©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transl Med. Dec 12, 2015; 4(3): 60-68
Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.60
Published online Dec 12, 2015. doi: 10.5528/wjtm.v4.i3.60
Contributions of neutrophils to the adaptive immune response in autoimmune disease
Kathryn M Pietrosimone, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Peng Liu, Department of Medicine and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Author contributions: Both authors contributed to this paper.
Supported by The National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIAMS-NIH), No. 1R01AR063132.
Conflict-of-interest statement: The authors declare no conflict of interest.
Correspondence to: Peng Liu, MD, PhD, Department of Medicine and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Thurston Building, CB#7280, Chapel Hill, NC 27599, United States. liupz@med.unc.edu
Telephone: +1-919-9660570 Fax: +1-919-9669269
Received: June 29, 2015
Peer-review started: July 4, 2015
First decision: September 17, 2015
Revised: October 3, 2015
Accepted: November 23, 2015
Article in press: November 25, 2015
Published online: December 12, 2015
Processing time: 200 Days and 12.2 Hours
Peer-review started: July 4, 2015
First decision: September 17, 2015
Revised: October 3, 2015
Accepted: November 23, 2015
Article in press: November 25, 2015
Published online: December 12, 2015
Processing time: 200 Days and 12.2 Hours
Core Tip
Core tip: Neutrophils guide the adaptive immune response in persistent inflammation by directly and indirectly interacting with T and B cells. Understanding and manipulating these roles of neutrophils will lead to novel therapeutic approaches to prevent and treat autoimmune diseases, such as rheumatoid arthritis.