Epigenetics and DNA methylation in cancer

doi:10.5528/wjtm.v4.i1.11

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue 1

This Article

Peer-Review Report of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (21977)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-13) series, Tables (1-5) series.

Item

Count

PDF

1096

WORD

495

HTML

12502

Figures (1-13)

953

Tables (1-5)

523

Sum=15569

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

804

Download

2147

Sum=2951

Publishing Process of This Article

Item

Count

Browse

1499

Download

1948

Sum=3447

Apr 12, 2015 (publication date) through Feb 19, 2026

Times Cited of This Article

Times Cited (6)

Journal Information of This Article

Publication Name

World Journal of Translational Medicine

ISSN

2220-6132

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Review

World J Transl Med. Apr 12, 2015; 4(1): 11-24
Published online Apr 12, 2015. doi: 10.5528/wjtm.v4.i1.11

Epigenetics and DNA methylation in cancer

Laura Lattanzio, Cristiana Lo Nigro

Laura Lattanzio, Cristiana Lo Nigro, Laboratory Cancer Genetics and Translational Oncology, Medical Oncology, S. Croce University Hospital, 12100 Cuneo, Italy

Author contributions: Lattanzio L and Lo Nigro C contributed to this paper.

Conflict-of-interest: The authors declare that they have no conflict of interest.

Correspondence to: Cristiana Lo Nigro, PhD, Laboratory Cancer Genetics and Translational Oncology, Medical Oncology, S. Croce University Hospital, Via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it

Telephone: +39-0171-616338 Fax: +39-0171-616331

Received: August 8, 2014
Peer-review started: August 9, 2014
First decision: October 14, 2014
Revised: February 19, 2015
Accepted: March 18, 2015
Article in press: March 20, 2015
Published online: April 12, 2015
Processing time: 249 Days and 1.5 Hours

Core Tip

Core tip: Carcinogenesis occurs through a combination of mutational and epimutational alterations involving key pathways in cellular growth and division. Tumour cells exhibit two main differences from normal cells in DNA methylation: a global reduction in DNA methylation and the hypermethylation of specific sequences, mainly CpG islands, that cause the transcriptional silencing of tumour suppressor genes, thus directly driving the carcinogenic. In this review, we’ll focus on our current understanding of this process, aiming to discuss how the analysis of cancer methylomes and the re-expression of epigenetically silenced genes have potential uses in developing more effective cancer therapies.