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World J Nephrol. Mar 6, 2016; 5(2): 189-194
Published online Mar 6, 2016. doi: 10.5527/wjn.v5.i2.189
Published online Mar 6, 2016. doi: 10.5527/wjn.v5.i2.189
Experimental models of renal calcium stones in rodents
Héloïse Bilbault, Jean-Philippe Haymann, Institut National de la Santé et de la Recherche Médicale, UMR_S 1155, 75020 Paris, France
Jean-Philippe Haymann, Service d’Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, 75020 Paris, France
Jean-Philippe Haymann, Sorbonne Universités, UPMC Univ Paris 06, DHUI2B, 75020 Paris, France
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Correspondence to: Dr. Jean-Philippe Haymann, MD, PhD, Service d’Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, 4 rue de la Chine, 75020 Paris, France. jean-philippe.haymann@tnn.aphp.fr
Telephone: +33-1-56016771 Fax: +33-1-56017003
Received: September 14, 2015
Peer-review started: September 17, 2015
First decision: October 30, 2015
Revised: December 8, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 6, 2016
Processing time: 167 Days and 9.5 Hours
Peer-review started: September 17, 2015
First decision: October 30, 2015
Revised: December 8, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 6, 2016
Processing time: 167 Days and 9.5 Hours
Core Tip
Core tip: We review here calcium rodent models classified upon the presence of nephrolithiasis or nephrocalcinosis which appear as two different entities. Nephrocalcinosis appears related to tubular cell injuries in the setting of urinary supersaturation whereas the pathophysiology of nephrolithiasis is mostly unraveled. Though few models are available, attachment of crystals in the fornix or in the papilla appear as a striking feature. Creating mice models of nephrolithiasis are thus required to understand the interaction between crystals and urothelium.