCS at above six months. However, they had significant improvement in all PROMs at both postoperative timepoints and the magnitude of improvement was similar to other groups. No significant differences were found in MCID and PASS achievement rates, likelihood of betterment on the GRC scale, return to activities, and complication/reoperation rates. CONCLUSIONS Class 2/3 obese patients have worse PROMs preoperatively and postoperatively. However, they show similar improvement in PROMs, MCID and PASS achievement rates, likelihood of betterment, recovery kinetics, and complication/reoperation rates as other BMI groups following minimally invasive decompression.
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Affiliation(s)
| | - Tejas Subramanian
- Hospital for Special Surgery, New York, NY
- Weill Cornell Medical College, New York, NY
| | | | | | | | | | | | | | - Chad Simon
- Hospital for Special Surgery, New York, NY
| | | | - Eric Mai
- Hospital for Special Surgery, New York, NY
| | | | - Cole Kwas
- Hospital for Special Surgery, New York, NY
| | | | - Eric Kim
- Hospital for Special Surgery, New York, NY
| | | | - Evan Sheha
- Hospital for Special Surgery, New York, NY
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23
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Andersen GØ, Milosevic S, Jensen MM, Carreon L, Pedersen CF, Andersen MØ, Helmig P. Comparing Patient-Reported Outcomes of Lateral to Paramedian Lumbar Disc Herniation: A Propensity Score-Matched Observational Study. World Neurosurg 2025; 195:123641. [PMID: 39798789 DOI: 10.1016/j.wneu.2024.123641] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2024] [Revised: 12/24/2024] [Accepted: 12/26/2024] [Indexed: 01/15/2025]
Abstract
OBJECTIVE To investigate patient-reported outcomes following lumbar discectomy in patients with lateral lumbar disc herniation (LDH) compared with patients with paramedian LDH. METHODS Data on patients with lateral and paramedian LDH operated on between 2017 and 2020 at a single public spine unit were extracted from the National Danish Spine Registry, DaneSpine. A propensity score-matched, case-control analysis was conducted to compare the 2 groups. Subgroup analysis was done by further dividing the lateral LDH group into foraminal and extraforaminal groups. Patient demographics, Oswestry Disability Index visual analog scale (VAS) leg and back pain (0-100), EuroQol-5D questionnaire, and measures of patient improvement and satisfaction were collected at baseline and 1 year postoperatively. RESULTS Of 887 eligible patients, baseline and 1-year follow-up data were available for 525 patients with paramedian LDH and 68 patients with lateral LDH. Following propensity score matching, the 2 groups were similar in terms of all baseline characteristics (P > 0.05). There were no significant differences between groups in Oswestry Disability Index, VAS leg pain, VAS back pain, and EuroQol-5D 1 year postoperatively. Both groups improved in all outcomes from inclusion to follow-up (P < 0.001). Subgroup analysis showed that patients with foraminal LDH compared with extraforaminal LDH had a significantly greater improvement in VAS leg pain (P = 0.016) with a larger number of patients with clinically significant leg pain improvement (P = 0.03). CONCLUSIONS Patients with lateral and paramedian LDH reported similar postsurgical outcomes. Spine surgeons should be less hesitant to operate on patients with lateral LDH. Patients with extraforaminal LDH experienced the least relief of leg pain.
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Affiliation(s)
| | - Stefan Milosevic
- Department of Clinical Medicine-Orthopedic Surgery, Aarhus University Hospital, Aarhus N, Denmark
| | - Mads Moss Jensen
- Department of Clinical Medicine-Orthopedic Surgery, Aarhus University Hospital, Aarhus N, Denmark
| | - Leah Carreon
- Center for Spine Surgery & Research, Middelfart Hospital, Middelfart, Denmark
| | | | | | - Peter Helmig
- Department of Clinical Medicine-Orthopedic Surgery, Aarhus University Hospital, Aarhus N, Denmark
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Muduli S, Sarkar S, Pal RK, Ghosh S, Alam SM, Saha S, Naskar S, Roy S, Saha A, Halder I, Ghosh P, Shaikh AR, Koley M, Mukherjee SK. Homeopathic Treatment of Chronic Low-Back Pain: A Double-Blind, Randomized, Placebo-Controlled Trial. JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE 2025. [PMID: 39951699 DOI: 10.1089/jicm.2024.0564] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/16/2025]
Abstract
Objectives: To detect differences between individualized homeopathic medicinal products (IHMPs) and placebo after 4 months of intervention in patients with chronic low-back pain (LBP). Design: Four-month, double-blind, randomized (1:1), placebo-controlled, two parallel arms trial. Setting: PG3 and research outpatient department of D. N. De Homoeopathic Medical College & Hospital. Subjects: Sixty participants with chronic LBP. Interventions: Verum (n = 30; IHMPs plus concomitant care) versus control (n = 30; placebos plus concomitant care). Outcome Measures: Primary-Oswestry LBP Disability Questionnaire (ODQ); Secondary-Roland Morris Pain and Disability Questionnaire (RMPDQ); McGill Pain Questionnaire-Short Form (SF-MPQ); measured at baseline, and every month, up to 4 months. Results: Group differences achieved significance or near significance in all the specified outcomes-ODQ score (F1, 58 = 4.331, p = 0.042), RMPDQ score (F1, 58 = 2.939, p = 0.092), and SF-MPQ total score (F1, 58 = 6.666, p = 0.012). Rhus toxicodendron (n = 13), Bryonia alba (n = 8), Hypericum perforatum, and Nux vomica (n = 5 each) were the most frequently prescribed medicines. Different repertories were used as per the need of the cases-Kent, Synthesis, Murphy, Pulford, Boericke, Boger Boenninghausen's Characteristics and Repertory, and Complete. Minor adverse events were reported from either group. Conclusions: Thus, homeopathic medicines worked significantly better than placebos in reducing chronic LBP. Independent replications are warranted to substantiate the findings. Clinical Trial Registration Number: CTRI/2022/04/041878.
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Affiliation(s)
- Sagarika Muduli
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Sanjib Sarkar
- Department of Anatomy, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences, Kolkata, West Bengal,India
| | - Rajat Kumar Pal
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Shubhamoy Ghosh
- Department of Pathology & Microbiology, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Sk Monsur Alam
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Subhranil Saha
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Satyajit Naskar
- Department of Organon of Medicine & Homoeopathic Philosophy, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Suhasish Roy
- Department of Orthopaedics & Spinal Surgery, Ramakrishna Mission Seva Prathisthan & Sishumangal Hospital, Kolkata, West Bengal,India
| | - Ankit Saha
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Indrani Halder
- Department of Repertory, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Priyanka Ghosh
- Department of Organon of Medicine and Homoeopathic Philosophy, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Abdur Rahaman Shaikh
- Department of Practice of Medicine, D. N. De Homoeopathic Medical College & Hospital, Govt. of West Bengal, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
| | - Munmun Koley
- Homoeopathic Medical Officer, East Bishnupur State Homoeopathic Dispensary, Chandi Daulatabad Block Primary Health Centre, Department of Health & Family Welfare, Govt. of West Bengal, Kolkata, West Bengal,India
| | - Shyamal Kumar Mukherjee
- Principal & Administrator, D. N. De Homoeopathic Medical College & Hospital, The West Bengal University of Health Sciences,Kolkata, West Bengal,India
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Hatakka J, Laaksonen I, Kostensalo J, Mäkelä KT, Salo H, Pernaa K. 1-year results of lumbar spinal stenosis surgery in Finland: a national FinSpine register study. Acta Orthop 2025; 96:154-160. [PMID: 39950642 PMCID: PMC11829219 DOI: 10.2340/17453674.2025.42849] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/26/2024] [Accepted: 12/22/2024] [Indexed: 02/17/2025] Open
Abstract
BACKGROUND AND PURPOSE While the rates of lumbar spinal stenosis (LSS) surgery have increased continuously internationally, the role of fusion surgery in the treatment of LSS has been under debate. We aimed to assess the outcome of LSS surgery at 1 year postoperatively and to compare decompression surgery with or without fusion based on the Finnish national spine register FinSpine data. METHODS FinSpine data of surgically treated LSS from 2015 to 2022 was included. The primary outcome was Oswestry Disability Index (ODI), and secondary ones were Visual Analogue Scale for leg and back pain. Predetermined minimal clinically important difference (MCID) for all outcome measures was used to assess the clinical significance of differences in outcomes. Propensity score matching was utilized to ensure that the treatment groups were comparable. RESULTS There were 8,647 LSS patients in the data, of whom 6,751 (77%) were the subject of decompression surgery. Over 90% of patients without spondylolisthesis received decompression alone. At 1-year follow-up, ODI was on average 20.6 (95% confidence interval [CI] 19.3-21.9]) for the fusion group and 23.3 (CI 22.5-24.0) for the decompression group. Differences in ODI, VAS leg pain, or VAS back pain were below the MCID. The share of patients reaching ODI percentage change score ≥ 30% was 74% (CI 71-78) in the fusion group and 66% (CI 63-68) in the decompression group. CONCLUSION Most of the LSS patients experienced significant improvement after LSS surgery. We found no clinical differences between decompression surgery with and without fusion.
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Affiliation(s)
- Juho Hatakka
- Department of Orthopaedics and Traumatology, Turku University Hospital, and University of Turku, Turku, Finland.
| | - Inari Laaksonen
- Department of Orthopaedics and Traumatology, Turku University Hospital, and University of Turku, Turku, Finland
| | - Joel Kostensalo
- Natural Resources Institute Finland, Natural Resources, Joensuu, Finland
| | - Keijo T Mäkelä
- Department of Orthopaedics and Traumatology, Turku University Hospital, and University of Turku, Turku, Finland
| | - Henri Salo
- Knowledge Brokers Department, Finnish Institute for Health and Welfare, Helsinki, Finland
| | - Katri Pernaa
- Department of Orthopaedics and Traumatology, Turku University Hospital, and University of Turku, Turku, Finland
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Shahi P, Subramanian T, Maayan O, Singh N, Araghi K, Singh S, Asada T, Korsun M, Tuma O, Pajak A, Sheha E, Dowdell J, Qureshi SA, Iyer S. Outcomes of Minimally Invasive Decompression Alone Versus Fusion for Predominant Back Pain. HSS J 2025; 21:42-48. [PMID: 39564421 PMCID: PMC11572594 DOI: 10.1177/15563316231223503] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/09/2023] [Accepted: 11/30/2023] [Indexed: 11/21/2024]
Abstract
Background Although a few recent studies showed good outcomes in back pain-predominant patients following decompression alone, none of the studies had a comparative fusion group. Purpose We sought to compare outcomes of minimally invasive decompression alone versus fusion in patients with predominant back pain. Methods This retrospective cohort study included patients who underwent minimally invasive decompression alone or fusion and had preoperative back pain > leg pain. Outcome measures were (1) patient-reported outcome measures (PROMs), (2) minimal clinically important difference (MCID) achievement, (3) patient acceptable symptom state (PASS) achievement, and (4) global rating change (GRC). As a subgroup analysis, MCID, PASS, and GRC rates were also compared between the decompression and fusion groups for patients with preoperative back pain < leg pain. Results Of 510 patients included, there were statistically significant improvements in all PROMs in both groups at <6 and >6 months with no significant difference in the magnitude of improvement. The fusion group showed significantly higher MCID achievement rates for Visual Analog Scale (VAS) back at <6 months (85% vs 70%) and Oswestry Disability Index (ODI) at >6 months (67% vs 51%). Proportion of patients achieving PASS and feeling better after surgery based on response to GRC showed no difference between the groups. The subgroup analysis for decompression versus fusion in patients with preoperative back pain < leg pain showed no differences in MCID, PASS, or GRC rates. Conclusions This retrospective cohort study found that in patients with predominant back pain, minimally invasive decompression alone had significantly less MCID achievement rates in VAS back at <6 months and ODI at >6 months. However, it did lead to an overall significant improvement in PROMs, similar PASS achievement rates, and similar responses on the GRC scale.
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Affiliation(s)
| | - Tejas Subramanian
- Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Omri Maayan
- Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | | | | | | | | | | | - Olivia Tuma
- Hospital for Special Surgery, New York, NY, USA
| | | | - Evan Sheha
- Hospital for Special Surgery, New York, NY, USA
| | | | - Sheeraz A. Qureshi
- Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
| | - Sravisht Iyer
- Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medical College, New York, NY, USA
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27
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Singh S, Shahi P, Song J, Subramanian T, Morse K, Maayan O, Araghi K, Singh N, Tuma O, Asada T, Korsun M, Mai E, Dowdell J, Sheha E, Sandhu H, Albert T, Qureshi S, Iyer S. Clinical and Radiologic Predictors of Slower Improvement and Nonimprovement After Surgical Treatment of L4-L5 Degenerative Spondylolisthesis: Preliminary Results. Spine (Phila Pa 1976) 2025; 50:187-195. [PMID: 38679887 DOI: 10.1097/brs.0000000000005019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/15/2024] [Accepted: 03/13/2024] [Indexed: 05/01/2024]
Abstract
STUDY DESIGN Retrospective cohort. OBJECTIVE To identify the predictors of slower and nonimprovement after surgical treatment of L4-5 degenerative lumbar spondylolisthesis (DLS). SUMMARY OF BACKGROUND DATA There is limited evidence regarding clinical and radiologic predictors of slower and nonimprovement following surgery for L4-5 DLS. METHODS Patients who underwent minimally invasive decompression or fusion for L4-5 DLS and had a minimum of 1-year follow-up were included. Outcome measures were: (1) minimal clinically important difference (MCID), (2) patient acceptable symptom state (PASS), and (3) global rating change (GRC). Clinical variables analyzed for predictors were age, gender, body mass index (BMI), surgery type, comorbidities, anxiety, depression, smoking, osteoporosis, and preoperative patient-reported outcome measures (PROMs) (Oswestry disability index, ODI; visual analog scale, VAS back and leg; 12-Item Short Form Survey Physical Component Score, SF-12 PCS). Radiologic variables analyzed were slip percentage, translational and angular motion, facet diastasis/cyst/orientation, laterolisthesis, disc height, scoliosis, main and fractional curve Cobb angles, and spinopelvic parameters. RESULTS Two hundred thirty-three patients (37% decompression and 63% fusion) were included. At less than three months, high pelvic tilt (PT) (OR: 0.92, P= 0.02) and depression (OR: 0.28, P= 0.02) were predictors of MCID nonachievement and GRC nonbetterment, respectively. Neither retained significance at above six months and hence, were identified as predictors of slower improvement. At above six months, low preoperative VAS leg (OR: 1.26, P= 0.01) and high facet orientation (OR: 0.95, P= 0.03) were predictors of MCID nonachievement, high L4-5 slip percentage (OR: 0.86, P= 0.03) and L5-S1 angular motion (OR: 0.78, P= 0.01) were predictors of GRC nonbetterment, and high preoperative ODI (OR: 0.96, P= 0.04) was a predictor of PASS nonachievement. CONCLUSIONS High PT and depression were predictors of slower improvement and low preoperative leg pain, high disability, high facet orientation, high slip percentage, and L5-S1 angular motion were predictors of nonimprovement. However, these are preliminary findings and further studies with homogeneous cohorts are required to establish these findings.
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Affiliation(s)
| | | | | | - Tejas Subramanian
- Hospital for Special Surgery
- Weill Cornell Medical College, New York, NY
| | | | - Omri Maayan
- Hospital for Special Surgery
- Weill Cornell Medical College, New York, NY
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Asada T, Simon CZ, Durbas A, Allen MRJ, DiSilvestro KJ, Hirase T, Bovonratwet P, Singh N, Tuma O, Araghi K, Subramanian T, Korsun MK, Zhang J, Kim ET, Kwas CT, Bay A, Lu AZ, Mai E, Kim YE, Vaishnav AS, Dowdell JE, Sheha ED, Qureshi SA, Iyer S. Influence of coronal lumbar Cobb angle and surgical level on short-segment lumbar surgery outcomes in degenerative scoliosis. EUROPEAN SPINE JOURNAL : OFFICIAL PUBLICATION OF THE EUROPEAN SPINE SOCIETY, THE EUROPEAN SPINAL DEFORMITY SOCIETY, AND THE EUROPEAN SECTION OF THE CERVICAL SPINE RESEARCH SOCIETY 2025; 34:773-781. [PMID: 39673606 PMCID: PMC11805618 DOI: 10.1007/s00586-024-08599-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 10/20/2024] [Accepted: 11/29/2024] [Indexed: 12/16/2024]
Abstract
PURPOSE This study investigates the relationship between surgical levels and coronal deformity to identify risk factors for failing to achieve a minimal clinically important difference (MCID) in the Oswestry Disability Index (ODI) following short-segment isolated decompression or fusion surgery in patients with degenerative scoliosis (DS) and concurrent lumbar canal stenosis (LCS), without severe sagittal deformity malalignment. METHODS Patients with degenerative scoliosis who underwent 1- or 2-level lumbar isolated decompression or fusion surgery were included. Surgical level was labeled as "Cobb-related" when decompression or surgical levels spanned or were between end vertebrae, and "outside" when the operative levels did not include the end vertebrae. Logistic regression analysis was conducted to assess the factor associated with MCID achievement in ODI at 1 year postoperatively. RESULTS A total of 129 DS patients with LCS and preoperative ODI > 30 were included. At 1-year follow-up, 91 patients (70.5%) achieved MCID in ODI. No significant differences were found in demographics or overall spinal alignment between patients who did and did not achieve MCID. Logistic regression analysis revealed that Cobb-related decompression was independently associated with decreased odds of achieving MCID in ODI (adjusted Odds Ratio 0.18, 95% CI 0.42-0.79, P = 0.025). CONCLUSION In patients with mild to moderate coronal deformity and minimal sagittal deformity, decompression alone at or across end vertebrae significantly lowers the likelihood of achieving the MCID in ODI compared to fusion surgery, with an 84% reduction in odds. No significant difference in MCID achievement was observed between decompression and fusion surgeries outside the Cobb angle.
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Affiliation(s)
- Tomoyuki Asada
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Chad Z Simon
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Atahan Durbas
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Myles R J Allen
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | | | - Takashi Hirase
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | | | - Nishtha Singh
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Olivia Tuma
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Kasra Araghi
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Tejas Subramanian
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
- Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA
| | | | - Joshua Zhang
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Eric T Kim
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Cole T Kwas
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Annika Bay
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Amy Z Lu
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
- Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA
| | - Eric Mai
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
- Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA
| | - Yeo Eun Kim
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
- Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA
| | - Avani S Vaishnav
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - James E Dowdell
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Evan D Sheha
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Sheeraz A Qureshi
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA
| | - Sravisht Iyer
- Hospital for Special Surgery, 535 E. 70th St, New York, NY, 10021, USA.
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Schwab F, Mekhail N, Patel KV, Langhorst M, Heros RD, Gentile J, Costandi S, Moore G, Gilmore C, Manion S, Chakravarthy K, Meyer SC, Bundy JV, Tate JL, Sanders R, Vaid S, Szentirmai O, Goree J, Patel VV, Lehmen J, Desai MJ, Pope JE, Giuffrida A, Hayek S, Virk SS, Paicius R, Klemme WR, Levy R, Gilligan C. Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifidus Dysfunction. Pain Ther 2025; 14:401-423. [PMID: 39812968 PMCID: PMC11751280 DOI: 10.1007/s40122-024-00689-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2024] [Accepted: 11/20/2024] [Indexed: 01/16/2025] Open
Abstract
INTRODUCTION Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. Restorative neurostimulation has been suggested as a specific treatment for mechanical CLBP resulting from multifidus dysfunction. In this randomized controlled trial, we report outcomes from a cohort of patients with CLBP associated with multifidus dysfunction treated with restorative neurostimulation compared to those randomized to a control group receiving optimal medical management (OMM) over 1 year. METHODS RESTORE is a multicenter, open-label randomized controlled trial. Candidates were assessed for CLBP associated with multifidus dysfunction, with no indication for or history of lumbar spine surgery. Participants were randomized to either restorative neurostimulation with the ReActiv8 system or OMM. The primary endpoint was a comparison of the mean change in the Oswestry Disability Index (ODI) between the treatment and control arms at 1 year, and secondary endpoints included pain (numeric rating scale [NRS]) and health-related quality of life (EuroQol Five-Dimension [EQ-5D-5L]). RESULTS A total of 203 patients, average age 47 years, and with an average 11-year history of low back pain, were included in the analysis. The primary endpoint was a statistically significant demonstration of a clinically relevant mean improvement in the Oswestry Disability Index (ODI) between restorative neurostimulation and OMM arms: ODI (-19.7 ± 1.4 vs. -2.9 ± 1.4; p < 0.001). Additionally, improvements in both the numeric rating scale (NRS) (-3.6 ± 0.2 vs. -0.6 ± 0.2; p < 0.001) and EuroQol Five-Dimension (EQ-5D-5L) (0.155 ± 0.012 vs. 0.008 ± 0.012; p < 0.001) were statistically and clinically significant in the restorative neurostimulation arm compared to the OMM arm. CONCLUSION The RESTORE trial demonstrates that restorative neurostimulation is a safe, reversible, clinically effective, and highly durable option for patients suffering with nonoperative CLBP associated with multifidus dysfunction. This demonstration of treatment superiority over OMM through 1 year is a significant milestone in addressing a major health burden and unmet clinical need. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT04803214.
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Affiliation(s)
- Frank Schwab
- Northwell Health Orthopaedic Institute at Lenox Hill, 130 East 77th Street, Black Hall 7th, 11th, and 12th Floors, New York, NY, 10075, USA.
| | | | - Kiran V Patel
- Northwell Health Pain Medicine, Anesthesiology, New York, NY, USA
| | | | | | | | | | | | - Christopher Gilmore
- Center for Clinical Research, Carolinas Pain Institute, Winston-Salem, NC, USA
| | | | | | | | | | | | | | | | | | - Johnathan Goree
- Department of Anesthesiology, University of Arkansas Medical Sciences, Little Rock, AR, USA
| | - Vikas V Patel
- Department of Orthopedic Surgery, University of Colorado, Denver, CO, USA
| | | | - Mehul J Desai
- International Spine Pain & Performance Center, Washington, DC, USA
| | | | - Anthony Giuffrida
- Cantor Spine Center, Paley Orthopedic and Spine Institute, Fort Lauderdale, FL, USA
| | - Salim Hayek
- Division of Pain Medicine, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA
| | | | | | - William R Klemme
- Uniformed Services University of the Health Sciences, Bethesda, MD, USA
| | - Robert Levy
- Anesthesia Pain Care Consultants, LLC, Tamarac, FL, USA
| | - Christopher Gilligan
- Robert Wood Johnson University Hospital/Rutgers Medical School, New Brunswick, NJ, USA
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30
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Yuan X, Tao R, Zhu M, Zhu J. Comparative Efficacy of 3 Methods of Lumbar Interbody Fusion for Lumbar Degenerative Diseases in a Tertiary Public Hospital. World Neurosurg 2025; 194:123553. [PMID: 39653081 DOI: 10.1016/j.wneu.2024.12.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Revised: 12/03/2024] [Accepted: 12/04/2024] [Indexed: 12/29/2024]
Abstract
OBJECTIVE To evaluate the clinical efficacy of large-channel endoscope-assisted posterior lumbar interbody fusion (Endo-PLIF), minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), and open posterior lumbar interbody fusion in treatment of degenerative diseases of the lumbar spine. METHODS Data of 110 patients with degenerative diseases of the lumbar spine were analyzed retrospectively: 31 patients underwent Endo-PLIF, 36 patients underwent MIS-TLIF, and 43 patients underwent modified TLIF. We compared operative duration, intraoperative blood loss, latent blood loss, intraoperative radiation dose, visual analog scale score, Oswestry Disability Index, anterior protrusion angle of the intervertebral space, postoperative ambulatory time, postoperative duration of hospital stay, and complications among the 3 groups. The prevalence of interbody fusion was observed at follow-up. RESULTS Operative duration of Endo-PLIF was longer than that of MIS-TLIF and modified TLIF (P < 0.05). In terms of intraoperative blood loss, latent blood loss, and recovery time, Endo-PLIF and MIS-TLIF had clear advantages (P < 0.05). Visual analog scale score and Oswestry Disability Index of the 3 groups were satisfactory, but low back pain of patients in the Endo-PLIF and MIS-TLIF groups was less than that in the modified TLIF group (P < 0.05). In terms of complications and prevalence of interbody fusion, there were no significant differences among the 3 groups (P > 0.05). CONCLUSIONS All 3 operative methods had satisfactory efficacy. Endo-PLIF can be employed to treat lumbar degenerative diseases more precisely and in a minimally invasive fashion, but a learning curve and improvement in surgical instruments are needed.
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Affiliation(s)
- Xiaofeng Yuan
- Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China
| | - Rui Tao
- Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China
| | - Mengfei Zhu
- Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China
| | - Jiajun Zhu
- Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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Shahi P, Subramanian T, Tuma O, Singh S, Araghi K, Asada T, Korsun M, Singh N, Simon C, Vaishnav A, Mai E, Zhang J, Kwas C, Allen M, Kim E, Heuer A, Sheha E, Dowdell J, Qureshi S, Iyer S. Temporal Trends of Improvement After Minimally Invasive Transforaminal Lumbar Interbody Fusion. Spine (Phila Pa 1976) 2025; 50:81-87. [PMID: 38708966 DOI: 10.1097/brs.0000000000005024] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/19/2024] [Accepted: 04/18/2024] [Indexed: 05/07/2024]
Abstract
STUDY DESIGN Retrospective review of prospectively collected data. OBJECTIVE To analyze temporal trends in improvement after minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA Although several studies have shown that patients improve significantly after MIS TLIF, evidence regarding the temporal trends in improvement is still largely lacking. METHODS Patients who underwent primary single-level MIS TLIF for degenerative conditions of the lumbar spine and had a minimum of 2-year follow-up were included. Outcome measures were: 1) patient reported outcome measures (PROMs) (Oswestry Disability Index, ODI; Visual Analog Scale, VAS back and leg; 12-Item Short Form Survey Physical Component Score, SF-12 PCS); 2) global rating change (GRC); 3) minimal clinically important difference (MCID); and 4) return to activities. Timepoints analyzed were preoperative, 2 weeks, 6 weeks, 3 months, 6 months, 1 year, and 2 years. Trends across these timepoints were plotted on graphs. RESULTS 236 patients were included. VAS back and VAS leg were found to have statistically significant improvement compared to the previous timepoint up to 3 months after surgery. ODI and SF-12 PCS were found to have statistically significant improvement compared to the previous timepoint up to 6 months after surgery. Beyond these timepoints, there was no significant improvement in PROMs. 80% of patients reported feeling better compared to preoperative by 3 months. >50% of patients achieved MCID in all PROMs by 3 months. Most patients returned to driving, returned to work, and discontinued narcotics at an average of 21, 20, and 10 days, respectively. CONCLUSIONS Patients are expected to improve up to 6 months after MIS TLIF. Back pain and leg pain improve up to 3 months and disability and physical function improve up to 6 months. Beyond these timepoints, the trends in improvement tend to reach a plateau. 80% of patients feel better compared to preoperative by 3 months after surgery.
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Wei R, Liu W, Yu M, Zhu Y, Yao R, Wang B, Li-Ling J. Delta large-channel endoscopy versus unilateral biportal endoscopy decompressive laminectomy for lumbar spinal stenosis: a prospective randomized controlled trial. J Orthop Surg Res 2025; 20:10. [PMID: 39754230 PMCID: PMC11699819 DOI: 10.1186/s13018-024-05409-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/29/2024] [Accepted: 12/23/2024] [Indexed: 01/06/2025] Open
Abstract
BACKGROUND Delta large-channel endoscopy and unilateral biportal endoscopy (UBE) are prominent minimally invasive techniques for treating lumbar spinal stenosis, known for minimal tissue damage, clear visualization, and quick recovery. However, rigorous controlled research comparing these procedures is scarce, necessitating further investigation into their respective complications and long-term effectiveness. This randomized controlled trial aims to compare their perioperative outcomes, focusing on postoperative recovery and complications over time. METHODS In total, 101 participants were randomly assigned to Delta large-channel endoscopy group (n = 50) or UBE group (n = 51). Primary measures were Oswestry Disability Index (ODI) scores and operation time. Secondary measures included VAS, EQ-5D, JOA scores, intraoperative blood loss, hospital stay duration, and costs. Perioperative complications such as dural tears, incision infections, hematomas, thrombosis, and reoperation rates were recorded. RESULTS The Delta group consistently showed lower mean ODI scores throughout the follow-up than UBE group, with significant differences at 2 weeks postoperative (P = 0.048), though they were not significant by 1 month (P = 0.124), 2 months (P = 0.821) and 3 months (P = 0.350). Operation times were shorter in the Delta group (P < 0.001). Hospitalization costs and intraoperative blood loss were slightly higher in the UBE group (P < 0.001). No significant differences were noted in the other secondary outcomes at various post-surgery intervals, such as VAS, EQ-5D, JOA scores, hospital stay duration and complications. CONCLUSION Both techniques are safe and effective when performed by experienced surgeons. Compared to UBE, Delta large-channel endoscopy can shorten surgery time and reduce blood loss, and more importantly, it promotes faster recovery of lumbar function in the early postoperative period. RESEARCH REGISTRATION UNIQUE IDENTIFYING NUMBER (UIN) Name of the registry: Chinese Clinical Trial Registry chictr.org.cn. ( http://www.chictr.org.cn/index.aspx ). Unique Identifying number or registration ID: ChiCTR2300076237. Hyperlink to your specific registration (must be publicly accessible and will be checked): https://www.chictr.org.cn/showproj.html?proj=207 ,844.
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Affiliation(s)
- Rushuo Wei
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China
| | - Weiqiang Liu
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China
| | - Mingdong Yu
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China
| | - Yushan Zhu
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China
| | - Ruzhan Yao
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China.
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China.
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China.
| | - Bingwu Wang
- Department of Spinal Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China.
- Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University, Weifang, Shandong, 261000, China.
- Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine-Engineering Transformation, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, 261000, China.
| | - Jesse Li-Ling
- Center of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
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Beckmann M, Odland K, Polly DW. A retrospective cohort review of BMI on SI joint fusion outcomes: examining the evidence to improve insurance guidelines. EUROPEAN SPINE JOURNAL : OFFICIAL PUBLICATION OF THE EUROPEAN SPINE SOCIETY, THE EUROPEAN SPINAL DEFORMITY SOCIETY, AND THE EUROPEAN SECTION OF THE CERVICAL SPINE RESEARCH SOCIETY 2025; 34:140-147. [PMID: 39191944 DOI: 10.1007/s00586-024-08475-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/21/2024] [Revised: 08/21/2024] [Accepted: 08/24/2024] [Indexed: 08/29/2024]
Abstract
PURPOSE The demand for SIJ fusion among obese patients has grown substantially. However, the clinical relevance of obesity in the context of SI joint fusion has not been well investigated specifically, whether there is a BMI cutoff above which the benefit-risk ratio is low. METHODS Adult patients ≥ 21 years of age who underwent minimally invasive SIJ fusion between 2020 and 2023. Participants were classified using the National Institutes for Health body mass index (BMI). Patients with a BMI of 30 to 39 with no significant comorbidity are considered obese, patients with a BMI of 35 to 39 with a significant comorbidity or a BMI of 40 or greater are considered morbidly obese. All subjects completed the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) at baseline and 12 months. One-way analysis of variance was used to examine the impact of BMI category on score changes. RESULTS Overall, mean VAS improved at 12 months by 2.5 points (p < .006). Over the 12-month follow-up period, BMI category did not impact mean improvement in VAS (ANOVA p = .08). Mean ODI at 12 months improved by 23.2 points (p < .001). BMI category did impact mean improvement in ODI (ANOVA p = .03). CONCLUSION This study demonstrates similar benefits across all BMI categories. This data suggests that obese patients do benefit from minimally invasive SIJ fusion, specifically the 35-40 BMI cohort of patients, and should not be denied this procedure based on arbitrary healthcare organizations BMI criteria.
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Affiliation(s)
- Michael Beckmann
- The Department of Orthopedic Surgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN, 55454, USA
| | - Kari Odland
- The Department of Orthopedic Surgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN, 55454, USA.
| | - David W Polly
- The Department of Orthopedic Surgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN, 55454, USA
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Katz L, Feinberg G, Kent V, Quinn M, Milner JD, Tabaddor R. Iliopsoas Injections: A Systematic Review of Patient Outcomes and Progression to Surgery. JBJS Rev 2025; 13:01874474-202501000-00001. [PMID: 39813362 DOI: 10.2106/jbjs.rvw.24.00162] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/18/2025]
Abstract
BACKGROUND Iliopsoas injuries are a common cause of anterior hip and groin pain and can be successfully managed with conservative treatment. Corticosteroid and local anesthetic injections can also be offered in conjunction with nonoperative management. Given the variability in reported injection guidelines, composition, and techniques, the purpose of this study was to systematically review the literature to assess progression to surgery and patient outcomes following iliopsoas injections. METHODS Four online databases (PubMed, Cochrane Library, MEDLINE, and Scopus) were searched for studies investigating the outcomes of iliopsoas injections from database inception until January 2024 in accordance with the Preferred Reporting Items for Systematic Meta-Analyses guidelines. Three reviewers screened titles, abstracts, and full-text articles independently and in duplicate. Recorded data included demographic data, patient-reported outcomes, complications, injection traits, and progression to surgery. RESULTS Six articles were included in the review (follow-up time = 28.6 months). These studies included patients with iliopsoas bursitis, tendinopathy, and snapping hip. Five studies used the iliopsoas bursa as the injection target. All studies used local anesthetics in their injection formulations, with 5 also adding a corticosteroid. In 3 studies, the Numeric Rating Scale improved from preinjection (mean = 7.33) to postinjection (mean = 2.47). Three studies demonstrated an improvement in Harris Hip Score from a mean of 58.49 preinjection to 89.91 postinjection. Following injections, 28.9% (68/235) of patients progressed to surgery, with psoas tenotomy (38.3%, 26/68) being the most common procedure. There were no complications reported in all of the included studies. CONCLUSION This study demonstrates that iliopsoas injections are a clinically effective treatment of a variety of pathologies, including bursitis, tendinopathy, and snapping hip, and have a low rate of complications. Physicians should consider using iliopsoas injections in patients whose symptoms are refractory to conservative management, including physical therapy. LEVEL OF EVIDENCE Level III. See Instructions for Authors for a complete description of levels of evidence.
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Affiliation(s)
- Luca Katz
- The Warren Alpert Medical School of Brown University, Providence, Rhode Island
| | - Griffin Feinberg
- The Warren Alpert Medical School of Brown University, Providence, Rhode Island
| | - Victoria Kent
- The Warren Alpert Medical School of Brown University, Providence, Rhode Island
| | - Matthew Quinn
- Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island
| | - John D Milner
- Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island
| | - Ramin Tabaddor
- Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island
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Forte ML. Facet Joint Block: A Temporary Fix for an Iatrogenic Problem After Oblique Lumbar Interbody Fusion?: Commentary on an article by Sung Hyeon Noh, MD, PhD, et al.: "Intraoperative Facet Joint Block Reduces Pain After Oblique Lumbar Interbody Fusion. A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial". J Bone Joint Surg Am 2025; 107:e2. [PMID: 40100015 DOI: 10.2106/jbjs.24.00887] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 03/20/2025]
Affiliation(s)
- Mary L Forte
- Minnesota Evidence-Based Practice Center, Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota
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Inose H, Takahashi S, Teraguchi M, Kato T, Yamada K, Yasuda H, Terakawa M, Minetama M, Tomori M, Nakagawa Y, Yoshii T. Romosozumab versus bisphosphonates for preventing subsequent vertebral fractures after balloon kyphoplasty: comparison using data from two prospective multicenter studies. JBMR Plus 2025; 9:ziae137. [PMID: 39664929 PMCID: PMC11629968 DOI: 10.1093/jbmrpl/ziae137] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Revised: 10/11/2024] [Accepted: 10/25/2024] [Indexed: 12/13/2024] Open
Abstract
Preventing subsequent fractures after vertebral augmentation is a critical clinical concern. The purpose of this study was to compare the effect of romosozumab and bisphosphonate administration on the occurrence of subsequent vertebral fractures after balloon kyphoplasty (BKP) and to identify factors associated with the occurrence of subsequent vertebral fractures. The study compared 24 patients who underwent BKP and received romosozumab with 58 control patients who underwent BKP and received bisphosphonates, all within 2 months of acute osteoporotic vertebral fracture and showing unfavorable magnetic resonance imaging prognostic factors. The primary outcome was the occurrence of subsequent fracture, and the secondary outcomes were improvement in back pain visual analog scale (VAS) score. Furthermore, logistic regression analysis was conducted to adjust for confounding factors and assess the effect of osteoporosis treatment type on subsequent vertebral fractures following BKP. Subsequent vertebral fractures occurred in 16 patients in the bisphosphonate group and in 1 patient in the romosozumab group (p = .02). There were no significant differences between the 2 groups in VAS scores and their change from preoperatively to 6 months after surgery. The multivariable logistic regression analysis identified the type of osteoporosis treatment as an independent factor associated with the occurrence of subsequent vertebral fractures (Odds ratio, 18.30, p = .02). This prospective, multicenter study demonstrates that romosozumab is more effective than bisphosphonates in preventing subsequent vertebral fractures within 6 months after BKP. Romosozumab's superior efficacy in reducing subsequent vertebral fractures may lead to improved long-term outcomes and quality of life, potentially making it a preferred treatment option over bisphosphonates for patients undergoing BKP.
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Affiliation(s)
- Hiroyuki Inose
- Department of Orthopaedic Surgery, Dokkyo Medical University Saitama Medical Center, Saitama 343-8555, Japan
- Department of Orthopedics, Institute of Science Tokyo, Tokyo 113-8519, Japan
| | - Shinji Takahashi
- Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan
| | - Masatoshi Teraguchi
- Department of Orthopedic Surgery, Wakayama Medical University, Wakayama 641-8510, Japan
| | - Tsuyoshi Kato
- Department of Orthopaedics, Ome Municipal General Hospital, Tokyo 198-0042, Japan
| | - Kentaro Yamada
- Department of Orthopedics, Institute of Science Tokyo, Tokyo 113-8519, Japan
| | - Hiroyuki Yasuda
- Department of Orthopaedic Surgery, Osaka General Hospital of West Japan Railway Company, Osaka 545-0053, Japan
| | - Masaki Terakawa
- Department of Orthopaedic Surgery, Osaka General Hospital of West Japan Railway Company, Osaka 545-0053, Japan
| | - Masakazu Minetama
- Spine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama 649-7113, Japan
| | - Masaki Tomori
- Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Saitama 332-8558, Japan
| | - Yukihiro Nakagawa
- Spine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama 649-7113, Japan
| | - Toshitaka Yoshii
- Department of Orthopedics, Institute of Science Tokyo, Tokyo 113-8519, Japan
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Miranda SP, Whitmore RG, Kanter A, Mummaneni PV, Bisson EF, Barker FG, Harrop J, Magge SN, Heary RF, Fehlings MG, Albert TJ, Arnold PM, Riew KD, Steinmetz MP, Wang MC, Heller JG, Benzel EC, Ghogawala Z. Patients May Return to Work Sooner After Laminoplasty: Occupational Outcomes of the Cervical Spondylotic Myelopathy Surgical Trial. Neurosurgery 2025; 96:131-141. [PMID: 38912784 DOI: 10.1227/neu.0000000000003048] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2024] [Accepted: 04/23/2024] [Indexed: 06/25/2024] Open
Abstract
BACKGROUND AND OBJECTIVES Return-to-work (RTW) is an important outcome for employed patients considering surgery for cervical spondylotic myelopathy (CSM). We conducted a post hoc analysis of patients as-treated in the Cervical Spondylotic Myelopathy Surgical Trial, a prospective, randomized trial comparing surgical approaches for CSM to evaluate factors associated with RTW. METHODS In the trial, patients were randomized (2:3) to either anterior surgery (anterior cervical decompression/fusion [ACDF]) or posterior surgery (laminoplasty [LP], or posterior cervical decompression/fusion [PCDF], at surgeon's discretion). Work status was recorded at 1, 3, 6, and 12 months postoperatively. For patients working full-time or part-time on enrollment, time to RTW was compared across as-treated surgical groups using discrete-time survival analysis. Multivariate logistic regression was used to assess predictors of RTW. Clinical outcomes were compared using a linear mixed-effects model. RESULTS A total of 68 (42%) of 163 patients were working preoperatively and were analyzed. In total, 27 patients underwent ACDF, 29 underwent PCDF, and 12 underwent LP. 45 (66%) of 68 patients returned to work by 12 months. Median time to RTW differed by surgical approach (LP = 1 month, ACDF = 3 months, PCDF = 6 months; P = .02). Patients with longer length-of-stay were less likely to be working at 1 month (odds ratio 0.51; 95% CI, 0.29-0.91; P = .022) and 3 months (odds ratio 0.39; 95% CI, 0.16-0.96; P = .04). At 3 months, PCDF was associated with lower Short-Form 36 physical component summary scores than ACDF (estimated mean difference [EMD]: 6.42; 95% CI, 1.4-11.4; P = .007) and LP (EMD: 7.98; 95% CI, 2.7-13.3; P = .003), and higher Neck Disability Index scores than ACDF (EMD: 12.48; 95% CI, 2.3-22.7; P = .01) and LP (EMD: 15.22; 95% CI, 2.3-28.1; P = .014), indicating worse perceived physical functioning and greater disability, respectively. CONCLUSION Most employed patients returned to work within 1 year. LP patients resumed employment earliest, while PCDF patients returned to work latest, with greater disability at follow-up, suggesting that choice of surgical intervention may influence occupational outcomes.
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Affiliation(s)
- Stephen P Miranda
- Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia , Pennsylvania , USA
| | - Robert G Whitmore
- Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington , Massachusetts , USA
| | - Adam Kanter
- Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh , Pennsylvania , USA
- Pickup Family Neurosciences Institute, Hoag Specialty Clinic, Los Angeles , California , USA
| | - Praveen V Mummaneni
- Department of Neurological Surgery, University of California San Francisco, San Francisco , California , USA
| | - Erica F Bisson
- Department of Neurosurgery Clinical Neurosciences Center, University of Utah School of Medicine, Salt Lake City , Utah , USA
| | - Fred G Barker
- Brain Tumor Center, Massachusetts General Hospital, Boston , Massachusetts , USA
| | - James Harrop
- Department of Neurological Surgery, Thomas Jefferson University, Philadelphia , Pennsylvania , USA
| | - Subu N Magge
- Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington , Massachusetts , USA
| | - Robert F Heary
- Department of Neurological Surgery, Hackensack Meridian School of Medicine, Nutley , New Jersey , USA
| | - Michael G Fehlings
- Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto , Ontario , Canada
- Division of Neurosurgery, Krembil Neuroscience Centre, University Health Network, Toronto , Ontario , Canada
| | - Todd J Albert
- Department of Orthopaedic Surgery, Hospital for Special Surgery, New York , New York , USA
- Department of Neurosurgery, Weill Cornell Medicine, New York , New York , USA
| | - Paul M Arnold
- Carle Neuroscience Institute, Carle Foundation Hospital, Urbana , Illinois , USA
| | - K Daniel Riew
- Department of Neurosurgery, Weill Cornell Medicine, New York , New York , USA
- Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York , New York , USA
| | - Michael P Steinmetz
- Center for Spine Health, Cleveland Clinic Foundation, Cleveland , Ohio , USA
| | - Marjorie C Wang
- Department of Neurosurgery, Medical College of Wisconsin, Milwaukee , Wisconsin , USA
| | - John G Heller
- The Emory Orthopaedics & Spine Center, Emory University School of Medicine, Atlanta , Georgia , USA
| | - Edward C Benzel
- Center for Spine Health, Cleveland Clinic Foundation, Cleveland , Ohio , USA
| | - Zoher Ghogawala
- Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington , Massachusetts , USA
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Longo UG, Campi S, De Salvatore S, Piergentili I, Bandini B, Lalli A, Ammendolia V, de Sire A, Papalia R. Minimum clinically important difference of 36-item short form health survey (SF-36) to assess post-surgery quality of life in knee osteoarthritis. J Back Musculoskelet Rehabil 2025; 38:158-164. [PMID: 39970460 DOI: 10.1177/10538127241296344] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/21/2025]
Abstract
BACKGROUND Quality of life in patients receiving knee arthroplasty is crucial for rehabilitation. Even if the validity of the 36-Item Short Form (SF-36) was already confirmed, the Substantial Clinical Benefit (SCB) and Patient Acceptable Symptom Score (PASS) values of this score remain unknown for both Total Knee Arthroplasty (TKA) and Unicompartmental Knee Arthroplasty (UKA). OBJECTIVE The purpose of this research was to compute the Minimal Clinically Important Difference (MCID) of the SF-36 after UKA, and the SCB and PASS of SF-36 after TKA and UKA, in order to assess post-surgery quality of life in knee osteoarthritis. METHODS Overall, 59 patients (40 women and 19 men, mean age 60.3 ± 13.1 years) completed the questionnaire until six months follow-up. Of these patients, 22 underwent the TKA procedure, while 37 patients underwent the UKA procedure. The anchor question for computing the MCID and SCB thresholds was "How would you describe your health condition in relation to your previous state?". The PASS scores were determined using the ROC curve and the 75th percentile of the cumulative percentage curve of respondents who believe their symptoms are under control. RESULTS The MCID values of global SF-36, Physical Component Summary (PCS) and Mental Component Summary (MCS) after UKA were 11.3, 14.5 and 11.4, respectively. The SCB values of global SF-36, PCS and MCS after UKA were 23.5, 23.1 and 15, respectively. The PASS values of global SF-36, PCS and MCS after TKA were 71.2, 75 and 69.3, respectively. The PASS values of global SF-36, PCS and MCS after UKA were 70.4, 72.1 and 67.5, respectively. CONCLUSION The SF-36 score represents a valid score for quality of life in patients with knee osteoarthritis. Taken together, the results showed a statistically significant improvement between inception and latest follow-up after TKA and UKA.
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Affiliation(s)
- Umile Giuseppe Longo
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Stefano Campi
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Sergio De Salvatore
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
- Research Unit of Ospedale Pediatrico Bambin Gesù, Department of Medicine and Surgery, Fiumicino, Italy
| | - Ilaria Piergentili
- CNR-IASI, Laboratorio di Biomatematica, Consiglio Nazionale delle Ricerche, Istituto di Analisi dei Sistemi ed Informatica, Rome, Italy
| | - Benedetta Bandini
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Alberto Lalli
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Valerio Ammendolia
- Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy
| | - Alessandro de Sire
- Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy
- Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro "Magna Graecia", Catanzaro, Italy
| | - Rocco Papalia
- Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
- Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
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Narayanan R, Tarawneh OH, Trenchfield D, Meade MH, Lee Y, Opara O, McCurdy MA, Pineda N, Kaye LD, Alhassan F, Vo M, Mangan JJ, Canseco JA, Hilibrand AS, Vaccaro AR, Kepler CK, Schroeder GD. Preoperative Hounsfield Units Predict Pedicle Screw Loosening in Osteoporotic Patients Following Short-Segment Lumbar Fusion. Spine (Phila Pa 1976) 2024; 49:1722-1728. [PMID: 38556736 DOI: 10.1097/brs.0000000000004995] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/08/2024] [Accepted: 02/23/2024] [Indexed: 04/02/2024]
Abstract
STUDY DESIGN Retrospective Cohort. OBJECTIVE (1) To determine if vertebral HU values obtained from preoperative CT predict postoperative outcomes following one to three level lumbar fusion and (2) to investigate whether decreased BMD values determined by HU predict cage subsidence and screw loosening. SUMMARY OF BACKGROUND DATA In light of suboptimal screening for osteoporosis, vertebral computerized tomography (CT) Hounsfield Units (HU), have been investigated as a surrogate for bone mineral density (BMD). MATERIALS AND METHODS In this retrospective study, adult patients who underwent one to three level posterior lumbar decompression and fusion (PLDF) or transforaminal lumbar interbody and fusion (TLIF) for degenerative disease between the years 2017 and 2022 were eligible for inclusion. Demographics and surgical characteristics were collected. Outcomes assessed included 90-day readmissions, 90-day complications, revisions, patient-reported outcomes (PROMs), cage subsidence, and screw loosening. Osteoporosis was defined as HU of ≤110 on preoperative CT at L1. RESULTS We assessed 119 patients with a mean age of 59.1, of whom 80.7% were white and 64.7% were nonsmokers. The majority underwent PLDF (63%) compared with TLIF (37%), with an average of 1.63 levels fused. Osteoporosis was diagnosed in 37.8% of the cohort with a mean HU in the osteoporotic group of 88.4 compared with 169 in nonosteoporotic patients. Although older in age, osteoporotic individuals did not exhibit increased 90-day readmissions, complications, or revisions compared with nonosteoporotic patients. A significant increase in the incidence of screw loosening was noted in the osteoporotic group with no differences observed in subsidence rates. On multivariable linear regression osteoporosis was independently associated with less improvement in visual analog scale (VAS) scores for back pain. CONCLUSIONS Osteoporosis predicts screw loosening and increased back pain. Clinicians should be advised of the importance of preoperative BMD optimization as part of their surgical planning and the utility of vertebral CT HU as a tool for risk stratification. LEVEL OF EVIDENCE 3.
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Affiliation(s)
- Rajkishen Narayanan
- Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA
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Solomito MJ, Kostyun RO, Makanji H. The PROMIS-10 Mental Health T-Score: An Independent Predictor of Recovery for Up to 1 Year After Elective Lumbar Spine Fusion. Spine (Phila Pa 1976) 2024; 49:1737-1742. [PMID: 39034689 DOI: 10.1097/brs.0000000000005103] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/28/2024] [Accepted: 07/10/2024] [Indexed: 07/23/2024]
Abstract
STUDY DESIGN Retrospective comparative cohort. OBJECTIVE Investigate how mental health, as measured by the PROMIS-10 Global Mental Health T-Score (MHT), influences a patient's recovery up to 1 year after elective lumbar fusion. SUMMARY OF BACKGROUND DATA Patients with mental health concerns in need of lumbar fusions have increased. Evidence suggests that mental disorders influence a patient's postoperative recovery; however, there is a paucity of information detailing the association between mental health and outcomes. METHODS A total of 351 patients who underwent 1- or 2-level elective lumbar fusion between April 2020 and June 2023 and completed all follow-up evaluations for up to 1 year postfusion were analyzed for this study. Patients were stratified by their MHT score (above average [AA] >50, average [A] 40-50, below average [BA] <40), regardless of mental illness diagnosis. Outcome measures including pain at hospital discharge and 3, 6, and 12 months after fusion, patient satisfaction, and the Oswestry Disability Index (ODI) score at 3, 6, and 12 months after fusion were compared among groups. RESULTS Nearly 20% of patients reported below-average mental health during their preoperative evaluation. After controlling for confounders, findings suggested that patients in the [BA] group reported 2 pain levels higher than the [AA] group at each time point and 1 point higher than the [A] group. Patients in the [BA] group performed worse on the ODI at all-time points compared with the other study groups. Patients in the [AA] group were 3 times more likely to be satisfied with their outcomes compared with the [BA] group. CONCLUSION The MHT was an independent predictor of pain, satisfaction, and ODI scores for up to 1 year post-fusion, while a mental disorder diagnosis was not. An MHT score below 40 may be a risk factor for patients undergoing elective lumbar fusion.
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Affiliation(s)
- Matthew J Solomito
- Research Department, The Bone and Joint Institute at Hartford Hospital, Hartford, CT
| | - Regina O Kostyun
- Research Department, The Bone and Joint Institute at Hartford Hospital, Hartford, CT
| | - Heeren Makanji
- Research Department, The Bone and Joint Institute at Hartford Hospital, Hartford, CT
- Orthopedic Spine Surgery, Orthopedic Associates of Hartford, Hartford, CT
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Khalil JG, Truumees E, Macadaeg K, Nguyen DT, Moore GA, Lukes D, Fischgrund J. Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials. INTERVENTIONAL PAIN MEDICINE 2024; 3:100529. [PMID: 39758714 PMCID: PMC11700295 DOI: 10.1016/j.inpm.2024.100529] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/06/2024] [Revised: 11/06/2024] [Accepted: 11/21/2024] [Indexed: 01/07/2025]
Abstract
Background Vertebrogenic pain is a documented source of anterior column chronic low back pain (CLBP) that stems from damaged vertebral endplates. Nociceptive signals are transmitted by the basivertebral nerve (BVN) and endplate damage is observed as Type 1 or Type 2 Modic changes (MC) on magnetic resonance imaging (MRI). The clinical impact and safety of intraosseous radiofrequency ablation of the BVN (BVNA) for the treatment of vertebrogenic pain has been demonstrated in three prospective clinical trials (two randomized and one single-arm study). Objective Report aggregate long-term BVNA outcomes at five years from three studies. Methods Pooled results at 5-years post-BVNA are reported for three clinical trials with similar inclusion/exclusion criteria and outcomes measurements: 1) a prospective, open label, single-arm follow-up of the treatment arm of a randomized controlled trial (RCT) comparing BVNA to sham ablation (SMART); 2) a prospective, open label, single-arm follow-up of the treatment arm of an RCT comparing BVNA to standard care (INTRACEPT); and 3) a prospective, open label, single-arm long-term follow-up study of BVNA-treated participants (CLBP Single-Arm). Paired datasets (baseline and 5-years) for mean changes in Oswestry disability index (ODI) and numeric pain scores (NPS) were analyzed using a two-sided paired t-test with a 0.05 level of significance. Secondary outcomes included responder rates, patient satisfaction, adverse events, and healthcare utilization. Results Two hundred forty-nine (249) of 320 BVNA-treated participants (78 % participation rate) completed a five-year visit (mean of 5.6 years follow-up). At baseline, 71.9 % of these participants reported back pain for ≥5 years, 27.7 % were taking opioids, and 61.8 % had prior therapeutic lumbar spinal injections. Pain and functional improvements were significant at 5-years with a mean improvement in NPS of 4.32 ± 2.45 points (95 % CI 4.01, 4.63; p < 0.0001) from 6.79 ± 1.32 at baseline and a mean improvement in ODI of 28.0 ± 17.5 (95 % CI 25.8, 30.2; p < 0.0001) from 44.5 ± 11.0 at baseline. Nearly one-third (32.1 %) of patients reported being pain-free (NPS = 0) at five years, 72.7 % of patients indicated their condition improved and 68.7 % had resumed activity levels they had prior to onset of CLBP. In the sixty-nine participants taking opioids at baseline, 65.2 % were no longer taking them at 5-years, and spinal injections decreased by 58.1 %. The rate of lumbosacral treatment (therapeutic spinal injection, radiofrequency ablation, or surgery) for the same index pain source and vertebral level was 33/249 (13.2 %) at 5 years post BVNA; including a 6.0 % rate of lumbar fusion. There were no serious device or device-procedure related adverse events reported during the long-term follow-up. Conclusion In this 5-year aggregate analysis, BVNA significantly improved pain and function scores compared to baseline. Similarly, there were significant reductions in opioid consumption and spinal injections post BVNA. Data demonstrate a strong safety profile with no serious device or device-related events and low healthcare utilization rate for the same index pain source through a mean of 5.6 years. Results demonstrate that intraosseous BVNA treatment for patients with vertebrogenic pain is safe, effective, and durable through five years.
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Affiliation(s)
- Jad G. Khalil
- Orthopaedic Surgery, Oakland University, William Beaumont School of Medicine, Department of Orthopaedic Surgery, Beaumont University Hospital, 3811 West 13 Mile Rd, Royal Oak, MI, 48073, USA
| | - Eeric Truumees
- Orthopaedic and Neurological Surgery, University of Texas, Dell Medical School, Ascension Spine & Scoliosis Center, Ascension Seton Medical Center, 1004 West 32nd Street #200, Austin, TX, 78705, USA
| | - Kevin Macadaeg
- Indiana Spine Group, 13225 N Meridian St, Carmel, IN, 46032, USA
- Indiana University School of Medicine, Department of Anesthesiology, IN, USA
| | - Daniel T.D. Nguyen
- Comprehensive Specialty Care, Neuroradiology & Pain Solutions of Oklahoma, 1023 Waterwood Parkway, Edmond, OK, 73034, USA
| | - Gregory A. Moore
- Pacific Sports and Spine, 217 Division Avenue, Eugene, OR, 97404, USA
| | - Dylan Lukes
- Statistics & Data Management, 730 Second Avenue South, Suite 500, Minneapolis, MN, 55402, USA
| | - Jeffrey Fischgrund
- Department of Orthopaedic Surgery, William Beaumont University Hospital, 3811 West 13 Mile Rd, Royal Oak, MI, USA
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Park SM, Song KS, Ham DW, Kim HJ, Kang MS, You KH, Park CK, Lee DK, Kim JS, Lee HJ, Park HJ. Safety Profile of Biportal Endoscopic Spine Surgery Compared to Conventional Microscopic Approach: A Pooled Analysis of 2 Randomized Controlled Trials. Neurospine 2024; 21:1190-1198. [PMID: 39765264 PMCID: PMC11744543 DOI: 10.14245/ns.2448718.359] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/20/2024] [Revised: 08/27/2024] [Accepted: 09/03/2024] [Indexed: 01/23/2025] Open
Abstract
OBJECTIVE To compare the safety profiles of biportal endoscopic spinal surgery (BESS) and microscopic spinal surgery (MSS) for lumbar disc herniation and spinal stenosis by analyzing the associated adverse events. METHODS We pooled data from 2 prospective randomized controlled trials involving 220 patients (110 in each group) who underwent single-level lumbar surgery. Participants aged 20-80 years with radiating pain due to lumbar disc herniation or spinal stenosis were included in this study. Adverse events were recorded and analyzed over a 12-month follow-up period. RESULTS The overall adverse event rates were 9.1% (10 of 110) in the BESS group and 17.3% (19 of 110) in the MSS group, which were not statistically significantly different (p=0.133). Notably, wound dehiscence occurred in 8.2% of MSS cases but in none of the BESS cases. Both groups showed similarly low rates of complications, such as dural tears, epidural hematoma, and nerve root injury. The most common adverse event in the BESS group was recurrent disc herniation (2.7%), whereas that in the MSS group was wound dehiscence (8.2%). CONCLUSION BESS demonstrated a safety profile comparable to that of MSS for the treatment of lumbar disc herniation and spinal stenosis, with a trend towards fewer overall complications. BESS offers particular advantages in terms of reducing wound-related complications. These findings suggest that BESS is a safe alternative to conventional MSS and potentially offers the benefits of a minimally invasive approach without compromising patient safety.
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Affiliation(s)
- Sang-Min Park
- Spine Center and Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
| | - Kwang-Sup Song
- Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
| | - Dae-Woong Ham
- Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
| | - Ho-Joong Kim
- Spine Center and Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
| | - Min-Seok Kang
- Department of Orthopedics Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
| | - Ki-Han You
- Department of Orthopedic Surgery, Spine Center, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
| | - Choon Keun Park
- Department of Neurosurgery, The Leon Wiltse Memorial Hospital, Suwon, Korea
| | - Dong-Keun Lee
- Department of Neurosurgery, The Leon Wiltse Memorial Hospital, Suwon, Korea
| | - Jin-Sung Kim
- Department of Neurosurgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea
| | - Hong-Jae Lee
- Department of Neurosurgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Daejeon, Korea
| | - Hyun-Jin Park
- Department of Orthopedic Surgery, Spine Center, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
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Makanji H, Solomito MJ. The oswestry disability index in elective single level lumbar fusion: Is 3 months follow up enough? NORTH AMERICAN SPINE SOCIETY JOURNAL 2024; 20:100571. [PMID: 39759222 PMCID: PMC11697366 DOI: 10.1016/j.xnsj.2024.100571] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/26/2024] [Revised: 11/01/2024] [Accepted: 11/02/2024] [Indexed: 01/07/2025]
Abstract
Background Prospective, longitudinal collection of patients reported outcomes (PRO) has become an essential metric in orthopedics. Despite the utility of PROs, data collection presents a significant challenge to the healthcare system. There is a need to better understand if serial data collection over a 1 to 2 year postoperative period is truly warranted. The purpose of this study was to determine if continued PRO collection after 3 months postop is needed in patients that underwent lumbar fusion. Methods This retrospective study utilized 239 patients that underwent an elective single level lumbar fusion between April 1, 2020 and February 1, 2023. Changes in the Oswestry Disability Index (ODI) scores over a 1 year period were assessed for all patients. Patients were placed into 1 of 3 study groups, those that improved by 10 points, those that worsened by 10 points, and those that did not change (score change less than 10 points in either direction). Movement between study groups, the minimal clinical important difference (MCID), and patient satisfaction were analyzed for each patient. Results Improvement between preoperative and the 3 month postoperative evaluations was noted for most patients. There was limited change in scores after 3 months. Patients in the improved group continued to improve through 1 year postoperative. Patients in the worsened group continued to decline by 1 year postoperative. Patients in the no change group demonstrated the highest potential to change groups. Conclusions Patients with substantial improvement or worsening at 3 months have a low likelihood of substantial clinical change thereafter. This subset of patients may not need further evaluation with PROs, but those in the worsened group may benefit from other interventions to potentially alter their course.
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Affiliation(s)
- Heeren Makanji
- Research Department, Hartford HealthCare Bone and Joint Institute, Hartford, CT, United States of America
- Orthopaedic Associates of Hartford, Hartford, CT, United States of America
| | - Matthew J. Solomito
- Research Department, Hartford HealthCare Bone and Joint Institute, Hartford, CT, United States of America
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Duculan R, Mancuso CA, Hambrecht J, Cammisa FP, Sama AA, Hughes AP, Lebl DR, Girardi FP. Previous Hip or Knee Arthroplasty is Associated With Less Favorable Patient-reported Outcomes of Lumbar Surgery. Clin Spine Surg 2024:01933606-990000000-00412. [PMID: 39588982 DOI: 10.1097/bsd.0000000000001744] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/20/2024] [Accepted: 11/06/2024] [Indexed: 11/27/2024]
Abstract
STUDY DESIGN Review of cohort studies. OBJECTIVE To ascertain if previous hip (THA) or knee (TKA) arthroplasty was associated with patients' outcomes assessments of subsequent lumbar surgery, specifically overall satisfaction, less disability due to pain, and an affective appraisal reflecting emotional assessment of results. BACKGROUND Hip, knee, and lumbar symptoms often co-exist and increasingly are managed with surgery. Whether previous total joint arthroplasty (TJA) impacts patients' perspectives of results of subsequent lumbar surgery is not known. METHODS Identical and systematically acquired preoperative and postoperative data from 3 studies assessing psychosocial characteristics and outcomes of lumbar surgery were pooled. Data obtained during interviews included preoperative demographic and clinical variables and 2-year postoperative global overall assessment (very satisfied/satisfied, neither, dissatisfied/very dissatisfied) and global affective assessment (delighted/pleased, mostly satisfied/mixed/mostly dissatisfied, unhappy/terrible). Patients completed the ODI and preoperative to postoperative change was analyzed according to an MCID (15 points). At 2 years patients also reported any untoward events since surgery (ie, fracture, infection, or repeat lumbar surgery). Associations with outcomes were assessed with multivariable logistic ordinal regression controlling for untoward events. Type of arthroplasty was evaluated in subanalyses. RESULTS Among 1227 patients (mean: 59 y, 50% women), 12% had arthroplasty (+TJA) and 88% did not (-TJA). In multivariable analysis, +TJA was associated with less global satisfaction (OR: 1.9, CI: 1.3-2.7, P=0.0007), worse global affective assessment (OR: 1.6, CI: 1.1-2.2, P=0.009), and not meeting MCID15 (OR: 1.5, CI: 1.0-2.3, P=0.05). Covariables associated with less favorable outcomes were not working, positive depression screen, and prior lumbar surgery. Compared with -TJA, patients with THA had worse affective assessments and patients with TKA had less satisfaction and were less likely to meet MCID15. CONCLUSIONS Previous hip or knee arthroplasty was associated with less favorable patient-reported outcomes of lumbar surgery. Surgeons and patients should discuss differences between procedures preoperatively and during shared postoperative outcome assessment. LEVEL OF EVIDENCE Level II.
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Affiliation(s)
| | - Carol A Mancuso
- Hospital for Special Surgery
- Weill Cornell Medical College, New York, NY
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Leyendecker J, Prasse T, Rückels P, Köster M, Rumswinkel L, Schunk V, Marossa I, Eysel P, Bredow J, Hofstetter CP, Khan I. Full-endoscopic spine-surgery in the elderly and patients with comorbidities. Sci Rep 2024; 14:29188. [PMID: 39587174 PMCID: PMC11589573 DOI: 10.1038/s41598-024-80235-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2024] [Accepted: 11/18/2024] [Indexed: 11/27/2024] Open
Abstract
Due to demographic changes, a growing number of elderly patients with comorbidities will require spine surgery in the next decades. However, age and multimorbidity have been associated with considerably worse postoperative outcomes, and is often associated with surgical invasiveness. Full-endoscopic spine-surgery (FESS), as a cornerstone of contemporary minimally invasive surgery, has the potential to mitigate some of these disparities. Thus, we conducted an analysis of all FESS cases at a national center. Utilizing the Charlson Comorbidity index (CCI) ≥ 3 as a frailty surrogate we separated patients in two groups for patients with and without comorbidities. Patients with (CCI) ≥ 3 exhibited a higher age (p < 0.001), and number of comorbidities (p < 0.001) than the control group. Thereafter, a propensity score matching was done to adjust for potential confounders. Postoperative safety measures in emergency department utilization, and clinic readmission did not significantly differ between the groups. Furthermore, patients of both groups reported similar postoperative pain improvements. However, patients with a (CCI) ≥ 3 were treated as inpatients more often (p < 0.001), had a higher length of stay (p < 0.001) and a smaller functional improvement after at a chronic postoperative timepoint (p = 0.045). The results underline safety and efficacy of FESS in patients with comorbidities. Additionally, they provide guidance for preoperative patient counselling and resource utilization when applying FESS in frail patients.
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Affiliation(s)
- Jannik Leyendecker
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA.
| | - Tobias Prasse
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA
| | - Pia Rückels
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA
- Department of Orthopedics and Trauma Surgery, Krankenhaus Porz am Rhein, University of Cologne, Cologne, Germany
| | - Malin Köster
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
| | - Lena Rumswinkel
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
| | - Valentina Schunk
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
| | - Isabella Marossa
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA
| | - Peer Eysel
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
| | - Jan Bredow
- Department of Orthopedics and Trauma Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
- Department of Orthopedics and Trauma Surgery, Krankenhaus Porz am Rhein, University of Cologne, Cologne, Germany
| | - Christoph P Hofstetter
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA
| | - Imad Khan
- Department of Neurological Surgery, University of Washington, 325 9th Avenue, Box 359924, Seattle, WA, 98104, USA
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Yang JH, Lee KJ, Lee SY, Kim IH, Seok SY, Suh H, Lee HR. Effects of Vacuum Phenomenon on Cage Subsidence and Fusion Outcomes in Oblique Lumbar Interbody Fusion: A Cohort Study. J Clin Med 2024; 13:7036. [PMID: 39685493 DOI: 10.3390/jcm13237036] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2024] [Revised: 11/05/2024] [Accepted: 11/20/2024] [Indexed: 12/18/2024] Open
Abstract
Background: Oblique lumbar interbody fusion (OLIF) is a minimally invasive technique used to manage degenerative lumbar conditions. The presence of vacuum phenomenon (VP) and associated endplate sclerosis may increase the risk of cage subsidence. This study evaluated the relationship between VP grade, endplate sclerosis, and subsidence in OLIF. Methods: This retrospective cohort study included 165 patients who underwent a single-level OLIF for lumbar stenosis. Patients were stratified into VP grades (0-3) based on preoperative computed tomography scans. Disc height, endplate sclerosis, and cage subsidence were radiologically assessed. Clinical outcomes, including back and leg pain visual analog scale, Oswestry Disability Index, and EuroQol-5 Dimension, were measured preoperatively and at follow-up. Results: High VP grades were associated with low preoperative disc height and increased endplate sclerosis. Although no significant differences in clinical outcomes or final fusion rates across VP grades were observed, the subsidence rate increased with VP grade, with a significant difference between VP grades 1 and 2 (p = 0.045) and between VP grades 2 and 3 (p = 0.032), indicating that subsidence rates increased as the VP grade advanced. Conclusions: High VP grades, particularly grades 2 and 3, may increase the risk of cage subsidence following OLIF. Therefore, VP grading may be worth considering during surgical planning to reduce the subsidence risk and improve outcomes.
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Affiliation(s)
- Jae-Hyuk Yang
- Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul 02708, Republic of Korea
| | - Kun-Joon Lee
- College of Medicine, Korea University, Seoul 02841, Republic of Korea
| | - Seung-Yup Lee
- Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul 02708, Republic of Korea
| | - In-Hee Kim
- National Police Hospital, Seoul 05715, Republic of Korea
| | - Sang Yun Seok
- Department of Orthopedic Surgery, Daejeon Eulji University Hospital, Daejeon 35233, Republic of Korea
| | - Hansongi Suh
- Department of Business Administration, Yonsei University School of Business, Seoul 03722, Republic of Korea
| | - Hyung Rae Lee
- Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul 02708, Republic of Korea
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Alvani E, Sheikhi B, Letafatkar A, Rossettini G. Effects of pain neuroscience education combined with neuromuscular exercises on pain, functional disability and psychological factors in chronic low back pain: A study protocol for a single-blind randomized controlled trial. PLoS One 2024; 19:e0309679. [PMID: 39495728 PMCID: PMC11534247 DOI: 10.1371/journal.pone.0309679] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/23/2024] [Accepted: 08/12/2024] [Indexed: 11/06/2024] Open
Abstract
OBJECTIVE Chronic low back pain (CLBP) is a prevalent health condition worldwide. Several therapeutic interventions aim to improve CLBP. Pain Neuroscience Education (PNE) helps patients better understand their pain from biological and physiological perspectives, which clinicians use to reduce pain and disability in patients with chronic musculoskeletal conditions. Neuromuscular exercises (NMS) are also treatments adopted in CLBP. This study will investigate whether PNE combined with an NMS program improves pain, functional and psychological outcomes more than NMS alone in patients with CLBP. METHODS In this single-blind randomized controlled trial, 60 patients (male and female; age range, 30-60 years) diagnosed with CLBP will be randomly assigned to one of the following groups: (1) PNE plus NMS (n = 30; 24 sessions of PNE plus NMS in a total of 8 weeks, 3 each week), and (2) NMS alone (n = 30; 24 sessions of NMS sessions in a total of 8 weeks, 3 each week). Outcome assessors will be blinded to the group allocation. The primary outcome will be pain. Secondary outcomes will be disability, fear-avoidance beliefs about work and physical activity, self-efficacy, exercise anxiety, and kinesiophobia. Outcomes will be assessed at baseline, after 8 weeks of intervention, and 6 months post-intervention. DISCUSSION The findings of this RCT will help shed light on new treatment strategies to address the biopsychosocial dimensions of CLBP. The study protocol will be conducted in a clinical setting, offering the opportunity for future implementation in healthcare systems. Moreover, it will help clarify whether a combined treatment (PNE with NMS) is more effective than NMS alone for improving pain, functional and psychological outcomes in CLBP. TRIAL REGISTRATION Study registration: The study was prospectively registered in the Iranian Registry of Clinical Trials-IRCT20190427043384N2 (https://www.irct.ir/trial/69146). Registered on March 17, 2023.
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Affiliation(s)
- Ehsan Alvani
- Faculty of Physical Education and Sport Sciences, Department of Biomechanics and Sport Injuries, Kharazmi University, Tehran, Iran
| | - Bahram Sheikhi
- Faculty of Physical Education and Sport Sciences, Department of Biomechanics and Sport Injuries, Kharazmi University, Tehran, Iran
| | - Amir Letafatkar
- Faculty of Physical Education and Sport Sciences, Department of Biomechanics and Sport Injuries, Kharazmi University, Tehran, Iran
| | - Giacomo Rossettini
- School of Physiotherapy, University of Verona, Verona, Italy
- Faculty of Sport Sciences, Department of Physiotherapy, Universidad Europea de Madrid, Calle Tajo s/n, Villaviciosa de Odón, Spain
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Pierce KE, Mir JM, Dave P, Lafage R, Lafage V, Park P, Nunley P, Mundis G, Gum J, Tretiakov P, Uribe J, Hostin R, Eastlack R, Diebo B, Kim HJ, Smith JS, Ames CP, Shaffrey C, Burton D, Hart R, Bess S, Klineberg E, Schwab F, Gupta M, Hamilton DK, Passias PG. The Incremental Clinical Benefit of Adding Layers of Complexity to the Planning and Execution of Adult Spinal Deformity Corrective Surgery. Oper Neurosurg (Hagerstown) 2024; 27:573-580. [PMID: 38771063 DOI: 10.1227/ons.0000000000001192] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2023] [Accepted: 03/01/2024] [Indexed: 05/22/2024] Open
Abstract
BACKGROUND AND OBJECTIVES For patients with surgical adult spinal deformity (ASD), our understanding of alignment has evolved, especially in the last 20 years. Determination of optimal restoration of alignment and spinal shape has been increasingly studied, yet the assessment of how these alignment schematics have incrementally added benefit to outcomes remains to be evaluated. METHODS Patients with ASD with baseline and 2-year were included, classified by 4 alignment measures: Scoliosis Research Society (SRS)-Schwab, Age-Adjusted, Roussouly, and Global Alignment and Proportion (GAP). The incremental benefits of alignment schemas were assessed in chronological order as our understanding of optimal alignment progressed. Alignment was considered improved from baseline based on SRS-Schwab 0 or decrease in severity, Age-Adjusted ideal match, Roussouly current (based on sacral slope) matching theoretical (pelvic incidence-based), and decrease in proportion. Patients separated into 4 first improving in SRS-Schwab at 2-year, second Schwab improvement and matching Age-Adjusted, third two prior with Roussouly, and fourth improvement in all four. Comparison was accomplished with means comparison tests and χ 2 analyses. RESULTS Sevenhundredthirty-two. patients met inclusion. SRS-Schwab BL: pelvic incidence-lumbar lordosis mismatch (++:32.9%), sagittal vertical axis (++: 23%), pelvic tilt (++:24.6%). 640 (87.4%) met criteria for first, 517 (70.6%) second, 176 (24%) third, and 55 (7.5%) fourth. The addition of Roussouly (third) resulted in lower rates of mechanical complications and proximal junctional kyphosis (48.3%) and higher rates of meeting minimal clinically important difference (MCID) for physical component summary and SRS-Mental ( P < .05) compared with the second. Fourth compared with the third had higher rates of MCID for ODI (44.2% vs third: 28.3%, P = .011) and SRS-Appearance (70.6% vs 44.8%, P < .001). Mechanical complications and proximal junctional kyphosis were lower with the addition of Roussouly ( P = .024), while the addition of GAP had higher rates of meeting MCID for SRS-22 Appearance ( P = .002) and Oswestry Disability Index ( P = .085). CONCLUSION Our evaluation of the incremental benefit that alignment schemas have provided in ASD corrective surgery suggests that the addition of Roussouly provided the greatest reduction in mechanical complications, while the incorporation of GAP provided the most significant improvement in patient-reported outcomes.
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Affiliation(s)
- Katherine E Pierce
- Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital, New York Spine Institute, New York , New York , USA
| | - Jamshaid M Mir
- Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital, New York Spine Institute, New York , New York , USA
| | - Pooja Dave
- Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital, New York Spine Institute, New York , New York , USA
| | - Renaud Lafage
- Department of Orthopedic, Lenox Hill Hospital, Northwell, New York , New York , USA
| | - Virginie Lafage
- Department of Orthopedic, Lenox Hill Hospital, Northwell, New York , New York , USA
| | - Paul Park
- Department of Neurologic Surgery, University of Michigan, Ann Arbor , Michigan , USA
| | - Pierce Nunley
- Spine Institute of Louisiana, Shreveport , Louisiana , USA
| | - Gregory Mundis
- San Diego Center for Spinal Disorders, La Jolla , California , USA
| | - Jeffrey Gum
- Norton Leatherman Spine Center, Louisville , Kentucky , USA
| | - Peter Tretiakov
- Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital, New York Spine Institute, New York , New York , USA
| | - Juan Uribe
- Department of Neurosurgery, University of South Florida, Tampa , Florida , USA
| | - Richard Hostin
- Department of Orthopaedic Surgery, Baylor Scoliosis Center, Dallas , Texas , USA
| | - Robert Eastlack
- Division of Orthopaedic Surgery, Scripps Clinic, La Jolla , California , USA
| | - Bassel Diebo
- Department of Orthopedic Surgery, SUNY Downstate, New York , New York , USA
| | - Han Jo Kim
- Department of Orthopedic, Lenox Hill Hospital, Northwell, New York , New York , USA
| | - Justin S Smith
- Department of Neurosurgery, University of Virginia, Charlottesville , Virginia , USA
| | - Christopher P Ames
- Department of Neurological Surgery, University of California, San Francisco, San Francisco , California , USA
| | - Christopher Shaffrey
- Departments of Neurosurgery and Orthopaedic Surgery, Duke University Medical Center, Durham , North Carolina , USA
| | - Douglas Burton
- Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City , Kansas , USA
| | - Robert Hart
- Department of Orthopaedic Surgery, Swedish Neuroscience Institute, Seattle , Washington , USA
| | - Shay Bess
- Department of Spine Surgery, Denver International Spine Clinic, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver , Colorado , USA
| | - Eric Klineberg
- Department of Orthopaedic Surgery, University of California, Davis, Davis , California , USA
| | - Frank Schwab
- Department of Orthopedic, Lenox Hill Hospital, Northwell, New York , New York , USA
| | - Munish Gupta
- Department of Orthopaedic Surgery, Washington University, St. Louis , Missouri , USA
| | - D Kojo Hamilton
- Departments of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh , Pennsylvania , USA
| | - Peter G Passias
- Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital, New York Spine Institute, New York , New York , USA
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Mukherjee RN, Pandey K, Kumar AG, Phalak M, Borkar S, Garg K, Chandra SP, Kale SS. Comparison of functional outcomes and patient satisfaction in patients with lumbar canal stenosis with and without concomitant obesity following lumbar decompression surgery and their correlation with BMI. J Clin Neurosci 2024; 129:110840. [PMID: 39293321 DOI: 10.1016/j.jocn.2024.110840] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/10/2024] [Accepted: 09/08/2024] [Indexed: 09/20/2024]
Abstract
BACKGROUND Obesity is an important predictor of development of Lumbar canal stenosis (LCS) and its symptoms. LCS further restricts the mobility of the patient and a vicious cycle develops. The operative decision on patients with LCS and obesity is a matter of debate. Hence, we attempted to compare changes in body mass index and patient satisfaction in patients with LCS with and without concomitant obesity, undergoing spinal decompression surgery. METHODS Patients undergoing decompression for LCS between 1st June 2019 to 31st May 2020 were included. Baseline characteristics including age, sex, co-morbidities, BMI, self-recorded maximal walking distance (SR-MWD) and Oswestry disability index score (ODI) were recorded. All patients were followed up prospectively at 1 year post surgery. Satisfaction was recorded on a five-point Likert scale. Participants were classified into non obesity (group 1) and obesity (group 2) groups according to JAPI and WHO classification and compared. RESULTS 55 patients met the inclusion criteria, 23 in group 1 and 32 in group 2. Group 2 showed a mean decrease in BMI of 0.95 ± 1.32 kg/m2 while other group had an increase of 0.14 ± 1.31 kg/m2 (p = 0.021). Significant weight change was seen in 31.3 % group 2 vs 8.7 % group 1 patients which was significant (p = 0.046). Pre operative BMI positively correlated with change in BMI after surgery (r = 0.406, p = 0.001) and with percentage weight reduction (r = 0.321, p = 0.017). Both the groups were comparable in improvement in ODI and SR-MWD scores and patient satisfaction. CONCLUSION Patients with obesity achieve significant reduction in weight and BMI following decompression surgery for LCS. It will further prevent other health conditions attributed to obesity. Both the groups were comparable in ODI, SR-MWD and satisfactory outcome following surgery. Hence obesity should not be a deterring factor for surgical consideration for patients with lumbar canal stenosis.
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Affiliation(s)
| | - Kushagra Pandey
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
| | - Akshay Ganesh Kumar
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
| | - Manoj Phalak
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
| | - Sachin Borkar
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
| | - Kanwaljeet Garg
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
| | - Sarat P Chandra
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
| | - Shashank Sharad Kale
- Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
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50
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Subramanian T, Maayan O, Shahi P, Du J, Araghi K, Amen TB, Shinn D, Song J, Dalal S, Sheha E, Dowdell J, Iyer S, Qureshi SA. Early Experiences With Single-Position Prone Lateral Lumbar Interbody Fusion: Safety and Outcomes. HSS J 2024; 20:515-521. [PMID: 39494427 PMCID: PMC11528793 DOI: 10.1177/15563316231183379] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/17/2023] [Accepted: 04/21/2023] [Indexed: 11/05/2024]
Abstract
Background Performing lateral lumbar interbody fusion (LLIF) in a single prone position may pose many advantages over the traditional lateral decubitus position, but there are questions concerning its safety profile and outcomes. Purpose We sought to study the safety and efficacy of LLIF performed with the patient in the prone position. Methods We conducted a retrospective cohort study including patients who underwent primary LLIF in the prone position for degenerative lumbar conditions. Complications and patient-reported outcome measures (PROMs) (Oswestry Disability Index [ODI], and visual analogue scale [VAS] scores for leg and back pain) were collected. Patients who underwent single-position prone LLIF were then propensity score matched for age, race, comorbidity index, number of levels, body mass index, and smoking status with patients who underwent single-position lateral LLIF. Patient-reported outcome measures and complications were compared between the 2 groups. Two postoperative timepoints were defined: early (<6 months) and late (≥6 months). Results Twenty single-position prone LLIF patients were included (35% 1-level, 35% 2-level, 15% 3-level, and 15% 4-level). No intraoperative complications were reported. Eleven (55%) patients experienced transient postoperative anterior thigh weakness. Five (25%) patients experienced postoperative complications such as anemia, urinary retention, ileus, and new-onset sensory symptoms. Oswestry Disability Index, VAS leg, and VAS back scores all improved at the >6-month time point compared with preoperative states. There were no significant differences at any postoperative time point for PROMs between prone and lateral LLIF groups. Among the matched cohort, complications were observed in 3 (21%) of patients compared with only 1 (7%) in the lateral group although this difference was not statistically significant. Conclusion This retrospective study suggests that prone LLIF procedures may be safe and effective. Ergonomic and logistic benefits from the approach may make it a beneficial approach for surgeons to begin implementing.
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Affiliation(s)
- Tejas Subramanian
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medicine, New York, NY, USA
| | - Omri Maayan
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medicine, New York, NY, USA
| | - Pratyush Shahi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Jerry Du
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Kasra Araghi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Troy B. Amen
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Daniel Shinn
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
- Weill Cornell Medicine, New York, NY, USA
| | - Junho Song
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Sidhant Dalal
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Evan Sheha
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - James Dowdell
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Sravisht Iyer
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
| | - Sheeraz A. Qureshi
- Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA
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