©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. May 6, 2015; 4(2): 307-312
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.307
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.307
Species differences in regulation of renal proximal tubule transport by certain molecules
George Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Author contributions: All the authors contributed to writing of this manuscript.
Conflict-of-interest: None.
Correspondence to: George Seki, MD, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. georgeseki-tky@umin.ac.jp
Telephone: +81-3-38155411 Fax: +81-3-58008806
Received: November 26, 2014
Peer-review started: November 27, 2014
First decision: December 18, 2014
Revised: December 24, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: May 6, 2015
Processing time: 163 Days and 20.8 Hours
Peer-review started: November 27, 2014
First decision: December 18, 2014
Revised: December 24, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: May 6, 2015
Processing time: 163 Days and 20.8 Hours
Core Tip
Core tip: Renal proximal tubule (PT) transport is essential for the regulation of plasma volume and blood pressure. Several species differences are found as to the stimulatory effects of thiazolidinediones, insulin, and angiotensin II on PT sodium transport. This review focuses on this topic, which may be relevant to species-specific mechanisms underlying edema formation and/or hypertension occurrence.