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World J Nephrol. Jun 25, 2026; 15(2): 110379
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.110379
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.110379
Factors associated with acute kidney injury in rhabdomyolysis: Insights from a prospective study
Hiba Ghabi, Amani Smai, Syrine Tlili, Lamia Rais, Ikram Mami, Mouhamed Karim Zouaghi, Department of Nephrology, la Rabta University Hospital, Tunis 1007, Tunisia
Hiba Ghabi, Amani Smai, Syrine Tlili, Lamia Rais, Bouthaina Mesbahi, Ines Bounaouas, Ikram Mami, Yosri Messaoudi, Mouhamed Karim Zouaghi, Tunis El Manar University, Faculty of Medicine of Tunis, Tunis 1007, Tunisia
Fethi Ben Hmida, Research Laboratory LR00SP01, Charles Nicole University Hospital, Tunis 1007, Tunisia
Bouthaina Mesbahi, Ines Bounaouas, Yosri Messaoudi, Department of Intensive Care, la Rabta University Hospital, Tunis 1007, Tunisia
Author contributions: Ghabi H contributed to the conceptualization and methodology; Smai A conducted the investigation, performed the formal analysis, and wrote the original draft; Bounaouas I and Mesbahi B curated the data; Zouaghi MK, Hmida FB, and Messaoudi Y supervised the study; Ghabi H, Tlili S, Mami I, and Rais L contributed to the review and editing of the manuscript; all authors reviewed and approved the final manuscript.
Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Rabta University Hospital.
Informed consent statement: All study participants or their legal guardians provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: The data presented in this study are available on request from the corresponding author due to privacy reasons.
Corresponding author: Hiba Ghabi, Assistant Professor, Department of Nephrology, la Rabta University Hospital, Jbel Lakhdar Street, Tunis 1007, Tunisia. hiba.ghabi@fmt.utm.tn
Received: June 7, 2025
Revised: July 23, 2025
Accepted: March 3, 2026
Published online: June 25, 2026
Processing time: 373 Days and 11.5 Hours
Revised: July 23, 2025
Accepted: March 3, 2026
Published online: June 25, 2026
Processing time: 373 Days and 11.5 Hours
Core Tip
Core Tip: To the best of our knowledge, this is the first prospective study specifically designed to explore factors associated with rhabdomyolysis-induced acute kidney injury. Our findings provide important clinical insights for nephrologists. These results may enhance risk stratification at the time of admission, allowing for earlier implementation of targeted preventive strategies and closer monitoring of renal function, ultimately contributing to improved patient outcomes.