Emerging therapies and diagnostic innovations for multidrug-resistant infections in kidney allograft recipients: Challenges and future directions

doi:10.5527/wjn.118797

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Sep 25, 2026; 15(3): 118797
Published online Sep 25, 2026. doi: 10.5527/wjn.118797

Emerging therapies and diagnostic innovations for multidrug-resistant infections in kidney allograft recipients: Challenges and future directions

Mythri Shankar, Aditya Shetty

Aditya Shetty, Department of Nephrology, AJ Institute of Medical Sciences and Research Centre, Mangalore 575008, Karnātaka, India

Mythri Shankar, Department of Nephrology, Institute of Nephro-Urology, Bengaluru 560102, Karnataka, India

Co-first authors: Aditya Shetty and Mythri Shankar.

Author contributions: Shetty A and Shankar M contributed to data collection; they contributed equally to this manuscript as co-first authors; Shetty A wrote the article; Shankar M reviewed and edited the article. All authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Corresponding author: Mythri Shankar, DM, MD, Associate Professor, Department of Nephrology, Institute of Nephro-Urology, Victoria Hospital Campus, KR Market, Bengaluru 560102, Karnataka, India. mythri.nish@gmail.com

Received: January 12, 2026
Revised: February 16, 2026
Accepted: March 27, 2026
Published online: September 25, 2026
Processing time: 214 Days and 14.4 Hours

Core Tip

Core Tip: Multidrug-resistant bacterial infections are now a leading threat to survival and long-term graft function after kidney transplantation. This mini-review synthesizes current data on multidrug-resistant epidemiology, risk factors, and outcomes in kidney transplant recipients, and highlights emerging tools, such as rapid molecular diagnostics, novel β-lactam/β-lactamase inhibitor combinations, siderophore cephalosporins, and individualized perioperative antibiotic strategies. A kidney transplant-specific antimicrobial stewardship framework is proposed to balance timely, effective therapy with preservation of allograft function and containment of resistance.