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World J Nephrol. Jun 25, 2026; 15(2): 118214
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.118214
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.118214
Post vaccination acute kidney injury and other renal complications after COVID-19 and influenza vaccination
Yunn Honey Aye Kyaw, Pierre Yip, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
Kay Choong See, Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, 119228, Singapore
Co-first authors: Yunn Honey Aye Kyaw and Pierre Yip.
Author contributions: Aye Kyaw YH, Yip P and See KC designed the research study; Aye Kyaw YH and Yip P, performed the research; Aye Kyaw YH and Yip P curated the data and performed the investigation; See KC provided supervision; Aye Kyaw YH and Yip P prepared the figures and visualizations; Aye Kyaw YH and Yip P wrote the original draft; Aye Kyaw YH, Yip P and See KC reviewed and edited the manuscript; Aye Kyaw YH and Yip P contributed equally to this manuscript and are co-first authors. All authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: See KC declares receipt of personal fees for lectures and advisory board participation from Bavarian Nordic, GlaxoSmithKline, Moderna, and Pfizer, outside the submitted work. The other authors declare no conflict of interest with the submitted work.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Yunn Honey Aye Kyaw, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore. e0974487@u.nus.edu
Received: December 28, 2025
Revised: January 14, 2026
Accepted: March 3, 2026
Published online: June 25, 2026
Processing time: 170 Days and 18.2 Hours
Revised: January 14, 2026
Accepted: March 3, 2026
Published online: June 25, 2026
Processing time: 170 Days and 18.2 Hours
Core Tip
Core Tip: Renal adverse events following coronavirus disease 2019 and influenza vaccination are rare at the population level. While case reports describe immune-mediated kidney diseases occurring in temporal association with vaccination, large observational studies consistently demonstrate a low absolute risk of acute kidney injury and other renal outcomes. Clinicians should remain vigilant for unusual renal presentations after vaccination, particularly in high-risk individuals, while continuing to advocate vaccination given its substantial overall benefits.