Hepatorenal syndrome: Update on diagnosis and treatment

doi:10.5527/wjn.v4.i5.511

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Nov 6, 2015; 4(5): 511-520
Published online Nov 6, 2015. doi: 10.5527/wjn.v4.i5.511

Hepatorenal syndrome: Update on diagnosis and treatment

Olga Baraldi, Chiara Valentini, Gabriele Donati, Giorgia Comai, Vania Cuna, Irene Capelli, Maria Laura Angelini, Maria Ilaria Moretti, Andrea Angeletti, Fabio Piscaglia, Gaetano La Manna

Olga Baraldi, Chiara Valentini, Gabriele Donati, Giorgia Comai, Vania Cuna, Irene Capelli, Maria Laura Angelini, Maria Ilaria Moretti, Andrea Angeletti, Gaetano La Manna, Department of Experimental, Diagnostic, Specialty Medicine, Nephrology, Dialysis, and Renal Transplant Unit, S. Orsola University Hospital, 40138 Bologna, Italy

Fabio Piscaglia, Division of Internal Medicine, Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy

Author contributions: Baraldi O and La Manna G designed the aim of the article, wrote the manuscript and made critical revisions; Valentini C, Donati G, Comai G, Cuna V, Capelli I, Angelini ML, Moretti MI, Angeletti A, Piscaglia F contributed equally to this work, generated the figures and wrote the manuscritps.

Conflict-of-interest statement: The authors do not have any disclosures to report.

Correspondence to: Gaetano La Manna, MD, PHD, Professor, Department of Experimental, Diagnostic, Specialty Medicine - Dialysis, Nephrology and Transplantation Unit, S. Orsola University Hospital, Via G. Massarenti 9, 40138 Bologna, Italy. gaetano.lamanna@unibo.it

Telephone: +39-51-2143255 Fax: +39-51-344439

Received: April 14, 2015
Peer-review started: April 15, 2015
First decision: May 13, 2015
Revised: August 13, 2015
Accepted: September 16, 2015
Article in press: September 18, 2015
Published online: November 6, 2015
Processing time: 211 Days and 12.5 Hours

Core Tip

Core tip: Hepatorenal syndrome is a functional and potentially reversible form of kidney failure. The pathophysiological bases of this disease are complex and not fully understood. The aim of this review is to focus the current diagnostic approach and the updated therapeutic protocols adopted in clinical practice.