Shankar M, Moorthy M, Shetty A, Gurusiddaiah SC. Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study. World J Nephrol 2026; 15(3): 119882 [DOI: 10.5527/wjn.119882]
Corresponding Author of This Article
Mythri Shankar, Associate Professor, Department of Nephrology, Institute of Nephrourology, Victoria Hospital Campus, Bengaluru 560102, Karnataka, India. mythri.nish@gmail.com
Research Domain of This Article
Urology & Nephrology
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research-article
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Shankar M, Moorthy M, Shetty A, Gurusiddaiah SC. Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study. World J Nephrol 2026; 15(3): 119882 [DOI: 10.5527/wjn.119882]
World J Nephrol. Sep 25, 2026; 15(3): 119882 Published online Sep 25, 2026. doi: 10.5527/wjn.119882
Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study
Sreedhara C Gurusiddaiah, Aditya Shetty, Manju Moorthy, Mythri Shankar
Mythri Shankar, Sreedhara C Gurusiddaiah, Department of Nephrology, Institute of Nephrourology, Bengaluru 560102, Karnataka, India
Manju Moorthy, Department of Bioinformatics, Theraques, Bangalore 560102, Karnātaka, India
Aditya Shetty, Department of Nephrology, AJ Institute of Medical Sciences and Research Centre, Mangalore 575008, Karnātaka, India
Author contributions: Shankar M conceptulised, procured grants, collected data, conducted the study, and wrote the article; Moorthy M designed the methodology, procured results, wrote and reviewed the article; Shetty A collected data; Gurusiddaiah SC reviewed the article.
Supported by the Rajiv Gandhi University of Health Sciences research grants for teaching faculty, No. 20MED276.
Institutional review board statement: The study was reviewed and approved by the Ethical Committee of the Institute of Nephro-urology (No. INU/IEC/CDSCO/11/20-21).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author. The data that support the findings of this study are openly available in GEO at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE263198, reference number No. GSE263198.
Corresponding author: Mythri Shankar, Associate Professor, Department of Nephrology, Institute of Nephrourology, Victoria Hospital Campus, Bengaluru 560102, Karnataka, India. mythri.nish@gmail.com
Received: February 10, 2026 Revised: March 4, 2026 Accepted: April 9, 2026 Published online: September 25, 2026 Processing time: 185 Days and 21.3 Hours
Core Tip
Core Tip: This case-control study evaluates urinary exosomal microRNAs (miRNAs) as noninvasive biomarkers for diagnosing immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis. In biopsy-proven IgAN, healthy controls, and diverse glomerular disease controls, a NanoString-based urinary exosomal miRNA panel was profiled, followed by least absolute shrinkage and selection operator feature selection, logistic regression, and combinatorial receiver operating characteristic analysis. A focused set of IgAN-associated miRNAs, and a minimal multi-miRNA combination, demonstrated good diagnostic performance to distinguish IgAN from both healthy individuals and other glomerular diseases, suggesting a potential future role for urine exosomal miRNA signatures in reducing reliance on invasive kidney biopsy.
