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World J Nephrol. Jun 25, 2026; 15(2): 118160
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.118160
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.118160
Multicentre comparative study of neural epidermal growth factor-like 1 protein vs M-type phospholipase A2 receptor-associated membranous nephropathy
Subrahmanian Sathiavageesan, Department of Nephrology, Sundaram Hospital, Tiruchirappalli 620017, Tamil Nādu, India
Abirami Krishnan, Department of Nephrology, Kauvery Hospital, Salem 636201, Tamil Nādu, India
Krishnaswamy Sampathkumar, Department of Nephrology, Meenakshi Mission Hospital, Madurai 625107, Tamil Nādu, India
Ranjanee Muthu, Department of Nephrology, Apollo Hospitals, Chennai 600006, Tamil Nādu, India
Author contributions: Sathiavageesan S contributed to study conceptualization and designing, data acquisition, data visualisation, literature review, statistical analysis and prepared the first draft of the manuscript, taking responsibility as guarantor for the originality and integrity of the manuscript; Krishnan A, Krishnaswamy S and Muthu R contributed to study design, data acquisition and visualization, literature review and critically reviewed and revised the manuscript.
Institutional review board statement: This study was a retrospective observational study. None of the study components was experimental. The study was approved by the Institutional Ethics Committee of participating centres.
Informed consent statement: Not applicable because of retrospective study design.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data generated during this research are available with the corresponding author and can be obtained by reasonable request.
Corresponding author: Subrahmanian Sathiavageesan, MD, Chief Physician, Department of Nephrology, Sundaram Hospital, 17, EVR Road, Puthur, Tiruchirappalli 620017, Tamil Nādu, India. spssubrahmanian@yahoo.co.in
Received: December 25, 2025
Revised: January 11, 2026
Accepted: February 12, 2026
Published online: June 25, 2026
Processing time: 172 Days and 15.6 Hours
Revised: January 11, 2026
Accepted: February 12, 2026
Published online: June 25, 2026
Processing time: 172 Days and 15.6 Hours
Core Tip
Core Tip: This retrospective cohort study is the first study that directly compared the outcomes of neural epidermal growth factor-like 1 protein-associated MN (NELL1-MN) with M-type phospholipase A2 receptor-associated MN (PLA2R-MN) using time-to-event analysis. NELL1-MN showed a favourable prognosis with a higher rate of remission, faster time-to-remission, more spontaneous remission and a lower rate of treatment-resistant nephrotic syndrome compared to PLA2R-MN. Additionally, this study also observed that NELL1-MN was more strongly associated with traditional indigenous medicine intake than PLA2R-MN. Antigen-specific outcomes research could inform prognosis and aid therapeutic decision-making.