Factors associated with acute kidney injury in rhabdomyolysis: Insights from a prospective study

Figure 1 Flowchart of patient selection. ICU: Intensive care unit; CKD: Chronic kidney disease; AKI: Acute kidney injury; CPK: Creatinine phosphokinase.

Figure 2 Receiver operating characteristic curve. A: Receiver operating characteristic (ROC) curve showing the performance of the McMahon score in predicting acute kidney injury. The optimal cut-off value was 4.75, with a sensitivity of 78.6% and a specificity of 76.9%, as determined by the Youden index. The area under the curve (AUC) was 0.791 (95%CI: 0.662-0.919; P < 0.001); B: For lactate dehydrogenase as a predictor of acute kidney injury in patients with rhabdomyolysis. The optimal cut-off value was 537.5 IU/L, with a sensitivity of 85.2% and a specificity of 80.8%, as determined by the Youden index. The AUC was 0.853 (95%CI: 0.748–0.958; P < 0.001); C: For bicarbonate level as a predictor of acute kidney injury in patients with rhabdomyolysis, the optimal cut-off value was 21.35 mmol/L, yielding a sensitivity of 83.3% and a specificity of 67%, as determined by the Youden index. The AUC was 0.798 (95%CI: 0.677-0.919; P < 0.001). AUC: Area under the curve; LDH: Lactate dehydrogenase; ROC: Receiver operating characteristic; AKI: Acute kidney injury.