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World J Nephrol. Jun 25, 2026; 15(2): 116961
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.116961
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.116961
Early detection of contrast-associated acute kidney injury after coronary angiography: A predictive value of osteopontin
Nashwa M Azoz, Noura G Nasr, Mohamad A Sobh, Department of Internal Medicine-Nephrology, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut 71711, Egypt
Ahmed Abdel-Galeel, Department of Cardiovascular Medicine, Assiut University Heart Hospital, Faculty of Medicine, Assiut University, Assiut 71711 Egypt
Randa A Elzohne, Department of Clinical Pathology, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut 71711, Egypt
Randa A Elzohne, Department of Clinical Pathology, Badr University in Assiut, New Nasser City 82516, Assiut, Egypt
Rabea A Gadelkareem, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
Alaa O Ahmed, Department of Internal Medicine-Critical Care Unit, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut 71711, Egypt
Author contributions: Azoz NM and Nasr NG designed the research, collected the data, and wrote the paper; Sobh MA, Abdel-Galeel A, Elzohne RA, Gadelkareem RA, and Ahmed AO contributed to the literature review, writing, and revision; Sobh MA, Abdel-Galeel A, and Gadelkareem RA contributed to supervision of the work; Elzohne RA and Ahmed AO contributed to statistical analysis; All authors read and approved the final version of the manuscript.
Supported by the Grants Office, Faculty of Medicine, Assiut University (Egypt), No. 2022-09-25-001.
Institutional review board statement: This prospective study was approved by the Ethics Committee of Faculty of Medicine, Assiut University (Approval No. 17200785).
Clinical trial registration statement: This study is registered at Clinical Trials (ClinicalTrials.gov). The registration identification number is NCT05547581.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The raw data will be available from the authors on reasonable request.
Corresponding author: Rabea A Gadelkareem, MD, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Received: November 25, 2025
Revised: December 20, 2025
Accepted: February 2, 2026
Published online: June 25, 2026
Processing time: 200 Days and 23.5 Hours
Revised: December 20, 2025
Accepted: February 2, 2026
Published online: June 25, 2026
Processing time: 200 Days and 23.5 Hours
Core Tip
Core Tip: Serum osteopontin (OPN) is a strong and independent biomarker for predicting contrast-associated acute kidney injury after percutaneous coronary intervention. Its combination with the Mehran risk score offers the highest diagnostic accuracy. The current study presented novel evidence that OPN levels, measured before and after percutaneous coronary intervention, were significantly elevated in patients with contrast-associated acute kidney injury, identifying OPN as a robust and independent predictor (alongside the Mehran score and contrast volume). Integrating OPN with the Mehran score yielded a diagnostic accuracy of 88%, suggesting that OPN should be incorporated into risk stratification strategies for timely preventive interventions.