©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Monoclonal gammopathy of renal significance: Diagnostic workup
Sofia O Correia, Sofia Santos, Jorge Malheiro, António Cabrita, La Salete Martins, Josefina Santos, Nephrology and Transplant Department, Centro Hospitalar do Porto, 4099-001 Porto, Portugal
Author contributions: All authors equally contributed to this paper with literature review, critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: None of the authors has any potential conflicts of interest related to this study.
Correspondence to: Sofia O Correia, MD, Nephrology and Transplant Department, Centro Hospitalar do Porto, Largo Prof.Abel Salazar, 4099-001 Porto, Portugal. soacorreia@gmail.com
Telephone: +351-222-077500 Fax: +351-222-033189
Received: August 25, 2016
Peer-review started: August 27, 2016
First decision: September 27, 2016
Revised: December 28, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 6, 2017
Processing time: 192 Days and 13.8 Hours
Peer-review started: August 27, 2016
First decision: September 27, 2016
Revised: December 28, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 6, 2017
Processing time: 192 Days and 13.8 Hours
Core Tip
Core tip: Monoclonal gammopathy of renal significance is a wide group of kidney diseases. We discuss the most common diagnostic difficulties and suggest an algorithm for clinical approach. Screening for monoclonal immunoglobulin and an appropriate hematologic workup are fundamental and, sometimes a difficult challenge. Kidney biopsy is required to determine the exact nature of the lesion and to evaluate the severity of renal disease. Therefore, clinical and pathologic features are also discussed.