Koukoulaki M, Iatrou C. The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis. World J Nephrol 2019; 8(4): 75-82 [PMID: 31523631 DOI: 10.5527/wjn.v8.i4.75]
Corresponding Author of This Article
Maria Koukoulaki, MD, MPhil, PhD, Associate Specialist, Center for Nephrology “G. Papadakis”, General Hospital of Nikaia - Piraeus “Agios Panteleimon”, D. Mantouvalou 3, Piraeus, Nikaia 18454, Greece. mkoukoulaki@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Koukoulaki M, Iatrou C. The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis. World J Nephrol 2019; 8(4): 75-82 [PMID: 31523631 DOI: 10.5527/wjn.v8.i4.75]
World J Nephrol. Aug 21, 2019; 8(4): 75-82 Published online Aug 21, 2019. doi: 10.5527/wjn.v8.i4.75
The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis
Maria Koukoulaki, Christos Iatrou
Maria Koukoulaki, Christos Iatrou, Center for Nephrology “G. Papadakis”, General Hospital of Nikaia – Piraeus “Agios Panteleimon”, Piraeus, Nikaia 18454, Greece
Author contributions: Koukoulaki M designed the study, acquired data, analyzed and interpreted data, drafted the article, and approved the final version submitted for review Iatrou C proposed the study, analyzed and interpreted data, critically revised the article, and approved the final version submitted for review.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Maria Koukoulaki, MD, MPhil, PhD, Associate Specialist, Center for Nephrology “G. Papadakis”, General Hospital of Nikaia - Piraeus “Agios Panteleimon”, D. Mantouvalou 3, Piraeus, Nikaia 18454, Greece. mkoukoulaki@gmail.com
Telephone: +30-213-2077658 Fax: +30-213-20176482
Received: March 4, 2019 Peer-review started: March 4, 2019 First decision: April 11, 2019 Revised: July 9, 2019 Accepted: July 16, 2019 Article in press: July 16, 2019 Published online: August 21, 2019 Processing time: 170 Days and 7.5 Hours
Core Tip
Core tip: Antineutrophil cytoplasmic antibody-associated vasculitis is characterized by a remitting - relapsing course of disease that requires long term immunosuppression. Mycophenolic acid has been evaluated as induction and remission maintenance agent in the treatment of antibody-associated vasculitis as a less toxic agent compared to cyclophosphamide and azathioprine. Mycophenolate has been proven a potent immunosuppressive agent and non-inferior to other available drugs with comparable side effect profile, but several studies have shown a higher relapse rate following discontinuation of mycophenolate or in mycophenolate treated subjects. In this review, the role of mycophenolate in treatment of antibody-associated vasculitis is further discussed.
