©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transl Med. Feb 12, 2026; 12(1): 113050
Published online Feb 12, 2026. doi: 10.5528/wjtm.v12.i1.113050
Published online Feb 12, 2026. doi: 10.5528/wjtm.v12.i1.113050
Tumor organoids in translational cancer research: Models for personalized therapy
Himanshu Agrawal, Himanshu Tanwar, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India
Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India
Author contributions: Agrawal H and Gupta N contributed to research conception and design, critical revision of the manuscript; Agrawal H and Tanwar H contributed to Data acquisition; Tanwar H and Agrawal H contributed to drafting of the manuscript; Gupta N contributed to supervision; all of the authors contributed to data analysis and interpretation, approval of the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Nikhil Gupta, Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Received: August 14, 2025
Revised: September 29, 2025
Accepted: January 4, 2026
Published online: February 12, 2026
Processing time: 181 Days and 18.1 Hours
Revised: September 29, 2025
Accepted: January 4, 2026
Published online: February 12, 2026
Processing time: 181 Days and 18.1 Hours
Core Tip
Core Tip: Tumor organoids are a promising tool for personalized cancer therapy, offering patient-specific models that replicate the tumor’s genetic, phenotypic, and microenvironmental characteristics for more effective treatment strategies.