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World J Nephrol. Mar 25, 2026; 15(1): 114142
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.114142
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.114142
Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction
Salih Toruk, Avni Babacan, Mustafa Arslan, Volkan Şıvgın, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara 06560, Türkiye
Şaban Cem Sezen, Department of Histology and Embryology, Faculty of Medicine, Kırıkkale University, Kırıkkale 71100, Türkiye
Hakan Boyunağa, Department of Medical Biochemistry, Faculty of Medicine, Kırıkkale University, Kırıkkale 71100, Türkiye
Co-corresponding authors: Salih Toruk and Mustafa Arslan.
Author contributions: Toruk S drafted the manuscript; Toruk S and Arslan M designed the research study, analyzed and interpreted the data, and they contributed equally to this manuscript as co-corresponding authors; Toruk S, Babacan A, and Şıvgın V performed the animal experiments; Sezen ŞC and Boyunağa H conducted biochemical and histopathological analyses. All authors critically revised the manuscript, approved the final version, and agreed to be accountable for all aspects of the work.
Institutional animal care and use committee statement: This experimental study was approved by the Animal Experiments Local Ethics Committee of Gazi University (approval No: G.Ü.ET-19.049) and conducted at the Gazi University Laboratory Animal Research Center.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Salih Toruk, MD, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, No. 47 Emniyet Mh. Mevlana Blv., Ankara 06560, Türkiye. salihtoruk@gmail.com
Received: September 12, 2025
Revised: October 27, 2025
Accepted: January 8, 2026
Published online: March 25, 2026
Processing time: 183 Days and 8.5 Hours
Revised: October 27, 2025
Accepted: January 8, 2026
Published online: March 25, 2026
Processing time: 183 Days and 8.5 Hours
Core Tip
Core Tip: This experimental study explores the protective effects of cerium oxide (CeO2), a powerful antioxidant nanoparticle, against renal injury induced by ibuprofen in rats with unilateral ureteral obstruction. Histopathological and biochemical analyses demonstrated that CeO2 significantly reduced tubular degeneration, glomerular vacuolization, and oxidative stress markers in both the obstructed and contralateral kidneys. These results indicate that CeO2 may function as a nephroprotective adjunct during non-steroidal anti-inflammatory drug therapy, potentially mitigating renal damage associated with obstructive uropathy.