Kidney transplantation in obese Black patients: Strategies to improve access and outcomes

doi:10.5527/wjn.v15.i1.114527

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Mar 25, 2026 (publication date) through Mar 14, 2026

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Mar 25, 2026; 15(1): 114527
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.114527

Table 1 Potential factors contributing to kidney graft dysfunction in obese Black patients

Modifiable factors	Effect on kidney graft dysfunction	Non-modifiable factors	Effect on kidney graft dysfunction
Increasing waiting time	Enhance	APOL1	Enhance
Hypertension	Enhance	MYH9 gene	Enhance
Cardiovascular risk factors	Enhance	CYP3A5	Enhance
Induction protocol; alemtuzumab; OKT3; ATG vs IL-2 Ab	Reduce	MDR1 polymorphism	Enhance
Poor medication compliance	Enhance
Persistent proteinuria	Enhance
New onset diabetes after transplant	Enhance
Increased leptin: Adiponectin ration	Enhance
Obesity	Enhance

OKT3: Muromonab (anti-CD3); ATG: Anti-thymocyte globulin; IL-2 Ab: Anti-interleukin-2 receptor antibody; APOL1: Apolipoprotein L1; MYH9: Myosin heavy chain 9; CYP3A5: Cytochrome P450 family 3 subfamily A member 5; MDR1: Multidrug resistance mutation 1.

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Citation: Oluyombo R, Karim M, Mason S, Halawa A. Kidney transplantation in obese Black patients: Strategies to improve access and outcomes. World J Nephrol 2026; 15(1): 114527
URL: https://www.wjgnet.com/2220-6124/full/v15/i1/114527.htm
DOI: https://dx.doi.org/10.5527/wjn.v15.i1.114527