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World J Nephrol. Jun 25, 2026; 15(2): 116474
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.116474
Published online Jun 25, 2026. doi: 10.5527/wjn.v15.i2.116474
Protective effect of boric acid on kidney tissue and oxidative stress after testicular torsion/detorsion in male rats
Uğur M Adam, Department of Anesthesiology and Reanimation, Uşak Training and Research Hospital, Uşak 64100, Türkiye
Metin Alkan, Mustafa Arslan, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara 06560, Türkiye
Şaban C Sezen, Department of Histology and Embryology, Kırıkkale University Faculty of Medicine, Kırıkkale 71450, Türkiye
Mustafa Kavutçu, Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara 06560, Türkiye
Co-corresponding authors: Uğur M Adam and Mustafa Arslan.
Author contributions: Adam UM, Alkan M and Arslan M designed the study, and analyzed and interpreted data, performed the experiments; Alkan M, Sezen ŞC and Kavutçu M confirm the authenticity of all the raw data; Adam UM, Kavutçu M, Arslan M and Sezen ŞC provided scientific and technical assistance, and critically revised the article for important intellectual content; Adam UM and Alkan M collected samples; Kavutçu M and Sezen ŞC performed biochemical and histopathological experiments. All authors have read and approved the final manuscript; Adam UM and Arslan M contributed equally as co-corresponding authors to this work, their responsibilities included overseeing the research process and conducting the final critical revision of the article.
Institutional animal care and use committee statement: Ethical approval for the study was obtained from Animal Research Committee of Gazi University.
Conflict-of-interest statement: All authors declare no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Uğur M Adam, MD, Department of Anesthesiology and Reanimation, Uşak Training and Research Hospital, Fevzi Çakmak Mh. No. 4 Denizli Cd., Uşak 64100, Türkiye. ugurmusa@hotmail.com
Received: November 12, 2025
Revised: December 30, 2025
Accepted: February 12, 2026
Published online: June 25, 2026
Processing time: 211 Days and 10 Hours
Revised: December 30, 2025
Accepted: February 12, 2026
Published online: June 25, 2026
Processing time: 211 Days and 10 Hours
Core Tip
Core Tip: Ischemia/reperfusion (I/R) injury is a serious problem that is encountered in several clinical settings. Testicular torsion/detorsion (T/D) is one example. It is known that damage to distant organs can occur following I/R. Significant scientific data and experimental studies demonstrate the antioxidant effects of boric acid (BA), such as increasing antioxidant enzyme levels and reducing oxidative stress. The protective role of BA against potential kidney damage has been investigated. These findings suggest that BA may protect against distant I/R damage from testicular T/D. This may facilitate further research into the use of BA as a treatment for I/R injury.