Raikwar SP, Raikwar AS, Chaurasia SS, Mohan RR. Gene editing for corneal disease management. World J Transl Med 2016; 5(1): 1-13 [PMID: 35757280 DOI: 10.5528/wjtm.v5.i1.1]
Corresponding Author of This Article
Rajiv R Mohan, PhD, FARVO, Professor, Ophthalmology and Molecular Medicine, One-health One-Medicine Ophthalmology and Vision Research, University of Missouri, 1600 E. Rollins Road, Columbia, MO 65211, United States. mohanr@health.missouri.edu
Research Domain of This Article
Cell Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transl Med. Apr 12, 2016; 5(1): 1-13 Published online Apr 12, 2016. doi: 10.5528/wjtm.v5.i1.1
Gene editing for corneal disease management
Sudhanshu P Raikwar, Apoorva S Raikwar, Shyam S Chaurasia, Rajiv R Mohan
Sudhanshu P Raikwar, Shyam S Chaurasia, Rajiv R Mohan, Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, United States
Sudhanshu P Raikwar, Rajiv R Mohan, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201, United States
Apoorva S Raikwar, Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
Rajiv R Mohan, Mason Eye Institute, School of Medicine, University of Missouri, Columbia, MO 65212, United States
Rajiv R Mohan, Ophthalmology and Molecular Medicine, One-health One-Medicine Ophthalmology and Vision Research, University of Missouri, Columbia, MO 65211, United States
Author contributions: Raikwar SP made substantial contributions in study design, literature, review, drafting the article and making critical revisions; Raikwar AS made graphic design; Chaurasia SS made critical reading; Mohan RR made substantial contributions in conception, study design, critical reading, graphic design, final approval, and submission of manuscript.
Supported by Veteran Health Affairs Merit grant, No. 1I01BX000357-05 (to Mohan RR); National Eye Institute, NIH grant, R01EY017294 (to Mohan RR); and the Ruth M. Kraeuchi Missouri Endowment of Ophthalmology (to Mohan RR).
Conflict-of-interest statement: There is no conflict of interest.
Correspondence to: Rajiv R Mohan, PhD, FARVO, Professor, Ophthalmology and Molecular Medicine, One-health One-Medicine Ophthalmology and Vision Research, University of Missouri, 1600 E. Rollins Road, Columbia, MO 65211, United States. mohanr@health.missouri.edu
Telephone: +1-573-8841449 Fax: +1-573-8844100
Received: September 29, 2015 Peer-review started: October 2, 2015 First decision: November 10, 2015 Revised: November 21, 2015 Accepted: March 7, 2016 Article in press: March 9, 2016 Published online: April 12, 2016 Processing time: 69 Days and 0.3 Hours
Core Tip
Core tip: Gene editing technology including Clustered Regularly Interspaced Short Palindromic Repeats/Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9, zinc finger nucleases, or transcription activator like effector nucleases has great potential for generating in vitro and in vivo models of corneal diseases including keratoconus and Fuchs’ endothelial corneal dystrophy. Furthermore, gene editing is a powerful tool for studying molecular mechanisms mediating corneal development, pathogenesis and developing next generation innovative gene therapies including the patient-specific personalized medicine for curing corneal diseases. This review discusses current status and latest developments in the field of gene editing. Gene editing based molecular therapy has the potential to revolutionize current practices in ophthalmology clinic for curing corneal blindness.
